Summary of query kinase
Query kinase ROS1 (P08922)
Kinase group TK
Number of inhibitors 54
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 ROS1 CHEMBL162 BD50059889 n/a 0.07 30 n/a n/a BindingDB BindingDB
1 ROS1 CHEMBL560733 BD50296896 n/a 199 n/a n/a n/a BindingDB BindingDB
2 ROS1 CHEMBL575265 BD50300460 n/a 209 n/a n/a n/a BindingDB BindingDB
3 ROS1 CHEMBL1834657 BD50355393 n/a 3263 n/a n/a n/a BindingDB BindingDB
4 ROS1 TAE_684 TAE_684 n/a n/a 0.49 n/a n/a NB2011DRx NB2011DRx
5 ROS1 PP_242 PP_242 n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
6 ROS1 EXEL_2880 EXEL_2880 n/a n/a 14 n/a n/a NB2011DRx NB2011DRx
7 ROS1 GSK_1838705A GSK_1838705A n/a n/a 15 n/a n/a NB2011DRx NB2011DRx
8 ROS1 cid_11409972 BD00031085 n/a n/a 1700 n/a n/a BindingDB BindingDB
9 ROS1 AST_487 AST_487 n/a n/a 1700 n/a n/a NB2008 NB2008
10 ROS1 AST_487 AST_487 n/a n/a 1700 n/a n/a NB2011DRx NB2011DRx
11 ROS1 CHEMBL603469 BD50308060 n/a n/a 26 n/a n/a BindingDB BindingDB
12 ROS1 CEP_701 CEP_701 n/a n/a 26 n/a n/a NB2011DRx NB2011DRx
13 ROS1 R406 R406 n/a n/a 29 n/a n/a NB2011DRx NB2011DRx
14 ROS1 Staurosporine Staurosporine n/a n/a 30 n/a n/a NB2008 NB2008
15 ROS1 Staurosporine Staurosporine n/a n/a 30 n/a n/a NB2011DRx NB2011DRx
16 ROS1 PHA_665752 PHA_665752 n/a n/a 3000 n/a n/a NB2011DRx NB2011DRx
17 ROS1 cid_11712649 BD00031093 n/a n/a 3100 n/a n/a BindingDB BindingDB
18 ROS1 MLN_8054 MLN_8054 n/a n/a 3100 n/a n/a NB2008 NB2008
19 ROS1 MLN_8054 MLN_8054 n/a n/a 3100 n/a n/a NB2011DRx NB2011DRx
20 ROS1 AG_013736 AG_013736 n/a n/a 3200 n/a n/a NB2011DRx NB2011DRx
21 ROS1 BIBF_1120der BIBF_1120der n/a n/a 3700 n/a n/a NB2011DRx NB2011DRx
22 ROS1 Crizotinib Crizotinib n/a n/a 4.1 n/a n/a NB2011DRx NB2011DRx
23 ROS1 CHEBI:668343 BD50298227 n/a n/a 430 n/a n/a BindingDB BindingDB
24 ROS1 CHEMBL608533 BD50326053 n/a n/a 430 n/a n/a BindingDB BindingDB
25 ROS1 PKC_412 PKC_412 n/a n/a 430 n/a n/a NB2008 NB2008
26 ROS1 PKC_412 PKC_412 n/a n/a 430 n/a n/a NB2011DRx NB2011DRx
27 ROS1 JNJ_28312141 JNJ_28312141 n/a n/a 4500 n/a n/a NB2011DRx NB2011DRx
28 ROS1 LY_333531 LY_333531 n/a n/a 5800 n/a n/a NB2011DRx NB2011DRx
29 ROS1 TG_101348 TG_101348 n/a n/a 600 n/a n/a NB2011DRx NB2011DRx
30 ROS1 VX-680 BD00013534 n/a n/a 610 n/a n/a BindingDB BindingDB
31 ROS1 VX_680 VX_680 n/a n/a 610 n/a n/a NB2008 NB2008
32 ROS1 VX_680 VX_680 n/a n/a 610 n/a n/a NB2011DRx NB2011DRx
33 ROS1 CHEMBL514409 BD50273571 n/a n/a 77 n/a n/a BindingDB BindingDB
34 ROS1 Pazopanib BD00026474 n/a n/a 920 n/a n/a BindingDB BindingDB
35 ROS1 GW_786034 GW_786034 n/a n/a 920 n/a n/a NB2008 NB2008
36 ROS1 Pazopanib Pazopanib n/a n/a 920 n/a n/a NB2011DRx NB2011DRx
37 ROS1 CAS120685_11_2 CAS120685_11_2 n/a n/a n/a n/a 6.53 NB2011RBC NB2011RBC
38 ROS1 CAS135897_06_2 CAS135897_06_2 n/a n/a n/a n/a 1.6 NB2011RBC NB2011RBC
39 ROS1 CAS136194_77_9 CAS136194_77_9 n/a n/a n/a n/a 1.18 NB2011RBC NB2011RBC
40 ROS1 CAS326914_10_7 CAS326914_10_7 n/a n/a n/a n/a 43.89 NB2011RBC NB2011RBC
41 ROS1 CAS347155_76_4 CAS347155_76_4 n/a n/a n/a n/a 26.67 NB2011RBC NB2011RBC
42 ROS1 CAS404828_08_6 CAS404828_08_6 n/a n/a n/a n/a 16.68 NB2011RBC NB2011RBC
43 ROS1 CAS443797_96_4 CAS443797_96_4 n/a n/a n/a n/a 39.45 NB2011RBC NB2011RBC
44 ROS1 CAS443798_55_8 CAS443798_55_8 n/a n/a n/a n/a 1.68 NB2011RBC NB2011RBC
45 ROS1 CAS444731_52_6 CAS444731_52_6 n/a n/a n/a n/a 16.99 NB2011RBC NB2011RBC
46 ROS1 CAS457081_03_7 CAS457081_03_7 n/a n/a n/a n/a 31.17 NB2011RBC NB2011RBC
47 ROS1 CAS496864_15_4 CAS496864_15_4 n/a n/a n/a n/a 37.47 NB2011RBC NB2011RBC
48 ROS1 CAS496864_16_5 CAS496864_16_5 n/a n/a n/a n/a 26.3 NB2011RBC NB2011RBC
49 ROS1 CAS601514_19_6 CAS601514_19_6 n/a n/a n/a n/a 39.7 NB2011RBC NB2011RBC
50 ROS1 CAS62996_74_1 CAS62996_74_1 n/a n/a n/a n/a 0.86 NB2011RBC NB2011RBC
51 ROS1 CAS639089_54_6 CAS639089_54_6 n/a n/a n/a n/a 30.22 NB2011RBC NB2011RBC
52 ROS1 CAS854171_35_0 CAS854171_35_0 n/a n/a n/a n/a 26.97 NB2011RBC NB2011RBC
53 ROS1 CAS97161_97_2 CAS97161_97_2 n/a n/a n/a n/a 1.55 NB2011RBC NB2011RBC