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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CAMK2D 203
CAMK CAMK2G 14
AGC CDC42BPA 77
AGC CDC42BPB 76
AGC CDC42BPG 71
CAMK CHEK1 9
CAMK CHEK2 220
CAMK DAPK1 13
CAMK DAPK2 23
AGC DMPK 81
CAMK MAPKAPK2 64
CAMK MKNK2 84
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN2 657
AGC PRKCD 349
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KB1 91
AGC RPS6KB2 67
Other SBK1 53
STE SLK 34
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
Other STK36 4
----YQLFEELGKGAFSVVRRCMK---IPTGQ---EYAAKIINTKKLSARDHQKLER-------EARICRLL-K---HPNIVRLHDSISE----EGFHYLVFDLVTGGELFEDIV--AREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA--SKSKGA-AVKLADFGLAIEV-------QGDQQ-AWFGFAGTPGYLSPEVLR-------KDPYGKPVDMWACGVILYILLVGYPPFWDE---------------DQ-HRLYQQIKAGAYDFPSPEW-D-T-VTPEAKDLINKMLTINPAK--RIT-----AS-EALKHPWI-----
----YQLFEELGKGAFSVVRRCVK---KTSTQ---EYAAKIINTKKLSARDHQKLER-------EARICRLL-K---HPNIVRLHDSISE----EGFHYLVFDLVTGGELFEDIV--AREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA--SKCKGA-AVKLADFGLAIEV-------QGEQQ-AWFGFAGTPGYLSPEVLR-------KDPYGKPVDIWACGVILYILLVGYPPFWDE---------------DQ-HKLYQQIKAGAYDFPSPEW-D-T-VTPEAKNLINQMLTINPAK--RIT-----AD-QALKHPWV-----
----FEILKVIGRGAFGEVAVVKL---KNADK---VFAMKILNKWEMLKRAETACFR------EERDVLVNG-D---NKWITTLHYAFQD----DNNLYLVMDYYVGGDLLTLLS-KFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMD--MNGHI----RLADFGSCLKL------MEDGTV-QSSVAVGTPDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAE------------SLV----ETYGKIMNHKERFQFPAQVT-D-VSENAKDLIRRLICSREHR---LGQ--NGIE-DFKKHPFF-----
----FEIIKVIGRGAFGEVAVVKM---KNTER---IYAMKILNKWEMLKRAETACFR------EERDVLVNG-D---CQWITALHYAFQD----ENHLYLVMDYYVGGDLLTLLS-KFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLD--VNGHI----RLADFGSCLKM-------NDDGTVQSSVAVGTPDYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE---------------SL-VETYGKIMNHEERFQFPSHVT-D-VSEEAKDLIQRLICSRE-R--RLGQ--NGIE-DFKKHAF-F----
----FEILKVIGRGAFGEVTVVRQ---RDTGQ---IFAMKMLHKWEMLKRAETACFR------EERDVLVKG-D---SRWVTTLHYAFQD----EEYLYLVMDYYAGGDLLTLLS-RFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLD--VNGHI----RLADFGSCLRL-------NTNGMVDSSVAVGTPDYISPEILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAE------------SLVET-YGKIM---NHEDHLQFPPD-VPD-VPASAQDLIRQLLCRQEERLGRGG-----LD-DFRNHPFF-----
---W-DLVQTLGEGAYGEVQLAVN---RVTEE---AVAVKIVDMKRAVDCPENI-KK-------EICINKML-N---HENVVKFYGHRRE----GNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD--ERDNL----KISDFGLATVFR-----YNNRER-LLNKMCGTLPYVAPELLK------RREFHAEPVDVWSCGIVLTAMLAGELPWDQP--------------SDS-CQEYSDWKEKKTYLNPWKK-I----DSAPLALLHKILVENPSA--RIT-----IP-DIKKDRW-Y----
--YI--MSKTLGSGACGEVKLAFE---RKTCK---KVAIKIISKRKFAIGSAREADPALN-VETEIEILKKL-N---HPCIIKIKNFF-D----AEDYYIVLELMEGGELFDKVV--GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS--SQEEDC-LIKITDFGHSKI--------LGETS-LMRTLCGTPTYLAPEVLVS----VGTAGYNRAVDCWSLGVILFICLSGYPPFSEH--------------RTQ-VSLKDQITSGKYNFIPEVW-A-E-VSEKALDLVKKLLVVDPKA--RFT-----TE-EALRHPWL-----
----YDTGEELGSGQFAVVKKCRE---KSTGL---QYAAKFIKKRRTKSSRRGVSREDI---EREVSILKEI-Q---HPNVITLHEVYEN----KTDVILILELVAGGELFDFLA--EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL--DRNVPKPRIKIIDFGLAHK--------IDFGN-EFKNIFGTPEFVAPEIVN-------YEPLGLEADMWSIGVITYILLSGASPFLGD---------------TK-QETLANVSAVNYEFEDEYF-S-N-TSALAKDFIRRLLVKDPKK--RMT-----IQ-DSLQHPWI-----
----YDIGEELGSGQFAIVKKCRE---KSTGL---EYAAKFIKKRQSRASRRGVSREEI---EREVSILRQV-L---HHNVITLHDVYEN----RTDVVLILELVSGGELFDFLA--QKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL--DKNIPIPHIKLIDFGLAHE--------IEDGV-EFKNIFGTPEFVAPEIVN-------YEPLGLEADMWSIGVITYILLSGASPFLGD---------------TK-QETLANITAVSYDFDEEFF-S-Q-TSELAKDFIRKLLVKETRK--RLT-----IQ-EALRHPWI-----
----FEILKVIGRGAFSEVAVVKM---KQTGQ---VYAMKIMNKWDMLKRGEVSCFR------EERDVLVNG-D---RRWITQLHFAFQD----ENYLYLVMEYYVGGDLLTLLS-KFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD--RCGHI----RLADFGSCLKL------RADGTV-RSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYAD------------STAET-YGKIVHYKE---HLSLPLV-D-EGVPEEARDFIQRLLCPP-ET--RLGR--GGAG-DFRTHPFF-----
-KVT---SQVLGLGINGKVLQIFN---KRTQE---KFALKMLQDCPKAR-------R-------EVELHWRASQ---CPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT--SKRPNA-ILKLTDFGFAKE--------TTSHN-SLTTPCYTPYYVAPEVLG-------PEKYDKSCDMWSLGVIMYILLCGYPPFYSN-----------HGLAIS-PGMKTRIRMGQYEFPNPEW-S-E-VSEEVKMLIRNLLKTEPTQ--RMT-----IT-EFMNHPWI-----
QLQE----DVLGEGAHARVQTCIN---LITSQ---EYAVKIIEKQPGHIRSR--VFR-------EVEMLYQCQG---HRNVLELIEFFEE----EDRFYLVFEKMRGGSILSHIH--KRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCE--HPNQVS-PVKICDFDLGSGIKLNGDCSPISTP-ELLTPCGSAEYMAPEVVEAF--SEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQ-NMLFESIQEGKYEFPDKDW-A-H-ISCAAKDLISKLLVRDAKQ--RLS-----AA-QVLQHPWV-----
----YEPKEILGRGVSSVVRRCIH---KPTSQ---EYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSG---HPNIIQLKDTYET----NTFFFLVFDLMKRGELFDYLT--EKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD--DNMNI----KLTDFGFSCQ--------LEPGE-RLREVCGTPSYLAPEIIECS-MNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHR---------------KQ-MLMLRMIMSGNYQFGSPEW-D-D-YSDTVKDLVSRFLVVQPQN--RYT-----AE-EALAHPFF-----
-YDP---KDVIGRGVSSVVRRCVH---RATGH---EFAVKIMEVTAERLSPEQLEEVREA-TRRETHILRQVAG---HPHIITLIDSYES----SSFMFLVFDLMRKGELFDYLT--EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD--DNMQI----RLSDFGFSCH--------LEPGE-KLRELCGTPGYLAPEILKCS-MDETHPGYGKEVDLWACGVILFTLLAGSPPFWHR---------------RQ-ILMLRMIMEGQYQFSSPEW-D-D-RSSTVKDLISRLLQVDPEA--RLT-----AE-QALQHPFF-----
--FR--CCAVLGRGHFGKVLLAEY---KNTNE---MFAIKALKKGDIVARDEVDSLM------CEKRIFETV-NSVRHPFLVNLFACFQT----KEHVCFVMEYAAGGDLMMHIH---TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLD--TEGFV----KIADFGLCKEG-------MGYGD-RTSTFCGTPEFLAPEVLT-------ETSYTRAVDWWGLGVLIYEMLVGESPFPGD---------------DE-EEVFDSIVNDEVRYPRFLS-------TEAISIMRRLLRRNPER--RLGASEKDAE-DVKKHPFF-----
--FI--FHKVLGKGSFGKVLLGEL---KGRGE---YFAIKALKKDVVLIDDDVECTM------VEKRVLTLAAE---NPFLTHLICTFQT----KDHLFFVMEFLNGGDLMYHIQ--DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD--RDGHI----KIADFGMCKEN-------IFGES-RASTFCGTPDYIAPEILQ-------GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD---------------DE-DELFESIRVDTPHYPRWIT-------KESKDILEKLFEREPTK--RLG----VTG-NIKIHPFF-----
--FI--LHKMLGKGSFGKVFLAEF---KKTNQ---FFAIKALKKDVVLMDDDVECTM------VEKRVLSLAWE---HPFLTHMFCTFQT----KENLFFVMEYLNGGDLMYHIQ--SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN-------MLGDA-KTNTFCGTPDYIAPEILL-------GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ---------------DE-EELFHSIRMDNPFYPRWLE-------KEAKDLLVKLFVREPEK--RLG-----VRGDIRQHPLF-----
--PD----EVLGSGQFGIVYGGKH---RKTGR---DVAIKIIDKLRFPTKQESQLRN-------EVAILQNL-H---HPGVVNLECMFET----PERVFVVMEKLHGDMLEMILS-SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI--------IGEKS-FRRSVVGTPAYLAPEVLR-------NKGYNRSLDMWSVGVIIYVSLSGTFPFNED------------------EDIHDQIQNAAFMYPPNPW-K-E-ISHEAIDLINNLLQVKMRK--RYS-----VD-KTLSHPWL-----
--PD----EVLGSGQFGVVYGGKH---RKTGR---DVAVKVIDKLRFPTKQESQLRN-------EVAILQSL-R---HPGIVNLECMFET----PEKVFVVMEKLHGDMLEMILS-SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA--SADPFP-QVKLCDFGFARI--------IGEKS-FRRSVVGTPAYLAPEVLL-------NQGYNRSLDMWSVGVIMYVSLSGTFPFNED------------------EDINDQIQNAAFMYPASPW-S-H-ISAGAIDLINNLLQVKMRK--RYS-----VD-KSLSHPWL-----
-FAD----EVLGSGQFGIVYGGKH---RKTGR---DVAIKVIDKMRFPTKQESQLRN-------EVAILQNL-H---HPGIVNLECMFET----PERVFVVMEKLHGDMLEMILS-SEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA--SAEPFP-QVKLCDFGFARI--------IGEKS-FRRSVVGTPAYLAPEVLR-------SKGYNRSLDMWSVGVIIYVSLSGTFPFNED------------------EDINDQIQNAAFMYPPNPW-R-E-ISGEAIDLINNLLQVKMRK--RYS-----VD-KSLSHPWL-----
----FELLRVLGKGGYGKVFQVRKVTGANTGK---IFAMKVLKKAMIVRNAKDTAHTK-----AERNILEEV-K---HPFIVDLIYAFQT----GGKLYLILEYLSGGELFMQLE--REGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLN--HQGHV----KLTDFGLCKES-------IHDGT-VTHTFCGTIEYMAPEILM-------RSGHNRAVDWWSLGALMYDMLTGAPPFTGE---------------NR-KKTIDKILKCKLNLPPYLT-------QEARDLLKKLLKRNAAS--RLGAGPGDAG-EVQAHPFF-----
----FELLRVLGKGGYGKVFQVRK---VQGTNLGKIYAMKVLRKAKIVRNAKDTAHTR-----AERNILESV-K---HPFIVELAYAFQT----GGKLYLILECLSGGELFTHLE--REGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLS--SQGHI----KLTDFGLCKES-------IHEGA-VTHTFCGTIEYMAPEILV-------RSGHNRAVDWWSLGALMYDMLTGSPPFTAE---------------NR-KKTMDKIIRGKLALPPYLT-------PDARDLVKKFLKRNPSQ--RIGGGPGDAA-DVQRHPFF-----
----YELVRELGKGTYGKVDLVVY---KGTGT---KMALKFVNKSKTKLKNF---LR-------EVSITNSLSS---SPFIIKVFDVVFE---TEDCYVFAQEYAPAGDLFDIIP--PQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRV----KLADFGMTR----------RVGC-RVKRVSGTIPYTAPEVCQAG--RADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAA------------SGADAFFEEFVRWQRGRLPGLPSQW-R-R-FTEPALRMFQRLLALEPER--RGP-----AK-EVF-----RFLKH
----WEIIGELGDGAFGKVYKAQN---KETSV---LAAAKVIDTKSEEELEDYM--V-------EIDILASC-D---HPNIVKLLDAFYY----ENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN-------TRTIQ-RRDSFIGTPYWMAPEVVMCE--TSKDRPYDYKADVWSLGITLIEMAEIEPPHHEL------------NPMRV-LLKIAKSEPPTLAQPSRWS-------SNFKDFLKKCLEKNVDA--RWT-----TS-QLLQHPFV-----
----WEIVGELGDGAFGKVYKAKN---KETGA---LAAAKVIETKSEEELEDYI--V-------EIEILATC-D---HPYIVKLLGAYYH----DGKLWIMIEFCPGGAVDAIML-ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMT--LEGDI----RLADFGVSAKN-------LKTLQ-KRDSFIGTPYWMAPEVVMCE--TMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL------------NPMRV-LLKIAKSDPPTLLTPSKWS-------VEFRDFLKIALDKNPET--RPS-----AA-QLLEHPFV-----
-LCP---GRELGRGKFAVVRKCIK---KDSGK---EFAAKFMRKRRKGQDCRMEIIH-------EIAVLELAQD---NPWVINLHEVYET----ASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI--------LKNSE-ELREIMGTPEYVAPEILS-------YDPISMATDMWSIGVLTYVMLTGISPFLGN---------------DK-QETFLNISQMNLSYSEEEF-D-V-LSESAVDFIRTLLVKKPED--RAT-----AE-ECLKHPWL-----
-ILT---SKELGRGKFAVVRQCIS---KSTGQ---EYAAKFLKKRRRGQDCRAEILH-------EIAVLELAKS---CPRVINLHEVYEN----TSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK--------IGHAC-ELREIMGTPEYLAPEILN-------YDPITTATDMWNIGIIAYMLLTHTSPFVGE---------------DN-QETYLNISQVNVDYSEETF-S-S-VSQLATDFIQSLLVKNPEK--RPT-----AE-ICLSHSWL-----
----YHVLEMIGEGSFGRVYKGRR---KYSAQ---VVALKFIPKLGRSEKELRNLQR-------EIEIMRGL-R---HPNIVHMLDSFET----DKEVVVVTDYAEG-ELFQILE--DDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA--KGGGI----KLCDFGFARAM-------STNTM-VLTSIKGTPLYMSPELVE-------ERPYDHTADLWSVGCILYELAVGTPPFYAT---------------SI-FQLVSLILKDPVRWPSTIS-------PCFKNFLQGLLTKDPRQ--RLS-----WP-DLLYHPFI-----
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