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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK ALK 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK CSF1R 582
TK FGFR1 478
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TK NTRK1 510
TK RET 724
TK SRC 270
-I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS-EQDELDFL-M-EALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR-ETRP--------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGRMDPPKNCP--GPVYRIMTQCWQHQPEDRPNFAIILER--I--
--ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR-EC-------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM--T--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP--EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQKLS----------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI--
--FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQKSC----------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWSV----HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--FEIGRPLGKGKFGNVYLARLK-------ESHFIVALKVLFKSQ-IEKEG--LEHQLRREIEIQAHL-QHPNILRLYNYFH--DARRVYLILEYAPRGELYKELQKSE----------------------------------------------------------------------KLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGF---RGEVKIADFGWSV----HTPSLRRKT---MCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLV-GYPP---------------FESA----SHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWV--
--LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-ST-AH-ADEKEALM-S-ELKIMSHLGQHENIVNLLGACT--HGGPVLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN---GHVAKIGDFGLARDI-MN--DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLVKDGYQMAQPAFAP--KNIYSIMQACWALEPTHRPTFQQICSFL----
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT-EKDLSDLI-S-EMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQ-ARRPPGLEY-----------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTE---DNVMKIADFGLARDI-HH--IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT--NELYMMMRDCWHAVPSQRPTFKQLVEDL----
--LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PG-SM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKGSLLDFLK-SD-------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI--E--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRALERGYRMPRPENCP--EELYNIMMRCWKNRPEERPTFEYIQSV--L--
--ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-EA-AS-MRERIEFL-N-EASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLR-SLRPEM-----------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCP--DMLFELMRMCWQYNPKMRPSFLEIISS--I--
--ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-ES-AS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS--KGQPTLVVMELMAHGDLKSYLR-SLRPEA-----------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI-YE--TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGYLDQPDNCP--ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
--LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EG-AM-SE--EDFI-E-EAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR-TQ--------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV--L--DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS--THVYQIMNHCWKERPEDRPAFSRLLRQL----
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ-KH--------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP--DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ-RH--------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP--AEVHELMKLCWAPSPQDRPSFSALGP---QL-
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI--E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L--
IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-EA-SE-SA-RQDFQ-R-EAELLTML-QHQHIVRFFGVCT--EGRPLLMVFEYMRHGDLNRFLR-SHGPDAKL------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI-YS--TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCITQGRELERPRACP--PEVYAIMRGCWQREPQQRHSIKDVHARL----
-L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-EN-AS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSG---------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV-YE--EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS--EEMYRLMLQCWKQEPDKRPVFADISKDL----
-L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
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