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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ALK 1116
CAMK CASK 12
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
TK EGFR 712
Other EIF2AK2 267
TK EPHA3 621
TK FGFR1 478
TK FGFR2 481
AGC GRK6 186
CMGC GSK3B 56
TKL IRAK4 186
TK LCK 245
STE MAP2K4 102
CMGC MAPK10 64
CMGC MAPK12 27
CAMK MAPKAPK2 64
Other NEK2 8
Other NEK7 34
STE OXSR1 17
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
Other PLK4 12
AGC PRKCI 245
TK PTK2 422
TK PTK2B 425
TK RET 724
STE STK24 24
TK TNK2 150
Other TTK 525
TK ZAP70 338
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR------EVEIQSHL--R-HPN--ILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVY-RELQ--------KLS-------------------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-S---AGEL----KIADFGWSV---------HAPSSRR-TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---------TYQETY-KRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K------EAAVMKEI--K-HPN--LVQLLGVCTR-----------------------------EPPFY--IITEFMTYG--NLL-DYLR---------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVG-E---NHLV----KVADFGLSRLM-------T--GDTY-TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SPYP-GI------DLSQVYELL-EKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS------FAEIHQA--F-----------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-E--V-CS-EQDEL-D-FL-M------EALIISKF--N-HQN--IVRCIGVSLQ-----------------------------SLPRF--ILLELMAGG--DLK-SFLR---------ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN-----HFIHRDIAARNCLLT-CPGPGRVA----KIGDFGMARDI---Y---R--ASYY-RKGGCAMLPVKWMPPEAFM-----------EGIFTSKTDTWSFGVLLWEIFSLGY-MPYP-SK------SNQEVLEFV-TSGGRMDPPKNCP-----------------------------------------GPVYRIMTQCWQHQPEDRPN------FAIILER--I-----------
----YELCEVIGKGPFSVVRRCINR-------ETGQQFAVKIVDVA--K-FTSSP--G-L-STEDL---KREASICHML--K-HPH--IVELLETYSS-----------------------------DGMLY--MVFEFMDGA--DLCFEIVKR-----ADAGF-------------------------VYSEAVASHYMRQILEALRYCHDN-----NIIHRDVKPHCVLLA-S---KENSA-PVKLGGFGVAIQL-------GESGLVA-GG---RVGTPHFMAPEVVK-----------REPYGKPVDVWGCGVILFILLS-GC-LPFY-GT----------KERLF-EGIIKGKYKMNPRQWSHIS-----------------------------------ESAKDLVRRMLMLDPAERIT------VYEALNHPWL-----------
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR------EISLLKEL--N-HPN--IVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLK-KFMDA------SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-T---EGAI----KLADFGLARAF-------GVPVRTY-TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFP-GD------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
----YEKLAKIGQGTFGEVFKARHR-------KTGQKVALKKVLME--N-EKEGF--P-I-TALR------EIKILQLL--K-HEN--VVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLA-GLLS-------NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHRN-----KILHRDMKAANVLIT-R---DGVL----KLADFGLARAFSL---AKNSQPNRY-TN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQ-GN------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID------SDDALNHDFF-----------
--YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKR--K-FAIGS--A-R-EADPALNVETEIEILKKL--N-HPC--IIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELF-DKVV--------GNK-------------------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-S---QEEDC-LIKITDFGHSKI--------LGETSLM-RT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH--------RTQVSLK-DQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
----YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPV--K-KKKIK--R-------------EIKILENL-RG-GPN--IITLADIVKDP---------------------------VSRTPA--LVFEHVNNT--DFK-QLY-----------Q-------------------------TLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHE---HRKL----RLIDWGLAEF--------YHPGQEY-NV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGH------DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AREAMEHPYF-----------
----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKR--R-TKSSR--R-G-VSREDI--EREVSILKEI--Q-HPN--VITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELF-DFLA--------EKE-------------------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-D---RNVPKPRIKIIDFGLAHK--------IDFGNEF-KN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GA-SPFL-GD---------TKQETL-ANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT------IQDSLQHPWI-----------
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKANK-E-IL-D------EAYVMASV--D-NPH--VCRLLGICL------------------------------TSTVQ--LITQLMPFG--CLL-DYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVK-T---PQHV----KITDFGLAKLL---G---A--EEKE-YHAEGGKVPIKWMALESIL-----------HRIYTHQSDVWSYGVTVWELMTFGS-KPYD-GI------PASEISSIL-EKGERLPQPPICT-----------------------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF---------
---F-KEIELIGSGGFGQVFKAKHR-------IDGKTYVIKRVKYN--N-EKAER----------------EVKALAKL--D-HVN--IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLE-QWIEK------RRGE-------------------------KLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV-D---TKQV----KIGDFGLVTS--------LKNDGKR-TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTAFE-T-------------SKF-FTDLRDGIISDIFDK----------------------------------------KEKTLLQKLLSKKPEDRPN------TSEILR----TLT--------
---I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V--G-YT-EKQRR-D-FL-G------EASIMGQF--D-HPN--IIRLEGVVTK-----------------------------SKPVM--IVTEYMENG--SLD-SFLR---------KH-----------------------DAQFTVIQLVGMLRGIASGMKYLSDM-----GYVHRDLAARNILIN-S---NLVC----KVSDFGLSRVL---E---D--DPEAAYTTRGGKIPIRWTSPEAIA-----------YRKFTSASDVWSYGIVLWEVMSYGE-RPYW-EM------SNQDVIKAV-DEGYRLPPPMDCP-----------------------------------------AALYQLMLDCWQKDRNNRPK------FEQIVSIL-------------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKDLS-D-LI-S------EMEMMKMIG-K-HKN--IINLLGACTQ-----------------------------DGPLY--VIVEYASKG--NLR-EYLQ---------ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK-----KCIHRDLAARNVLVT-E---DNVM----KIADFGLARDI---H---H--IDYY-KKTTNGRLPVKWMAPEALF-----------DRIYTHQSDVWSFGVLLWEIFTLGG-SPYP-GV------PVEELFKLL-KEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S------EMEMMKMIG-K-HKN--IINLLGACTQ-----------------------------DGPLY--VIVEYASKG--NLR-EYLR---------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ-----KCIHRDLAARNVLVT-E---NNVM----KIADFGLARDI---N---N--IDYY-KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SPYP-GI------PVEELFKLL-KEGHRMDKPANCT-----------------------------------------NELYMMMRDCWHAVPSQRPT------FKQLVEDL-------------
---F-RQYRVLGKGGFGEVCACQVR-------ATGKMYACKKLEKK--R-IKKRK--G-E-AMAL-----NEKQILEKV--N-SRF--VVSLAYAYET-----------------------------KDALC--LVLTLMNGG--DLK-FHIYH------MGQA-------------------------GFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-D---HGHI----RISDLGLAVH--------VPEGQTI-KG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQ-SPFQ-QR------KKKIKREEV-ERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
----YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQD--K-RFKNR----------------ELQIMRKL--D-HCN--IVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA----RHY----SRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPD---TAVL----KLCDFGSAKQ--------LVRGEPN-VS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF-----------
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFD-----QEIKVMAKC--Q-HEN--LVELLGFSSD-----------------------------GDDLC--LVYVYMPNG--SLL-DRLSC-----LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLD-E---AFTA----KISDFGLARASE-----KFAQTVMT-SR---IVGTTAYMAPEALR------------GEITPKSDIYSFGVVLLEIIT-GL-PAVD-EH------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD---------------------------STSVEAMYSVASQCLHEKKNKRPD------IKKVQQ----LLQ--------
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A------EANLMKQL--Q-HQR--LVRLYAVVT------------------------------QEPIY--IITEYMENG--SLV-DFLK---------TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVS-D---TLSC----KIADFGLARLI-------E--DNEY-TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IPYP-GM------TNPEVIQNL-ERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT------FDYLRSV--L-----------
--LK--DLGEIGRGAYGSVNKMVHK-------PSGQIMAVKRIRST--V-DEKEQ--K-Q-L-LM------DLDVVMRS-SD-CPY--IVQFYGALFR-----------------------------EGDCW--ICMELMSTSFDKFY-KYVYS------VLDD-------------------------VIPEEILGKITLATVKALNHLKEN----LKIIHRDIKPSNILLD-R---SGNI----KLCDFGISGQ--------LVDSIAK-TR---DAGCRPYMAPERIDP-------SASRQGYDVRSDVWSLGITLYELAT-GR-FPYP-KW-------NSVFDQLT-QVVKGDPPQLSNSEEREFS-----------------------------------PSFINFVNLCLTKDESKRPK------YKELLKHPFI-----------
----YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRP--F-QNQTH--A-K-RAYR------ELVLMKCV--N-HKN--IISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLC-QVIQ----------M-------------------------ELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-S---DCTL----KILDFGLART--------AGTSFMM-TP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HK-ILFP-GR------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS------VDDALQHPYI-----------
----YRDLQPVGSGAYGAVCSAVDG-------RTGAKVAIKKLYRP--F-QSELF--A-K-RAYR------ELRLLKHM--R-HEN--VIGLLDVFTPDET-----------------------LDDFTDFY--LVMPFMGT---DLG-KLMK---------HE-------------------------KLGEDRIQFLVYQMLKGLRYIHAA-----GIIHRDLKPGNLAVN-E---DCEL----KILDFGLAR----------QADSEM-TG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFK-GS------DHLDQLKEI-MKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT------AGEALAHPYF-----------
-KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDC--P-KAR-----------R------EVELHWRA-SQ-CPH--IVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELF-SRIQD------RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-S---KRPNA-ILKLTDFGFAKE--------TTSHNSL-TT---PCYTPYYVAPEVLG-----------PEKYDKSCDMWSLGVIMYILLC-GY-PPFY-SN-----HGLAISPGMK-TRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
----YEVLYTIGTGSYGRCQKIRRK-------SDGKILVWKELDYG--S-MTEAE--K-Q-MLVS------EVNLLREL--K-HPN--IVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLA-SVITKG----TKERQ-------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-G---KQNV----KLGDFGLARIL-------NHDTSFA-KT---FVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LM-PPFT-AF---------SQKELA-GKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
----FRIEKKIGRGQFSEVYRAACL-------LDGVPVALKKVQIF--D-LMDAK--A-R-ADCI-----KEIDLLKQL--N-HPN--VIKYYASFIE-----------------------------DNELN--IVLELADAG--DLS-RMIKHF----KKQKR-------------------------LIPERTVWKYFVQLCSALEHMHSR-----RVMHRDIKPANVFIT-A---TGVV----KLGDLGLGRFF-------SSKTTAA-HS---LVGTPYYMSPERIH-----------ENGYNFKSDIWSLGCLLYEMAA-LQ-SPFY-GD-------KMNLYSLC-KKIEQCDYPPLPSDHYS-------------------------------------EELRQLVNMCINPDPEKRPD------VTYV------YDVA-------
----YELQEVIGSGATAVVQAAYCA-------PKKEKVAIKRINLE--K-CQTSM--D-E--LLK------EIQAMSQC--H-HPN--IVSYYTSFVV-----------------------------KDELW--LVMKLLSGG--SVL-DIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLG-E---DGSV----QIADFGVSAFLAT--GGDITRNKVR-KT---FVGTPCWMAPEVME----------QVRGYDFKADIWSFGITAIELAT-GA-APYH-KY------PPMKVLMLT-LQNDPPSLETGVQDKE--MLK------------------------------KYGKSFRKMISLCLQKDPEKRPT------AAELLRHKFF-----------
---F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR------ERDVMSRL--D-HPF--FVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELL-KYIR--------KIG-------------------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-E---DMHI----QITDFGTAKVLS-----PESKQARA-NS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GL-PPFR-AG---------NEYLIF-QKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
----YQVGPLLGSGGFGSVYSGIRV-------SDNLPVAIKHVEKD--R-ISDWG--E-L-PNGTRV--PMEVVLLKKV--S-SGFSGVIRLLDWFER-----------------------------PDSFV--LILERPEPV-QDLF-DFIT--------ERG-------------------------ALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLN---RGEL----KLIDFGSGA---------LLKDTVY-TD---FDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVC-GD-IPFE-HD----------------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM-----------
--YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMS-----MEISIHRSL--A-HQH--VVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLL-ELHK--------RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-E---DLEV----KIGDFGLATKV-------EYDGERK-KT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GK-PPFE-TS---------CLKETY-LRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF-----------
---F-KVGNLLGKGSFAGVYRAESI-------HTGLEVAIKMIDKK--A-MYKAG--M-V-QRVQ-----NEVKIHCQL--K-HPS--ILELYNYFED-----------------------------SNYVY--LVLEMCHNG--EMN-RYLK-------NRVK-------------------------PFSENEARHFMHQIITGMLYLHSH-----GILHRDLTLSNLLLT-R---NMNI----KIADFGLATQL-------KMPHEKH-YT---LCGTPNYISPEIAT-----------RSAHGLESDVWSLGCMFYTLLI-GR-PPFD-TD---------TVKNTL-NKVVLADYEMPSFLS---------------------------------------IEAKDLIHQLLRRNPADRLS------LSSVLDHPFM-----------
---F-DLLRVIGRGSYAKVLLVRLK-------KTDRIYAMKVVKKE--L-VNDDE--D-I-DWVQ-----TEKHVFEQA-SN-HPF--LVGLHSCFQT-----------------------------ESRLF--FVIEYVNGG--DLM-FHMQ--------RQR-------------------------KLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLD-S---EGHI----KLTDYGMCKEG-------LRPGDTT-ST---FCGTPNYIAPEILR-----------GEDYGFSVDWWALGVLMFEMMA-GR-SPFD-IVGSSDNPDQNTEDYLF-QVILEKQIRIPRSLS---------------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
----IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVRE-K-FL-Q------EALTMRQF--D-HPH--IVKLIGVIT------------------------------ENPVW--IIMELCTLG--ELR-SFLQ---------VR-----------------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVS-S---NDCV----KLGDFGLSRYM-------E--DSTY-YKASKGKLPIKWMAPESIN-----------FRRFTSASDVWMFGVCMWEILMHGV-KPFQ-GV------KNNDVIGRI-ENGERLPMPPNCP-----------------------------------------PTLYSLMTKCWAYDPSRRPR------FTELKAQL-------------
---V-VLNRILGEGFFGEVYEGVYT----NHKGEKINVAVKTCK-K--D-CT-LDNKE-K-FM-S------EAVIMKNL--D-HPH--IVKLIGIIE------------------------------EEPTW--IIMELYPYG--ELG-HYLE---------RN-----------------------KNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVA-S---PECV----KLGDFGLSRYI-------E--DEDY-YKASVTRLPIKWMSPESIN-----------FRRFTTASDVWMFAVCMWEILSFGK-QPFF-WL------ENKDVIGVL-EKGDRLPKPDLCP-----------------------------------------PVLYTLMTRCWDYDPSDRPR------FTELVCS--L-----------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS-PSELR-D-LL-S------EFNVLKQV--N-HPH--VIKLYGACSQ-----------------------------DGPLL--LIVEYAKYG--SLR-GFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVA-E---GRKM----KISDFGLSRDV---Y---E--EDSY-VKRSQGRIPVKWMAIESLF-----------DHIYTTQSDVWSFGVLLWEIVTLGG-NPYP-GI------PPERLFNLL-KTGHRMERPDNCS-----------------------------------------EEMYRLMLQCWKQEPDKRPV------FADISKDL-------------
----FTKLEKIGKGSFGEVFKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q------EITVLSQC--D-SPY--VTKYYGSYLK-----------------------------DTKLW--IIMEYLGGG--SAL-DLLE---------PG-------------------------PLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-E---HGEV----KLADFGVAGQL-------TDTQIKR-NT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GE-PPHS-EL------HPMKVLFLI-PKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSFRPT------AKELLKHKFI-----------
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R------EVNAMHSL--D-HRN--LIRLYGVVL------------------------------TPPMK--MVTELAPLG--SLL-DRLR---------KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESK-----RFIHRDLAARNLLLA-T---RDLV----KIGDFGLMRAL--PQ---N--DDHY-VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EPWI-GL------NGSQILHKIDKEGERLPRPEDCP-----------------------------------------QDIYNVMVQCWAHKPEDRPT------FVALRDF--L-----------
----YSILKQIGSGGSSKVFQVLNE-------KKQ-IYAIKYVNLE--E-ADNQT--L-D-SYRN------EIAYLNKL-QQHSDK--IIRLYDYEIT-----------------------------DQYIY--MVMECGNI---DLN-SWLK--------KKK-------------------------SIDPWERKSYWKNMLEAVHTIHQH-----GIVHSDLKPANFLIV-----DGML----KLIDFGIANQMQ-----PDTTSVVK-DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TPFQ-QI--------INQISKL-HAIIDPNHEIEFPDIPE-------------------------------------KDLQDVLKCCLKRDPKQRIS------IPELLAHPYV-----------
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R------EAQIMHQL--D-NPY--IVRLIGVCQ------------------------------AEALM--LVMEMAGGG--PLH-KFLV---------GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLV-N---RHYA----KISDFGLSKAL--GA---D--DSYY-TARSAGKWPLKWYAPECIN-----------FRKFSSRSDVWSYGVTMWEALSYGQ-KPYK-KM------KGPEVMAFI-EQGKRMECPPECP-----------------------------------------PELYALMSDCWIYKWEDRPD------FLTVEQR--M-----------
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