Allelic Variants
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There are no related allelic variants
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| Number of involved diseases in the family |
100 |
| Number of LCK related diseases |
2 |
All kinase in this family
LCK
Allelic
Variants |
Disease Description |
Involved kinases
(This family) |
Inhibitor of
Involved Kinases |
Search
Disease |
| n/a | Tuberculosis | IRAK4, JAK2, MAPK14, PLK3,
RAF1, SRC, SYK | 24 | Link | | Prostate cancer | BRAF, CDK2, EGFR, FGFR1,
FGFR2, IGF1R, RAF1 | 87 | Link | | n/a | Epstein-Barr virus infection | CDC2, CDK2, FGR, LYN,
MAPK14, SYK | 22 | Link | | Leukemia | ABL1, BRAF, JAK2, KIT, RAF1,
TGFBR1 | 30 | Link | | n/a | Influenza A | IRAK4, JAK2, MAPK14, PRKCA,
RAF1 | 14 | Link | | Melanoma | BRAF, EGFR, FGFR1, IGF1R,
RAF1 | 69 | Link | | n/a | Epithelial cell signaling in Helicobacter pylori infection | CSK, EGFR, LYN, MAPK14, SRC | 41 | Link | | n/a | Hepatitis C | BRAF, EGFR, MAPK14, RAF1 | 44 | Link | | n/a | Measles | CDK2, FYN, IRAK4, JAK2 | 22 | Link | | Lung cancer | ALK, BRAF, CDK2, EGFR | 56 | Link | | n/a | Herpes simplex infection | CDC2, CDK2, JAK2 | 24 | Link | | n/a | Toxoplasmosis | IRAK4, JAK2, MAPK14 | 8 | Link | | n/a | Shigellosis | ABL1, MAPK14, SRC | 13 | Link | | n/a | Leishmaniasis | IRAK4, JAK2, MAPK14 | 8 | Link | | n/a | Chagas disease | IRAK4, MAPK14, TGFBR1 | 10 | Link | | n/a | Pathogenic Escherichia coli infection | ABL1, FYN, PRKCA | 7 | Link | | n/a | Viral myocarditis | ABL1, FYN | 3 | Link | | Jackson-Weiss syndrome | FGFR1, FGFR2 | 9 | Link | | n/a | Pertussis | IRAK4, MAPK14 | 2 | Link | | n/a | Immunodeficiencies | LCK, ZAP70 | 26 | Link | | Pfeiffer syndrome | FGFR1, FGFR2 | 9 | Link | | Colon cancer | AURKA, SRC | 15 | Link | | Gastric cancer | EGFR, FGFR2 | 35 | Link | | n/a | Alcoholism | BRAF, RAF1 | 13 | Link | | n/a | Thyroid cancer | BRAF, RET | 16 | Link | | Adenocarcinoma of lung | BRAF, EGFR | 42 | Link | | Noonan syndrome | BRAF, RAF1 | 13 | Link | | LEOPARD syndrome | BRAF, RAF1 | 13 | Link | | n/a | Cervical cancer | EGFR | 30 | Link | | Trigonocephaly | FGFR1 | 4 | Link | | n/a | Glioma | EGFR | 30 | Link | | Apert syndrome | FGFR2 | 5 | Link | | Beare-Stevenson cutis gyrata syndrome | FGFR2 | 5 | Link | | n/a | Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis | FGFR2 | 5 | Link | | Kallmann syndrome | FGFR1 | 4 | Link | | n/a | Laryngeal cancer | EGFR | 30 | Link | | Hypogonadotropic hypogonadism | FGFR1 | 4 | Link | | Osteoglophonic dysplasia | FGFR1 | 4 | Link | | n/a | Bladder cancer | EGFR | 30 | Link | | n/a | Choriocarcinoma | EGFR | 30 | Link | | n/a | Agammaglobulinemias | BTK | 1 | Link | | Colorectal cancer | BRAF | 12 | Link | | Cardiofaciocutaneous syndrome | BRAF | 12 | Link | | n/a | Noonan syndrome and related disorders | BRAF | 12 | Link | | n/a | Maturity onset diabetes of the young | BLK | 1 | Link | | n/a | Pituitary Dwarfism | BTK | 1 | Link | | Agammaglobulinemia | BTK | 1 | Link | | n/a | Esophageal cancer | EGFR | 30 | Link | | n/a | Malignant melanoma | BRAF | 12 | Link | | n/a | Oral cancer | EGFR | 30 | Link | | Bent bone dysplasia syndrome | FGFR2 | 5 | Link | | n/a | Agammaglobulinemia and isolated hormone deficiency | BTK | 1 | Link | | Neuroblastoma | ALK | 1 | Link | | LADD syndrome | FGFR2 | 5 | Link | | Craniofacial-skeletal-dermatologic dysplasia | FGFR2 | 5 | Link | | n/a | Amoebiasis | PRKCA | 5 | Link | | n/a | Pituitary tumor | PRKCA | 5 | Link | | n/a | Renal agenesis and Renal adysplasia | RET | 4 | Link | | n/a | African trypanosomiasis | PRKCA | 5 | Link | | n/a | Vibrio cholerae infection | PRKCA | 5 | Link | | Mastocytosis with associated hematologic disorder | KIT | 1 | Link | | SCID | LCK | 15 | Link | | n/a | Amyotrophic lateral sclerosis | MAPK14 | 1 | Link | | n/a | Salmonella infection | MAPK14 | 1 | Link | | Hirschsprung disease | RET | 4 | Link | | n/a | Congenital central hypoventilation syndrome | RET | 4 | Link | | Loeys-Dietz syndrome | TGFBR1 | 8 | Link | | n/a | Familial thoracic aortic aneurysm and dissection | TGFBR1 | 8 | Link | | Multiple self-healing squamous epithelioma | TGFBR1 | 8 | Link | | Selective T-cell defect | ZAP70 | 15 | Link | | n/a | Transient erythroblastopenia of childhood | TEC | 1 | Link | | Renal agenesis | RET | 4 | Link | | Central hypoventilation syndrome | RET | 4 | Link | | n/a | Medullary thyroid carcinoma | RET | 4 | Link | | Multiple endocrine neoplasia | RET | 4 | Link | | Pheochromocytoma | RET | 4 | Link | | Mast cell leukemia | KIT | 1 | Link | | n/a | Germ cell tumors | KIT | 1 | Link | | n/a | Malignant pleural mesothelioma | IGF1R | 25 | Link | | n/a | Synovial sarcoma | IGF1R | 25 | Link | | Insulin-like growth factor I | IGF1R | 25 | Link | | n/a | Leprechaunism | INSR | 4 | Link | | n/a | Prion diseases | FYN | 1 | Link | | n/a | Scaphocephaly and Axenfeld-Rieger anomaly | FGFR2 | 5 | Link | | Craniosynostosis | FGFR2 | 5 | Link | | Crouzon syndrome | FGFR2 | 5 | Link | | n/a | Saethre-Chotzen syndrome | FGFR2 | 5 | Link | | Scaphocephaly | FGFR2 | 5 | Link | | Rabson-Mendenhall syndrome | INSR | 4 | Link | | Diabetes mellitus | INSR | 4 | Link | | n/a | Myeloproliferative disorder | JAK2 | 7 | Link | | Thrombocythemia | JAK2 | 7 | Link | | Piebaldism | KIT | 1 | Link | | Gastrointestinal stromal tumor | KIT | 1 | Link | | Myelofibrosis | JAK2 | 7 | Link | | n/a | Budd-Chiari syndrome | JAK2 | 7 | Link | | Hyperinsulinemic hypoglycemia | INSR | 4 | Link | | n/a | Invasive pneumococcal disease | IRAK4 | 1 | Link | | IRAK4 deficiency | IRAK4 | 1 | Link | | Polycythemia vera | JAK2 | 7 | Link |
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