KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 3EKNA_GS3 (PDB code: 3EKN, chain A)
Number of involved diseases in the family	127
Number of ROS1 related diseases	1

All kinase in this family ROS1

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
	Prostate cancer	EGFR, EPHB2, ERBB2, FGFR1, FGFR2, IGF1R, INSRR, PDGFRA, PDGFRB	128	Link
n/a	Measles	FYN, IRAK4, JAK1, JAK2, JAK3, MAP3K7, TYK2	3	Link
	Melanoma	EGFR, FGFR1, IGF1R, MET, PDGFRA, PDGFRB	147	Link
n/a	Tuberculosis	IRAK4, JAK1, JAK2, RIPK2, SRC, SYK	11	Link
n/a	Epstein-Barr virus infection	FGR, JAK1, JAK3, MAP3K7, SYK, TYK2	2	Link
n/a	Toxoplasmosis	IRAK4, JAK1, JAK2, MAP3K7, TYK2	2	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	CSK, EGFR, MET, SRC	38	Link
n/a	Herpes simplex infection	JAK1, JAK2, MAP3K7, TYK2	2	Link
	Gastric cancer	EGFR, ERBB2, FGFR2, MET	32	Link
n/a	Influenza A	IRAK4, JAK1, JAK2, TYK2	2	Link
	Lung cancer	ALK, EGFR, PTK2, ROS1	16	Link
n/a	Leishmaniasis	IRAK4, JAK1, JAK2, MAP3K7	2	Link
	Leukemia	ABL1, JAK2, KIT, PDGFRB	8	Link
n/a	Hepatitis C	EGFR, JAK1, TYK2	11	Link
n/a	Cervical cancer	EGFR, ERBB2, FGFR3	13	Link
n/a	Immunodeficiencies	JAK3, LCK, ZAP70	22	Link
n/a	Shigellosis	ABL1, RIPK2, SRC	11	Link
n/a	Glioma	EGFR, PDGFRA, PDGFRB	15	Link
n/a	Bladder cancer	EGFR, ERBB2, FGFR3	13	Link
n/a	Choriocarcinoma	CSF1R, EGFR, ERBB2	15	Link
	Neuroblastoma	ALK, NTRK1, NTRK2	7	Link
	Jackson-Weiss syndrome	FGFR1, FGFR2	7	Link
	Crouzon syndrome	FGFR2, FGFR3	3	Link
	SCID	JAK3, LCK	10	Link
	Hemangioma	FLT4, KDR	4	Link
n/a	Myeloproliferative disorder	JAK2, PDGFRB	7	Link
n/a	Cholangiocarcinoma	ERBB2, MET	26	Link
	Pfeiffer syndrome	FGFR1, FGFR2	7	Link
	LADD syndrome	FGFR2, FGFR3	3	Link
	Gastrointestinal stromal tumor	KIT, PDGFRA	2	Link
n/a	Viral myocarditis	ABL1, FYN	3	Link
	Adenocarcinoma of lung	EGFR, ERBB2	12	Link
n/a	Thyroid cancer	NTRK1, RET	2	Link
n/a	Medullary thyroid carcinoma	NTRK1, RET	2	Link
n/a	Pathogenic Escherichia coli infection	ABL1, FYN	3	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	1	Link
n/a	Saethre-Chotzen syndrome	FGFR2	1	Link
	Scaphocephaly	FGFR2	1	Link
n/a	Pituitary Dwarfism	BTK	1	Link
	Agammaglobulinemia	BTK	1	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	1	Link
	Craniosynostosis	FGFR2	1	Link
n/a	Multiple myeloma	FGFR3	3	Link
n/a	Achondroplasia	FGFR3	3	Link
n/a	CATSHL syndrome	FGFR3	3	Link
n/a	Maturity onset diabetes of the young	BLK	1	Link
n/a	Agammaglobulinemias	BTK	1	Link
	Colorectal cancer	FGFR3	3	Link
n/a	FGFR3-related short limb skeletal dysplasias	FGFR3	3	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	1	Link
n/a	Hypochondroplasia	FGFR3	3	Link
n/a	Leukoencephalopathy, diffuse hereditary, with spheroids	CSF1R	4	Link
	Ovarian cancer	ERBB2	6	Link
n/a	Muenke syndrome	FGFR3	3	Link
	Trigonocephaly	FGFR1	7	Link
	Osteoglophonic dysplasia	FGFR1	7	Link
	Hypogonadotropic hypogonadism	FGFR1	7	Link
	Breast cancer	ERBB2	6	Link
	Endometrial Cancer	ERBB2	6	Link
	Glioblastoma	ERBB2	6	Link
n/a	Pancreatic cancer	ERBB2	6	Link
	Kallmann syndrome	FGFR1	7	Link
	Bent bone dysplasia syndrome	FGFR2	1	Link
n/a	Oral cancer	EGFR	10	Link
n/a	Spondylometaepiphyseal dysplasia	DDR2	1	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	1	Link
	Apert syndrome	FGFR2	1	Link
n/a	Laryngeal cancer	EGFR	10	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	1	Link
n/a	Esophageal cancer	EGFR	10	Link
n/a	Lymphedema	FLT4	2	Link
n/a	Nevus	FGFR3	3	Link
n/a	Amoebiasis	PTK2	1	Link
n/a	Renal agenesis and Renal adysplasia	RET	2	Link
	Hirschsprung disease	RET	2	Link
	Central hypoventilation syndrome	RET	2	Link
n/a	Congenital central hypoventilation syndrome	RET	2	Link
n/a	Hypereosinophilic syndrome	PDGFRA	1	Link
n/a	Obesity	NTRK2	2	Link
	Hepatocellular carcinoma	MET	21	Link
n/a	Congenital myasthenic syndrome	MUSK	1	Link
n/a	Myasthenic syndrome	MUSK	1	Link
n/a	Alcoholism	NTRK2	2	Link
n/a	Insensitivity to pain	NTRK1	1	Link
	Multiple endocrine neoplasia	RET	2	Link
	Pheochromocytoma	RET	2	Link
n/a	Transient erythroblastopenia of childhood	TEC	1	Link
	Venous malformations	TEK	2	Link
n/a	Rheumatoid arthritis	TEK	2	Link
	Selective T-cell defect	ZAP70	13	Link
n/a	Tyrosine kinase 2 deficiency	TYK2	2	Link
n/a	Basal cell carcinoma	STK36	1	Link
	Colon cancer	SRC	11	Link
	Renal agenesis	RET	2	Link
n/a	Popliteal pterygium syndrome	RIPK4	1	Link
n/a	Non-syndromic X-linked mental retardation	RPS6KA3	1	Link
	Mental retardation	RPS6KA3	1	Link
n/a	Coffin-Lowry syndrome	RPS6KA3	1	Link
n/a	Autism suseptibility	MET	21	Link
n/a	Malaria	MET	21	Link
	Insulin-like growth factor I	IGF1R	114	Link
n/a	Leprechaunism	INSR	18	Link
	Rabson-Mendenhall syndrome	INSR	18	Link
	Hyperinsulinemic hypoglycemia	INSR	18	Link
	Diabetes mellitus	INSR	18	Link
n/a	Synovial sarcoma	IGF1R	114	Link
n/a	Malignant pleural mesothelioma	IGF1R	114	Link
n/a	Spermatocytic seminoma	FGFR3	3	Link
n/a	Thanatophoric dysplasia	FGFR3	3	Link
n/a	Cancer progression/metastasis	FGFR4	1	Link
n/a	Prion diseases	FYN	2	Link
n/a	Lymphedemas	FLT4	2	Link
n/a	Pertussis	IRAK4	1	Link
n/a	Chagas disease	IRAK4	1	Link
n/a	Germ cell tumors	KIT	2	Link
	Mast cell leukemia	KIT	2	Link
	Mastocytosis with associated hematologic disorder	KIT	2	Link
	Renal cell carcinoma	MET	21	Link
	Retinitis pigmentosa	MERTK	1	Link
	Piebaldism	KIT	2	Link
	Thrombocythemia	JAK2	2	Link
	IRAK4 deficiency	IRAK4	1	Link
n/a	Invasive pneumococcal disease	IRAK4	1	Link
	Lymphoproliferative syndrome	ITK	1	Link
	Polycythemia vera	JAK2	2	Link
	Myelofibrosis	JAK2	2	Link
n/a	Budd-Chiari syndrome	JAK2	2	Link

BioXGEM.

KIDFamMap

Allelic Variants