Summary of query kinase
Query kinase FGFR2 (P21802)
Kinase group TK
Number of inhibitors 117
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 FGFR2 CHEMBL1834657 BD50355393 n/a 1.4 n/a n/a n/a BindingDB BindingDB
1 FGFR2 CHEMBL1784637 BD50345579 n/a 1.5 n/a n/a n/a BindingDB BindingDB
2 FGFR2 CHEMBL169854 BD50141810 n/a 100 n/a n/a n/a BindingDB BindingDB
3 FGFR2 CHEMBL1172957 BD50321943 n/a 10000 n/a n/a n/a BindingDB BindingDB
4 FGFR2 CHEMBL167425 BD50141832 n/a 130 n/a n/a n/a BindingDB BindingDB
5 FGFR2 Pyrazine-Pyridine Biheteroaryl 41 BD00006418 n/a 1400 n/a n/a n/a BindingDB BindingDB
6 FGFR2 Pyrazine-Pyridine Biheteroaryl 58 BD00006421 n/a 153 n/a n/a n/a BindingDB BindingDB
7 FGFR2 CHEMBL178455 BD50162147 n/a 170 n/a n/a n/a BindingDB BindingDB
8 FGFR2 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f BD00006870 n/a 180 n/a n/a n/a BindingDB BindingDB
9 FGFR2 CHEMBL171413 BD50141821 n/a 190 n/a n/a n/a BindingDB BindingDB
10 FGFR2 CHEMBL276125 BD50141814 n/a 200 n/a n/a n/a BindingDB BindingDB
11 FGFR2 CHEMBL169397 BD50141816 n/a 200 n/a n/a n/a BindingDB BindingDB
12 FGFR2 CHEMBL354902 BD50141824 n/a 200 n/a n/a n/a BindingDB BindingDB
13 FGFR2 CHEMBL569880 BD50300027 n/a 2000 n/a n/a n/a BindingDB BindingDB
14 FGFR2 Pyrazine-Pyridine Biheteroaryl 7 BD00006416 n/a 210 n/a n/a n/a BindingDB BindingDB
15 FGFR2 JNJ-7706621 BD00006866 n/a 220 680 n/a n/a BindingDB BindingDB
16 FGFR2 CHEMBL171509 BD50141817 n/a 23 n/a n/a n/a BindingDB BindingDB
17 FGFR2 Pyrazine-Pyridine Biheteroaryl 39 BD00006417 n/a 2360 n/a n/a n/a BindingDB BindingDB
18 FGFR2 CHEMBL354224 BD50141811 n/a 260 n/a n/a n/a BindingDB BindingDB
19 FGFR2 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c BD00006867 n/a 270 n/a n/a n/a BindingDB BindingDB
20 FGFR2 Pyrazine-Pyridine Biheteroaryl 56 BD00006419 n/a 293 n/a n/a n/a BindingDB BindingDB
21 FGFR2 Pyrazine-Pyridine Biheteroaryl 57 BD00006420 n/a 326 n/a n/a n/a BindingDB BindingDB
22 FGFR2 CHEMBL162 BD50059889 n/a 34 100 n/a n/a BindingDB BindingDB
23 FGFR2 CHEMBL352534 BD50141828 n/a 3400 n/a n/a n/a BindingDB BindingDB
24 FGFR2 CHEMBL598797 BD50307768 n/a 3430 n/a n/a n/a BindingDB BindingDB
25 FGFR2 CHEMBL355436 BD50141831 n/a 350 n/a n/a n/a BindingDB BindingDB
26 FGFR2 CHEMBL1779202 BD50344664 n/a 360 n/a n/a n/a BindingDB BindingDB
27 FGFR2 CHEMBL502835 BD50279080 n/a 37 n/a n/a n/a BindingDB BindingDB
28 FGFR2 CHEMBL1802916 BD50347659 n/a 39 n/a n/a n/a BindingDB BindingDB
29 FGFR2 CHEMBL170519 BD50141829 n/a 40 n/a n/a n/a BindingDB BindingDB
30 FGFR2 CHEMBL571040 BD50300026 n/a 4100 n/a n/a n/a BindingDB BindingDB
31 FGFR2 CHEMBL170415 BD50141827 n/a 440 n/a n/a n/a BindingDB BindingDB
32 FGFR2 CHEMBL352342 BD50141808 n/a 4600 n/a n/a n/a BindingDB BindingDB
33 FGFR2 CHEMBL169837 BD50141822 n/a 54 n/a n/a n/a BindingDB BindingDB
34 FGFR2 FIIN-1 BD00081377 n/a 6.2 6.9 n/a n/a BindingDB BindingDB
35 FGFR2 CHEMBL170907 BD50141819 n/a 63 n/a n/a n/a BindingDB BindingDB
36 FGFR2 CHEMBL602471 BD50306677 n/a 6900 n/a n/a n/a BindingDB BindingDB
37 FGFR2 CHEMBL354898 BD50141812 n/a 70 n/a n/a n/a BindingDB BindingDB
38 FGFR2 CHEMBL168335 BD50141813 n/a 71 n/a n/a n/a BindingDB BindingDB
39 FGFR2 CHEMBL414643 BD50141823 n/a 71 n/a n/a n/a BindingDB BindingDB
40 FGFR2 CHEMBL354830 BD50141826 n/a 780 n/a n/a n/a BindingDB BindingDB
41 FGFR2 CHEMBL352308 BD50141809 n/a 88 n/a n/a n/a BindingDB BindingDB
42 FGFR2 CHEMBL172746 BD50141825 n/a 8900 n/a n/a n/a BindingDB BindingDB
43 FGFR2 Tetracyclic Pyridone, 1 BD00026198 n/a 940 n/a n/a n/a BindingDB BindingDB
44 FGFR2 Staurosporine Staurosporine n/a n/a 100 n/a n/a NB2008 NB2008
45 FGFR2 Staurosporine Staurosporine n/a n/a 100 n/a n/a NB2011DRx NB2011DRx
46 FGFR2 AG_013736 AG_013736 n/a n/a 110 n/a n/a NB2011DRx NB2011DRx
47 FGFR2 BMS_540215 BMS_540215 n/a n/a 110 n/a n/a NB2011DRx NB2011DRx
48 FGFR2 ZD6474 BD00004655 n/a n/a 1100 n/a n/a BindingDB BindingDB
49 FGFR2 Vandetanib Vandetanib n/a n/a 1100 n/a n/a NB2011DRx NB2011DRx
50 FGFR2 ZD_6474 ZD_6474 n/a n/a 1100 n/a n/a NB2008 NB2008
51 FGFR2 BMS-354825 BD00013216 n/a n/a 1400 n/a n/a BindingDB BindingDB
52 FGFR2 Dasatinib Dasatinib n/a n/a 1400 n/a n/a NB2008 NB2008
53 FGFR2 Dasatinib Dasatinib n/a n/a 1400 n/a n/a NB2011DRx NB2011DRx
54 FGFR2 Staurosporine BD00002579 n/a n/a 160 n/a n/a BindingDB BindingDB
55 FGFR2 cid_11712649 BD00031093 n/a n/a 1700 n/a n/a BindingDB BindingDB
56 FGFR2 MLN_8054 MLN_8054 n/a n/a 1700 n/a n/a NB2008 NB2008
57 FGFR2 MLN_8054 MLN_8054 n/a n/a 1700 n/a n/a NB2011DRx NB2011DRx
58 FGFR2 cid_11409972 BD00031085 n/a n/a 1900 n/a n/a BindingDB BindingDB
59 FGFR2 Tarceva BD00005446 n/a n/a 1900 n/a n/a BindingDB BindingDB
60 FGFR2 AST_487 AST_487 n/a n/a 1900 n/a n/a NB2008 NB2008
61 FGFR2 AST_487 AST_487 n/a n/a 1900 n/a n/a NB2011DRx NB2011DRx
62 FGFR2 Pazopanib BD00026474 n/a n/a 210 n/a n/a BindingDB BindingDB
63 FGFR2 GW_786034 GW_786034 n/a n/a 210 n/a n/a NB2008 NB2008
64 FGFR2 Pazopanib Pazopanib n/a n/a 210 n/a n/a NB2011DRx NB2011DRx
65 FGFR2 PP_242 PP_242 n/a n/a 210 n/a n/a NB2011DRx NB2011DRx
66 FGFR2 CHEBI:668343 BD50298227 n/a n/a 2400 n/a n/a BindingDB BindingDB
67 FGFR2 CHEMBL608533 BD50326053 n/a n/a 2400 n/a n/a BindingDB BindingDB
68 FGFR2 PKC_412 PKC_412 n/a n/a 2400 n/a n/a NB2008 NB2008
69 FGFR2 PKC_412 PKC_412 n/a n/a 2400 n/a n/a NB2011DRx NB2011DRx
70 FGFR2 TAE_684 TAE_684 n/a n/a 250 n/a n/a NB2011DRx NB2011DRx
71 FGFR2 BAY 439006 BD00016673 n/a n/a 2700 n/a n/a BindingDB BindingDB
72 FGFR2 Sorafenib Sorafenib n/a n/a 2700 n/a n/a NB2008 NB2008
73 FGFR2 Sorafenib Sorafenib n/a n/a 2700 n/a n/a NB2011DRx NB2011DRx
74 FGFR2 PD_173955 PD_173955 n/a n/a 31 n/a n/a NB2011DRx NB2011DRx
75 FGFR2 PLX_4720 PLX_4720 n/a n/a 3100 n/a n/a NB2011DRx NB2011DRx
76 FGFR2 AZD_2171 AZD_2171 n/a n/a 35 n/a n/a NB2011DRx NB2011DRx
77 FGFR2 BIBF_1120der BIBF_1120der n/a n/a 350 n/a n/a NB2011DRx NB2011DRx
78 FGFR2 JNJ_28312141 JNJ_28312141 n/a n/a 3600 n/a n/a NB2011DRx NB2011DRx
79 FGFR2 CHEMBL522892 BD50265677 n/a n/a 410 n/a n/a BindingDB BindingDB
80 FGFR2 CHIR_258 CHIR_258 n/a n/a 410 n/a n/a NB2008 NB2008
81 FGFR2 CHIR_258 CHIR_258 n/a n/a 410 n/a n/a NB2011DRx NB2011DRx
82 FGFR2 TG_101348 TG_101348 n/a n/a 470 n/a n/a NB2011DRx NB2011DRx
83 FGFR2 FRIN-1 BD00081378 n/a n/a 5.6 n/a n/a BindingDB BindingDB
84 FGFR2 PHA_665752 PHA_665752 n/a n/a 5200 n/a n/a NB2011DRx NB2011DRx
85 FGFR2 SU11248 BD00004814 n/a n/a 530 n/a n/a BindingDB BindingDB
86 FGFR2 VX-680 BD00013534 n/a n/a 570 n/a n/a BindingDB BindingDB
87 FGFR2 Sunitinib Sunitinib n/a n/a 570 n/a n/a NB2008 NB2008
88 FGFR2 Sunitinib Sunitinib n/a n/a 570 n/a n/a NB2011DRx NB2011DRx
89 FGFR2 VX_680 VX_680 n/a n/a 570 n/a n/a NB2008 NB2008
90 FGFR2 VX_680 VX_680 n/a n/a 570 n/a n/a NB2011DRx NB2011DRx
91 FGFR2 CHEMBL603469 BD50308060 n/a n/a 660 n/a n/a BindingDB BindingDB
92 FGFR2 CEP_701 CEP_701 n/a n/a 660 n/a n/a NB2011DRx NB2011DRx
93 FGFR2 JNJ_7706621 JNJ_7706621 n/a n/a 680 n/a n/a NB2008 NB2008
94 FGFR2 R406 R406 n/a n/a 73 n/a n/a NB2011DRx NB2011DRx
95 FGFR2 cid_10138259 BD00031095 n/a n/a 790 n/a n/a BindingDB BindingDB
96 FGFR2 SU_14813 SU_14813 n/a n/a 790 n/a n/a NB2008 NB2008
97 FGFR2 SU_14813 SU_14813 n/a n/a 790 n/a n/a NB2011DRx NB2011DRx
98 FGFR2 EXEL_2880 EXEL_2880 n/a n/a 800 n/a n/a NB2011DRx NB2011DRx
99 FGFR2 KW_2449 KW_2449 n/a n/a 850 n/a n/a NB2011DRx NB2011DRx
100 FGFR2 CHEMBL230686 BD50198782 493 n/a n/a n/a n/a BindingDB BindingDB
101 FGFR2 3RH 3RH n/a n/a n/a n/a n/a PDB PDB
102 FGFR2 AA2 AA2 n/a n/a n/a n/a n/a PDB PDB
103 FGFR2 ABG ABG n/a n/a n/a n/a n/a PDB PDB
104 FGFR2 CAS120685_11_2 CAS120685_11_2 n/a n/a n/a n/a 49.5 NB2011RBC NB2011RBC
105 FGFR2 CAS135897_06_2 CAS135897_06_2 n/a n/a n/a n/a 34.11 NB2011RBC NB2011RBC
106 FGFR2 CAS326914_10_7 CAS326914_10_7 n/a n/a n/a n/a 29.28 NB2011RBC NB2011RBC
107 FGFR2 CAS330161_87_0 CAS330161_87_0 n/a n/a n/a n/a 49.25 NB2011RBC NB2011RBC
108 FGFR2 CAS405169_16_6 CAS405169_16_6 n/a n/a n/a n/a 21.99 NB2011RBC NB2011RBC
109 FGFR2 CAS443798_55_8 CAS443798_55_8 n/a n/a n/a n/a 7.43 NB2011RBC NB2011RBC
110 FGFR2 CAS443913_73_3 CAS443913_73_3 n/a n/a n/a n/a 38.37 NB2011RBC NB2011RBC
111 FGFR2 CAS444731_52_6 CAS444731_52_6 n/a n/a n/a n/a 40.17 NB2011RBC NB2011RBC
112 FGFR2 CAS601514_19_6 CAS601514_19_6 n/a n/a n/a n/a 46.12 NB2011RBC NB2011RBC
113 FGFR2 CAS608512_97_6 CAS608512_97_6 n/a n/a n/a n/a 37.6 NB2011RBC NB2011RBC
114 FGFR2 CAS62996_74_1 CAS62996_74_1 n/a n/a n/a n/a 3.25 NB2011RBC NB2011RBC
115 FGFR2 CAS97161_97_2 CAS97161_97_2 n/a n/a n/a n/a 45.41 NB2011RBC NB2011RBC
116 FGFR2 M33 M33 n/a n/a n/a n/a n/a PDB PDB