Summary of query kinase
Query kinase MKNK2 (Q9HBH9)
Kinase group CAMK
Number of inhibitors 84
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 MKNK2 CHEMBL1651521 BD50335374 n/a 150 n/a n/a n/a BindingDB BindingDB
1 MKNK2 CHEMBL576817 BD50298223 n/a 1600 n/a n/a n/a BindingDB BindingDB
2 MKNK2 CHEMBL1240885 BD50326431 n/a 1600 n/a n/a n/a BindingDB BindingDB
3 MKNK2 Pyrrolopyridinone, 1 BD00027344 n/a 171 n/a n/a n/a BindingDB BindingDB
4 MKNK2 CHEMBL1241462 BD50326412 n/a 575 n/a n/a n/a BindingDB BindingDB
5 MKNK2 CHEMBL603469 BD50308060 n/a n/a 1.4 n/a n/a BindingDB BindingDB
6 MKNK2 CEP_701 CEP_701 n/a n/a 1.4 n/a n/a NB2011DRx NB2011DRx
7 MKNK2 SP600125 BD00016018 n/a n/a 1000 n/a n/a BindingDB BindingDB
8 MKNK2 Erlotinib Erlotinib n/a n/a 1000 n/a n/a NB2011DRx NB2011DRx
9 MKNK2 BIRB-796 BD00013533 n/a n/a 1100 n/a n/a BindingDB BindingDB
10 MKNK2 AZD_1152HQPA AZD_1152HQPA n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
11 MKNK2 Gefitinib Gefitinib n/a n/a 1200 n/a n/a NB2008 NB2008
12 MKNK2 Gefitinib Gefitinib n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
13 MKNK2 KW_2449 KW_2449 n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
14 MKNK2 CHEMBL511337 BD50273636 n/a n/a 1230 n/a n/a BindingDB BindingDB
15 MKNK2 BAY 439006 BD00016673 n/a n/a 130 n/a n/a BindingDB BindingDB
16 MKNK2 R406 R406 n/a n/a 130 n/a n/a NB2011DRx NB2011DRx
17 MKNK2 Sorafenib Sorafenib n/a n/a 130 n/a n/a NB2008 NB2008
18 MKNK2 Sorafenib Sorafenib n/a n/a 130 n/a n/a NB2011DRx NB2011DRx
19 MKNK2 CI-1033 BD00004779 n/a n/a 1300 n/a n/a BindingDB BindingDB
20 MKNK2 Tarceva BD00005446 n/a n/a 1600 n/a n/a BindingDB BindingDB
21 MKNK2 BIBW_2992 BIBW_2992 n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
22 MKNK2 BIRB_796 BIRB_796 n/a n/a 1600 n/a n/a NB2008 NB2008
23 MKNK2 BIRB_796 BIRB_796 n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
24 MKNK2 CP_690550 CP_690550 n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
25 MKNK2 CHEMBL162 BD50059889 n/a n/a 17 n/a n/a BindingDB BindingDB
26 MKNK2 Staurosporine Staurosporine n/a n/a 17 n/a n/a NB2008 NB2008
27 MKNK2 Staurosporine Staurosporine n/a n/a 17 n/a n/a NB2011DRx NB2011DRx
28 MKNK2 ZD6474 BD00004655 n/a n/a 1700 n/a n/a BindingDB BindingDB
29 MKNK2 Vandetanib Vandetanib n/a n/a 1700 n/a n/a NB2011DRx NB2011DRx
30 MKNK2 ZD_6474 ZD_6474 n/a n/a 1700 n/a n/a NB2008 NB2008
31 MKNK2 CI_1033 CI_1033 n/a n/a 1800 n/a n/a NB2008 NB2008
32 MKNK2 CI_1033 CI_1033 n/a n/a 1800 n/a n/a NB2011DRx NB2011DRx
33 MKNK2 FLAVOPIRIDOL BD50088605 n/a n/a 1900 n/a n/a BindingDB BindingDB
34 MKNK2 INCB18424 INCB18424 n/a n/a 200 n/a n/a NB2011DRx NB2011DRx
35 MKNK2 Staurosporine BD00002579 n/a n/a 22 n/a n/a BindingDB BindingDB
36 MKNK2 CHEMBL576982 BD50300690 n/a n/a 2600 n/a n/a BindingDB BindingDB
37 MKNK2 AC220 AC220 n/a n/a 2600 n/a n/a NB2011DRx NB2011DRx
38 MKNK2 ABT-869 BD00021079 n/a n/a 270 n/a n/a BindingDB BindingDB
39 MKNK2 ABT_869 ABT_869 n/a n/a 270 n/a n/a NB2008 NB2008
40 MKNK2 ABT_869 ABT_869 n/a n/a 270 n/a n/a NB2011DRx NB2011DRx
41 MKNK2 cid_11409972 BD00031085 n/a n/a 3 n/a n/a BindingDB BindingDB
42 MKNK2 AST_487 AST_487 n/a n/a 3 n/a n/a NB2008 NB2008
43 MKNK2 AST_487 AST_487 n/a n/a 3 n/a n/a NB2011DRx NB2011DRx
44 MKNK2 EXEL_2880 EXEL_2880 n/a n/a 3.7 n/a n/a NB2011DRx NB2011DRx
45 MKNK2 Flavopiridol Flavopiridol n/a n/a 3200 n/a n/a NB2008 NB2008
46 MKNK2 Flavopiridol Flavopiridol n/a n/a 3200 n/a n/a NB2011DRx NB2011DRx
47 MKNK2 A_674563 A_674563 n/a n/a 3400 n/a n/a NB2011DRx NB2011DRx
48 MKNK2 Iressa BD00005447 n/a n/a 360 n/a n/a BindingDB BindingDB
49 MKNK2 TG_101348 TG_101348 n/a n/a 380 n/a n/a NB2011DRx NB2011DRx
50 MKNK2 BMS_387032 BMS_387032 n/a n/a 4300 n/a n/a NB2011DRx NB2011DRx
51 MKNK2 TAE_684 TAE_684 n/a n/a 44 n/a n/a NB2011DRx NB2011DRx
52 MKNK2 VX_680 VX_680 n/a n/a 5200 n/a n/a NB2011DRx NB2011DRx
53 MKNK2 cid_10138259 BD00031095 n/a n/a 5500 n/a n/a BindingDB BindingDB
54 MKNK2 SU_14813 SU_14813 n/a n/a 5500 n/a n/a NB2008 NB2008
55 MKNK2 SU_14813 SU_14813 n/a n/a 5500 n/a n/a NB2011DRx NB2011DRx
56 MKNK2 Sunitinib Sunitinib n/a n/a 5700 n/a n/a NB2011DRx NB2011DRx
57 MKNK2 TG_100_115 TG_100_115 n/a n/a 720 n/a n/a NB2011DRx NB2011DRx
58 MKNK2 PP_242 PP_242 n/a n/a 820 n/a n/a NB2011DRx NB2011DRx
59 MKNK2 cid_9874913 BD00031340 n/a n/a 840 n/a n/a BindingDB BindingDB
60 MKNK2 CP_724714 CP_724714 n/a n/a 840 n/a n/a NB2008 NB2008
61 MKNK2 CHEBI:668343 BD50298227 n/a n/a 950 n/a n/a BindingDB BindingDB
62 MKNK2 CHEMBL608533 BD50326053 n/a n/a 950 n/a n/a BindingDB BindingDB
63 MKNK2 PKC_412 PKC_412 n/a n/a 950 n/a n/a NB2008 NB2008
64 MKNK2 PKC_412 PKC_412 n/a n/a 950 n/a n/a NB2011DRx NB2011DRx
65 MKNK2 CAS135897_06_2 CAS135897_06_2 n/a n/a n/a n/a 9.71 NB2011RBC NB2011RBC
66 MKNK2 CAS136194_77_9 CAS136194_77_9 n/a n/a n/a n/a 17.96 NB2011RBC NB2011RBC
67 MKNK2 CAS171179_06_9 CAS171179_06_9 n/a n/a n/a n/a 32.27 NB2011RBC NB2011RBC
68 MKNK2 CAS171745_13_4 CAS171745_13_4 n/a n/a n/a n/a 34.25 NB2011RBC NB2011RBC
69 MKNK2 CAS174709_30_9 CAS174709_30_9 n/a n/a n/a n/a 32.24 NB2011RBC NB2011RBC
70 MKNK2 CAS175178_82_2 CAS175178_82_2 n/a n/a n/a n/a 39.52 NB2011RBC NB2011RBC
71 MKNK2 CAS179248_59_0 CAS179248_59_0 n/a n/a n/a n/a 47.93 NB2011RBC NB2011RBC
72 MKNK2 CAS211555_04_3 CAS211555_04_3 n/a n/a n/a n/a 18.05 NB2011RBC NB2011RBC
73 MKNK2 CAS216661_57_3 CAS216661_57_3 n/a n/a n/a n/a 37.51 NB2011RBC NB2011RBC
74 MKNK2 CAS244148_46_7 CAS244148_46_7 n/a n/a n/a n/a 35.04 NB2011RBC NB2011RBC
75 MKNK2 CAS443798_55_8 CAS443798_55_8 n/a n/a n/a n/a 17.21 NB2011RBC NB2011RBC
76 MKNK2 CAS546102_60_7 CAS546102_60_7 n/a n/a n/a n/a 43.95 NB2011RBC NB2011RBC
77 MKNK2 CAS608512_97_6 CAS608512_97_6 n/a n/a n/a n/a 17.64 NB2011RBC NB2011RBC
78 MKNK2 CAS62996_74_1 CAS62996_74_1 n/a n/a n/a n/a 5 NB2011RBC NB2011RBC
79 MKNK2 CAS7272_84_6 CAS7272_84_6 n/a n/a n/a n/a 39.18 NB2011RBC NB2011RBC
80 MKNK2 CAS852045_46_6 CAS852045_46_6 n/a n/a n/a n/a 18.57 NB2011RBC NB2011RBC
81 MKNK2 CAS896138_40_2 CAS896138_40_2 n/a n/a n/a n/a 46.75 NB2011RBC NB2011RBC
82 MKNK2 CAS97161_97_2 CAS97161_97_2 n/a n/a n/a n/a 4.23 NB2011RBC NB2011RBC
83 MKNK2 STU STU n/a n/a n/a n/a n/a PDB PDB