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Example1
Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
2 ACVR1 related diseases
H00430
Fibrodysplasia ossificans progressiva (FOP)
135100
Fibrodysplasia ossificans progressiva
Summary of query kinase
Query kinase
ACVR1 (
Q04771
)
Kinase group
TKL
Number of conformation types
2
Number of structural templates
4 (
Total 47 inhibitors
)
Number of ACVR1 related diseases
2 (
H00430
135100
)
Number of allelic variants
8 (
G328E
G328R
G328W
G356D
R202I
R206H
R258S
R375P
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
3
3Q4UA_LDN
(ACVR1)
TKL
LDN193189
I
11
37
43
A
3Q4UA_LDN
(ACVR1)
TKL
LDN193189
I
11
37
43
11
37
43
A
3MTFA_A3F
(ACVR1)
TKL
Erlotinib
I
7
15
33
7
15
33
A
3OOMA_507
(ACVR1)
TKL
AC1NURHU
I
1
1
1
1
1
1
B
1
3H9RA_TAK
(ACVR1)
TKL
dorsomorphin
I
15
67
37
B
3H9RA_TAK
(ACVR1)
TKL
dorsomorphin
I
15
67
37
15
67
37