Summary of query kinase
Query kinase TNIK (Q9UKE5)
Kinase group STE
Number of inhibitors 79
Index Target Inhibitor Inhibitor 2D Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) POC Source Link
0 TNIK BIRB-796 BD00013533 n/a >10000 9.9 n/a n/a BindingDB BindingDB
1 TNIK TAE_684 TAE_684 n/a n/a 1200 n/a n/a NB2011DRx NB2011DRx
2 TNIK R406 R406 n/a n/a 1300 n/a n/a NB2011DRx NB2011DRx
3 TNIK A_674563 A_674563 n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
4 TNIK BIRB_796 BIRB_796 n/a n/a 140 n/a n/a NB2008 NB2008
5 TNIK BIRB_796 BIRB_796 n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
6 TNIK HKI_272 HKI_272 n/a n/a 140 n/a n/a NB2011DRx NB2011DRx
7 TNIK JNJ_28312141 JNJ_28312141 n/a n/a 150 n/a n/a NB2011DRx NB2011DRx
8 TNIK SB203580 BD00013336 n/a n/a 1500 n/a n/a BindingDB BindingDB
9 TNIK cid_11656518 BD00031088 n/a n/a 1500 n/a n/a BindingDB BindingDB
10 TNIK CHIR_265 CHIR_265 n/a n/a 1500 n/a n/a NB2008 NB2008
11 TNIK CHIR_265 CHIR_265 n/a n/a 1500 n/a n/a NB2011DRx NB2011DRx
12 TNIK CHEMBL516312 BD50273541 n/a n/a 160 n/a n/a BindingDB BindingDB
13 TNIK BMS_540215 BMS_540215 n/a n/a 160 n/a n/a NB2011DRx NB2011DRx
14 TNIK SB-202190 BD50104383 n/a n/a 1600 n/a n/a BindingDB BindingDB
15 TNIK CHEBI:668343 BD50298227 n/a n/a 1600 n/a n/a BindingDB BindingDB
16 TNIK CHEMBL608533 BD50326053 n/a n/a 1600 n/a n/a BindingDB BindingDB
17 TNIK PKC_412 PKC_412 n/a n/a 1600 n/a n/a NB2008 NB2008
18 TNIK PKC_412 PKC_412 n/a n/a 1600 n/a n/a NB2011DRx NB2011DRx
19 TNIK SB_202190 SB_202190 n/a n/a 1600 n/a n/a NB2008 NB2008
20 TNIK EKB_569 EKB_569 n/a n/a 170 n/a n/a NB2008 NB2008
21 TNIK AG_013736 AG_013736 n/a n/a 180 n/a n/a NB2011DRx NB2011DRx
22 TNIK VX-680 BD00013534 n/a n/a 1800 n/a n/a BindingDB BindingDB
23 TNIK VX_680 VX_680 n/a n/a 1800 n/a n/a NB2008 NB2008
24 TNIK VX_680 VX_680 n/a n/a 1800 n/a n/a NB2011DRx NB2011DRx
25 TNIK BMS-354825 BD00013216 n/a n/a 2000 n/a n/a BindingDB BindingDB
26 TNIK Dasatinib Dasatinib n/a n/a 2000 n/a n/a NB2008 NB2008
27 TNIK Dasatinib Dasatinib n/a n/a 2000 n/a n/a NB2011DRx NB2011DRx
28 TNIK EXEL_2880 EXEL_2880 n/a n/a 210 n/a n/a NB2011DRx NB2011DRx
29 TNIK ZD6474 BD00004655 n/a n/a 2300 n/a n/a BindingDB BindingDB
30 TNIK GDC_0879 GDC_0879 n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
31 TNIK Ki_20227 Ki_20227 n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
32 TNIK Vandetanib Vandetanib n/a n/a 2300 n/a n/a NB2011DRx NB2011DRx
33 TNIK ZD_6474 ZD_6474 n/a n/a 2300 n/a n/a NB2008 NB2008
34 TNIK CHEMBL522892 BD50265677 n/a n/a 24 n/a n/a BindingDB BindingDB
35 TNIK CHIR_258 CHIR_258 n/a n/a 24 n/a n/a NB2008 NB2008
36 TNIK CHIR_258 CHIR_258 n/a n/a 24 n/a n/a NB2011DRx NB2011DRx
37 TNIK SU11248 BD00004814 n/a n/a 25 n/a n/a BindingDB BindingDB
38 TNIK Sunitinib Sunitinib n/a n/a 25 n/a n/a NB2008 NB2008
39 TNIK Sunitinib Sunitinib n/a n/a 25 n/a n/a NB2011DRx NB2011DRx
40 TNIK PLX_4720 PLX_4720 n/a n/a 2500 n/a n/a NB2011DRx NB2011DRx
41 TNIK PP_242 PP_242 n/a n/a 270 n/a n/a NB2011DRx NB2011DRx
42 TNIK KW_2449 KW_2449 n/a n/a 28 n/a n/a NB2011DRx NB2011DRx
43 TNIK ABT_869 ABT_869 n/a n/a 2800 n/a n/a NB2011DRx NB2011DRx
44 TNIK AC220 AC220 n/a n/a 2800 n/a n/a NB2011DRx NB2011DRx
45 TNIK SKI_606 SKI_606 n/a n/a 31 n/a n/a NB2011DRx NB2011DRx
46 TNIK Pazopanib BD00026474 n/a n/a 310 n/a n/a BindingDB BindingDB
47 TNIK GW_786034 GW_786034 n/a n/a 310 n/a n/a NB2008 NB2008
48 TNIK Pazopanib Pazopanib n/a n/a 310 n/a n/a NB2011DRx NB2011DRx
49 TNIK PHA_665752 PHA_665752 n/a n/a 310 n/a n/a NB2011DRx NB2011DRx
50 TNIK CHEMBL162 BD50059889 n/a n/a 4.7 n/a n/a BindingDB BindingDB
51 TNIK Staurosporine Staurosporine n/a n/a 4.7 n/a n/a NB2008 NB2008
52 TNIK Staurosporine Staurosporine n/a n/a 4.7 n/a n/a NB2011DRx NB2011DRx
53 TNIK PD_173955 PD_173955 n/a n/a 430 n/a n/a NB2011DRx NB2011DRx
54 TNIK cid_6445562 BD00031090 n/a n/a 45 n/a n/a BindingDB BindingDB
55 TNIK CHEBI:259924 BD50119072 n/a n/a 45 n/a n/a BindingDB BindingDB
56 TNIK Erlotinib Erlotinib n/a n/a 4500 n/a n/a NB2011DRx NB2011DRx
57 TNIK cid_451705 BD00031096 n/a n/a 4700 n/a n/a BindingDB BindingDB
58 TNIK SP600125 BD00016018 n/a n/a 480 n/a n/a BindingDB BindingDB
59 TNIK CHEMBL603469 BD50308060 n/a n/a 5.4 n/a n/a BindingDB BindingDB
60 TNIK CEP_701 CEP_701 n/a n/a 5.4 n/a n/a NB2011DRx NB2011DRx
61 TNIK BIBF_1120der BIBF_1120der n/a n/a 53 n/a n/a NB2011DRx NB2011DRx
62 TNIK LY333531 BD00017055 n/a n/a 5800 n/a n/a BindingDB BindingDB
63 TNIK Staurosporine BD00002579 n/a n/a 6 n/a n/a BindingDB BindingDB
64 TNIK cid_11409972 BD00031085 n/a n/a 69 n/a n/a BindingDB BindingDB
65 TNIK AST_487 AST_487 n/a n/a 69 n/a n/a NB2008 NB2008
66 TNIK AST_487 AST_487 n/a n/a 69 n/a n/a NB2011DRx NB2011DRx
67 TNIK Gefitinib Gefitinib n/a n/a 6900 n/a n/a NB2011DRx NB2011DRx
68 TNIK Sorafenib Sorafenib n/a n/a 7900 n/a n/a NB2011DRx NB2011DRx
69 TNIK AZD_2171 AZD_2171 n/a n/a 810 n/a n/a NB2011DRx NB2011DRx
70 TNIK CHEBI:668344 BD50298226 n/a n/a 820 n/a n/a BindingDB BindingDB
71 TNIK SB_203580 SB_203580 n/a n/a 820 n/a n/a NB2008 NB2008
72 TNIK SB_203580 SB_203580 n/a n/a 820 n/a n/a NB2011DRx NB2011DRx
73 TNIK CI_1033 CI_1033 n/a n/a 8200 n/a n/a NB2011DRx NB2011DRx
74 TNIK AZD_1152HQPA AZD_1152HQPA n/a n/a 8500 n/a n/a NB2011DRx NB2011DRx
75 TNIK cid_10138259 BD00031095 n/a n/a 90 n/a n/a BindingDB BindingDB
76 TNIK SU_14813 SU_14813 n/a n/a 90 n/a n/a NB2008 NB2008
77 TNIK SU_14813 SU_14813 n/a n/a 90 n/a n/a NB2011DRx NB2011DRx
78 TNIK 824 824 n/a n/a n/a n/a n/a PDB PDB