Allelic Variants

There are no related allelic variants
Related diseases of KIF 2F4JA_VX6 (PDB code: 2F4J, chain A)
Number of involved diseases in the family 134
Number of MAP4K4 related diseases 0
All kinase in this family  MAP4K4
Allelic
Variants
Disease Description Involved kinases
(This family)
Inhibitor of
Involved Kinases
Search
Disease
n/aEpstein-Barr virus infectionCDC2, CDK2, FGR, JAK1, JAK3,
LYN, MAP3K7, MAPK14, PRKACA,
RIPK1, SYK, TYK2
20Link
n/aMeaslesCDK2, FYN, IRAK4, JAK1,
JAK2, JAK3, MAP3K7, PRKCQ,
TYK2
34Link
Prostate cancerCDK2, EPHB2, FGFR1, FGFR2,
IGF1R, INSRR, MAP2K1,
PDGFRA, PDGFRB
18Link
n/aTuberculosisIRAK4, JAK1, JAK2, MAPK14,
PLK3, SRC, SYK
28Link
LeukemiaABL1, ABL2, JAK2, KIT,
MAP2K1, PDGFRB, TGFBR1
17Link
n/aToxoplasmosisIRAK4, JAK1, JAK2, MAP3K7,
MAPK14, TYK2
16Link
n/aHerpes simplex infectionCDC2, CDK2, JAK1, JAK2,
MAP3K7, TYK2
25Link
n/aInfluenza AIRAK4, JAK1, JAK2, MAP2K1,
MAPK14, TYK2
16Link
MelanomaFGFR1, IGF1R, MAP2K1, MET,
PDGFRA, PDGFRB
7Link
n/aEpithelial cell signaling in Helicobacter pylori infectionCSK, LYN, MAPK14, MET, SRC15Link
n/aLeishmaniasisIRAK4, JAK1, JAK2, MAP3K7,
MAPK14
16Link
n/aHepatitis CJAK1, MAPK14, RIPK1, TYK24Link
NeuroblastomaALK, NTRK1, NTRK2, NTRK35Link
n/aShigellosisABL1, MAPK14, SRC17Link
n/aCardiomyopathyPRKAA1, PRKAA2, PRKACA3Link
n/aChagas diseaseIRAK4, MAPK14, TGFBR13Link
n/aAlcoholismMAP2K1, NTRK2, PRKACA4Link
n/aSalmonella infectionMAPK14, PKN1, PKN24Link
n/aViral myocarditisABL1, ABL2, FYN5Link
n/aPrion diseasesFYN, MAP2K1, PRKACA3Link
Lung cancerALK, CDK2, ROS114Link
Gastrointestinal stromal tumorKIT, PDGFRA3Link
Pfeiffer syndromeFGFR1, FGFR22Link
Jackson-Weiss syndromeFGFR1, FGFR22Link
HemangiomaFLT4, KDR7Link
SCIDJAK3, LCK9Link
n/aImmunodeficienciesJAK3, LCK9Link
LADD syndromeFGFR2, FGFR32Link
n/aPertussisIRAK4, MAPK143Link
Diabetes mellitusINSR, PRKCD16Link
Crouzon syndromeFGFR2, FGFR32Link
n/aMyeloproliferative disorderJAK2, PDGFRB14Link
n/aPathogenic Escherichia coli infectionABL1, FYN5Link
Gastric cancerFGFR2, MET2Link
n/aThyroid cancerNTRK1, RET5Link
n/aMedullary thyroid carcinomaNTRK1, RET5Link
n/aType I diabetes mellitusERBB3, PRKCQ10Link
Colon cancerAURKA, SRC71Link
n/aCocaine addictionCDK5, PRKACA2Link
n/aGliomaPDGFRA, PDGFRB2Link
ScaphocephalyFGFR22Link
AgammaglobulinemiaBTK2Link
n/aSaethre-Chotzen syndromeFGFR22Link
n/aMaturity onset diabetes of the youngBLK2Link
n/aAgammaglobulinemia and isolated hormone deficiencyBTK2Link
n/aScaphocephaly and Axenfeld-Rieger anomalyFGFR22Link
n/aMultiple myelomaFGFR32Link
n/aPrader-Willi and Angelman syndromesCDKL51Link
n/aAchondroplasiaFGFR32Link
n/aCervical cancerFGFR32Link
Colorectal cancerFGFR32Link
n/aCATSHL syndromeFGFR32Link
n/aFGFR3-related short limb skeletal dysplasiasFGFR32Link
n/aPituitary DwarfismBTK2Link
n/aAgammaglobulinemiasBTK2Link
n/aBladder cancerFGFR32Link
n/aChrondrodysplasiaBMPR1B1Link
Fibrodysplasia ossificans progressivaACVR12Link
n/aEarly infantile epileptic encephalopathyCDKL51Link
Kallmann syndromeFGFR12Link
n/aLeukoencephalopathy, diffuse hereditary, with spheroidsCSF1R2Link
n/aChoriocarcinomaCSF1R2Link
n/aSpondylometaepiphyseal dysplasiaDDR22Link
n/aHypochondroplasiaFGFR32Link
n/aLethal congenital contractural syndromeERBB31Link
Osteoglophonic dysplasiaFGFR12Link
TrigonocephalyFGFR12Link
BrachydactylyBMPR1B1Link
n/aEpileptic encephalopathyCDKL51Link
Craniofacial-skeletal-dermatologic dysplasiaFGFR22Link
CraniosynostosisFGFR22Link
Hypogonadotropic hypogonadismFGFR12Link
n/aAngelman syndrome-likeCDKL51Link
Bent bone dysplasia syndromeFGFR22Link
n/aAntley-Bixler syndrome without genital anomalies or disordered steroidogenesisFGFR22Link
Apert syndromeFGFR22Link
Beare-Stevenson cutis gyrata syndromeFGFR22Link
n/aMalignant pleural mesotheliomaIGF1R7Link
n/aMuenke syndromeFGFR32Link
n/aAmoebiasisPRKACA1Link
n/aRenal agenesis and Renal adysplasiaRET3Link
Hirschsprung diseaseRET3Link
Central hypoventilation syndromeRET3Link
n/aCongenital central hypoventilation syndromeRET3Link
n/aVibrio cholerae infectionPRKACA1Link
n/aHypereosinophilic syndromePDGFRA2Link
Hepatocellular carcinomaMET2Link
n/aCongenital myasthenic syndromeMUSK2Link
n/aMyasthenic syndromeMUSK2Link
n/aObesityNTRK23Link
n/aInsensitivity to painNTRK15Link
Multiple endocrine neoplasiaRET3Link
PheochromocytomaRET3Link
n/aRheumatoid arthritisTEK3Link
Loeys-Dietz syndromeTGFBR11Link
n/aFamilial thoracic aortic aneurysm and dissectionTGFBR11Link
n/aTyrosine kinase 2 deficiencyTYK21Link
Multiple self-healing squamous epitheliomaTGFBR11Link
Venous malformationsTEK3Link
n/aTransient erythroblastopenia of childhoodTEC1Link
Renal agenesisRET3Link
n/aPopliteal pterygium syndromeRIPK41Link
n/aNon-syndromic X-linked mental retardationRPS6KA32Link
Mental retardationRPS6KA32Link
n/aCoffin-Lowry syndromeRPS6KA32Link
n/aAutism suseptibilityMET2Link
n/aMalariaMET2Link
Insulin-like growth factor IIGF1R7Link
n/aLeprechaunismINSR7Link
Rabson-Mendenhall syndromeINSR7Link
n/aInvasive pneumococcal diseaseIRAK41Link
Hyperinsulinemic hypoglycemiaINSR7Link
n/aSynovial sarcomaIGF1R7Link
n/aLymphedemaFLT42Link
n/aNevusFGFR32Link
n/aSpermatocytic seminomaFGFR32Link
n/aThanatophoric dysplasiaFGFR32Link
n/aLymphedemasFLT42Link
n/aCancer progression/metastasisFGFR42Link
IRAK4 deficiencyIRAK41Link
Lymphoproliferative syndromeITK2Link
n/aNoonan syndrome and related disordersMAP2K12Link
Cardiofaciocutaneous syndromeMAP2K12Link
n/aAmyotrophic lateral sclerosisMAPK142Link
n/aCholangiocarcinomaMET2Link
Renal cell carcinomaMET2Link
Mastocytosis with associated hematologic disorderKIT3Link
Mast cell leukemiaKIT3Link
n/aBudd-Chiari syndromeJAK214Link
Polycythemia veraJAK214Link
MyelofibrosisJAK214Link
ThrombocythemiaJAK214Link
n/aGerm cell tumorsKIT3Link
PiebaldismKIT3Link