KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 2ZYBA_KSL (PDB code: 2ZYB, chain A)
Number of involved diseases in the family	80
Number of ROS1 related diseases	1

All kinase in this family ROS1

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Leukemia	ABL1, ABL2, CHUK, JAK2, KIT, PDGFRB, RAF1, TGFBR1	47	Link
	Prostate cancer	CDK2, CHUK, EGFR, FGFR1, INSRR, PDGFRB, RAF1	56	Link
n/a	Epstein-Barr virus infection	CDC2, CDK2, CHUK, EIF2AK2, MAPK14, SYK	25	Link
n/a	Tuberculosis	IRAK4, JAK2, MAPK14, RAF1, SRC, SYK	55	Link
n/a	Measles	CDK2, CHUK, EIF2AK2, FYN, IRAK4, JAK2	38	Link
n/a	Hepatitis C	CHUK, EGFR, EIF2AK2, MAPK14, RAF1	45	Link
n/a	Herpes simplex infection	CDC2, CDK2, CHUK, EIF2AK2, JAK2	36	Link
n/a	Influenza A	EIF2AK2, IRAK4, JAK2, MAPK14, RAF1	21	Link
	Lung cancer	CDK2, CHUK, EGFR, ROS1	50	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	CHUK, EGFR, MAPK14, SRC	73	Link
n/a	Chagas disease	CHUK, IRAK4, MAPK14, TGFBR1	23	Link
n/a	Shigellosis	ABL1, CHUK, MAPK14, SRC	45	Link
n/a	Toxoplasmosis	CHUK, IRAK4, JAK2, MAPK14	30	Link
	Melanoma	EGFR, FGFR1, PDGFRB, RAF1	38	Link
n/a	Leishmaniasis	IRAK4, JAK2, MAPK14	19	Link
n/a	Viral myocarditis	ABL1, ABL2, FYN	3	Link
	Neuroblastoma	NTRK1, NTRK2, NTRK3	1	Link
n/a	Glioma	EGFR, PDGFRB	36	Link
n/a	Bladder cancer	DAPK1, EGFR	32	Link
n/a	Pertussis	IRAK4, MAPK14	3	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	21	Link
n/a	Choriocarcinoma	CSF1R, EGFR	32	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN	3	Link
	Colon cancer	AURKA, SRC	32	Link
n/a	Alcoholism	NTRK2, RAF1	2	Link
n/a	Medullary thyroid carcinoma	NTRK1, RET	5	Link
n/a	Thyroid cancer	NTRK1, RET	5	Link
n/a	Agammaglobulinemias	BTK	1	Link
n/a	Pituitary Dwarfism	BTK	1	Link
	Jackson-Weiss syndrome	FGFR1	1	Link
	Trigonocephaly	FGFR1	1	Link
	Osteoglophonic dysplasia	FGFR1	1	Link
	Hypogonadotropic hypogonadism	FGFR1	1	Link
	Agammaglobulinemia	BTK	1	Link
	Adenocarcinoma of lung	EGFR	31	Link
n/a	Cocoon syndrome	CHUK	11	Link
n/a	Oral cancer	EGFR	31	Link
n/a	Leukoencephalopathy, diffuse hereditary, with spheroids	CSF1R	1	Link
	Kallmann syndrome	FGFR1	1	Link
n/a	Esophageal cancer	EGFR	31	Link
	Gastric cancer	EGFR	31	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	1	Link
n/a	Laryngeal cancer	EGFR	31	Link
n/a	Cervical cancer	EGFR	31	Link
	Rabson-Mendenhall syndrome	INSR	1	Link
	Pfeiffer syndrome	FGFR1	1	Link
	Noonan syndrome	RAF1	1	Link
n/a	Renal agenesis and Renal adysplasia	RET	5	Link
	LEOPARD syndrome	RAF1	1	Link
n/a	Obesity	NTRK2	1	Link
n/a	Amyotrophic lateral sclerosis	MAPK14	1	Link
n/a	Salmonella infection	MAPK14	1	Link
n/a	Insensitivity to pain	NTRK1	1	Link
	Hirschsprung disease	RET	5	Link
n/a	Congenital central hypoventilation syndrome	RET	5	Link
n/a	Familial thoracic aortic aneurysm and dissection	TGFBR1	10	Link
	Multiple self-healing squamous epithelioma	TGFBR1	10	Link
	Loeys-Dietz syndrome	TGFBR1	10	Link
	Renal agenesis	RET	5	Link
	Central hypoventilation syndrome	RET	5	Link
	Multiple endocrine neoplasia	RET	5	Link
	Pheochromocytoma	RET	5	Link
	SCID	LCK	44	Link
n/a	Immunodeficiencies	LCK	44	Link
	IRAK4 deficiency	IRAK4	2	Link
	Lymphoproliferative syndrome	ITK	5	Link
n/a	Invasive pneumococcal disease	IRAK4	2	Link
	Hyperinsulinemic hypoglycemia	INSR	1	Link
n/a	Prion diseases	FYN	1	Link
n/a	Leprechaunism	INSR	1	Link
	Diabetes mellitus	INSR	1	Link
	Polycythemia vera	JAK2	16	Link
n/a	Budd-Chiari syndrome	JAK2	16	Link
	Mast cell leukemia	KIT	2	Link
	Mastocytosis with associated hematologic disorder	KIT	2	Link
n/a	Germ cell tumors	KIT	2	Link
	Gastrointestinal stromal tumor	KIT	2	Link
	Myelofibrosis	JAK2	16	Link
	Thrombocythemia	JAK2	16	Link
	Piebaldism	KIT	2	Link

BioXGEM.

KIDFamMap

Allelic Variants