Allelic Variants
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There are no related allelic variants
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| Number of involved diseases in the family |
123 |
| Number of FRK related diseases |
0 |
All kinase in this family
FRK
Allelic
Variants |
Disease Description |
Involved kinases
(This family) |
Inhibitor of
Involved Kinases |
Search
Disease |
| Prostate cancer | BRAF, EGFR, EPHB2, FGFR2,
IGF1R, INSRR, PDGFRA,
PDGFRB, PDPK1 | 2 | Link | | n/a | Epstein-Barr virus infection | FGR, JAK1, JAK3, LYN, SYK,
TYK2 | 3 | Link | | Melanoma | BRAF, EGFR, IGF1R, MET,
PDGFRA, PDGFRB | 9 | Link | | n/a | Measles | FYN, IRAK4, JAK1, JAK2,
JAK3, TYK2 | 1 | Link | | Leukemia | ABL1, ABL2, BRAF, JAK2, KIT,
PDGFRB | 1 | Link | | n/a | Epithelial cell signaling in Helicobacter pylori infection | CSK, EGFR, LYN, MET, SRC | 9 | Link | | n/a | Tuberculosis | IRAK4, JAK1, JAK2, SRC, SYK | 3 | Link | | n/a | Hepatitis C | BRAF, EGFR, JAK1, TYK2 | 2 | Link | | n/a | Influenza A | IRAK4, JAK1, JAK2, TYK2 | 1 | Link | | n/a | Toxoplasmosis | IRAK4, JAK1, JAK2, TYK2 | 1 | Link | | Neuroblastoma | ALK, NTRK1, NTRK2, NTRK3 | 3 | Link | | Lung cancer | ALK, BRAF, EGFR, ROS1 | 4 | Link | | n/a | Leishmaniasis | IRAK4, JAK1, JAK2 | 1 | Link | | n/a | Bladder cancer | DAPK1, EGFR, FGFR3 | 2 | Link | | n/a | Herpes simplex infection | JAK1, JAK2, TYK2 | 1 | Link | | n/a | Glioma | EGFR, PDGFRA, PDGFRB | 2 | Link | | Gastric cancer | EGFR, FGFR2, MET | 9 | Link | | n/a | Immunodeficiencies | JAK3, LCK, ZAP70 | 1 | Link | | n/a | Thyroid cancer | BRAF, NTRK1, RET | 1 | Link | | n/a | Viral myocarditis | ABL1, ABL2, FYN | 1 | Link | | n/a | Alcoholism | BRAF, NTRK2 | 1 | Link | | Colorectal cancer | BRAF, FGFR3 | 1 | Link | | Colon cancer | AURKA, SRC | 5 | Link | | Gastrointestinal stromal tumor | KIT, PDGFRA | 1 | Link | | n/a | Myeloproliferative disorder | JAK2, PDGFRB | 1 | Link | | LADD syndrome | FGFR2, FGFR3 | 1 | Link | | n/a | Medullary thyroid carcinoma | NTRK1, RET | 1 | Link | | Crouzon syndrome | FGFR2, FGFR3 | 1 | Link | | n/a | Cervical cancer | EGFR, FGFR3 | 2 | Link | | SCID | JAK3, LCK | 1 | Link | | n/a | Shigellosis | ABL1, SRC | 1 | Link | | Hemangioma | FLT4, KDR | 1 | Link | | n/a | Choriocarcinoma | CSF1R, EGFR | 2 | Link | | n/a | Pathogenic Escherichia coli infection | ABL1, FYN | 1 | Link | | Adenocarcinoma of lung | BRAF, EGFR | 2 | Link | | Craniosynostosis | FGFR2 | 1 | Link | | n/a | FGFR3-related short limb skeletal dysplasias | FGFR3 | 1 | Link | | Bent bone dysplasia syndrome | FGFR2 | 1 | Link | | Craniofacial-skeletal-dermatologic dysplasia | FGFR2 | 1 | Link | | n/a | CATSHL syndrome | FGFR3 | 1 | Link | | n/a | Multiple myeloma | FGFR3 | 1 | Link | | n/a | Achondroplasia | FGFR3 | 1 | Link | | Scaphocephaly | FGFR2 | 1 | Link | | n/a | Scaphocephaly and Axenfeld-Rieger anomaly | FGFR2 | 1 | Link | | n/a | Saethre-Chotzen syndrome | FGFR2 | 1 | Link | | Jackson-Weiss syndrome | FGFR2 | 1 | Link | | Pfeiffer syndrome | FGFR2 | 1 | Link | | Apert syndrome | FGFR2 | 1 | Link | | Beare-Stevenson cutis gyrata syndrome | FGFR2 | 1 | Link | | Agammaglobulinemia | BTK | 2 | Link | | n/a | Agammaglobulinemia and isolated hormone deficiency | BTK | 2 | Link | | n/a | Leukoencephalopathy, diffuse hereditary, with spheroids | CSF1R | 1 | Link | | n/a | Pituitary Dwarfism | BTK | 2 | Link | | n/a | Agammaglobulinemias | BTK | 2 | Link | | Cardiofaciocutaneous syndrome | BRAF | 1 | Link | | LEOPARD syndrome | BRAF | 1 | Link | | Noonan syndrome | BRAF | 1 | Link | | n/a | Spondylometaepiphyseal dysplasia | DDR2 | 1 | Link | | n/a | Oral cancer | EGFR | 2 | Link | | n/a | Chrondrodysplasia | BMPR1B | 1 | Link | | Brachydactyly | BMPR1B | 1 | Link | | n/a | Maturity onset diabetes of the young | BLK | 1 | Link | | n/a | Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis | FGFR2 | 1 | Link | | n/a | Laryngeal cancer | EGFR | 2 | Link | | n/a | Hypochondroplasia | FGFR3 | 1 | Link | | n/a | Esophageal cancer | EGFR | 2 | Link | | n/a | Noonan syndrome and related disorders | BRAF | 1 | Link | | n/a | Malignant melanoma | BRAF | 1 | Link | | n/a | Lymphedemas | FLT4 | 1 | Link | | n/a | Muenke syndrome | FGFR3 | 1 | Link | | n/a | Insensitivity to pain | NTRK1 | 1 | Link | | n/a | Obesity | NTRK2 | 1 | Link | | n/a | Hypereosinophilic syndrome | PDGFRA | 1 | Link | | n/a | Salmonella infection | PKN1 | 1 | Link | | n/a | Short rib-polydactyly syndorme | NEK1 | 1 | Link | | n/a | Myasthenic syndrome | MUSK | 1 | Link | | n/a | Cholangiocarcinoma | MET | 8 | Link | | n/a | Malaria | MET | 8 | Link | | n/a | Autism suseptibility | MET | 8 | Link | | n/a | Congenital myasthenic syndrome | MUSK | 1 | Link | | Hepatocellular carcinoma | MET | 8 | Link | | n/a | Renal agenesis and Renal adysplasia | RET | 1 | Link | | Hirschsprung disease | RET | 1 | Link | | Mental retardation | RPS6KA3 | 1 | Link | | n/a | Basal cell carcinoma | STK36 | 1 | Link | | n/a | Transient erythroblastopenia of childhood | TEC | 1 | Link | | Selective T-cell defect | ZAP70 | 1 | Link | | n/a | Tyrosine kinase 2 deficiency | TYK2 | 1 | Link | | n/a | Coffin-Lowry syndrome | RPS6KA3 | 1 | Link | | n/a | Non-syndromic X-linked mental retardation | RPS6KA3 | 1 | Link | | n/a | Congenital central hypoventilation syndrome | RET | 1 | Link | | Central hypoventilation syndrome | RET | 1 | Link | | Multiple endocrine neoplasia | RET | 1 | Link | | Renal agenesis | RET | 1 | Link | | Pheochromocytoma | RET | 1 | Link | | Renal cell carcinoma | MET | 8 | Link | | Retinitis pigmentosa | MERTK | 1 | Link | | n/a | Synovial sarcoma | IGF1R | 1 | Link | | Insulin-like growth factor I | IGF1R | 1 | Link | | n/a | Leprechaunism | INSR | 8 | Link | | Diabetes mellitus | INSR | 8 | Link | | Rabson-Mendenhall syndrome | INSR | 8 | Link | | n/a | Malignant pleural mesothelioma | IGF1R | 1 | Link | | n/a | Prion diseases | FYN | 1 | Link | | n/a | Nevus | FGFR3 | 1 | Link | | n/a | Spermatocytic seminoma | FGFR3 | 1 | Link | | n/a | Thanatophoric dysplasia | FGFR3 | 1 | Link | | n/a | Lymphedema | FLT4 | 1 | Link | | n/a | Cancer progression/metastasis | FGFR4 | 1 | Link | | Hyperinsulinemic hypoglycemia | INSR | 8 | Link | | n/a | Pertussis | IRAK4 | 1 | Link | | Thrombocythemia | JAK2 | 1 | Link | | Piebaldism | KIT | 1 | Link | | n/a | Germ cell tumors | KIT | 1 | Link | | Mastocytosis with associated hematologic disorder | KIT | 1 | Link | | Mast cell leukemia | KIT | 1 | Link | | Myelofibrosis | JAK2 | 1 | Link | | n/a | Budd-Chiari syndrome | JAK2 | 1 | Link | | n/a | Chagas disease | IRAK4 | 1 | Link | | n/a | Invasive pneumococcal disease | IRAK4 | 1 | Link | | IRAK4 deficiency | IRAK4 | 1 | Link | | Polycythemia vera | JAK2 | 1 | Link | | Lymphoproliferative syndrome | ITK | 1 | Link |
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