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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ABL1 203
TK ABL2 288
TK ALK 1116
TK BLK 241
TK BMX 422
TK BTK 402
CAMK CHEK2 220
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK EGFR 712
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB4 615
TK EPHB6 670
TK ERBB4 718
TK FER 563
TK FES 561
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
CAMK HUNK 61
TK INSR 1023
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
CAMK KIAA0999 66
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CAMK MARK2 53
CAMK MARK4 59
TK MATK 235
CAMK MGC42105 74
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
TK PDGFRA 593
TK PDGFRB 600
AGC PRKACG 44
AGC PRKCA 339
TK PTK2 422
TK PTK6 191
TK RET 724
TK ROS1 1945
CAMK SIK2 20
CAMK SNRK 16
TK SRC 270
TK SRMS 230
CAMK STK17A 61
STE STK24 24
STE STK25 20
TK SYK 371
TK TEC 370
Other TLK2 440
TK TNK1 116
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
TK ZAP70 338
----ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--DTM-EV---EEFL-K------EAAVMKEI--KHPNLVQLLGVCT--R-EPP--FYIITEFMTYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG-E-----NHLV---KVADFGLSRLM----------T--GDTY--------------TAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EKDYR---MERPEGCP------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--------------
----ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--DTM-EV---EEFL-K------EAAVMKEI--KHPNLVQLLGVCT--L-EPP--FYIVTEYMPYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG-E-----NHVV---KVADFGLSRLM----------T--GDTY--------------TAHAGAKFPIKWTAPESLA----YNTFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EKGYR---MEQPEGCP------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F--------------
---I-TLIRGLGHGAFGEVYEGQVSG-----------MPNDPSPLQVAVKTL---P-E--VCS-EQD-ELDFL-M------EALIISKF--NHQNIVRCIGVSL--Q-SLP--RFILLELMAGGDLKSFLR---ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--HFIHRDIAARNCLLT-CP--GPGRVA---KIGDFGMARDI-----Y----R--ASYY--------------RKGGCAMLPVKWMPPEAFM----EGIFTSKTDTWSFGVLLWEIFSLGY-MP---------------YPSK-SNQEVLEFV----TSGGR---MDPPKNCP------GPVYR-IMTQCWQHQPEDRPN-----FAIILER--I--------------
---L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--GTM-SP---EAFL-G------EANVMKAL--QHERLVRLYAVVT----KEP--IYIVTEYMARGCLLDFLK---TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANILVS-E-----ALCC---KIADFGLARII-------------DSEY--------------TAQEGAKFPIKWTAPEAIH----FGVFTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ERGYR---MPRPDTCP------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--------------
----ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAVKMI---K-E--GSM-SE---DEFF-Q------EAQTMMKL--SHPKLVKFYGVCS--K-EYP--IYIVTEYISNGCLLNYLR---SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--QFIHRDLAARNCLVD-R-----DLCV---KVSDFGMTRYV----------L--DDQY--------------VSSVGTKFPVKWSAPEVFH----YFKYSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY-DNSQVVLKV----SQGHR---LYRPHLAS------DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I--------------
----LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--GSM-SE---DEFI-E------EAKVMMNL--SHEKLVQLYGVCT--K-QRP--IFIITEYMANGCLLNYLR---EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVN-D-----QGVV---KVSDFGLSRYV----------L--DDEY--------------TSSVGSKFPVRWSPPEVLM----YSKFSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQGLR---LYRPHLAS------EKVYT-IMYSCWHEKADERPT-----FKILLSN--I--------------
--YI--MSKTLGSGACGEVKLAFER----------------KTCKKVAIKII---SKR--KFAIGS---AREADPALNVETEIEILKKL--NHPCIIKIKNFF---D-AED--YYIVLELMEGGELFDKVV--GNK----------------------------------------------------------------------------------------------------RLKEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLS-S-----QEEDCLIKITDFGHSKI-----------LGETSLM--------------RT---LCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GY-PP---------------FSEH---RTQVSLK----DQITS---GKYNFIPEVWAEVSEKALD-LVKKLLVVDPKARFT-----TEEALRHPWL--------------
----LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--TAH-ADE-KEALM-S------ELKIMSHLG-QHENIVNLLGACT--H-GGP--VLVITEYCCYGDLLNFLR---RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--NCIHRDVAARNVLLT-N-----GHVA---KIGDFGLARDI-----M----N--DSNY--------------IVKGNARLPVKWMAPESIF----DCVYTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KDGYQ---MAQPAFAP------KNIYS-IMQACWALEPTHRPT-----FQQICSFL----------------
----LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--DAT-AQ----AFL-A------EASVMTQL--RHSNLVQLLGVIV-EE-KGG--LYIVTEYMAKGSLVDYLR---SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--NFVHRDLAARNVLVS-E-----DNVA---KVSDFGLTKEA----------------S--------------STQDTGKLPVKWTAPEALR----EKKFSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDVVPRV----EKGYK---MDAPDGCP------PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL----------------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--DAT-KNA-RNDFL-K------EVKIMSRL--KDPNIIRLLGVCV--Q-DDP--LCMITDYMENGDLNQFLS---AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--NFVHRDLATRNCLVG-E-----NFTI---KIADFGMSRNL-----Y----A--GDYY--------------RVQGRAVLPIRWMAWECIL----MGKFTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRDQGRQVYLSRPPACP------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL----------------
---F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--ATS-PKA-NKEIL-D------EAYVMASV--DNPHVCRLLGICL----TST--VQLITQLMPFGCLLDYVR---EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVK-T-----PQHV---KITDFGLAKLL-----G----A--EEKE--------------YHAEGGKVPIKWMALESIL----HRIYTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EKGER---LPQPPICT------IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF------------
----IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---K-A--GYT-ERQ-RRDFL-S------EASIMGQF--DHPNIIRLEGVVT--R-GRL--AMIVTEYMENGSLDTFLR---TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--GYVHRDLAARNVLVD-S-----NLVC---KVSDFGLSRVL-----E----D--DPDA-------------AYTTTGGKIPIRWTAPEAIA----FRTFSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EEGYR---LPAPMGCP------HALHQ-LMLDCWHKDRAQRPR-----FSQIVSVL----------------
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--GYS-EKQ-RRDFL-S------EASIMGQF--DHPNIIRLEGVVT--K-SRP--VMIITEFMENGALDSFLR---QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--NYVHRDLAARNILVN-S-----NLVC---KVSDFGLSRYLQ--DDT----S--DPTY--------------TSSLGGKIPVRWTAPEAIA----YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQDYR---LPPPMDCP------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL----------------
---V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--GYT-EKQ-RRDFL-S------EASIMGQF--DHPNVIHLEGVVT--K-STP--VMIITEFMENGSLDSFLR---QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--NYVHRDLAARNILVN-S-----NLVC---KVSDFGLSRFLE--DDT----S--DPTY--------------TSALGGKIPIRWTAPEAIQ----YRKFTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-TNQDVINAI----EQDYR---LPPPMDCP------SALHQ-LMLDCWQKDRNHRPK-----FGQIVNTL----------------
---V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAIKTL---K-G--GYT-ERQ-RREFL-S------EASIMGQF--EHPNIIRLEGVVT--N-SMP--VMILTEFMENGALDSFLR---LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--SYVHRDLAARNILVN-S-----NLVC---KVSDFGLSRFLE--ENS----S--DPTY--------------TSSLGGKIPIRWTAPEAIA----FRKFTSASDAWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQDYR---LPPPPDCP------TSLHQ-LMLDCWQKDRNARPR-----FPQVVSAL----------------
----IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAIQAL---W-A--GGA-ESL-QMTFL-G------RAAVLGQF--QHPNILRLEGVVT--K-SRP--LMVLTEFMELGPLDSFLR---QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--AFVHRSLSAHSVLVN-S-----HLVC---KVARLGHSPQG------------------------------------PSCLLRWAAPEVIA----HGKHTTSSDVWSFGILMWEVMSYGE-RP---------------YWDM-SEQEVLNAI----EQEFR---LPPPPGCP------PGLHL-LMLDTWQKDRARRPH-----FDQLVA---AF-------------
---L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAIKIL---N-E--TTG-PKA-NVEFM-D------EALIMASM--DHPHLVRLLGVCL----SPT--IQLVTQLMPHGCLLEYVH---EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--RLVHRDLAARNVLVK-S-----PNHV---KITDFGLARLL-----E----G--DEKE--------------YNADGGKMPIKWMALECIH----YRKFTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREIPDLL----EKGER---LPQPPICT------IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F--------------
--VI--LGELLGKGNFGEVYKGTLK-----------------DKTSVAVKTC---K-E--DLP-QEL-KIKFL-Q------EAKILKQY--DHPNIVKLIGVCT--Q-RQP--VYIIMELVSGGDFLTFLR---RK--------------------------------------------------------------------------------------------------KDELKLKQLVKFSLDAAAGMLYLESK--NCIHRDLAARNCLVG-E-----NNVL---KISDFGMSRQE----------D--GGVY--------------SSSGLKQIPIKWTAPEALN----YGRYSSESDVWSFGILLWETFSLGV-CP---------------YPGM-TNQQAREQV----ERGYR---MSAPQHCP------EDISK-IMMKCWDYKPENRPK-----FSELQKEL----------------
---L-VLGEQIGRGNFGEVFSGRLR----------------ADNTLVAVKSC---R-E--TLP-PDL-KAKFL-Q------EARILKQY--SHPNIVRLIGVCT--Q-KQP--IYIVMELVQGGDFLTFLR---TE--------------------------------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK--CCIHRDLAARNCLVT-E-----KNVL---KISDFGMSREE-----A----D--GVYA--------------ASGGLRQVPVKWTAPEALN----YGRYSSESDVWSFGILLWETFSLGA-SP---------------YPNL-SNQQTREFV----EKGGR---LPCPELCP------DAVFR-LMEQCWAYEPGQRPS-----FSTIYQEL----------------
---L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKML---K-S--DAT-EKD-LSDLI-S------EMEMMKMIG-KHKNIINLLGACT--Q-DGP--LYVIVEYASKGNLREYLQ---ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVT-E-----DNVM---KIADFGLARDI-----H----H--IDYY--------------KKTTNGRLPVKWMAPEALF----DRIYTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGV-PVEELFKLL----KEGHR---MDKPSNCT------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKML---K-D--DAT-EKD-LSDLV-S------EMEMMKMIG-KHKNIINLLGACT--Q-DGP--LYVIVEYASKGNLREYLR---ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVT-E-----NNVM---KIADFGLARDI-----N----N--IDYY--------------KKTTNGRLPVKWMAPEALF----DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR---MDKPANCT------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL----------------
----LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAVKML---K-D--DAT-DKD-LSDLV-S------EMEMMKMIG-KHKNIINLLGACT--Q-GGP--LYVLVEYAAKGNLREFLR---ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVT-E-----DNVM---KIADFGLARDV-----H----N--LDYY--------------KKTTNGRLPVKWMAPEALF----DRVYTHQSDVWSFGVLLWEIFTLGG-SP---------------YPGI-PVEELFKLL----KEGHR---MDKPANCT------HDLYM-IMRECWHAAPSQRPT-----FKQLVEDL----------------
---L-VLGKPLGEGCFGQVVRAEAFGM---------DPARPDQASTVAVKML---K-D--NAS-DKD-LADLV-S------EMEVMKLIG-RHKNIINLLGVCT--Q-EGP--LYVIVECAAKGNLREFLR---ARRPPGPDL-----------------------------------------------------------------------------------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--KCIHRDLAARNVLVT-E-----DNVM---KIADFGLARGV-----H----H--IDYY--------------KKTSNGRLPVKWMAPEALF----DRVYTHQSDVWSFGILLWEIFTLGG-SP---------------YPGI-PVEELFSLL----REGHR---MDRPPHCP------PELYG-LMRECWHAAPSQRPT-----FKQLVEAL----------------
----ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTL---K-P--GTM-SP---KAFL-E------EAQVMKLL--RHDKLVQLYAVVS----EEP--IYIVTEFMCHGSLLDFLK---NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--NYIHRDLRAANILVG-E-----RLAC---KIADFGLARLI----------K--DDEY--------------NPCQGSKFPIKWTAPEAAL----FGRFTIKSDVWSFGILLTELITKGR-IP---------------YPGM-NKREVLEQV----EQGYH---MPCPPGCP------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL----------------
----IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---K-P--GSM-DP---NDFL-R------EAQIMKNL--RHPKLIQLYAVCT--L-EDP--IYIITELMRHGSLQEYLQ---ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--NYIHRDLAARNVLVG-E-----HNIY---KVADFGLARVFK---VD----N--EDIY--------------ESRHEIKLPVKWTAPEAIR----SNKFSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQNYR---LPQPSNCP------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L--------------
----LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---K-P--GTM-SP---ESFL-E------EAQIMKKL--KHDKLVQLYAVVS----EEP--IYIVTEYMNKGSLLDFLK---DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--NYIHRDLRSANILVG-N-----GLIC---KIADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ERGYR---MPCPQDCP------ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL----------------
----LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--GSM-SV---EAFL-A------EANVMKTL--QHDKLVKLHAVVT----KEP--IYIITEFMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--NYIHRDLRAANILVS-A-----SLVC---KIADFGLARVI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN----FGSFTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ERGYR---MPRPENCP------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--------------
-IGS----RKLGEGSFAKVREGLHV----------------LTGEKVAIKVI---DKK--RAKKDT---YVTKNLR----REGQIQQMI--RHPNITQLLDILE--T-ENS--YYLVMELCPGGNLMHKIY--EKK----------------------------------------------------------------------------------------------------RLEESEARRYIRQLISAVEHLHRA--GVVHRDLKIENLLLD-E-----DNNI---KLIDFGLSNCAG--------ILGYSDPF--------------ST---QCGSPAYAAPELLA----RKKYGPKIDVWSIGVNMYAMLT-GT-LP---------------FTVE--PFSLRALY----QKMVD----KEMNPLPTQ--LSTGAIS-FLRSLLEPDPVKRPN-----IQQALANRWL--------------
----ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAVKTV---N-E--SAS-LRE-RIEFL-N------EASVMKGF--TCHHVVRLLGVVS--K-GQP--TLVVMELMAHGDLKSYLR---SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--KFVHRDLAARNCMVA-H-----DFTV---KIGDFGMTRDI-----Y----E--TDYY--------------RKGGKGLLPVRWMAPESLK----DGVFTTSSDMWSFGVVLWEITSLAE-QP---------------YQGL-SNEQVLKFV----MDGGY---LDQPDNCP------ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----------------
----LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--GAM-SE---EDFI-E------EAEVMMKL--SHPKLVQLYGVCL--E-QAP--ICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA--CVIHRDLAARNCLVG-E-----NQVI---KVSDFGMTRFV----------L--DDQY--------------TSSTGTKFPVKWASPEVFS----FSRYSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----STGFR---LYKPRLAS------THVYQ-IMNHCWKERPEDRPA-----FSRLLRQL----------------
---L-KRIRDLGEGHFGKVELCRYDP------------EGDNTGEQVAVKSL---K-P--ESG-GNH-IADLK-K------EIEILRNL--YHENIVKYKGICT-ED--GGNGIKLIMEFLPSGSLKEYLP---KN--------------------------------------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGSR--QYVHRDLAARNVLVE-S-----EHQV---KIGDFGLTKAI----ET----D--KEYY--------------TVKDDRDSPVFWYAPECLM----QSKFYIASDVWSFGVTLHELLTYCD-SDSSPMALF-LKMIGPTHGQM-TVTRLVNTL----KEGKR---LPCPPNCP------DEVYQ-LMRKCWEFQPSNRTS-----FQNLIE---GF-------------
----LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--STE--EH-LRDFE-R------EIEILKSL--QHDNIVKYKGVCYSAG-RRN--LKLIMEYLPYGSLRDYLQ---KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVE-N-----ENRV---KIGDFGLTKVL----PQ----D--KEYY--------------KVKEPGESPIFWYAPESLT----ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KNNGR---LPRPDGCP------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV------------
---L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--SGP-DQ--QRDFQ-R------EIQILKAL--HSDFIVKYRGVSYGPG-RQS--LRLVMEYLPSGCLRDFLQ---RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--RCVHRDLAARNILVE-S-----EAHV---KIADFGLAKLL----PL----D--KDYY--------------VVREPGQSPIFWYAPESLS----DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL----EEGQR---LPAPPACP------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL-------------
----YEIDRTIGKGNFAVVKRATHL----------------VTKAKVAIKII---DKT--QLDEEN---LKKIFR------EVQIMKML--CHPHIIRLYQVME--T-ERM--IYLVTEYASGGEIFDHLV--AHG----------------------------------------------------------------------------------------------------RMAEKEARRKFKQIVTAVYFCHCR--NIVHRDLKAENLLLD-A-----NLNI---KIADFGFSNL-----------FTPGQLL--------------KT---WCGSPPYAAPELFE---GKEYDGPKVDIWSLGVVLYVLVC-GA-LP---------------FDGS----TLQNLR----ARVLS---GKFRIPFFMS----TECEH-LIRHMLVLDPNKRLS-----MEQICKHKWM--------------
----LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML---K-P--SAH-LTE-REALM-S------ELKVLSYLG-NHMNIVNLLGACT--I-GGP--TLVITEYCCYGDLLNFLR---RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLT-H-----GRIT---KICDFGLARDI-----K----N--DSNY--------------VVKGNARLPVKWMAPESIF----NCVYTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KEGFR---MLSPEHAP------AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I--------------
----LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL---K-Q--GSM-SP---DAFL-A------EANLMKQL--QHQRLVRLYAVVT----QEP--IYIITEYMENGSLVDFLK---TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVS-D-----TLSC---KIADFGLARLI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN----YGTFTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ERGYR---MVRPDNCP------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--------------
---V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--LCS-PQD-ELDFL-M------EALIISKF--RHQNIVRCVGLSL--R-ATP--RLILLELMSGGDMKSFLR---HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN--HFIHRDIAARNCLLS-CA--GPSRVA---KIGDFGMARDI-----Y----R--ASYY--------------RRGDRALLPVKWMPPEAFL----EGIFTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-TNQEVLDFV----VGGGR---MDPPRGCP------GPVYR-IMTQCWQHEPELRPS-----FASILERL----------------
----IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---K-P--GTM-SV---QAFL-E------EANLMKTL--QHDKLVRLYAVVT--R-EEP--IYIITEYMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--NYIHRDLRAANVLVS-E-----SLMC---KIADFGLARVI----------E--DNEY--------------TAREGAKFPIKWTAPEAIN----FGCFTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQGYR---MPRVENCP------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L--------------
----YRLLKTIGKGNFAKVKLARHI----------------LTGKEVAVKII---DKT--QLNSSS---LQKLFR------EVRIMKVL--NHPNIVKLFEVIE--T-EKT--LYLVMEYASGGEVFDYLV--AHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVQYCHQK--FIVHRDLKAENLLLD-A-----DMNI---KIADFGFSNE-----------FTFGNKL--------------DT---FCGSPPYAAPELFQ---GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FDGQ----NLKELR----ERVLR---GKYRIPFYMS----TDCEN-LLKKFLILNPSKRGT-----LEQIMKDRWM--------------
----YRLLRTIGKGNFAKVKLARHI----------------LTGREVAIKII---DKT--QLNPSS---LQKLFR------EVRIMKGL--NHPNIVKLFEVIE--T-EKT--LYLVMEYASAGEVFDYLV--SHG----------------------------------------------------------------------------------------------------RMKEKEARAKFRQIVSAVHYCHQK--NIVHRDLKAENLLLD-A-----EANI---KIADFGFSNE-----------FTLGSKL--------------DT---FCGSPPYAAPELFQ---GKKYDGPEVDIWSLGVILYTLVS-GS-LP---------------FDGH----NLKELR----ERVLR---GKYRVPFYMS----TDCES-ILRRFLVLNPAKRCT-----LEQIMKDKWI--------------
----LTLGAQIGEGEFGAVLQGEYL------------------GQKVAVKNI---K-C--DVT-AQ----AFL-D------ETAVMTKM--QHENLVRLLGVIL----HQG--LYIVMEHVSKGNLVNFLR---TR-------------------------------------------------------------------------------------------------GRALVNTAQLLQFSLHVAEGMEYLESK--KLVHRDLAARNILVS-E-----DLVA---KVSDFGLAKAE----------------R--------------KGLDSSRLPVKWTAPEALK----HGKFTSKSDVWSFGVLLWEVFSYGR-AP---------------YPKM-SLKEVSEAV----EKGYR---MEPPEGCP------GPVHV-LMSSCWEAEPARRPP-----FRKLAEKL----------------
----YRIRGEIGSGNFSQVKLGIHS----------------LTKEKVAIKIL---DKT--KLDQKT---QRLLSR------EISSMEKL--HHPNIIRLYEVVE--T-LSK--LHLVMEYAGGGELFGKIS--TEG----------------------------------------------------------------------------------------------------KLSEPESKLIFSQIVSAVKHMHEN--QIIHRDLKAENVFYT-S-----NTCV---KVGDFGFSTV-----------SKKGEML--------------NT---FCGSPPYAAPELFR---DEHYIGIYVDIWALGVLLYFMVT-GT-MP---------------FRAE----TVAKLK----KSILE---GTYSVPPHV----SEPCHR-LIRGVLQQIPTERYG-----IDCIMNDEWM--------------
---I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--EAS-ADM-QADFQ-R------EAALMAEF--DNPNIVKLLGVCA--V-GKP--MCLLFEYMAYGDLNEFLR---SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER--KFVHRDLATRNCLVG-E-----NMVV---KIADFGLSRNI-----Y----S--ADYY--------------KANENDAIPIRWMPPESIF----YNRYTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-AHEEVIYYV----RDGNI---LSCPENCP------VELYN-LMRLCWSKLPADRPS-----FTSIHRIL----------------
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--ASD-NA--RKDFH-R------EAELLTNL--QHEHIVKFYGVCV--E-GDP--LIMVFEYMKHGDLNKFLR---AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVG-E-----NLLV---KIGDFGMSRDV-----Y----S--TDYY--------------RVGGHTMLPIRWMPPESIM----YRKFTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQGRV---LQRPRTCP------QEVYE-LMLGCWQREPHMRKN-----IKGIHTL--L--------------
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--PTL-AA--RKDFQ-R------EAELLTNL--QHEHIVKFYGVCG--D-GDP--LIMVFEYMKHGDLNKFLR---AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVG-A-----NLLV---KIGDFGMSRDV-----Y----S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM----YRKFTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQGRV---LERPRVCP------KEVYD-VMLGCWQREPQQRLN-----IKEIYKIL----------------
----YELQETLGKGTYGKVKRATER----------------FSGRVVAIKSI---RKD--KIKDEQ---DMVHIR-----REIEIMSSL--NHPHIISIYEVFE--N-KDK--IVIIMEYASKGELYDYIS--ERR----------------------------------------------------------------------------------------------------RLSERETRHFFRQIVSAVHYCHKN--GVVHRDLKLENILLD-D-----NCNI---KIADFGLSNL-----------YQKDKFL--------------QT---FCGSPLYASPEIVN---GRPYRGPEVDSWALGVLLYTLVY-GT-MP---------------FDGF----DHKNLI----RQISS---GEYREPTQP-----SDARG-LIRWMLMVNPDRRAT-----IEDIANHWW-V-------------
----YEFLETLGKGTYGKVKKARES----------------SGR-LVAIKSI---RKD--KIKDEQ---DLMHIR-----REIEIMSSL--NHPHIIAIHEVFE--N-SSK--IVIVMEYASRGDLYDYIS--ERQ----------------------------------------------------------------------------------------------------QLSEREARHFFRQIVSAVHYCHQN--RVVHRDLKLENILLD-A-----NGNI---KIADFGLSNL-----------YHQGKFL--------------QT---FCGSPLYASPEIVN---GKPYTGPEVDSWSLGVLLYILVH-GT-MP---------------FDGH----DHKILV----KQISN---GAYREPPK-----PSDACG-LIRWLLMVNPTRRAT-----LEDVASHWW-V-------------
---L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML---K-P--TAR-SSE-KQALM-S------ELKIMTHLG-PHLNIVNLLGACT--K-SGP--IYIITEYCFYGDLVNYLH---KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--NCVHRDLAARNVLLA-Q-----GKIV---KICDFGLARDI-----M----H--DSNY--------------VSKGSTFLPVKWMAPESIF----DNLYTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KSGYR---MAKPDHAT------SEVYE-IMVKCWNSEPEKRPS-----FYHLSE---IV-------------
---L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML---K-S--TAR-SSE-KQALM-S------ELKIMSHLG-PHLNVVNLLGACT--K-GGP--IYIITEYCRYGDLVDYLH---RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--NCVHRDLAARNVLIC-E-----GKLV---KICDFGLARDI-----M----R--DSNY--------------ISKGSTFLPLKWMAPESIF----NSLYTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KRGYR---MAQPAHAS------DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL-------------
----FERLRTLGMGSFGRVMLVRHQ----------------ETGGHYAMKIL---NKQ--KVVKMK---QVEHIL-----NEKRILQAI--DFPFLVKLQFSFK--D-NSY--LYLVMEYVPGGEMFSRLQ--RVG----------------------------------------------------------------------------------------------------RFSEPHACFYAAQVVLAVQYLHSL--DLIHRDLKPENLLID-Q-----QGYL---QVTDFGFAK-------------RVKGRT--------------WT---LCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAV-GF-PP---------------FYAD----QPIQIY----EKIVS---GRVRFPSKLS----SDLKH-LLRSLLQVDLTKRFGNLRNGVGDIKNHKWF--------------
---F-NFLMVLGKGSFGKVMLADRK----------------GTEELYAIKIL---KKD--VVIQDD---DVECTM-----VEKRVLALL-DKPPFLTQLHSCFQ--T-VDR--LYFVMEYVNGGDLMYHIQ--QVG----------------------------------------------------------------------------------------------------KFKEPQAVFYAAEISIGLFFLHKR--GIIYRDLKLDNVMLD-S-----EGHI---KIADFGMCKEH----------MMDGVTT--------------RT---FCGTPDYIAPEIIA----YQPYGKSVDWWAYGVLLYEMLA-GQ-PP---------------FDGE----DEDELF----QSIME---HNVSYPKSLS----KEAVS-VCKGLMTKHPAKRLG-----C---------GPEGERDVREHAFF
----IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--CTS-DSV-REKFL-Q------EALTMRQF--DHPHIVKLIGVIT----ENP--VWIIMELCTLGELRSFLQ---VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK--RFVHRDIAARNVLVS-S-----NDCV---KLGDFGLSRYM----------E--DSTY--------------YKASKGKLPIKWMAPESIN----FRRFTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-KNNDVIGRI----ENGER---LPMPPNCP------PTLYS-LMTKCWAYDPSRRPR-----FTELKAQL----------------
---F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAIKVI---S-R--DNL-LH--QQMLQ-S------EIQAMKKL--RHKHILALYAVVS--V-GDP--VYIITELMAKGSLLELLR---DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--NYIHRDLAARNILVG-E-----NTLC---KVGDFGLARLI-------------KEDV--------------YLSHDHNIPYKWTAPEALS----RGHYSTKSDVWSFGILLHEMFSRGQ-VP---------------YPGM-SNHEAFLRV----DAGYR---MPCPLECP------PSVHK-LMLTCWCRDPEQRPC-----FKALRERL----------------
---L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--NAS-PSE-LRDLL-S------EFNVLKQV--NHPHVIKLYGACS--Q-DGP--LLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVA-E-----GRKM---KISDFGLSRDV-----Y----E--EDSY--------------VKRSQGRIPVKWMAIESLF----DHIYTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KTGHR---MERPDNCS------EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----------------
--LT--LRLLLGSGAFGEVYEGTAVDI----------LGVGSGEIKVAVKTL---K-K--GST-DQE-KIEFL-K------EAHLMSKF--NHPNILKQLGVCL--L-NEP--QYIILELMEGGDLLTYLR---KARM--------------------------------------------------------------------------------------------ATFYGPLLTLVDLVDLCVDISKGCVYLERM--HFIHRDLAARNCLVS-VKDYTSPRIV---KIGDFGLARDI-----Y----K--NDYY--------------RKRGEGLLPVRWMAPESLM----DGIFTTQSDVWSFGILIWEILTLGH-QP---------------YPAH-SNLDVLNYV----QTGGR---LEPPRNCP------DDLWN-LMTQCWAQEPDQRPT-----FHRIQDQL----------------
----YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAIKII---DKS--QLDAVN---LEKIYR------EVQIMKML--DHPHIIKLYQVME--T-KSM--LYLVTEYAKNGEIFDYLA--NHG----------------------------------------------------------------------------------------------------RLNESEARRKFWQILSAVDYCHGR--KIVHRDLKAENLLLD-N-----NMNI---KIADFGFGNF-----------FKSGELL--------------AT---WCGSPPYAAPEVFE---GQQYEGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP----TLPILR----QRVLE---GRFRIPYFMS----EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM--------------
----YDLDKTLGRGHFAVVKLARHV----------------FTGEKVAVKVI---DKT--KLDTLA---TGHLFQ------EVRCMKLV--QHPNIVRLYEVID--T-QTK--LYLILELGDGGDMFDYIM-KHEE----------------------------------------------------------------------------------------------------GLNEDLAKKYFAQIVHAISYCHKL--HVVHRDLKPENVVFFEK-----QGLV---KLTDFGFSNK-----------FQPGKKL--------------TT---SCGSLAYSAPEILL---GDEYDAPAVDIWSLGVILFMLVC-GQ-PP---------------FQEA----NDSETL----TMIMD---CKYTVPSHVS----KECKD-LITRMLQRDPKRRAS-----LEEIENHPWL--------------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--GTM-SP---EAFL-Q------EAQVMKKL--RHEKLVQLYAVVS----EEP--IYIVTEYMSKGSLLDFLK---GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--NYVHRDLRAANILVG-E-----NLVC---KVADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ERGYR---MPCPPECP------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--------------
--FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAIKVI---K-S--ANM-K---LTDLA-K------EIQTLKGL--RHERLIRLHAVCS--G-GEP--VYIVTELMRKGNLQAFLG---TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--RVVHRDLAARNVLVD-D-----GLAC---KVADFGLARLL----------K--DDIY--------------SPSSSSKIPVKWTAPEAAN----YRVFSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM-TNHETLQQI----MRGYR---LPRPAACP------AEVYV-LMLECWRSSPEERPS-----FATLREKL----------------
-LCP---GRELGRGKFAVVRKCIKK----------------DSGKEFAAKFM---RKR--RKGQDC---RMEIIH------EIAVLELA-QDNPWVINLHEVYE--T-ASE--MILVLEYAAGGEIFDQCVADREE----------------------------------------------------------------------------------------------------AFKEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLT-S-----ESPLGDIKIVDFGLSRI-----------LKNSEEL--------------RE---IMGTPEYVAPEILS----YDPISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN----DKQETF----LNISQ---MNLSYSEEEFDVLSESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL--------------
----FTKLEKIGKGSFGEVFKGIDN----------------RTQKVVAIKII---DLE--EAEDEI---EDIQ-Q------EITVLSQC--DSPYVTKYYGSYL--K-DTK--LWIIMEYLGGGSALDLLE---PG----------------------------------------------------------------------------------------------------PLDETQIATILREILKGLDYLHSE--KKIHRDIKAANVLLS-E-----HGEV---KLADFGVAGQL----------TDTQIKR--------------NT---FVGTPFWMAPEVIK----QSAYDSKADIWSLGITAIELAR-GE-PP---------------HSEL-HPMKVLFLI----PKNNP---PTLEGNYS------KPLKE-FVEACLNKEPSFRPT-----AKELLKHKFI--------------
---F-TKLDRIGKGSFGEVYKGIDN----------------HTKEVVAIKII---DLE--EAEDEI---EDIQ-Q------EITVLSQC--DSPYITRYFGSYL--K-STK--LWIIMEYLGGGSALDLLK---PG----------------------------------------------------------------------------------------------------PLEETYIATILREILKGLDYLHSE--RKIHRDIKAANVLLS-E-----QGDV---KLADFGVAGQL----------TDTQIKR--------------NT---FVGTPFWMAPEVIK----QSAYDFKADIWSLGITAIELAK-GE-PP---------------NSDL-HPMRVLFLI----PKNSP---PTLEGQHS------KPFKE-FVEACLNKDPRFRPT-----AKELLKHKFI--------------
-TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAVKIL---K-N--EAN-DPALKDELL-A------EANVMQQL--DNPYIVRMIGICE----AES--WMLVMEMAELGPLNKYLQ---QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--NFVHRDLAARNVLLV-T-----QHYA---KISDFGLSKAL-----R----A--DENY-------------YKAQTHGKWPVKWYAPECIN----YYKFSSKSDVWSFGVLMWEAFSYGQ-KP---------------YRGM-KGSEVTAML----EKGER---MGCPAGCP------REMYD-LMNLCWTYDVENRPG-----FAAVE----LRL------------
----LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAIKAI---R-E--GAM-CE---EDFI-E------EAKVMMKL--THPKLVQLYGVCT--Q-QKP--IYIVTEFMERGCLLNFLR---QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--SFIHRDLAARNCLVS-E-----AGVV---KVSDFGMARYV----------L--DDQY--------------TSSSGAKFPVKWCPPEVFN----YSRFSSKSDVWSFGVLMWEVFTEGR-MP---------------FEKY-TNYEVVTMV----TRGHR---LYQPKLAS------NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I--------------
--YL--LLHLLGRGGFSEVYKAFDL----------------TEQRYVAVKIH---QLN--KNWRDE---KKENYHKH-ACREYRIHKEL--DHPRIVKLYDYFS--LDTDS--FCTVLEYCEGNDLDFYLK--QHK----------------------------------------------------------------------------------------------------LMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLV-N-----GTACGEIKITDFGLSKIMDDD---SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN--QSQQDILQ----ENTIL---KATEVQFPPKPVVTPEAKA-FIRRCLAYRKEDRID-----VQQLACDPYL--------------
-VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--GPM-GTE-LGDFL-R------EVSVMMNL--EHPHVLRLHGLVL----GQP--LQMVMELAPLGSLHARLT---AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--GLVHRDLATRNLLLA-S-----PRTI---KVADFGLVRPL----GG----A--RGRY--------------VMGGPRPIPYAWCAPESLR----HGAFSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-PPYLILQRL----EDRAR---LPRPPLCS------RALYS-LALRCWAPHPADRPS-----FSHLE----GLL------------
---L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVLSQ-PEA-MDDFI-R------EVNAMHSL--DHRNLIRLYGVVL----TPP--MKMVTELAPLGSLLDRLR---KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLA-T-----RDLV---KIGDFGLMRAL----PQ----N--DDHY--------------VMQEHRKVPFAWCAPESLK----TRTFSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKI---DKEGER---LPRPEDCP------QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L--------------
---L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAIKAI---N-E--GSM-SE---EDFI-E------EAKVMMKL--SHSKLVQLYGVCI--Q-RKP--LYIVTEFMENGCLLNYLR---EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--GYIHRDLAARNCLVS-S-----TCIV---KISDFGMTRYV----------L--DDEY--------------VSSFGAKFPIKWSPPEVFL----FNKYSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQVVEAI----SEGFR---LYRPHLAP------MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV-------------
---L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAVKAL---K-A--DCG-PQH-RSGWK-Q------EIDILRTL--YHEHIIKYKGCCEDQG-EKS--LQLVMEYVPLGSLRDYLP---RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--HYIHRDLAARNVLLD-N-----DRLV---KIGDFGLAKAV----PE----G--HEYY--------------RVREDGDSPVFWYAPECLK----EYKFYYASDVWSFGVTLYELLTHCD-SSQSPPTKF-LELIGIAQGQM-TVLRLTELL----ERGER---LPRPDKCP------CEVYH-LMKNCWETEASFRPT-----FENLIP---IL-------------
---L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--GTM-MP---EAFL-Q------EAQIMKKL--RHDKLVPLYAVVS----EEP--IYIVTEFMSKGSLLDFLK---EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--NYIHRDLRAANILVG-E-----NLVC---KIADFGLARLI----------E--DNEY--------------TARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ERGYR---MPCPQGCP------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR--------------MRKKQIDVAIKVL---K-Q--GTE-KAD-TEEMM-R------EAQIMHQL--DNPYIVRLIGVCQ----AEA--LMLVMEMAGGGPLHKFLV---GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK--NFVHRDLAARNVLLV-N-----RHYA---KISDFGLSKAL----GA----D--DSYY--------------TARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM-KGPEVMAFI----EQGKR---MECPPECP------PELYA-LMSDCWIYKWEDRPD-----FLTVEQR--M--------------
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