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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC AKT3 203
Other AURKC 43
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDKL2 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK DAPK1 13
CAMK DAPK2 23
CAMK DAPK3 13
TK FGFR1 478
AGC GRK1 190
AGC GRK4 187
AGC GRK7 191
CMGC HIPK2 199
CMGC HIPK3 197
TK JAK3 822
TK LCK 245
CAMK MAPKAPK2 64
STE PAK3 268
AGC PDPK1 82
CAMK PHKG1 20
CAMK PIM1 38
CAMK PIM2 132
CAMK PIM3 40
AGC PKN1 615
AGC PKN2 657
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCH 355
AGC PRKCI 245
AGC PRKCQ 380
AGC PRKCZ 252
TK SRC 270
CAMK STK17A 61
--FD--YLKLLGKGTFGKVILVREK-------ASGKYYAMKILKKEVIIAKD--EV-AHTL------TESRVLKNT--R-----HPF-----LTSLKYSFQ--T----KDRLCFVMEY-VNGG-ELFFHLS----RER-----------------VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLD-KDGHI----KITDFGLCKEG----ITDAATMKT---FCGTPEYLAPEVLE------DNDYGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ---------DHEKLFELILMEDIKFPRTLS---------------------------------------------------------------------SDAKSLLSGLLIKDPNKRLGGG--PDDAK-EIMRHSFF--------------
----FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKSQIEKEG--LE-HQLR------REIEIQAHL--Q-----HPN-----ILRLYNYFH--D----ARRVYLILEY-APRG-ELYKELQ----KSE-----------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEV----KIADFGWSV------HTPSLRRKT---MCGTLDYLPPEMIE------GRTYDEKVDLWCIGVLCYELLV-GYPP-------------FESA---------SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------------LGARDLISRLLRYQPLERLP-------LA-QILKHPWV--------------
----YQLFEELGKGAFSVVRRCMKI-------PTGQEYAAKIINTKKLSARD--HQ-KLER-------EARICRLL--K-----HPN-----IVRLHDSIS--E----EGFHYLVFDL-VTGG-ELFEDIV----ARE-----------------YYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLA-SKSKGA-AVKLADFGLAIEV----QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GYPP-------------FWDE---------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------PEAKDLINKMLTINPAKRIT-------AS-EALKHPWI--------------
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLESEEEGV--PS-TAIR-------EISLLKEL--R-----HPN-----IVSLQDVLM--Q----DSRLYLIFEF-LSM--DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI----KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPL-------------FHGD------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GK-MALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PS-TAIR-------EISLLKEL--N-----HPN-----IVKLLDVIH--T----ENKLYLVFEF-LHQ--DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
----FQKVEKIGEGTYGVVYKAKNR-------ETGQLVALKKIRLDLEMEGV--PS-TAIR-------EISLLKEL--K-----HPN-----IVRLLDVVH--N----ERKLYLVFEF-LSQ--DLKKYMDS--TPGS-----------------ELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI----KLADFGLARAF----GVPLRTYTH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RKAL-------------FPGD------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AK-TALAHPYF--------------
----YENLGLVGEGSYGMVMKCRNK-------DTGRIVAIKKFLESDDDKMV--KK-IAMR-------EIKLLKQL--R-----HEN-----LVNLLEVCK--K----KKRWYLVFEF-VDHT-ILDDLEL----FPN-----------------GLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVS-QSGVV----KLCDFGFARTL----AAPGEVYTD---YVATRWYRAPELLV-----GDVKYGKAVDVWAIGCLVTEMFM-GEPL-------------FPGD------SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CA-ELLHHDFF--------------
----FEILGVVGEGAYGVVLKCRHK-------ETHEIVAIKKFKDSEENEEV--KE-TTLR-------ELKMLRTL--K-----QEN-----IVELKEAFR--R----RGKLYLVFEY-VEK--NMLELLE---EMPN-----------------GVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLIS-HNDVL----KLCDFGFARNL---SEGNNANYTE---YVATRWYRSPELLL------GAPYGKSVDMWSVGCILGELSD-GQPL-------------FPGE------SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TE-QCLNHPTF--------------
---W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKRAVDCP--EN-I-KK-------EICINKML--N-----HEN-----VVKFYGHRR--E----GNIQYLFLEY-CSGG-ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELP-------------WDQP--------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------SAPLALLHKILVENPSARIT-------IP-DIKKDRW-Y-------------
----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKRRTKSSR--RG-VSREDI---EREVSILKEI--Q-----HPN-----VITLHEVYE--N----KTDVILILEL-VAGG-ELFDFLA----EKE-----------------SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGD---------TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT-------IQ-DSLQHPWI--------------
----YDIGEELGSGQFAIVKKCREK-------STGLEYAAKFIKKRQSRASR--RG-VSREEI---EREVSILRQV--L-----HHN-----VITLHDVYE--N----RTDVVLILEL-VSGG-ELFDFLA----QKE-----------------SLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLL-DKNIPIPHIKLIDFGLAHE-----IEDGVEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGD---------TKQETLANITAVSYDFDEEFFSQTS-----------------------------------------------------------------ELAKDFIRKLLVKETRKRLT-------IQ-EALRHPWI--------------
----YEMGEELGSGQFAIVRKCRQK-------GTGKEYAAKFIKKRRLSSSR--RG-VSREEI---EREVNILREI--R-----HPN-----IITLHDIFE--N----KTDVVLILEL-VSGG-ELFDFLA----EKE-----------------SLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLL-DKNVPNPRIKLIDFGIAHK-----IEAGNEFKN---IFGTPEFVAPEIVN------YEPLGLEADMWSIGVITYILLS-GASP-------------FLGE---------TKQETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-------IA-QSLEHSWI--------------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSD-LI-S-------EMEMMKMIG-K-----HKN-----IINLLGACT--Q----DGPLYVIVEY-ASKG-NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM----KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF------DRIYTHQSDVWSFGVLLWEIFTLGGSP-------------YPGV------PVEELFKLLKEGHRMDKPSNCT-----------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-------FK-QLVEDL----------------
FLDF----RVLGKGGFGEVSACQMK-------ATGKLYACKKLNKKRLKKRK--GY-QGAM------VEKKILMKV--H-----SRF-----IVSLAYAFE--T----KADLCLVMTI-MNGG-DIRYHIYNVNEENP-----------------GFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLD-NDGNV----RISDLGLAVEL----LDGQSKTKG---YAGTPGFMAPELLQ------GEEYDFSVDYFALGVTLYEMIA-ARGP-------------FRAR-----GEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-------FR-D-------ETCDKLRAHPLF--
--FR--HYRVLGKGGFGEVCACQVR-------ATGKMYACKKLQKKRIKKRK--GE-AMAL------NEKRILEKV--Q-----SRF-----VVSLAYAYE--T----KDALCLVLTI-MNGG-DLKFHIYN--LGNP-----------------GFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLD-DRGHI----RISDLGLATE-----IPEGQRVRG---RVGTVGYMAPEVVN------NEKYTFSPDWWGLGCLIYEMIQ-GHSP-------------FKKY------KEKVKWEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCR--GEGAA-GVKQHPV-F-------------
---F-TEFRVLGKGGFGEVCAVQVK-------NTGKMYACKKLDKKRLKKKG--GE-KMAL------LEKEILEKV--S-----SPF-----IVSLAYAFE--S----KTHLCLVMSL-MNGG-DLKFHIYN--VGTR-----------------GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLD-DLGNC----RLSDLGLAVE-----MKGGKPITQ---RAGTNGYMAPEILM-----EKVSYSYPVDWFAMGCSIYEMVA-GRTP-------------FKDY-----KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-------SR-E-------KSDDPR--------
----YEVLEFLGRGTFGQVVKCWKR-------GTNEIVAIKILKNHPSYARQ--GQ-I----------EVSILARL--STESADDYN-----FVRAYECFQ--H----KNHTCLVFEM-LEQ--NLYDFLKQ--NKFS-----------------PLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV-DPSRQPYRVKVIDFGSAS------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YPGA------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-------PI-ETLNHPFV--------------
----YEVLDFLGRGTFGQVVKCWKR-------GTNEIVAIKILKNHPSYARQ--GQ-I----------EVSILARL--S-----TENADEYNFVRAYECFQ--H----RNHTCLVFEM-LEQ--NLYDFLKQ--NKFS-----------------PLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLV-DPVRQPYRVKVIDFGSAS------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GWPL-------------YPGA------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-------PA-ETLNHPFV--------------
---L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HSGP-DQ-QRD-FQ-R-------EIQILKAL--H-----SDF-----IVKYRGVSYGPG----RQSLRLVMEY-LPSG-CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV----KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS------DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV-P----ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DA-FL-A-------EANLMKQL--Q-----HQR-----LVRLYAVVT-------QEPIYIITEY-MENG-SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC----KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN------YGTFTIKSDVWSFGILLTEIVTHGRIP-------------YPGM------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------------------------------------EELYQLMRLCWKERPEDRPT-------FD-YLRSV--L--------------
-KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDCPKAR----------R-------EVELHWRA-SQ-----CPH-----IVRIVDVYE--NLYAGRKCLLIVMEC-LDGG-ELFSRIQD--RGDQ-----------------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE-----TTSHNSLTT---PCYTPYYVAPEVLG------PEKYDKSCDMWSLGVIMYILLC-GYPP-------------FYSN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT-------IT-EFMNHPWI--------------
----YTRFEKIGQGASGTVYTALDI-------ATGQEVAIKQMNLQQQPKKE--LI-I--N-------EILVMREN--K-----NPN-----IVNYLDSYL--V----GDELWVVMEY-LAGG-SLTDVVT-----ET-----------------CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLG-MDGSV----KLTDFGFCAQI----TPEQSKRST---MVGTPYWMAPEVVT------RKAYGPKVDIWSLGIMAIEMVE-GEPP-------------YLNE------NPLRALYLIATNGTPELQNPERLS---------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS-------AK-ELLQHPFL--------------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRHIIKEN--KVPYVTR-------ERDVMSRL--D-----HPF-----FVKLYFTFQ--D----DEKLYFGLSY-AKNG-ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPP-------------FRAG---------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---
----YEPKEILGRGVSSVVRRCIHK-------PTSQEYAVKVIDVTGGGSFS--PE-EVRELREATLKEVDILRKV-SG-----HPN-----IIQLKDTYE--T----NTFFFLVFDL-MKRG-ELFDYLT----EKV-----------------TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI----KLTDFGFSCQ-----LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPP-------------FWHR---------KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-------AE-EALAHPFF--------------
----YQVGPLLGSGGFGSVYSGIRV-------SDNLPVAIKHVEKDRISDWG--EL-PNGTRV---PMEVVLLKKV--S-----SGFS---GVIRLLDWFE--R----PDSFVLILER-PEPVQDLFDFIT----ERG-----------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVC-GDIP-------------FEHD---------------EEIIRGQVFFRQRVS---------------------------------------------------------------------SECQHLIRWCLALRPSDRPT-------FE-EIQNHPWM--------------
----YRLGPLLGKGGFGTVFAGHRL-------TDRLQVAIKVIPRNRVLGWS--PL-SDSVTC---PLEVALLWKV--GAG-GGHPG-----VIRLLDWFE--T----QEGFMLVLERPLPAQ-DLFDYIT----EKG-----------------PLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA----KLIDFGSGA------LLHDEPYTD---FDGTRVYSPPEWIS-----RHQYHALPATVWSLGILLYDMVC-GDIP-------------FERD---------------QEILEAELHFPAHVS---------------------------------------------------------------------PDCCALIRRCLAPKPSSRPS-------LE-EILLDPWM--------------
----YQVGAVLGSGGFGTVYAGSRI-------ADGLPVAVKHVVKERVTEWG--SL-GGATV----PLEVVLLRKV--GAA-GGARG-----VIRLLDWFE--R----PDGFLLVLER-PEPAQDLFDFIT----ERG-----------------ALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL----KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIP-------------FEQD---------------EEILRGRLLFRRRVS---------------------------------------------------------------------PECQQLIRWCLSLRPSERPS-------LD-QIAAHPWM--------------
---F-KFLAVLGRGHFGKVLLSEFR-------PSGELFAIKALKKGDIVARD--EV-ESLM------CEKRILAAV--TS--AGHPF-----LVNLFGCFQ--T----PEHVCFVMEY-SAGG-DLMLHIH-----SD-----------------VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLD-TEGYV----KIADFGLCKEG----MGYGDRTST---FCGTPEFLAPEVLT------DTSYTRAVDWWGLGVLLYEMLV-GESP-------------FPGD---------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------AEAIGIMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
--FR--CCAVLGRGHFGKVLLAEYK-------NTNEMFAIKALKKGDIVARD--EV-DSLM------CEKRIFETV--NS--VRHPF-----LVNLFACFQ--T----KEHVCFVMEY-AAGG-DLMMHIH-----TD-----------------VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLD-TEGFV----KIADFGLCKEG----MGYGDRTST---FCGTPEFLAPEVLT------ETSYTRAVDWWGLGVLIYEMLV-GESP-------------FPGD---------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF--------------
---F-NFLMVLGKGSFGKVMLADRK-------GTEELYAIKILKKDVVIQDD--DV-ECTM------VEKRVLALL-DK-----PPF-----LTQLHSCFQ--T----VDRLYFVMEY-VNGG-DLMYHIQ----QVG-----------------KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEH----MMDGVTTRT---FCGTPDYIAPEIIA------YQPYGKSVDWWAYGVLLYEMLA-GQPP-------------FDGE---------DEDELFQSIMEHNVSYPKSLS---------------------------------------------------------------------KEAVSVCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
---F-NFLMVLGKGSFGKVMLSERK-------GTDELYAVKILKKDVVIQDD--DV-ECTM------VEKRVLALP-GK-----PPF-----LTQLHSCFQ--T----MDRLYFVMEY-VNGG-DLMYHIQ----QVG-----------------RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHI----KIADFGMCKEN----IWDGVTTKT---FCGTPDYIAPEIIA------YQPYGKSVDWWAFGVLLYEMLA-GQAP-------------FEGE---------DEDELFQSIMEHNVAYPKSMS---------------------------------------------------------------------KEAVAICKGLMTKHPGKRLG-------C----------GPEGERDIKEHAFF
--FI--FHKVLGKGSFGKVLLGELK-------GRGEYFAIKALKKDVVLIDD--DV-ECTM------VEKRVLTLA-AE-----NPF-----LTHLICTFQ--T----KDHLFFVMEF-LNGG-DLMYHIQ----DKG-----------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI----KIADFGMCKEN----IFGESRAST---FCGTPDYIAPEILQ------GLKYTFSVDWWSFGVLLYEMLI-GQSP-------------FHGD---------DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------KESKDILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
---F-NFIKVLGKGSFGKVMLAELK-------GKDEVYAVKVLKKDVILQDD--DV-DCTM------TEKRILALA-RK-----HPY-----LTQLYCCFQ--T----KDRLFFVMEY-VNGG-DLMFQIQ----RSR-----------------KFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLD-AEGHC----KLADFGMCKEG----ILNGVTTTT---FCGTPDYIAPEILQ------ELEYGPSVDWWALGVLMYEMMA-GQPP-------------FEAD---------NEDDLFESILHDDVLYPVWLS---------------------------------------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
----FEFIRVLGKGSFGKVMLARVK-------ETGDLYAVKVLKKDVILQDD--DV-ECTM------TEKRILSLA-RN-----HPF-----LTQLFCCFQ--T----PDRLFFVMEF-VNGG-DLMFHIQ----KSR-----------------RFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD-HEGHC----KLADFGMCKEG----ICNGVTTAT---FCGTPDYIAPEILQ------EMLYGPAVDWWAMGVLLYEMLC-GHAP-------------FEAE---------NEDDLFEAILNDEVVYPTWLH---------------------------------------------------------------------EDATGILKSFMTKNPTMRLGSLT-QGGEH-AILRHPF-F-------------
---F-DLLRVIGRGSYAKVLLVRLK-------KTDRIYAMKVVKKELVNDDE--DI-DWVQ------TEKHVFEQA-SN-----HPF-----LVGLHSCFQ--T----ESRLFFVIEY-VNGG-DLMFHMQ----RQR-----------------KLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD-SEGHI----KLTDYGMCKEG----LRPGDTTST---FCGTPNYIAPEILR------GEDYGFSVDWWALGVLMFEMMA-GRSP-------------FDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS---------------------------------------------------------------------VKAASVLKSFLNKDPKERLGCHP-QTGFA-DIQGHPF-F-------------
--FI--LHKMLGKGSFGKVFLAEFK-------KTNQFFAIKALKKDVVLMDD--DV-ECTM------VEKRVLSLA-WE-----HPF-----LTHMFCTFQ--T----KENLFFVMEY-LNGG-DLMYHIQ----SCH-----------------KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHI----KIADFGMCKEN----MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQSP-------------FHGQ---------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
---F-DLIRVIGRGSYAKVLLVRLK-------KNDQIYAMKVVKKELVHDDE--DI-DWVQ------TEKHVFEQA-SS-----NPF-----LVGLHSCFQ--T----TSRLFLVIEY-VNGG-DLMFHMQ----RQR-----------------KLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLD-ADGHI----KLTDYGMCKEG----LGPGDTTST---FCGTPNYIAPEILR------GEEYGFSVDWWALGVLMFEMMA-GRSP-------------FDIITD--NPDMNTEDYLFQVILEKPIRIPRFLS---------------------------------------------------------------------VKASHVLKGFLNKDPKERLGCRP-QTGF----------SDIKSHAFF-----
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EA-FL-Q-------EAQVMKKL--R-----HEK-----LVQLYAVVS-------EEPIYIVTEY-MSKG-SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC----KVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL------YGRFTIKSDVWSFGILLTELTTKGRVP-------------YPGM------VNREVLDQVERGYRMPCPPECP-----------------------------------------------------------------------ESLHDLMCQCWRKEPEERPT-------FE-YLQAF--L--------------
-LCP---GRELGRGKFAVVRKCIKK-------DSGKEFAAKFMRKRRKGQDC--RM-EIIH-------EIAVLELA-QD-----NPW-----VINLHEVYE--T----ASEMILVLEY-AAGG-EIFDQCVA--DREE-----------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-SESPLG-DIKIVDFGLSRI-----LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GISP-------------FLGN---------DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-------AE-ECLKHPWL--------------
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