|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT3 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
Other CAMKK2 165
CAMK CASK 12
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDKL1 5
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
AGC GRK5 186
AGC GRK6 186
CAMK HUNK 61
CMGC ICK 4
CAMK KIAA0999 66
CMGC MAPK13 25
CAMK MAPKAPK2 64
CAMK MAPKAPK5 22
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK3 56
CAMK MARK4 59
CAMK MGC42105 74
Other NEK2 8
Other NEK5 4
Other NEK8 4
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK1 270
STE PAK2 249
STE PAK3 268
CMGC PCTK1 165
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCE 408
AGC PRKCH 355
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
CAMK SIK1 27
CAMK SIK2 20
CAMK SNRK 16
CAMK STK17A 61
STE STK24 24
STE STK25 20
Other STK36 4
Other TLK2 440
CAMK TSSK1B 12
CAMK TSSK2 12
Other TTK 525
---FD--YLKLLGKGTFGKV---ILVREKASGK---YYAMKILKKEV-IIAKDEVAHTL------------------------TESRVLKNT-R----HPF--LTSLKYSFQT----------KDRLCFVMEY-VNGG-ELF-FHLS-----------------------RERVFSEDRTRFYGAEIVSALDYLHSG-----KIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG-------ITDAATMKTFCGTPEYLAPEVLE------------------DND--YGRAVDWWGLGVVMYEMMC-GRLPFY-NQ-----DHEKLFELILMEDIKFPRTLS----------------------------------SDAKSLLSGLLIKDPNKRLGGG--PDDAKEIMRHSFF--------------
-----FEIGRPLGKGKFGNV---YLAREKQSKF---ILALKVLFKAQLEKAGVEHQLRR-------------------------EVEIQSHL-R----HPN--ILRLYGYFHD----------ATRVYLILEY-APLG-TVY-RELQ-----------------------KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV---------HAPSSRRTTLCGTLDYLPPEMIE------------------GRM--HDEKVDLWSLGVLCYEFLV-GKPPFE-AN-----TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM-------LREVLEHPWI--------------
-----FEIGRPLGKGKFGNV---YLAREKKSHF---IVALKVLFKSQ-IEKEGVEHQLR------------------------REIEIQAHL-H----HPN--ILRLYNYFYD----------RRRIYLILEY-APRG-ELY-KELQ-----------------------KSCTFDEQRTATIMEELADALMYCHGK-----KVIHRDIKPENLLLG-LKGEL----KIADFGWSV---------HAPSLRRKTMCGTLDYLPPEMIE------------------GRM--HNEKVDLWCIGVLCYELLV-GNPPFE-SA-----SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSERLP-------LAQVSAHPWV--------------
-----FEIGRPLGKGKFGNV---YLARLKESHF---IVALKVLFKSQ-IEKEGLEHQLR------------------------REIEIQAHL-Q----HPN--ILRLYNYFHD----------ARRVYLILEY-APRG-ELY-KELQ-----------------------KSEKLDEQRTATIIEELADALTYCHDK-----KVIHRDIKPENLLLG-FRGEV----KIADFGWSV---------HTPSLRRKTMCGTLDYLPPEMIE------------------GRT--YDEKVDLWCIGVLCYELLV-GYPPFE-SA-----SHSETYRRILKVDVRFPLSMP----------------------------------LGARDLISRLLRYQPLERLP-------LAQILKHPWV--------------
-----YRLEKTLGKGQTGLV---KLGVHCITGQ---KVAIKIVNREK-LSESVLMKVER-------------------------EIAILKLI-E----HPH--VLKLHDVYEN----------KKYLYLVLEH-VSGG-ELF-DYLV-----------------------KKGRLTPKEARKFFRQIVSALDFCHSY-----SICHRDLKPENLLLD-EKNNI----RIADFGMASL--------QVGDSLLETSCGSPHYACPEVIK-----------------GEKY--DGRRADMWSCGVILFALLV-GALPFD-DD-----NLRQLLEKVKRGVFHMPHFIP----------------------------------PDCQSLLRGMIEVEPEKRLS-------LEQIQKHPW-Y-------------
-----YRLEKTLGKGQTGLV---KLGVHCVTCQ---KVAIKIVNREK-LSESVLMKVER-------------------------EIAILKLI-E----HPH--VLKLHDVYEN----------KKYLYLVLEH-VSGG-ELF-DYLV-----------------------KKGRLTPKEARKFFRQIISALDFCHSH-----SICHRDLKPENLLLD-EKNNI----RIADFGMASL--------QVGDSLLETSCGSPHYACPEVIR-----------------GEKY--DGRKADVWSCGVILFALLV-GALPFD-DD-----NLRQLLEKVKRGVFHMPHFIP----------------------------------PDCQSLLRGMIEVDAARRLT-------LEHIQKHIW-Y-------------
-----YQLYEDIGKGAFSVV---RRCVKLCTGH---EYAAKIINTKK-LSARDHQKLER-------------------------EARICRLL-K----HSN--IVRLHDSISE----------EGFHYLVFDL-VTGG-ELF-EDIV-----------------------AREYYSEADASHCIQQILEAVLHCHQM-----GVVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV-------QGDQQAWFGFAGTPGYLSPEVLR------------------KEA--YGKPVDIWACGVILYILLV-GYPPFW-DE-----DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKNLINQMLTINPAKRIT-------AHEALKHPWV--------------
-----YQLFEELGKGAFSVV---RRCMKIPTGQ---EYAAKIINTKK-LSARDHQKLER-------------------------EARICRLL-K----HPN--IVRLHDSISE----------EGFHYLVFDL-VTGG-ELF-EDIV-----------------------AREYYSEADASHCIQQILESVNHCHLN-----GIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV-------QGDQQAWFGFAGTPGYLSPEVLR------------------KDP--YGKPVDMWACGVILYILLV-GYPPFW-DE-----DQHRLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKDLINKMLTINPAKRIT-------ASEALKHPWI--------------
-----YQLFEELGKGAFSVV---RRCVKKTSTQ---EYAAKIINTKK-LSARDHQKLER-------------------------EARICRLL-K----HPN--IVRLHDSISE----------EGFHYLVFDL-VTGG-ELF-EDIV-----------------------AREYYSEADASHCIHQILESVNHIHQH-----DIVHRDLKPENLLLA-SKCKGA-AVKLADFGLAIEV-------QGEQQAWFGFAGTPGYLSPEVLR------------------KDP--YGKPVDIWACGVILYILLV-GYPPFW-DE-----DQHKLYQQIKAGAYDFPSPEWDTVT------------------------------PEAKNLINQMLTINPAKRIT-------ADQALKHPWV--------------
-----YTLKDEIGKGSYGVV---KLAYNENDNT---YYAMKVLSKKK-LIRQAGFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D----HPN--VVKLVEVLDDP--------NEDHLYMVFEL-VNQG-PVM-EVPT------------------------LKPLSEDQARFYFQDLIKGIEYLHYQ-----KIIHRDIKPSNLLVG-EDGHI----KIADFGVSNEF-------KGSDALLSNTVGTPAFMAPESLS-----------------ETRKIFSGKALDVWAMGVTLYCFVF-GQCPFM-DE-----RIMCLHSKIKSQALEFPDQPDIA--------------------------------EDLKDLITRMLDKNPESRIV-------VPEIKLHPWV--------------
-----YELCEVIGKGPFSVV---RRCINRETGQ---QFAVKIVDVAK-FTSSPGLSTEDL----------------------KREASICHML-K----HPH--IVELLETYSS----------DGMLYMVFEF-MDGA-DLCFEIVKR--------------------ADAGFVYSEAVASHYMRQILEALRYCHDN-----NIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL-------GESGLVAGGRVGTPHFMAPEVVK------------------REP--YGKPVDVWGCGVILFILLS-GCLPFY-GT------KERLFEGIIKGKYKMNPRQWSHIS------------------------------ESAKDLVRRMLMLDPAERIT-------VYEALNHPWL--------------
-----FQKVEKIGEGTYGVV---YKARNKLTGE---VVALKKIRLDT-ETEGVPSTAIR-------------------------EISLLKEL-N----HPN--IVKLLDVIHT----------ENKLYLVFEF-LHQ--DLK-KFMDA---------------------SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF-------GVPVRTYTHEVVTLWYRAPEILL-----------------GCKY--YSTAVDIWSLGCIFAEMVT-RRALFP-GD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AKAALAHPFF--------------
-----FQKVEKIGEGTYGVV---YKAKNRETGQ---LVALKKIRLDL-EMEGVPSTAIR-------------------------EISLLKEL-K----HPN--IVRLLDVVHN----------ERKLYLVFEF-LSQ--DLK-KYMDS---------------------TPGSELPLHLIKSYLFQLLQGVSFCHSH-----RVIHRDLKPQNLLIN-ELGAI----KLADFGLARAF-------GVPLRTYTHEVVTLWYRAPEILL-----------------GSKF--YTTAVDIWSIGCIFAEMVT-RKALFP-GD--SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR--------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AKTALAHPYF--------------
-----YEKLEKIGEGTYGTV---FKAKNRETHE---IVALKRVRLDD-DDEGVPSSALR-------------------------EICLLKEL-K----HKN--IVRLHDVLHS----------DKKLTLVFEF-CDQ--DLK-KYFD----------------------SCNGDLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLIN-RNGEL----KLADFGLARAF-------GIPVRCYSAEVVTLWYRPPDVLF-----------------GAKL--YSTSIDMWSAGCIFAELANAGRPLFP-GN--DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-------AEEALQHPYF--------------
-----YEKIGKIGEGSYGVV---FKCRNRDTGQ---IVAIKKFLESE-DDPVIKKIALR-------------------------EIRMLKQL-K----HPN--LVNLLEVFRR----------KRRLHLVFEY-CDHT-VLH-ELDR-----------------------YQRGVPEHLVKSITWQTLQAVNFCHKH-----NCIHRDVKPENILIT-KHSVI----KLCDFGFARLL-------AGPSDYYTDYVATRWYRSPELLV-----------------GDTQ--YGPPVDVWAIGCVFAELLS-GVPLWP-GK--SDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED------MEPLELKFPNISYPALGLLKGCLHMDPTQRLT-------CEQLLHHPYF--------------
-----YENLGLVGEGSYGMV---MKCRNKDTGR---IVAIKKFLESD-DDKMVKKIAMR-------------------------EIKLLKQL-R----HEN--LVNLLEVCKK----------KKRWYLVFEF-VDHT-ILD-DLEL-----------------------FPNGLDYQVVQKYLFQIINGIGFCHSH-----NIIHRDIKPENILVS-QSGVV----KLCDFGFARTL-------AAPGEVYTDYVATRWYRAPELLV-----------------GDVK--YGKAVDVWAIGCLVTEMFM-GEPLFP-GD--SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CAELLHHDFF--------------
-----YETLGKVGEGSYGTV---MKCKHKNTGQ---IVAIKIFYERP-EQSVNK-IAMR-------------------------EIKFLKQF-H----HEN--LVNLIEVFRQ----------KKKIHLVFEF-IDHT-VLD-ELQH-----------------------YCHGLESKRLRKYLFQILRAIDYLHSN-----NIIHRDIKPENILVS-QSGIT----KLCDFGFARTL-------AAPGDIYTDYVATRWYRAPELVL-----------------KDTS--YGKPVDIWALGCMIIEMAT-GNPYLP-SS--SDLDLLHKIVLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQ-----HPKNARKKYPKLNGLLADIVHACLQIDPADRIS-------SSDLLHHEYF--------------
-----FEILGVVGEGAYGVV---LKCRHKETHE---IVAIKKFKDSE-ENEEVKETTLR-------------------------ELKMLRTL-K----QEN--IVELKEAFRR----------RGKLYLVFEY-VEK--NML-ELLE----------------------EMPNGVPPEKVKSYIYQLIKAIHWCHKN-----DIVHRDIKPENLLIS-HNDVL----KLCDFGFARNL------SEGNNANYTEYVATRWYRSPELLL------------------GAP--YGKSVDMWSVGCILGELSD-GQPLFP-GE--SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH-----PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TEQCLNHPTF--------------
----W-DLVQTLGEGAYGEV---QLAVNRVTEE---AVAVKIVDMKR-AVDCPENI-KK-------------------------EICINKML-N----HEN--VVKFYGHRRE----------GNIQYLFLEY-CSGG-ELF-DRIE-----------------------PDIGMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLD-ERDNL----KISDFGLATVFR-----YNNRERLLNKMCGTLPYVAPELLK-----------------RREF--HAEPVDVWSCGIVLTAMLA-GELPWD-QP----SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARIT-------IPDIKKDRW-Y-------------
---YI--MSKTLGSGACGEV---KLAFERKTCK---KVAIKIISKRK-FAIGSAREADPALN-------------------VETEIEILKKL-N----HPC--IIKIKNFF-D----------AEDYYIVLEL-MEGG-ELF-DKVV-----------------------GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI--------LGETSLMRTLCGTPTYLAPEVLVS---------------VGTAG--YNRAVDCWSLGVILFICLS-GYPPFS-EH----RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT-------TEEALRHPWL--------------
-----YQLVRKLGRGKYSEV---FEAINITNNE---KVVVKILKPVK-KKKIKR------------------------------EIKILENLRG----GPN--IITLADIVKDP--------VSRTPALVFEH-VNNT-DFK-QLY--------------------------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF--------YHPGQEYNVRVASRYFKGPELLV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RKEPFFHGH--DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-------AREAMEHPYF--------------
-----YQLVRKLGRGKYSEV---FEAINITNNE---RVVVKILKPVK-KKKIKR------------------------------EVKILENLRG----GTN--IIKLIDTVKDP--------VSKTPALVFEY-INNT-DFK-QLY--------------------------QILTDFDIRFYMYELLKALDYCHSK-----GIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF--------YHPAQEYNVRVASRYFKGPELLV-----------------DYQM--YDYSLDMWSLGCMLASMIF-RREPFFHGQ--DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-------AKEAMEHPYF--------------
-----YDTGEELGSGQFAVV---KKCREKSTGL---QYAAKFIKKRR-TKSSRRGVSREDI---------------------EREVSILKEI-Q----HPN--VITLHEVYEN----------KTDVILILEL-VAGG-ELF-DFLA-----------------------EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK--------IDFGNEFKNIFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GASPFL-GD-----TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT-------IQDSLQHPWI--------------
-----YDIGEELGSGQFAIV---KKCREKSTGL---EYAAKFIKKRQ-SRASRRGVSREEI---------------------EREVSILRQV-L----HHN--VITLHDVYEN----------RTDVVLILEL-VSGG-ELF-DFLA-----------------------QKESLSEEEATSFIKQILDGVNYLHTK-----KIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE--------IEDGVEFKNIFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GASPFL-GD-----TKQETLANITAVSYDFDEEFFSQTS------------------------------ELAKDFIRKLLVKETRKRLT-------IQEALRHPWI--------------
-----YEMGEELGSGQFAIV---RKCRQKGTGK---EYAAKFIKKRR-LSSSRRGVSREEI---------------------EREVNILREI-R----HPN--IITLHDIFEN----------KTDVVLILEL-VSGG-ELF-DFLA-----------------------EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK--------IEAGNEFKNIFGTPEFVAPEIVN------------------YEP--LGLEADMWSIGVITYILLS-GASPFL-GE-----TKQETLTNISAVNYDFDEEYFSNTS------------------------------ELAKDFIRRLLVKDPKRRMT-------IAQSLEHSWI--------------
----F-RQYRVLGKGGFGEV---CACQVRATGK---MYACKRLEKKR-IKKRKGESMAL------------------------NEKQILEKV-N----SQF--VVNLAYAYET----------KDALCLVLTI-MNGG-DLK-FHIYN---------------------MGNPGFEEERALFYAAEILCGLEDLHRE-----NTVYRDLKPENILLD-DYGHI----RISDLGLAVK--------IPEGDLIRGRVGTVGYMAPEVLN------------------NQR--YGLSPDYWGLGCLIYEMIE-GQSPFR-GR-----KEKVKREEVDRRVLETEEVYSHKFS------------------------------EEAKSICKMLLTKDAKQRLGCQ--EEGAAEVKRHPFF--------------
----F-RQYRVLGKGGFGEV---CACQVRATGK---MYACKKLEKKR-IKKRKGEAMAL------------------------NEKQILEKV-N----SRF--VVSLAYAYET----------KDALCLVLTL-MNGG-DLK-FHIYH---------------------MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH--------VPEGQTIKGRVGTVGYMAPEVVK------------------NER--YTFSPDWWALGCLLYEMIA-GQSPFQ-QR--KKKIKREEVERLVK-EVPEEYSER--FS------------------------------PQARSLCSQLLCKDPAERLGCR--GGSAREVKEHPLF--------------
--IGS----RKLGEGSFAKV---REGLHVLTGE---KVAIKVIDKKR-AKKDTYVTKNLR-----------------------REGQIQQMI-R----HPN--ITQLLDILET----------ENSYYLVMEL-CPGG-NLM-HKIY-----------------------EKKRLEESEARRYIRQLISAVEHLHRA-----GVVHRDLKIENLLLD-EDNNI----KLIDFGLSNCAG-----ILGYSDPFSTQCGSPAYAAPELLA------------------RKK--YGPKIDVWSIGVNMYAMLT-GTLPFT-VE---PFSLRALYQKMVD-KEMNPLPTQ--LS------------------------------TGAISFLRSLLEPDPVKRPN-------IQQALANRWL--------------
-----YTTIRQLGDGTYGSV---LLGRSIESGE---LIAIKKMKRKF-YSWEEC-MNLR-------------------------EVKSLKKL-N----HAN--VVKLKEVIRE----------NDHLYFIFEY-MKE--NLY-QLIK----------------------ERNKLFPESAIRNIMYQILQGLAFIHKH-----GFFHRDLKPENLLCM-GPELV----KIADFGLARE--------IRSKPPYTDYVSTRWYRAPEVLL-----------------RSTN--YSSPIDVWAVGCIMAEVYT-LRPLFP-GA--SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV-------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------ASQALRYPYF--------------
-----YEIDRTIGKGNFAVV---KRATHLVTKA---KVAIKIIDKTQ-LDEENLKKIFR-------------------------EVQIMKML-C----HPH--IIRLYQVMET----------ERMIYLVTEY-ASGG-EIF-DHLV-----------------------AHGRMAEKEARRKFKQIVTAVYFCHCR-----NIVHRDLKAENLLLD-ANLNI----KIADFGFSNL--------FTPGQLLKTWCGSPPYAAPELFE-----------------GKEY--DGPKVDIWSLGVVLYVLVC-GALPFD-GS-----TLQNLRARVLSGKFRIPFFMS----------------------------------TECEHLIRHMLVLDPNKRLS-------MEQICKHKWM--------------
-YVSP----THVGSGAYGSV---CSAIDKRSGE---KVAIKKLSRPF-QSEIFAKRAYR-------------------------ELLLLKHM-Q----HEN--VIGLLDVFTPASS----LRNFYDFYLVMPF-MQT--DLQ-KIM-------------------------GMEFSEEKIQYLVYQMLKGLKYIHSA-----GVVHRDLKPGNLAVN-EDCEL----KILDFGLAR----------HADAEMTGYVVTRWYRAPEVIL-----------------SWMH--YNQTVDIWSVGCIMAEMLT-GKTLFK-GK--DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP------RKDFTQLFPRASPQAADLLEKMLELDVDKRLT-------AAQALTHPFF--------------
--KVT---SQVLGLGINGKV---LQIFNKRTQE---KFALKMLQDCP-KAR-------R-------------------------EVELHWRASQ----CPH--IVRIVDVYENLY------AGRKCLLIVMEC-LDGG-ELF-SRIQD---------------------RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE--------TTSHNSLTTPCYTPYYVAPEVLG------------------PEK--YDKSCDMWSLGVIMYILLC-GYPPFY-SN-HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT-------ITEFMNHPWI--------------
--INW---TQKLGAGISGPV---RVCVKKSTQE---RFALKILLDRP-KAR-------N-------------------------EVRLHMMCAT----HPN--IVQIIEVFANSVQFPHESSPRARLLIVMEM-MEGG-ELF-HRIS-----------------------QHRHFTEKQASQVTKQIALALRHCHLL-----NIAHRDLKPENLLFK-DNS-LDAPVKLCDFGFAK----------IDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT--YNKSCDLWSLGVIIYVMLC-GYPPFY-SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQIS------------------------------EMAKDVVRKLLKVKPEERLT-------IEGVLDHPWL--------------
-----YRLQKTIGKGNFAKV---KLARHVLTGR---EVAVKIIDKTQ-LNPTSLQKLFR-------------------------EVRIMKIL-N----HPN--IVKLFEVIET----------EKTLYLVMEY-ASGG-EVF-DYLV-----------------------AHGRMKEKEARAKFRQIVSAVQYCHQK-----YIVHRDLKAENLLLD-GDMNI----KIADFGFSNE--------FTVGNKLDTFCGSPPYAAPELFQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GSLPFD-GQ-----NLKELRERVLRGKYRIPFYMS----------------------------------TDCENLLKKLLVLNPIKRGS-------LEQIMKDRWM--------------
-----YRLLKTIGKGNFAKV---KLARHILTGK---EVAVKIIDKTQ-LNSSSLQKLFR-------------------------EVRIMKVL-N----HPN--IVKLFEVIET----------EKTLYLVMEY-ASGG-EVF-DYLV-----------------------AHGRMKEKEARAKFRQIVSAVQYCHQK-----FIVHRDLKAENLLLD-ADMNI----KIADFGFSNE--------FTFGNKLDTFCGSPPYAAPELFQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GSLPFD-GQ-----NLKELRERVLRGKYRIPFYMS----------------------------------TDCENLLKKFLILNPSKRGT-------LEQIMKDRWM--------------
-----YRLLKTIGKGNFAKV---KLARHILTGR---EVAIKIIDKTQ-LNPTSLQKLFR-------------------------EVRIMKIL-N----HPN--IVKLFEVIET----------EKTLYLIMEY-ASGG-EVF-DYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQK-----RIVHRDLKAENLLLD-ADMNI----KIADFGFSNE--------FTVGGKLDTFCGSPPYAAPELFQ-----------------GKKY--DGPEVDVWSLGVILYTLVS-GSLPFD-GQ-----NLKELRERVLRGKYRIPFYMS----------------------------------TDCENLLKRFLVLNPIKRGT-------LEQIMKDRWI--------------
-----YRLLRTIGKGNFAKV---KLARHILTGR---EVAIKIIDKTQ-LNPSSLQKLFR-------------------------EVRIMKGL-N----HPN--IVKLFEVIET----------EKTLYLVMEY-ASAG-EVF-DYLV-----------------------SHGRMKEKEARAKFRQIVSAVHYCHQK-----NIVHRDLKAENLLLD-AEANI----KIADFGFSNE--------FTLGSKLDTFCGSPPYAAPELFQ-----------------GKKY--DGPEVDIWSLGVILYTLVS-GSLPFD-GH-----NLKELRERVLRGKYRVPFYMS----------------------------------TDCESILRRFLVLNPAKRCT-------LEQIMKDKWI--------------
-----YRIRGEIGSGNFSQV---KLGIHSLTKE---KVAIKILDKTK-LDQKTQRLLSR-------------------------EISSMEKL-H----HPN--IIRLYEVVET----------LSKLHLVMEY-AGGG-ELF-GKIS-----------------------TEGKLSEPESKLIFSQIVSAVKHMHEN-----QIIHRDLKAENVFYT-SNTCV----KVGDFGFSTV--------SKKGEMLNTFCGSPPYAAPELFR-----------------DEHY--IGIYVDIWALGVLLYFMVT-GTMPFR-AE-----TVAKLKKSILEGTYSVPPHV----S------------------------------EPCHRLIRGVLQQIPTERYG-------IDCIMNDEWM--------------
-----YEVLYTIGTGSYGRC---QKIRRKSDGK---ILVWKELDYGS-MTEAEKQMLVS-------------------------EVNLLREL-K----HPN--IVRYYDRIIDR--------TNTTLYIVMEY-CEGG-DLA-SVITKG-------------------TKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL-------NHDTSFAKTFVGTPYYMSPEQMN------------------RMS--YNEKSDIWSLGCLLYELCA-LMPPFT-AF-----SQKELAGKIREGKFRRIPYRY---S------------------------------DELNEIITRMLNLKDYHRPS-------VEEILENPL-I-------------
-----YDVIKAIGQGAFGKA---YLAKGKSDSK---HCVIKEINFEK-MPIQEKEASKK-------------------------EVILLEKM-K----HPN--IVAFFNSFQE----------NGRLFIVMEY-CDGG-DLM-KRINR---------------------QRGVLFSEDQILGWFVQISLGLKHIHDR-----KILHRDIKAQNIFLS-KNGMV---AKLGDFGIARVL-------NNSMELARTCIGTPYYLSPEICQ------------------NKP--YNNKTDIWSLGCVLYELCT-LKHPFE-GN-----NLQQLVLKICQAHFAPISPGF---S------------------------------RELHSLISQLFQVSPRDRPS-------INSILKRPFL--------------
-----YERIRVVGRGAFGIV---HLCLRKADQK---LVIIKQIPVEQ-MTKEERQAAQN-------------------------ECQVLKLL-N----HPN--VIEYYENFLE----------DKALMIAMEY-APGG-TLA-EFIQK---------------------RCNSLLEEETILHFFVQILLALHHVHTH-----LILHRDLKTQNILLDKHRMVV----KIGDFGISKI--------LSSKSKAYTVVGTPCYISPELCE------------------GKP--YNQKSDIWALGCVLYELAS-LKRAFE-AA-----NLPALVLKIMSGTFAPISDRY---S------------------------------PELRQLVLSLLSLEPAQRPP-------LSHIMAQP--LC------------
-----YELQETLGKGTYGKV---KRATERFSGR---VVAIKSIRKDK-IKDEQDMVHIR------------------------REIEIMSSL-N----HPH--IISIYEVFEN----------KDKIVIIMEY-ASKG-ELY-DYIS-----------------------ERRRLSERETRHFFRQIVSAVHYCHKN-----GVVHRDLKLENILLD-DNCNI----KIADFGLSNL--------YQKDKFLQTFCGSPLYASPEIVN-----------------GRPY--RGPEVDSWALGVLLYTLVY-GTMPFD-GF-----DHKNLIRQISSGEYREPTQP-----------------------------------SDARGLIRWMLMVNPDRRAT-------IEDIANHWW-V-------------
-----YEFLETLGKGTYGKV---KKARESSGR----LVAIKSIRKDK-IKDEQDLMHIR------------------------REIEIMSSL-N----HPH--IIAIHEVFEN----------SSKIVIVMEY-ASRG-DLY-DYIS-----------------------ERQQLSEREARHFFRQIVSAVHYCHQN-----RVVHRDLKLENILLD-ANGNI----KIADFGLSNL--------YHQGKFLQTFCGSPLYASPEIVN-----------------GKPY--TGPEVDSWSLGVLLYILVH-GTMPFD-GH-----DHKILVKQISNGAYREPPK-----P------------------------------SDACGLIRWLLMVNPTRRAT-------LEDVASHWW-V-------------
-----YTRFEKIGQGASGTV---YTAMDVATGQ---EVAIKQMNLQQ-QPKKELII--N-------------------------EILVMREN-K----NPN--IVNYLDSYLV----------GDELWVVMEY-LAGG-SLT-DVVT------------------------ETCMDEGQIAAVCRECLQALEFLHSN-----QVIHRDIKSDNILLG-MDGSV----KLTDFGFCAQI-------TPEQSKRSTMVGTPYWMAPEVVT------------------RKA--YGPKVDIWSLGIMAIEMIE-GEPPYL-NE--NPLRALYLIATNGTPELQNPEKLS----------------------------------AIFRDFLNRCLEMDVEKRGS-------AKELLQHQFL--------------
-----YTRYEKIGQGASGTV---FTATDVALGQ---EVAIKQINLQK-QPKKELII--N-------------------------EILVMKEL-K----NPN--IVNFLDSYLV----------GDELFVVMEY-LAGG-SLT-DVVT------------------------ETCMDEAQIAAVCRECLQALEFLHAN-----QVIHRDIKSDNVLLG-MEGSV----KLTDFGFCAQI-------TPEQSKRSTMVGTPYWMAPEVVT------------------RKA--YGPKVDIWSLGIMAIEMVE-GEPPYL-NE--NPLRALYLIATNGTPELQNPEKLS----------------------------------PIFRDFLNRCLEMDVEKRGS-------AKELLQHPFL--------------
-----YTRFEKIGQGASGTV---YTALDIATGQ---EVAIKQMNLQQ-QPKKELII--N-------------------------EILVMREN-K----NPN--IVNYLDSYLV----------GDELWVVMEY-LAGG-SLT-DVVT------------------------ETCMDEGQIAAVCRECLQALDFLHSN-----QVIHRDIKSDNILLG-MDGSV----KLTDFGFCAQI-------TPEQSKRSTMVGTPYWMAPEVVT------------------RKA--YGPKVDIWSLGIMAIEMVE-GEPPYL-NE--NPLRALYLIATNGTPELQNPERLS----------------------------------AVFRDFLNRCLEMDVDRRGS-------AKELLQHPFL--------------
----Y-IKLDKLGEGTYATV---YKGKSKLTDN---LVALKEIRLEH-EEGAPC-TAIR-------------------------EVSLLKDL-K----HAN--IVTLHDIIHT----------EKSLTLVFEY-LDK--DLK-QYLD----------------------DCGNIINMHNVKLFLFQLLRGLAYCHRQ-----KVLHRDLKPQNLLIN-ERGEL----KLADFGLARAK-------SIPTKTYSNEVVTLWYRPPDILL-----------------GSTD--YSTQIDMWGVGCIFYEMAT-GRPLFP-GS--TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR-------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-------AEDAMKHPFF--------------
-----YEPKEILGRGVSSVV---RRCIHKPTSQ---EYAVKVIDVTG-GGSFSPEEVRELRE------------------ATLKEVDILRKVSG----HPN--IIQLKDTYET----------NTFFFLVFDL-MKRG-ELF-DYLT-----------------------EKVTLSEKETRKIMRALLEVICTLHKL-----NIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ--------LEPGERLREVCGTPSYLAPEIIECS------------MNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPPFW-HR-----KQMLMLRMIMSGNYQFGSPEWDDYS------------------------------DTVKDLVSRFLVVQPQNRYT-------AEEALAHPFF--------------
--YDP---KDVIGRGVSSVV---RRCVHRATGH---EFAVKIMEVTA-ERLSPEQLEEVREA-------------------TRRETHILRQVAG----HPH--IITLIDSYES----------SSFMFLVFDL-MRKG-ELF-DYLT-----------------------EKVALSEKETRSIMRSLLEAVSFLHAN-----NIVHRDLKPENILLD-DNMQI----RLSDFGFSCH--------LEPGEKLRELCGTPGYLAPEILKCS------------MDETHPG--YGKEVDLWACGVILFTLLA-GSPPFW-HR-----RQILMLRMIMEGQYQFSSPEWDDRS------------------------------STVKDLISRLLQVDPEARLT-------AEQALQHPFF--------------
-----YQVGPLLGSGGFGSV---YSGIRVSDNL---PVAIKHVEKDR-ISDWGELPNGTRV---------------------PMEVVLLKKV-S----SGFSGVIRLLDWFER----------PDSFVLILER-PEPVQDLF-DFIT-----------------------ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR-----------------YHRY--HGRSAAVWSLGILLYDMVC-GDIPFE-HD-----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-------FEEIQNHPWM--------------
-----YRLGPLLGKGGFGTV---FAGHRLTDRL---QVAIKVIPRNR-VLGWSPLSDSVTC---------------------PLEVALLWKV-GAGGGHPG--VIRLLDWFET----------QEGFMLVLERPLPAQ-DLF-DYIT-----------------------EKGPLGEGPSRCFFGQVVAAIQHCHSR-----GVVHRDIKDENILIDLRRGCA----KLIDFGSGA---------LLHDEPYTDFDGTRVYSPPEWIS-----------------RHQY--HALPATVWSLGILLYDMVC-GDIPFE-RD-----------QEILEAELHFPAHVS----------------------------------PDCCALIRRCLAPKPSSRPS-------LEEILLDPWM--------------
-----YQVGAVLGSGGFGTV---YAGSRIADGL---PVAVKHVVKER-VTEWGSLGGATV----------------------PLEVVLLRKV-GAAGGARG--VIRLLDWFER----------PDGFLLVLER-PEPAQDLF-DFIT-----------------------ERGALDEPLARRFFAQVLAAVRHCHSC-----GVVHRDIKDENLLVDLRSGEL----KLIDFGSGA---------LLKDTVYTDFDGTRVYSPPEWIR-----------------YHRY--HGRSATVWSLGVLLYDMVC-GDIPFE-QD-----------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPS-------LDQIAAHPWM--------------
----Y-CRGKVLGKGGFAKC---YEMTDLTNNK---VYAAKIIPHSR-VAKPHQREKID------------------------KEIELHRIL-H----HKH--VVQFYHYFED----------KENIYILLEY-CSRR-SMA-HILK-----------------------ARKVLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFIN-EAMEL----KVGDFGLAARL-------EPLEHRRRTICGTPNYLSPEVLN------------------KQG--HGCESDIWALGCVMYTMLL-GRPPFE-TT-----NLKETYRCIREARYTMPSSLL----------------------------------APAKHLIASMLSKNPEDRPS-------LDDIIRHDFF--------------
---YL--KGRLLGKGGFARC---YEATDTETGS---AYAVKVIPQSR-VAKPHQREKIL------------------------NEIELHRDL-Q----HRH--IVRFSHHFED----------ADNIYIFLEL-CSRK-SLA-HIWK-----------------------ARHTLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFIT-ENMEL----KVGDFGLAARL-------EPPEQRKKTICGTPNYVAPEVLL------------------RQG--HGPEADVWSLGCVMYTLLC-GSPPFE-TA-----DLKETYRCIKQVHYTLPASLS----------------------------------LPARQLLAAILRASPRDRPS-------IDQILRHDFF--------------
----F-NFLMVLGKGSFGKV---MLADRKGTEE---LYAIKILKKDV-VIQDDDVECTM------------------------VEKRVLALLDK----PPF--LTQLHSCFQT----------VDRLYFVMEY-VNGG-DLM-YHIQ-----------------------QVGKFKEPQAVFYAAEISIGLFFLHKR-----GIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH-------MMDGVTTRTFCGTPDYIAPEIIA------------------YQP--YGKSVDWWAYGVLLYEMLA-GQPPFD-GE-----DEDELFQSIMEHNVSYPKSLS----------------------------------KEAVSVCKGLMTKHPAKRLG-------C---------GPEGERDVREHAFF
----F-NFLMVLGKGSFGKV---MLSERKGTDE---LYAVKILKKDV-VIQDDDVECTM------------------------VEKRVLALPGK----PPF--LTQLHSCFQT----------MDRLYFVMEY-VNGG-DLM-YHIQ-----------------------QVGRFKEPHAVFYAAEIAIGLFFLQSK-----GIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN-------IWDGVTTKTFCGTPDYIAPEIIA------------------YQP--YGKSVDWWAFGVLLYEMLA-GQAPFE-GE-----DEDELFQSIMEHNVAYPKSMS----------------------------------KEAVAICKGLMTKHPGKRLG-------C---------GPEGERDIKEHAFF
----F-NFIKVLGKGSFGKV---MLAELKGKDE---VYAVKVLKKDV-ILQDDDVDCTM------------------------TEKRILALARK----HPY--LTQLYCCFQT----------KDRLFFVMEY-VNGG-DLM-FQIQ-----------------------RSRKFDEPRSRFYAAEVTSALMFLHQH-----GVIYRDLKLDNILLD-AEGHC----KLADFGMCKEG-------ILNGVTTTTFCGTPDYIAPEILQ------------------ELE--YGPSVDWWALGVLMYEMMA-GQPPFE-AD-----NEDDLFESILHDDVLYPVWLS----------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHP--FF------------
-----FEFIRVLGKGSFGKV---MLARVKETGD---LYAVKVLKKDV-ILQDDDVECTM------------------------TEKRILSLARN----HPF--LTQLFCCFQT----------PDRLFFVMEF-VNGG-DLM-FHIQ-----------------------KSRRFDEARARFYAAEIISALMFLHDK-----GIIYRDLKLDNVLLD-HEGHC----KLADFGMCKEG-------ICNGVTTATFCGTPDYIAPEILQ------------------EML--YGPAVDWWAMGVLLYEMLC-GHAPFE-AE-----NEDDLFEAILNDEVVYPTWLH----------------------------------EDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPF-F-------------
---PD----EVLGSGQFGIV---YGGKHRKTGR---DVAIKIIDKLR-FPTKQESQLRN-------------------------EVAILQNL-H----HPG--VVNLECMFET----------PERVFVVMEK-LHGD-MLE-MILS----------------------SEKGRLPEHITKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI--------IGEKSFRRSVVGTPAYLAPEVLR------------------NKG--YNRSLDMWSVGVIIYVSLS-GTFPFN-ED-------EDIHDQIQNAAFMYPPNPWKEIS------------------------------HEAIDLINNLLQVKMRKRYS-------VDKTLSHPWL--------------
---PD----EVLGSGQFGVV---YGGKHRKTGR---DVAVKVIDKLR-FPTKQESQLRN-------------------------EVAILQSL-R----HPG--IVNLECMFET----------PEKVFVVMEK-LHGD-MLE-MILS----------------------SEKGRLPERLTKFLITQILVALRHLHFK-----NIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI--------IGEKSFRRSVVGTPAYLAPEVLL------------------NQG--YNRSLDMWSVGVIMYVSLS-GTFPFN-ED-------EDINDQIQNAAFMYPASPWSHIS------------------------------AGAIDLINNLLQVKMRKRYS-------VDKSLSHPWL--------------
--FAD----EVLGSGQFGIV---YGGKHRKTGR---DVAIKVIDKMR-FPTKQESQLRN-------------------------EVAILQNL-H----HPG--IVNLECMFET----------PERVFVVMEK-LHGD-MLE-MILS----------------------SEKSRLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLA-SAEPFP-QVKLCDFGFARI--------IGEKSFRRSVVGTPAYLAPEVLR------------------SKG--YNRSLDMWSVGVIIYVSLS-GTFPFN-ED-------EDINDQIQNAAFMYPPNPWREIS------------------------------GEAIDLINNLLQVKMRKRYS-------VDKSLSHPWL--------------
-----FELLKVLGQGSFGKVFLVRKVTRPDSGH---LYAMKVLKKAT-LKVRDRVRTKM-------------------------ERDILADV-N----HPF--VVKLHYAFQT----------EGKLYLILDF-LRGG-DLF-TRLS-----------------------KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA-------IDHEKKAYSFCGTVEYMAPEVVN------------------RQG--HSHSADWWSYGVLMFEMLT-GSLPFQ-GK-----DRKETMTLILKAKLGMPQFLS----------------------------------TEAQSLLRALFKRNPANRLGSG--PDGAEEIKRHV--FY------------
-----FELLKVLGQGSYGKV---FLVRKVKGSDAGQLYAMKVLKKAT-LKVRDRVRSKM-------------------------ERDILAEV-N----HPF--IVKLHYAFQT----------EGKLYLILDF-LRGG-DLF-TRLS-----------------------KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD-EEGHI----KITDFGLSKEA-------IDHDKRAYSFCGTIEYMAPEVVN------------------RRG--HTQSADWWSFGVLMFEMLT-GSLPFQ-GK-----DRKETMALILKAKLGMPQFLS----------------------------------GEAQSLLRALFKRNPCNRLGAG--IDGVEEIKRHPFF--------------
-----FELLKVLGQGSFGKV---FLVKKISGSDARQLYAMKVLKKAT-LKVRDRVRTKM-------------------------ERDILVEV-N----HPF--IVKLHYAFQT----------EGKLYLILDF-LRGG-DLF-TRLS-----------------------KEVMFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKES-------IDHEKKAYSFCGTVEYMAPEVVN------------------RRG--HTQSADWWSFGVLMFEMLT-GTLPFQ-GK-----DRKETMTMILKAKLGMPQFLS----------------------------------PEAQSLLRMLFKRNPANRLGAG--PDGVEEIKRHSFF--------------
-----FELLKVLGQGSFGKV---FLVRKKTGPDAGQLYAMKVLKKAS-LKVRDRVRTKM-------------------------ERDILVEV-N----HPF--IVKLHYAFQT----------EGKLYLILDF-LRGG-DVF-TRLS-----------------------KEVLFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLD-EIGHI----KLTDFGLSKES-------VDQEKKAYSFCGTVEYMAPEVVN------------------RRG--HSQSADWWSYGVLMFEMLT-GTLPFQ-GK-----DRNETMNMILKAKLGMPQFLS----------------------------------AEAQSLLRMLFKRNPANRLGS----EGVEEIKRHLFF--------------
-----YDIERTLGKGNFAVV---KLARHRVTKT---QVAIKIIDKTR-LDSSNLEKIYR-------------------------EVQLMKLL-N----HPH--IIKLYQVMET----------KDMLYIVTEF-AKNG-EMF-DYLT-----------------------SNGHLSENEARKKFWQILSAVEYCHDH-----HIVHRDLKTENLLLD-GNMDI----KLADFGFGNF--------YKSGEPLSTWCGSPPYAAPEVFE-----------------GKEY--EGPQLDIWSLGVVLYVLVC-GSLPFD-GP-----NLPTLRQRVLEGRFRIPFFMS----------------------------------QDCESLIRRMLVVDPARRIT-------IAQIRQHRWM--------------
-----YDIEGTLGKGNFAVV---KLGRHRITKT---EVAIKIIDKSQ-LDAVNLEKIYR-------------------------EVQIMKML-D----HPH--IIKLYQVMET----------KSMLYLVTEY-AKNG-EIF-DYLA-----------------------NHGRLNESEARRKFWQILSAVDYCHGR-----KIVHRDLKAENLLLD-NNMNI----KIADFGFGNF--------FKSGELLATWCGSPPYAAPEVFE-----------------GQQY--EGPQLDIWSMGVVLYVLVC-GALPFD-GP-----TLPILRQRVLEGRFRIPYFMS----------------------------------EDCEHLIRRMLVLDPSKRLT-------IAQIKEHKWM--------------
-----YDLDKTLGRGHFAVV---KLARHVFTGE---KVAVKVIDKTK-LDTLATGHLFQ-------------------------EVRCMKLV-Q----HPN--IVRLYEVIDT----------QTKLYLILEL-GDGG-DMF-DYIM----------------------KHEEGLNEDLAKKYFAQIVHAISYCHKL-----HVVHRDLKPENVVFFEKQGLV----KLTDFGFSNK--------FQPGKKLTTSCGSLAYSAPEILL-----------------GDEY--DAPAVDIWSLGVILFMLVC-GQPPFQ-EA-----NDSETLTMIMDCKYTVPSHVS----------------------------------KECKDLITRMLQRDPKRRAS-------LEEIENHPWL--------------
--LCP---GRELGRGKFAVV---RKCIKKDSGK---EFAAKFMRKRR-KGQDCRMEIIH-------------------------EIAVLELAQD----NPW--VINLHEVYET----------ASEMILVLEY-AAGG-EIF-DQCVA---------------------DREEAFKEKDVQRLMRQILEGVHFLHTR-----DVVHLDLKPQNILLT-SESPLG-DIKIVDFGLSRI--------LKNSEELREIMGTPEYVAPEILS------------------YDP--ISMATDMWSIGVLTYVMLT-GISPFL-GN-----DKQETFLNISQMNLSYSEEEFDVLS------------------------------ESAVDFIRTLLVKKPEDRAT-------AEECLKHPWL--------------
-----FTKLEKIGKGSFGEV---FKGIDNRTQK---VVAIKIIDLEE-AEDEIEDIQ-Q-------------------------EITVLSQC-D----SPY--VTKYYGSYLK----------DTKLWIIMEY-LGGG-SAL-DLLE------------------------PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL-------TDTQIKRNTFVGTPFWMAPEVIK------------------QSA--YDSKADIWSLGITAIELAR-GEPPHS-EL--HPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKEFVEACLNKEPSFRPT-------AKELLKHKFI--------------
----F-TKLDRIGKGSFGEV---YKGIDNHTKE---VVAIKIIDLEE-AEDEIEDIQ-Q-------------------------EITVLSQC-D----SPY--ITRYFGSYLK----------STKLWIIMEY-LGGG-SAL-DLLK------------------------PGPLEETYIATILREILKGLDYLHSE-----RKIHRDIKAANVLLS-EQGDV----KLADFGVAGQL-------TDTQIKRNTFVGTPFWMAPEVIK------------------QSA--YDFKADIWSLGITAIELAK-GEPPNS-DL--HPMRVLFLIPKNSPPTLEGQHS------------------------------------KPFKEFVEACLNKDPRFRPT-------AKELLKHKFI--------------
-----YHVLEMIGEGSFGRV---YKGRRKYSAQ---VVALKFIPKLG-RSEKELRNLQR-------------------------EIEIMRGL-R----HPN--IVHMLDSFET----------DKEVVVVTDY-AEG--ELF-QILE-----------------------DDGKLPEDQVQAIAAQLVSALYYLHSH-----RILHRDMKPQNILLA-KGGGI----KLCDFGFARAM-------STNTMVLTSIKGTPLYMSPELVE------------------ERP--YDHTADLWSVGCILYELAV-GTPPFY-AT-----SIFQLVSLILKDPVRWPSTIS----------------------------------PCFKNFLQGLLTKDPRQRLS-------WPDLLYHPFI--------------
---YL--LLHLLGRGGFSEV---YKAFDLTEQR---YVAVKIHQLNK-NWRDEKKENYHKH--------------------ACREYRIHKEL-D----HPR--IVKLYDYFSL---------DTDSFCTVLEY-CEGN-DLD-FYLK-----------------------QHKLMSEKEARSIIMQIVNALKYLNEIK---PPIIHYDLKPGNILLV-NGTACG-EIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVV--------------GKEPPK--ISNKVDVWSVGVIFYQCLY-GRKPFG-HN---QSQQDILQENTILKATEVQFPPKPVVT------------------------------PEAKAFIRRCLAYRKEDRID-------VQQLACDPYL--------------
YLLGI-----NLGEGSYAKV---KSAYSERLKF---NVAIKIIDRKK-APADFLEKFLP------------------------REIEILAML-N----HCS--IIKTYEIFET---------SHGKVYIVMEL-AVQG-DLL-ELIK-----------------------TRGALHEDEARKKFHQLSLAIKYCHDL-----DVVHRDLKCDNLLLD-KDFNI----KLSDFSFSKRCLR---DDSGRMALSKTFCGSPAYAAPEVLQ-----------------GIPY--QPKVYDIWSLGVILYIMVC-GSMPYD-DS-----NIKKMLRIQKEHRVNFPRSKHLT--------------------------------GECKDLIYHMLQPDVNRRLH-------IDEILSHCWM--------------
YIVGI-----NLGKGSYAKV---KSAYSERLKF---NVAVKIIDRKK-TPTDFVERF-LP-----------------------REMDILATV-N----HGS--IIKTYEIFET---------SDGRIYIIMEL-GVQG-DLL-EFIK-----------------------CQGALHEDVARKMFRQLSSAVKYCHDL-----DIVHRDLKCENLLLD-KDFNI----KLSDFGFSKRCLR---DSNGRIILSKTFCGSAAYAAPEVLQ-----------------SIPY--QPKVYDIWSLGVILYIMVC-GSMPYD-DS-----DIRKMLRIQKEHRVDFPRSKNLT--------------------------------CECKDLIYRMLQPDVSQRLH-------IDEILSHSWL--------------
-----YSILKQIGSGGSSKV---FQVLNEKKQ----IYAIKYVNLEE-ADNQTLDSYRN-------------------------EIAYLNKLQQ---HSDK--IIRLYDYEIT----------DQYIYMVMEC-GNI--DLN-SWLK-----------------------KKKSIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV--DGML----KLIDFGIANQMQ-----PDTTSVVKDSQVGTVNYMPPEAIKDMSSS-------RENGKSKSK--ISPKSDVWSLGCILYYMTY-GKTPFQ-QI----INQISKLHAIIDPNHEIEFPDIPE--------------------------------KDLQDVLKCCLKRDPKQRIS-------IPELLAHPYV--------------
|