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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT2 203
AGC AKT1 150
AGC AKT3 148
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CAMK CHEK2 220
AGC CIT 97
CAMK DAPK3 13
AGC GRK1 190
AGC GRK7 191
CMGC GSK3A 119
CAMK PIM1 38
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
AGC PRKACA 44
AGC PRKACB 44
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD3 576
AGC PRKG1 375
AGC PRKG2 453
AGC PRKX 49
TK RET 724
AGC ROCK1 76
AGC ROCK2 92
---F-EYLKLLGKGTFGKVILVKEK-----ATGRYYAMKILKKEVIVAKD--EVAHTL-----TENRVLQNS-R----HPF--LTALKYSFQT----HDRLC--FVMEYANGG--ELFFHLS----RER-------------------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHI----KITDFGLCKEG---IKDGATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ----DHEKLFELILMEEIRFPRTLG--------------------------PEAKSLLSGLLKKDPKQ--RLGGG--SEDAK-EIMQHRFF------------
--FD--YLKLLGKGTFGKVILVREK-----ASGKYYAMKILKKEVIIAKD--EVAHTL-----TESRVLKNT-R----HPF--LTSLKYSFQT----KDRLC--FVMEYVNGG--ELFFHLS----RER-------------------------VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG---ITDAATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ----DHEKLFELILMEDIKFPRTLS--------------------------SDAKSLLSGLLIKDPNK--RLGGG--PDDAK-EIMRHSFF------------
----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGV--PSTAIR------EISLLKEL-R----HPN--IVSLQDVLMQ----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLID-DKGTI----KLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-------GK-MALNHPYF------------
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PSTAIR------EISLLKEL-N----HPN--IVKLLDVIHT----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-------AK-AALAHPFF------------
---W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMKRAVDCP--ENI-KK------EICINKML-N----HEN--VVKFYGHRRE----GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHG-IGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP---SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSA--RIT-------IP-DIKKDRW-Y-----------
--YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKIISKRKFAIGS--AREADPALNVETEIEILKKL-N----HPC--IIKIKNFF-D----AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKA--RFT-------TE-EALRHPWL------------
---F-EVRSLVGCGHFAEVQVVREK-----ATGDIYAMKVMKKKALLAQE--QVSFFE-----EERNILSRS-T----SPW--IPQLQYAFQD----KNHLY--LVMEYQPGG--DLLSLLN---RYED-------------------------QLDENLIQFYLAELILAVHSVHL-MGYVHRDIKPENILVD-RTGHI----KLVDFGSAAKM--NSNKMVNAKL---PIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIY-GRSPFAEG----TSARTFNNIMNFQRFLKFPDDPKVS----------------------SDFLDLIQSLLCG-QKE--RLK-------FE-GLCCHPFF------------
----YEMGEELGSGQFAIVRKCRQK-----GTGKEYAAKFIKKRRLSSSR--RGVSREEI--EREVNILREI-R----HPN--IITLHDIFEN----KTDVV--LILELVSGG--ELFDFLA----EKE-------------------------SLTEDEATQFLKQILDGVHYLHS-KRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK----IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASPFLGE----TKQETLTNISAVNYDFDEEYFSNTS----------------------ELAKDFIRRLLVKDPKR--RMT-------IA-QSLEHSWI------------
FLDF----RVLGKGGFGEVSACQMK-----ATGKLYACKKLNKKRLKKRK--GYQGAM-----VEKKILMKV-H----SRF--IVSLAYAFET----KADLC--LVMTIMNGG--DIRYHIYNVNEENP-------------------------GFPEPRALFYTAQIICGLEHLHQ-RRIVYRDLKPENVLLD-NDGNV----RISDLGLAVEL---LDGQSKTKG---YAGTPGFMAPELLQ------GEEYDFSVDYFALGVTLYEMIA-ARGPFRARGEKVENKELKHRIISEPVKYPDKFS--------------------------QASKDFCEALLEKDPEK--RLG-------FR-D-------ETCDKLRAHPLF
---F-TEFRVLGKGGFGEVCAVQVK-----NTGKMYACKKLDKKRLKKKG--GEKMAL-----LEKEILEKV-S----SPF--IVSLAYAFES----KTHLC--LVMSLMNGG--DLKFHIYN--VGTR-------------------------GLDMSRVIFYSAQIACGMLHLHE-LGIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE----MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNF---T----------------------EEAKDICRLFLAKKPEQ--RLG-------SR-E-------KSDDPR------
----YTDIKVIGNGSFGVVYQARLA-----ETRELVAIKKVLQDKRFKNR--------------ELQIMRKL-D----HCN--IVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-------PL-EACAHSFF------------
----YQVGPLLGSGGFGSVYSGIRV-----SDNLPVAIKHVEKDRISDWG--ELPNGTRV--PMEVVLLKKV-S----SGFSGVIRLLDWFER----PDSFV--LILERPEPV-QDLFDFIT----ERG-------------------------ALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGEL----KLIDFGSGA-----LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD----------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSD--RPT-------FE-EIQNHPWM------------
----YQVGAVLGSGGFGTVYAGSRI-----ADGLPVAVKHVVKERVTEWG--SLGGATV---PLEVVLLRKV-GAAGGARG--VIRLLDWFER----PDGFL--LVLERPEPA-QDLFDFIT----ERG-------------------------ALDEPLARRFFAQVLAAVRHCHS-CGVVHRDIKDENLLVDLRSGEL----KLIDFGSGA-----LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIPFEQD----------EEILRGRLLFRRRVS--------------------------PECQQLIRWCLSLRPSE--RPS-------LD-QIAAHPWM------------
---F-KFLAVLGRGHFGKVLLSEFR-----PSGELFAIKALKKGDIVARD--EVESLM-----CEKRILAAV-TS-AGHPF--LVNLFGCFQT----PEHVC--FVMEYSAGG--DLMLHIH-----SD-------------------------VFSEPRAIFYSACVVLGLQFLHE-HKIVYRDLKLDNLLLD-TEGYV----KIADFGLCKEG---MGYGDRTST---FCGTPEFLAPEVLT------DTSYTRAVDWWGLGVLLYEMLV-GESPFPGD----DEEEVFDSIVNDEVRYPRFLS--------------------------AEAIGIMRRLLRRNPER--RLGSS--ERDAE-DVKKQPFF------------
--FR--CCAVLGRGHFGKVLLAEYK-----NTNEMFAIKALKKGDIVARD--EVDSLM-----CEKRIFETV-NS-VRHPF--LVNLFACFQT----KEHVC--FVMEYAAGG--DLMMHIH-----TD-------------------------VFSEPRAVFYAACVVLGLQYLHE-HKIVYRDLKLDNLLLD-TEGFV----KIADFGLCKEG---MGYGDRTST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GESPFPGD----DEEEVFDSIVNDEVRYPRFLS--------------------------TEAISIMRRLLRRNPER--RLGAS--EKDAE-DVKKHPFF------------
---F-ERIKTLGTGSFGRVMLVKHK-----ETGNHYAMKILDKQKVVKLK--QIEHTL-----NEKRILQAV-N----FPF--LVKLEFSFKD----NSNLY--MVMEYVPGG--EMFSHLR----RIG-------------------------RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-QQGYI----QVTDFGFAK------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD----QPIQIYEKIVSGKVRFPSHFS--------------------------SDLKDLLRNLLQVDLTK--RFGNL--KNGVN-DIKNHKWF------------
---F-ERKKTLGTGSFGRVMLVKHK-----ATEQYYAMKILDKQKVVKLK--QIEHTL-----NEKRILQAV-N----FPF--LVRLEYAFKD----NSNLY--MVMEYVPGG--EMFSHLR----RIG-------------------------RFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-HQGYI----QVTDFGFAK------RVKGRTWT---LCGTPEYLAPEIIL------SKGYNKAVDWWALGVLIYEMAA-GYPPFFAD----QPIQIYEKIVSGKVRFPSHFS--------------------------SDLKDLLRNLLQVDLTK--RFGNL--KNGVS-DIKTHKWF------------
--FI--FHKVLGKGSFGKVLLGELK-----GRGEYFAIKALKKDVVLIDD--DVECTM-----VEKRVLTLAAE----NPF--LTHLICTFQT----KDHLF--FVMEFLNGG--DLMYHIQ----DKG-------------------------RFELYRATFYAAEIMCGLQFLHS-KGIIYRDLKLDNVLLD-RDGHI----KIADFGMCKEN---IFGESRAST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQSPFHGD----DEDELFESIRVDTPHYPRWIT--------------------------KESKDILEKLFEREPTK--RLG------VTG-NIKIHPFF------------
---F-NFIKVLGKGSFGKVMLAELK-----GKDEVYAVKVLKKDVILQDD--DVDCTM-----TEKRILALARK----HPY--LTQLYCCFQT----KDRLF--FVMEYVNGG--DLMFQIQ----RSR-------------------------KFDEPRSRFYAAEVTSALMFLHQ-HGVIYRDLKLDNILLD-AEGHC----KLADFGMCKEG---ILNGVTTTT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQPPFEAD----NEDDLFESILHDDVLYPVWLS--------------------------KEAVSILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF----------
----FEFIRVLGKGSFGKVMLARVK-----ETGDLYAVKVLKKDVILQDD--DVECTM-----TEKRILSLARN----HPF--LTQLFCCFQT----PDRLF--FVMEFVNGG--DLMFHIQ----KSR-------------------------RFDEARARFYAAEIISALMFLHD-KGIIYRDLKLDNVLLD-HEGHC----KLADFGMCKEG---ICNGVTTAT---FCGTPDYIAPEILQ------EMLYGPAVDWWAMGVLLYEMLC-GHAPFEAE----NEDDLFEAILNDEVVYPTWLH--------------------------EDATGILKSFMTKNPTM--RLGSLT-QGGEH-AILRHPF-F-----------
--FI--LHKMLGKGSFGKVFLAEFK-----KTNQFFAIKALKKDVVLMDD--DVECTM-----VEKRVLSLAWE----HPF--LTHMFCTFQT----KENLF--FVMEYLNGG--DLMYHIQ----SCH-------------------------KFDLSRATFYAAEIILGLQFLHS-KGIVYRDLKLDNILLD-KDGHI----KIADFGMCKEN---MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQSPFHGQ----DEEELFHSIRMDNPFYPRWLE--------------------------KEAKDLLVKLFVREPEK--RLG-------VRGDIRQHPLF------------
--PD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKIIDKLRFPTKQ--ESQLRN------EVAILQNL-H----HPG--VVNLECMFET----PERVF--VVMEKLHGD--MLEMILS---SEKG-------------------------RLPEHITKFLITQILVALRHLHF-KNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLR------NKGYNRSLDMWSVGVIIYVSLS-GTFPFNED------EDIHDQIQNAAFMYPPNPWKEIS----------------------HEAIDLINNLLQVKMRK--RYS-------VD-KTLSHPWL------------
-FAD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKVIDKMRFPTKQ--ESQLRN------EVAILQNL-H----HPG--IVNLECMFET----PERVF--VVMEKLHGD--MLEMILS---SEKS-------------------------RLPERITKFMVTQILVALRNLHF-KNIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLR------SKGYNRSLDMWSVGVIIYVSLS-GTFPFNED------EDINDQIQNAAFMYPPNPWREIS----------------------GEAIDLINNLLQVKMRK--RYS-------VD-KSLSHPWL------------
---F-NIIDTLGVGGFGRVELVQLKS----EESKTFAMKILKKRHIVDTR--QQEHIR-----SEKQIMQGA-H----SDF--IVRLYRTFKD----SKYLY--MLMEACLGG--ELWTILR----DRG-------------------------SFEDSTTRFYTACVVEAFAYLHS-KGIIYRDLKPENLILD-HRGYA----KLVDFGFAKK----IGFGKKTWT---FCGTPEYVAPEIIL------NKGHDISADYWSLGILMYELLT-GSPPFSGP----DPMKTYNIILRGIDMIEFPKKIA------------------------KNAANLIKKLCRDNPSE--RLGNL--KNGVK-DIQKHKWF------------
---L-EIIATLGVGGFGRVELVKVK-----NENVAFAMKCIRKKHIVDTK--QQEHVY-----SEKRILEEL-C----SPF--IVKLYRTFKD----NKYVY--MLLEACLGG--ELWSILR----DRG-------------------------SFDEPTSKFCVACVTEAFDYLHR-LGIIYRDLKPENLILD-AEGYL----KLVDFGFAKK----IGSGQKTWT---FCGTPEYVAPEVIL------NKGHDFSVDFWSLGILVYELLT-GNPPFSGV----DQMMTYNLILKGIEKMDFPRKIT------------------------RRPEDLIRRLCRQNPTE--RLGNL--KNGIN-DIKKHRWL------------
--FD--TLATVGTGTFGRVHLVKEK-----TAKHFFALKVMSIPDVIRLK--QEQHVH-----NEKSVLKEV-S----HPF--LIRLFWTWHD----ERFLY--MLMEYVPGG--ELFSYLR----NRG-------------------------RFSSTTGLFYSAEIICAIEYLHS-KEIVYRDLKPENILLD-RDGHI----KLTDFGFAKK------LVDRTWT---LCGTPEYLAPEVIQ------SKGHGRAVDWWALGILIFEMLS-GFPPFFDD----NPFGIYQKILAGKIDFPRHLD--------------------------FHVKDLIKKLLVVDRTR--RLGNM--KNGAN-DVKHHRWF------------
---L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRDLL-S------EFNVLKQV-N----HPH--VIKLYGACSQ----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVA-EGRKM----KISDFGLSRDV-Y-E--EDSYVKRSQGRIPVKWMAIESLF------DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDK--RPV-------FA-DISKDL--------------
----YEVVKVIGRGAFGEVQLVRHK-----STRKVYAMKLLSKFEMIKRS--DSAFFW-----EERDIMAFA-N----SPW--VVQLFYAFQD----DRYLY--MVMEYMPGG--DLVNLMS-----NY-------------------------DVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLD-KSGHL----KLADFGTCMKM--NKEGMVRCDT---AVGTPDYISPEVLKS--QGGDGYYGRECDWWSVGVFLYEMLV-GDTPFYAD----SLVGTYSKIMNHKNSLTFPDDNDIS----------------------KEAKNLICAFLTDREVRLGRNG-------VE-EIKRHLFF------------
----YDVVKVIGRGAFGEVQLVRHK-----ASQKVYAMKLLSKFEMIKRS--DSAFFW-----EERDIMAFA-N----SPW--VVQLFYAFQD----DRYLY--MVMEYMPGG--DLVNLMS-----NY-------------------------DVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD-KHGHL----KLADFGTCMKM--DETGMVHCDT---AVGTPDYISPEVLKS--QGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYAD----SLVGTYSKIMDHKNSLCFPEDAEIS----------------------KHAKNLICAFLTDREVRLGRNG-------VE-EIRQHPFF------------
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