|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ABL1 203
TK CSF1R 582
TK KDR 834
TK LCK 245
TK LYN 247
CMGC MAPK14 24
ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLREC-------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN--DSNYIVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL--
LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGAT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDYVRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL--
LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLKTP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
IKLVKRLGAGQFGEVWMGYYN------NSTKVAVKTLK-PGTM-SV--QAFL-EEANLMKTL-QHDKLVRLYAVVT-R------EEPIYIITEYMAKGSLLDFLKSD-------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI-E--DNEYTAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIPYPGR-TNADVMTALSQGYRMPRVENCP------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L
YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVKCQ----------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
|