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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 ROS1 related diseases
H00014
Non-small cell lung cancer
Summary of query kinase
Query kinase
ROS1 (
P08922
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
49 (
Total 54 inhibitors
)
Number of ROS1 related diseases
1 (
H00014
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
29
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
2JFLA_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2J51A_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
3B2WA_9NH
(LCK)
TK
MLS000911569
II
30
32
98
30
32
98
A
3C4FA_C4F
(FGFR1)
TK
AC1O6YNE
I
23
45
56
23
45
56
A
3KMMA_LHL
(LCK)
TK
AZD_1152HQPA
I
29
99
95
29
99
95
A
3PJ1A_LHL
(BTK)
TK
AZD_1152HQPA
I
30
99
96
30
99
96
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
3LXLA_IZA
(JAK3)
TK
Pyridone 6
I
30
11
63
30
11
63
A
3LXPA_IZA
(TYK2)
TK
Pyridone 6
I
9
3
20
9
3
20
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
2HK5A_1BM
(HCK)
TK
1BM
I
24
121
70
24
121
70
A
2ZYBA_KSL
(LCK)
TK
DB08056
I
36
172
80
36
172
80
A
3ACJA_KSS
(LCK)
TK
6,7-dimethox...
I
13
7
25
13
7
25
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
3ACKA_KSR
(LCK)
TK
AC1O6YMO
I
23
42
56
23
42
56
B
18
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2X9FA_X9F
(EPHB4)
TK
X9F
I
46
19
86
46
19
86
B
2WKMA_PFY
(MET)
TK
PHA-665752
I
38
34
98
38
34
98
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
B
2B7AA_IZA
(JAK2)
TK
Pyridone 6
I
34
12
65
34
12
65
B
3EYHA_IZA
(JAK1)
TK
Pyridone 6
I
21
19
54
21
19
54
B
3EKKA_GS2
(INSR)
TK
pyrrolo[2,3-...
I
33
131
65
33
131
65
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
3NZ0A_IZA
(TYK2)
TK
Pyridone 6
I
12
3
24
12
3
24
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
D
2
1R0PA_KSA
(MET)
TK
k-252a
I
28
79
64
D
1R0PA_KSA
(MET)
TK
k-252a
I
28
79
64
28
79
64
D
2WGJA_VGH
(MET)
TK
Crizotinib
I
21
23
55
21
23
55