KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 3MIYA_B49 (PDB code: 3MIY, chain A)
Number of involved diseases in the family	110
Number of ITK related diseases	1

All kinase in this family ITK

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Prostate cancer	AKT2, CDK2, EGFR, FGFR2, IGF1R, INSRR, PDGFRA, PDGFRB	58	Link
	Melanoma	AKT2, CDK4, CDK6, EGFR, IGF1R, MET, PDGFRA, PDGFRB	54	Link
	Lung cancer	AKT2, ALK, CDK2, CDK4, CDK6, EGFR, ROS1	42	Link
	Leukemia	ABL1, AKT2, CDK4, CDK6, JAK2, KIT, PDGFRB	31	Link
n/a	Measles	AKT2, CDK2, CDK4, CDK6, IRAK4, JAK2	16	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	EGFR, MET, PAK1, SRC	39	Link
n/a	Tuberculosis	AKT2, IRAK4, JAK2, SRC	12	Link
n/a	Epstein-Barr virus infection	AKT2, CDC2, CDK2, RIPK1	13	Link
	Neuroblastoma	ALK, NTRK1, NTRK2, NTRK3	10	Link
n/a	Glioma	CDK4, EGFR, PDGFRA, PDGFRB	50	Link
n/a	Herpes simplex infection	CDC2, CDK2, JAK2	14	Link
n/a	Cervical cancer	CDK4, EGFR, FGFR3	32	Link
n/a	Influenza A	AKT2, IRAK4, JAK2	8	Link
n/a	Toxoplasmosis	AKT2, IRAK4, JAK2	8	Link
	Gastric cancer	EGFR, FGFR2, MET	35	Link
n/a	Hepatitis C	AKT2, EGFR, RIPK1	30	Link
n/a	Bladder cancer	EGFR, FGFR3	32	Link
	Crouzon syndrome	FGFR2, FGFR3	7	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	19	Link
	LADD syndrome	FGFR2, FGFR3	7	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	29	Link
	Colon cancer	AURKA, SRC	11	Link
	Diabetes mellitus	AKT2, INSR	6	Link
n/a	Medullary thyroid carcinoma	NTRK1, RET	9	Link
n/a	Chagas disease	AKT2, IRAK4	6	Link
n/a	Leishmaniasis	IRAK4, JAK2	8	Link
n/a	Thyroid cancer	NTRK1, RET	9	Link
n/a	Shigellosis	ABL1, SRC	11	Link
	Scaphocephaly	FGFR2	6	Link
	Adenocarcinoma of lung	EGFR	29	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	6	Link
	Apert syndrome	FGFR2	6	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	6	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	6	Link
n/a	Saethre-Chotzen syndrome	FGFR2	6	Link
	Jackson-Weiss syndrome	FGFR2	6	Link
	Pfeiffer syndrome	FGFR2	6	Link
	Craniosynostosis	FGFR2	6	Link
	Bent bone dysplasia syndrome	FGFR2	6	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	6	Link
n/a	Malignant melanoma	CDK4	3	Link
n/a	Laryngeal cancer	EGFR	29	Link
	Hypoinsulinemic hypoglycemia	AKT2	2	Link
n/a	Maturity onset diabetes of the young	BLK	7	Link
n/a	Familial partial lipodystrophy	AKT2	2	Link
	Ovarian cancer	AKT2	2	Link
n/a	Pathogenic Escherichia coli infection	ABL1	8	Link
n/a	Viral myocarditis	ABL1	8	Link
n/a	Agammaglobulinemias	BTK	2	Link
n/a	Pituitary Dwarfism	BTK	2	Link
n/a	Esophageal cancer	EGFR	29	Link
n/a	Choriocarcinoma	EGFR	29	Link
n/a	Oral cancer	EGFR	29	Link
n/a	Spondylometaepiphyseal dysplasia	DDR2	3	Link
	Agammaglobulinemia	BTK	2	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	2	Link
n/a	Multiple myeloma	FGFR3	7	Link
n/a	Achondroplasia	FGFR3	7	Link
n/a	FGFR3-related short limb skeletal dysplasias	FGFR3	7	Link
	Hepatocellular carcinoma	MET	8	Link
n/a	Congenital myasthenic syndrome	MUSK	4	Link
n/a	Myasthenic syndrome	MUSK	4	Link
n/a	Short rib-polydactyly syndorme	NEK1	1	Link
n/a	Autism suseptibility	MET	8	Link
n/a	Malaria	MET	8	Link
n/a	Immunodeficiencies	LCK	8	Link
	SCID	LCK	8	Link
	REtinitis pigmentosa	MAK	1	Link
n/a	Cholangiocarcinoma	MET	8	Link
	Renal cell carcinoma	MET	8	Link
n/a	Insensitivity to pain	NTRK1	8	Link
n/a	Alcoholism	NTRK2	8	Link
	Central hypoventilation syndrome	RET	9	Link
	Multiple endocrine neoplasia	RET	9	Link
	Pheochromocytoma	RET	9	Link
	Renal agenesis	RET	9	Link
n/a	Congenital central hypoventilation syndrome	RET	9	Link
	Hirschsprung disease	RET	9	Link
n/a	Obesity	NTRK2	8	Link
n/a	Non-syndromic X-linked mental retardation	PAK3	5	Link
	Mental retardation	PAK3	5	Link
n/a	Renal agenesis and Renal adysplasia	RET	9	Link
n/a	Hypereosinophilic syndrome	PDGFRA	7	Link
	Mastocytosis with associated hematologic disorder	KIT	19	Link
	Mast cell leukemia	KIT	19	Link
n/a	Cancer progression/metastasis	FGFR4	2	Link
n/a	Endocrine-cerebroosteodysplasia	ICK	4	Link
n/a	Malignant pleural mesothelioma	IGF1R	3	Link
n/a	Synovial sarcoma	IGF1R	3	Link
n/a	Thanatophoric dysplasia	FGFR3	7	Link
n/a	Spermatocytic seminoma	FGFR3	7	Link
n/a	CATSHL syndrome	FGFR3	7	Link
	Colorectal cancer	FGFR3	7	Link
n/a	Hypochondroplasia	FGFR3	7	Link
n/a	Nevus	FGFR3	7	Link
n/a	Muenke syndrome	FGFR3	7	Link
	Insulin-like growth factor I	IGF1R	3	Link
n/a	Leprechaunism	INSR	6	Link
n/a	Budd-Chiari syndrome	JAK2	6	Link
	Myelofibrosis	JAK2	6	Link
	Thrombocythemia	JAK2	6	Link
n/a	Germ cell tumors	KIT	19	Link
	Piebaldism	KIT	19	Link
	Polycythemia vera	JAK2	6	Link
	Lymphoproliferative syndrome	ITK	12	Link
	Rabson-Mendenhall syndrome	INSR	6	Link
	Hyperinsulinemic hypoglycemia	INSR	6	Link
n/a	Pertussis	IRAK4	5	Link
	IRAK4 deficiency	IRAK4	5	Link
n/a	Invasive pneumococcal disease	IRAK4	5	Link

BioXGEM.

KIDFamMap

Allelic Variants