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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
6 PRKX related diseases
hsa05020
Prion diseases
hsa05030
Cocaine addiction
hsa05110
Vibrio cholerae infection
hsa05146
Amoebiasis
hsa05169
Epstein-Barr virus infection
hsa05414
Dilated cardiomyopathy
Summary of query kinase
Query kinase
PRKX (
P51817
)
Kinase group
AGC
Number of conformation types
0
Number of structural templates
22 (
Total 21 inhibitors
)
Number of PRKX related diseases
6 (
hsa05020
hsa05030
hsa05110
hsa05146
hsa05169
hsa05414
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
11
1NVQA_UCN
(CHEK1)
AGC
UCN 02
I
179
65
79
A
1NVQA_UCN
(CHEK1)
AGC
UCN 02
I
179
65
79
179
65
79
A
1NVRA_STU
(CHEK1)
AGC
staurosporine
I
179
71
79
179
71
79
A
2HZ4A_4ST
(ABL1)
AGC
staurosporine
I
159
103
156
159
103
156
A
2ETKA_HFS
(ROCK1)
AGC
HMS2231N23
I
6
12
24
6
12
24
A
3D9VA_H52
(ROCK1)
AGC
H-1152P
I
7
16
24
7
16
24
A
3HA8A_5JZ
(MAPK14)
AGC
DEL-B, 14b
I
59
89
62
59
89
62
A
2JDOA_I5S
(AKT2)
AGC
I5S
I
10
22
29
10
22
29
A
1NVSA_UCM
(CHEK1)
AGC
SB218078
I
97
6
53
97
6
53
A
3D0EA_G93
(AKT2)
AGC
9-N-ethyl-8-...
I
30
15
45
30
15
45
A
2JDRA_L20
(AKT2)
AGC
A-443654
I
44
255
61
44
255
61
A
3L8XA_N4D
(MAPK14)
AGC
3cg2
I
91
104
65
91
104
65
B
11
3CD3A_STU
(FES)
AGC
staurosporine
I
131
107
138
B
3CD3A_STU
(FES)
AGC
staurosporine
I
131
107
138
131
107
138
B
3D7TA_STU
(CSK)
AGC
staurosporine
I
70
68
99
70
68
99
B
1OKYA_STU
(PDPK1)
AGC
staurosporine
I
179
67
109
179
67
109
B
1OKZA_UCN
(PDPK1)
AGC
UCN 02
I
179
60
109
179
60
109
B
1WVYA_STU
(DAPK1)
AGC
staurosporine
I
83
23
55
83
23
55
B
3BKBA_STU
(FES)
AGC
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
AGC
staurosporine
I
131
107
138
131
107
138
B
3NYNA_SGV
(GRK6)
AGC
SMR000127424
I
54
7
47
54
7
47
B
3EFWA_AK8
(AURKA)
AGC
3efw
I
100
59
105
100
59
105
B
3L9MA_L9M
(PRKACA)
AGC
VX_680
I
37
65
42
37
65
42
B
2ESMA_M77
(ROCK1)
AGC
HMS2231N23
I
6
15
24
6
15
24