Protein Surface  Ribbon
Inhibitor WFE
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 5 kinases in KIF 3MVHA_WFE (AKT1, PDB code: 3MVH, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
AGC        AKT3         203 
AGC        AKT1         150 
AGC        ROCK1         76 
AGC        ROCK2         92 



FD--YLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHIKITDFGLCKEG-ITDAATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLS----SDAKSLLSGLLIKDPNK--RLGGGPDDAKEIMRHSFF
-F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLG----PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF
--YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWARFYTAEVVLALDAIHS-MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF
--YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMS-NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF