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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
CAMK PIM1 38
CAMK PIM3 40
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EHQLRR------EVEIQSHL-R----HPN--ILRLYGYFH--D-----ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
--FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEK---EG--VEHQLR-----REIEIQAHL-H----HPN--ILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIE---GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
--YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PSTAIR------EISLLKEL-R----HPN--IVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PSTAIR------EISLLKEL-N----HPN--IVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PISTVR------EVALLRRL-EA-FEHPN--VVRLMDVCA--TSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--
--YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLDD-DDE---GV--PSSALR------EICLLKEL-K----HKN--IVRLHDVLH--S-----DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF----GIPVRCYSA---EVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--
-W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKR-AVD---CP--ENI-KK------EICINKML-N----HEN--VVKFYGHRR--E-----GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-
YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKRK-FAI---GS--AREADPALNVETEIEILKKL-N----HPC--IIKIKNFF---D-----AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT----EKDLSDLI-S------EMEMMKMIGK----HKN--IINLLGACT--Q-----DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM---KIADFGLARDI--H-H--IDYYKKTTNGRLPVKWMAPEALF---DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
--YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQDK-RFK---NR--------------ELQIMRKL-D----HCN--IVRLRYFFY--SSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF--
--YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDK-RFK---NR--------------ELQIMRKL-D----HCN--IVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--
--LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EG-AM----SE--EDFI-E------EAEVMMKL-S----HPK--LVQLYGVCL--E-----QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI---KVSDFGMTRFV----L--DDQYTSSTGTKFPVKWASPEVFS---FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE-----EHLRDFE-R------EIEILKSL-Q----HDN--IVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV---KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT---ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP----DQ-QRDFQ-R------EIQILKAL-H----SDF--IVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV---KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS---DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM----SP--DAFL-A------EANLMKQL-Q----HQR--LVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP----------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
--YQVGPLLGSGGFGSVYSGIRV-------SDNLPVAIKHVEKDR-ISD---WG--ELPNGTRV--PMEVVLLKKV-S----SGFSGVIRLLDWFE--R-----PDSFV--LILERPEPV-QDLFDFIT----ERG-----------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD----------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM--
--YQVGAVLGSGGFGTVYAGSRI-------ADGLPVAVKHVVKER-VTE---WG--SLGGATV---PLEVVLLRKV-GAAGGARG--VIRLLDWFE--R-----PDGFL--LVLERPEPA-QDLFDFIT----ERG-----------------ALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL---KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR--YHRYHGRSATVWSLGVLLYDMVC-GDIP---------------FEQD----------EEILRGRLLFRRRVS--------------------------PECQQLIRWCLSLRPSERPSLDQIAAHPWM--
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