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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BMX 422
TK BTK 402
CMGC CDC2 4
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK5 4
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
Other CHUK 15
CAMK DAPK3 13
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK FGFR4 467
AGC GRK4 187
CMGC GSK3B 56
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK LCK 245
CAMK MAPKAPK2 64
CAMK MARK1 60
CAMK MARK3 56
Other NEK5 4
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK3 62
Other PLK4 12
AGC PRKCD 349
AGC PRKCQ 380
CMGC PRPF4B 687
TK RET 724
TKL RIPK1 17
STE SLK 34
STE STK10 36
CAMK STK17A 61
STE STK24 24
TK SYK 371
Other TLK1 477
TK TNK1 116
TK TNK2 150
----FEIGRPLGKGKFGNVYLAREK-------Q-SKFILALKVL---FKA--QLEKAGV---E-HQLRR-------EVEIQSHL--R------HPNILRLYGYFH--D-----ATRVY--LILEYAPLG--TVYRELQ-----------------------KLS-------------------------KFDEQRTATYITELANALSYCHSK--RVIHRDIKPENLLLG-S---AGEL----KIADFGWSV-------------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN--------------TYQETY-KRISRVE---FTFPDFVT---------------------------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI---------
----ITMKHKLGGGQYGEVYEGVWK-------K-YSLTVAVKTL---K-E--D-TM-EV---E-EFL-K-------EAAVMKEI--K------HPNLVQLLGVCT--R-----EPPFY--IITEFMTYG--NLLDYLR------------------------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG-E---NHLV----KVADFGLSRLM-----------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK--FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYELL-EKDYRME---RPEGCP-----------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F---------
----ITMKHKLGGGQYGEVYVGVWK-------K-YSLTVAVKTL---K-E--D-TM-EV---E-EFL-K-------EAAVMKEI--K------HPNLVQLLGVCT--L-----EPPFY--IVTEYMPYG--NLLDYLR------------------------EC----------------------NREEVTAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG-E---NHVV----KVADFGLSRLM-----------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNT--FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYDLL-EKGYRME---QPEGCP-----------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FA-ETHQA--F---------
---I-TLIRGLGHGAFGEVYEGQVSG--MPNDP-SPLQVAVKTL---P-E--V-CS-EQD-EL-DFL-M-------EALIISKF--N------HQNIVRCIGVSL--Q-----SLPRF--ILLELMAGG--DLKSFLR------------------------ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN--HFIHRDIAARNCLLT-CPGPGRVA----KIGDFGMARDI-------Y---R--ASYY--------------RKGGCAMLPVKWMPPEAFM------EGI--FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-----------SNQEVLEFV-TSGGRMD---PPKNCP-----------------------------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I---------
----FEIGRPLGKGKFGNVYLAREK-------K-SHFIVALKVL---FKS--Q-IEKEG---V-EHQLR------REIEIQAHL--H------HPNILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ-----------------------KSC-------------------------TFDEQRTATIMEELADALMYCHGK--KVIHRDIKPENLLLG-L---KGEL----KIADFGWSV-------------HAPSLRR--------------KT---MCGTLDYLPPEMIE------GRM--HNEKVDLWCIGVLCYELLV-GNPP---------------FESA--------------SHNETY-RRIVKVD---LKFPASVP---------------------------------------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV---------
----FEIGRPLGKGKFGNVYLARLK-------E-SHFIVALKVL---FKS--Q-IEKEG---L-EHQLR------REIEIQAHL--Q------HPNILRLYNYFH--D-----ARRVY--LILEYAPRG--ELYKELQ-----------------------KSE-------------------------KLDEQRTATIIEELADALTYCHDK--KVIHRDIKPENLLLG-F---RGEV----KIADFGWSV-------------HTPSLRR--------------KT---MCGTLDYLPPEMIE------GRT--YDEKVDLWCIGVLCYELLV-GYPP---------------FESA--------------SHSETY-RRILKVD---VRFPLSMP---------------------------------------------------------LGARD-LISRLLRYQPLERLP-----LA-QILKHPWV---------
---L-RLVRKLGSGQFGEVWMGYYK---------NNMKVAIKTL---K-E--G-TM-SP---E-AFL-G-------EANVMKAL--Q------HERLVRLYAVVT--------KEPIY--IVTEYMARG--CLLDFLK------------------------TD----------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANILVS-E---ALCC----KIADFGLARII--------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV--FTIKADVWSFGVLLMEVVTYGRVP---------------YPGM-----------SNPEVIRNL-ERGYRMP---RPDTCP-----------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L---------
----ITLLKELGSGQFGVVQLGKWK---------GQYDVAVKMI---K-E--G-SM-SE---D-EFF-Q-------EAQTMMKL--S------HPKLVKFYGVCS--K-----EYPIY--IVTEYISNG--CLLNYLR------------------------SH-----------------------GKGLEPSQLLEMCYDVCEGMAFLESH--QFIHRDLAARNCLVD-R---DLCV----KVSDFGMTRYV-----------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFK--YSSKSDVWAFGILMWEVFSLGKQP---------------YDLY-----------DNSQVVLKV-SQGHRLY---RPHLAS-----------------------------------------------------------DTIYQ-IMYSCWHELPEKRPT-----FQ-QLLSS--I---------
----LTFLKELGTGQFGVVKYGKWR---------GQYDVAIKMI---K-E--G-SM-SE---D-EFI-E-------EAKVMMNL--S------HEKLVQLYGVCT--K-----QRPIF--IITEYMANG--CLLNYLR------------------------EM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVN-D---QGVV----KVSDFGLSRYV-----------L--DDEY--------------TSSVGSKFPVRWSPPEVLM------YSK--FSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-----------TNSETAEHI-AQGLRLY---RPHLAS-----------------------------------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I---------
----YTKIEKIGEGTYGVVYKGRHK-------T-TGQVVAMKKI---RLE--S-EEEGV---P-STAIR-------EISLLKEL--R------HPNIVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS--------------------IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSR--RVLHRDLKPQNLLID-D---KGTI----KLADFGLARAF-----------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-----------SEIDQLFRI-FRALGTP---NNEVWPEVESLQDYKNTFPKWKP-------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GK-MALNHPYF---------
----FQCLNRIEEGTYGVVYRAKDK-------K-TDEIVALKRL---KME--K-EKEGF---P-ITSLR-------EINTILKA--Q------HPNIVTVREIVV--GS---NMDKIY--IVMNYVEH---DLKSLME----------------------TMKQ-------------------------PFLPGEVKTLMIQLLRGVKHLHDN--WILHRDLKTSNLLLS-H---AGIL----KVGDFGLAREY-----------GSPLKAY--------------TP---VVVTLWYRAPELLL-----GAKE--YSTAVDMWSVGCIFGELLT-QKPL---------------FPGK-----------SEIDQINKV-FKDLGTP---SEKIWPGYSELPAVKKMTFSEHPY-----------------------------NNLRKRFGALLSDQGFD-LMNKFLTYFPGRRIS-----AE-DGLKHEYF---------
----FQKVEKIGEGTYGVVYKARNK-------L-TGEVVALKKI---RLD--T-ETEGV---P-STAIR-------EISLLKEL--N------HPNIVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA---------------------SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLIN-T---EGAI----KLADFGLARAF-----------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-----------SEIDQLFRI-FRTLGTP---DEVVWPGVTSMPDYKPSFPKWAR-------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF---------
----YEKLEKIGEGTYGTVFKAKNR-------E-THEIVALKRV---RLD--D-DDEGV---P-SSALR-------EICLLKEL--K------HKNIVRLHDVLH--S-----DKKLT--LVFEFCDQ---DLKKYFD----------------------SCNG-------------------------DLDPEIVKSFLFQLLKGLGFCHSR--NVLHRDLKPQNLLIN-R---NGEL----KLADFGLARAF-----------GIPVRCY--------------SA---EVVTLWYRPPDVLF-----GAKL--YSTSIDMWSAGCIFAELANAGRPL---------------FPGN-----------DVDDQLKRI-FRLLGTP---TEEQWPSMTKLPDYKPYPMYPAT-------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AE-EALQHPYF---------
----YENLGLVGEGSYGMVMKCRNK-------D-TGRIVAIKKF---LES--D-DDKMV---K-KIAMR-------EIKLLKQL--R------HENLVNLLEVCK--K-----KKRWY--LVFEFVDHT--ILDDLEL-----------------------FPN-------------------------GLDYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENILVS-Q---SGVV----KLCDFGFARTL-----------AAPGEVY--------------TD---YVATRWYRAPELLV-----GDVK--YGKAVDVWAIGCLVTEMFM-GEPL---------------FPGD-----------SDIDQLYHI-MMCLGNL---IPRHQELFNKNPVFAGVRLPEIKE-----------------------------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF---------
----YETLGKVGEGSYGTVMKCKHK-------N-TGQIVAIKIF---YER--P-EQSVN---K--IAMR-------EIKFLKQF--H------HENLVNLIEVFR--Q-----KKKIH--LVFEFIDHT--VLDELQH-----------------------YCH-------------------------GLESKRLRKYLFQILRAIDYLHSN--NIIHRDIKPENILVS-Q---SGIT----KLCDFGFARTL-----------AAPGDIY--------------TD---YVATRWYRAPELVL-----KDTS--YGKPVDIWALGCMIIEMAT-GNPY---------------LPSS-----------SDLDLLHKI-VLKVGN----LSPHLQNIFSKSPIFAGVVLPQVQ----------------------------HPKNARKKYPKLNGLLAD-IVHACLQIDPADRIS-----SS-DLLHHEYF---------
----FEILGVVGEGAYGVVLKCRHK-------E-THEIVAIKKF---KDS--E-ENEEV---K-ETTLR-------ELKMLRTL--K------QENIVELKEAFR--R-----RGKLY--LVFEYVEK---NMLELLE----------------------EMPN-------------------------GVPPEKVKSYIYQLIKAIHWCHKN--DIVHRDIKPENLLIS-H---NDVL----KLCDFGFARNL----------SEGNNANY--------------TE---YVATRWYRSPELLL------GAP--YGKSVDMWSVGCILGELSD-GQPL---------------FPGE-----------SEIDQLFTI-QKVLGPL---PSEQMKLFYSNPRFHGLRFPAVNH----------------------------PQSLERRYLGILNSVLLD-LMKNLLKLDPADRYL-----TE-QCLNHPTF---------
---W-DLVQTLGEGAYGEVQLAVNR-------V-TEEAVAVKIV---DMK--R-AVDCP---E-NI-KK-------EICINKML--N------HENVVKFYGHRR--E-----GNIQY--LFLEYCSGG--ELFDRIE-----------------------PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGI--GITHRDIKPENLLLD-E---RDNL----KISDFGLATVFR---------YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-------------SDSCQEY-SDWKEKK---TYLNPWKKI--D-----------------------------------------------------SAPLA-LLHKILVENPSARIT-----IP-DIKKDRW-Y--------
---W-EMRERLGTGGFGNVCLYQHR-------E-LDLKIAIKSC---RLE--L-STKNR---E-R-WCH-------EIQIMKKL--N------HANVVKACDVPE--ELNILIHDVPL--LAMEYCSGG--DLRKLLNK--------------------PENCC-------------------------GLKESQILSLLSDIGSGIRYLHEN--KIIHRDLKPENIVLQ-D---VGGKI-IHKIIDLGYAKD------------VDQGSLC--------------TS---FVGTLQYLAPELFE------NKP--YTATVDYWSFGTMVFECIA-GYRP---------------FLHHLQPFTWHEKIKKKDPKCIFA-CEEMSGE---VRFSSHLPQPNSLCS-----------------------------------------------LVVEPMEN-WLQLMLNWDPQQRG-----------------GPVDLTLKQ
----YEMGEELGSGQFAIVRKCRQK-------G-TGKEYAAKFI---KKR--R-LSSSR---R-GVSREEI---EREVNILREI--R------HPNIITLHDIFE--N-----KTDVV--LILELVSGG--ELFDFLA-----------------------EKE-------------------------SLTEDEATQFLKQILDGVHYLHSK--RIAHFDLKPENIMLL-D---KNVPNPRIKLIDFGIAHK------------IEAGNEF--------------KN---IFGTPEFVAPEIVN------YEP--LGLEADMWSIGVITYILLS-GASP---------------FLGE--------------TKQETL-TNISAVN---YDFDEEYFSNTS-----------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IA-QSLEHSWI---------
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPN-RVTKVAVKML---K-S--D-AT-EKD-LS-DLI-S-------EMEMMKMIG-K------HKNIINLLGACT--Q-----DGPLY--VIVEYASKG--NLREYLQ------------------------ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVT-E---DNVM----KIADFGLARDI-------H---H--IDYY--------------KKTTNGRLPVKWMAPEALF------DRI--YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-----------PVEELFKLL-KEGHRMD---KPSNCT-----------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-----------
----LTLGKPLGEGCFGQVVMAEAVGIDKDKPK-EAVTVAVKML---K-D--D-AT-EKD-LS-DLV-S-------EMEMMKMIG-K------HKNIINLLGACT--Q-----DGPLY--VIVEYASKG--NLREYLR------------------------ARRPPGMEY--------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVT-E---NNVM----KIADFGLARDI-------N---N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI-----------PVEELFKLL-KEGHRMD---KPANCT-----------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-----------
----LTLGKPLGEGCFGQVVMAEAIGIDKDRAA-KPVTVAVKML---K-D--D-AT-DKD-LS-DLV-S-------EMEMMKMIG-K------HKNIINLLGACT--Q-----GGPLY--VLVEYAAKG--NLREFLR------------------------ARRPPGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVT-E---DNVM----KIADFGLARDV-------H---N--LDYY--------------KKTTNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI-----------PVEELFKLL-KEGHRMD---KPANCT-----------------------------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL-----------
---L-VLGKPLGEGCFGQVVRAEAFGMDPARPD-QASTVAVKML---K-D--N-AS-DKD-LA-DLV-S-------EMEVMKLIG-R------HKNIINLLGVCT--Q-----EGPLY--VIVECAAKG--NLREFLR------------------------ARRPPGPDL--------SPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESR--KCIHRDLAARNVLVT-E---DNVM----KIADFGLARGV-------H---H--IDYY--------------KKTSNGRLPVKWMAPEALF------DRV--YTHQSDVWSFGILLWEIFTLGGSP---------------YPGI-----------PVEELFSLL-REGHRMD---RPPHCP-----------------------------------------------------------PELYG-LMRECWHAAPSQRPT-----FK-QLVEAL-----------
--FR--HYRVLGKGGFGEVCACQVR-------A-TGKMYACKKL---QKK--R-IKKRK---G-EAMAL------NEKRILEKV--Q------SRFVVSLAYAYE--T-----KDALC--LVLTIMNGG--DLKFHIYN---------------------LGNP-------------------------GFDEQRAVFYAAELCCGLEDLQRE--RIVYRDLKPENILLD-D---RGHI----RISDLGLATE------------IPEGQRV--------------RG---RVGTVGYMAPEVVN------NEK--YTFSPDWWGLGCLIYEMIQ-GHSP---------------FKKY-----------KEKVKWEEV-DQRIKND---TEEYSE---KFS-----------------------------------------------------EDAKS-ICRMLLTKNPSKRLGCRGEGAA-GVKQHPV-F--------
----YTDTKVIGNGSFGVVYQAKLC-------D-SGELVAIKKV---LQD--K-RFKNR-----------------ELQIMRKL--D------HCNIVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHY-------------------SRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSF--GICHRDIKPQNLLLDPD---TAVL----KLCDFGSAKQ------------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATD--YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-----------SGVDQLVEI-IKVLGTP---TREQIREMNPNYTEFKFPQIKAH-------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PL-EACAHSFF---------
-VGG----NKMGEGGFGVVYKGYVN-------N-TT--VAVKKL---AAM--V-DITTE---ELKQQFD------QEIKVMAKC--Q------HENLVELLGFSS--D-----GDDLC--LVYVYMPNG--SLLDRLSC--------------------LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLD-E---AFTA----KISDFGLARASE---------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE--ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH-----------REPQLLLDI-KEEIEDE---EKTIEDYIDKKMNDAD---------------------------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IK-KVQQ----LLQ------
----LKFLQQLGKGNFGSVEMCRYDP---LQDN-TGEVVAVKKL---Q-H--S-TE--EH-LR-DFE-R-------EIEILKSL--Q------HDNIVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ------------------------KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVE-N---ENRV----KIGDFGLTKVL------PQ---D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK--FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELL-KNNGRLP---RPDGCP-----------------------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV-------
---L-KYISQLGKGNFGSVELCRYDP---LGDN-TGALVAVKQL---Q-H--S-GP-DQ--QR-DFQ-R-------EIQILKAL--H------SDFIVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ------------------------RH-----------------------RARLDASRLLLYSSQICKGMEYLGSR--RCVHRDLAARNILVE-S---EAHV----KIADFGLAKLL------PL---D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P---------ALCRLLELL-EEGQRLP---APPACP-----------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL--------
----LKLVERLGAGQFGEVWMGYYN---------GHTKVAVKSL---K-Q--G-SM-SP---D-AFL-A-------EANLMKQL--Q------HQRLVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK------------------------TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVS-D---TLSC----KIADFGLARLI-----------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT--FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-----------TNPEVIQNL-ERGYRMV---RPDNCP-----------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L---------
-KVT---SQVLGLGINGKVLQIFNK-------R-TQEKFALKML---QDC--P-KAR-----------R-------EVELHWRA-SQ------CPHIVRIVDVYE--NLY-AGRKCLL--IVMECLDGG--ELFSRIQD---------------------RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSI--NIAHRDVKPENLLYT-S---KRPNA-ILKLTDFGFAKE------------TTSHNSL--------------TT---PCYTPYYVAPEVLG------PEK--YDKSCDMWSLGVIMYILLC-GYPP---------------FYSN----------HGLAISPGMK-TRIRMGQ---YEFPNPEWSEVS-----------------------------------------------------EEVKM-LIRNLLKTEPTQRMT-----IT-EFMNHPWI---------
----YRLQKTIGKGNFAKVKLARHV-------L-TGREVAVKII---DKT--Q-LNPTS---L-QKLFR-------EVRIMKIL--N------HPNIVKLFEVIE--T-----EKTLY--LVMEYASGG--EVFDYLV-----------------------AHG-------------------------RMKEKEARAKFRQIVSAVQYCHQK--YIVHRDLKAENLLLD-G---DMNI----KIADFGFSNE------------FTVGNKL--------------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVS-GSLP---------------FDGQ--------------NLKELR-ERVLRGK---YRIPFYMS---------------------------------------------------------TDCEN-LLKKLLVLNPIKRGS-----LE-QIMKDRWM---------
----YRLLKTIGKGNFAKVKLARHI-------L-TGREVAIKII---DKT--Q-LNPTS---L-QKLFR-------EVRIMKIL--N------HPNIVKLFEVIE--T-----EKTLY--LIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV-------------------------QVSFDLLSLMFTFIVSAVQYCHQK--RIVHRDLKAENLLLD-A---DMNI----KIADFGFSNE------------FTVGGKL--------------DT---FCGSPPYAAPELFQ-----GKKY--DGPEVDVWSLGVILYTLVS-GSLP---------------FDGQ--------------NLKELR-ERVLRGK---YRIPFYMS---------------------------------------------------------TDCEN-LLKRFLVLNPIKRGT-----LE-QIMKDRWI---------
----YDVIKAIGQGAFGKAYLAKGK-------S-DSKHCVIKEI---NFE--K-MPIQE---K-EASKK-------EVILLEKM--K------HPNIVAFFNSFQ--E-----NGRLF--IVMEYCDGG--DLMKRINR---------------------QRGV-------------------------LFSEDQILGWFVQISLGLKHIHDR--KILHRDIKAQNIFLS-K---NGMV---AKLGDFGIARVL-----------NNSMELA--------------RT---CIGTPYYLSPEICQ------NKP--YNNKTDIWSLGCVLYELCT-LKHP---------------FEGN--------------NLQQLV-LKICQAH---FAPISPGF---S-----------------------------------------------------RELHS-LISQLFQVSPRDRPS-----IN-SILKRPFL---------
--IV--LKWELGEGAFGKVFLAECHN--LLPEQ-DKMLVAVKAL---K-E--A-SE-SA--RQ-DFQ-R-------EAELLTML--Q------HQHIVRFFGVCT--E-----GRPLL--MVFEYMRHG--DLNRFLR------------------------SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGL--HFVHRDLATRNCLVG-Q---GLVV----KIGDFGMSRDI-------Y---S--TDYY--------------RVGGRTMLPIRWMPPESIL------YRK--FTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-----------SNTEAIDCI-TQGRELE---RPRACP-----------------------------------------------------------PEVYA-IMRGCWQREPQQRHS-----IK-DVHARL-----------
---I-VLKRELGEGAFGKVFLAECYN--LCPEQ-DKILVAVKTL---K-D--A-SD-NA--RK-DFH-R-------EAELLTNL--Q------HEHIVKFYGVCV--E-----GDPLI--MVFEYMKHG--DLNKFLR------------------------AHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVG-E---NLLV----KIGDFGMSRDV-------Y---S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSLGVVLWEIFTYGKQP---------------WYQL-----------SNNEVIECI-TQGRVLQ---RPRTCP-----------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-----IK-GIHTL--L---------
---I-VLKRELGEGAFGKVFLAECYN--LSPTK-DKMLVAVKAL---K-D--P-TL-AA--RK-DFQ-R-------EAELLTNL--Q------HEHIVKFYGVCG--D-----GDPLI--MVFEYMKHG--DLNKFLR------------------------AHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVG-A---NLLV----KIGDFGMSRDV-------Y---S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSFGVILWEIFTYGKQP---------------WFQL-----------SNTEVIECI-TQGRVLE---RPRVCP-----------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-----IK-EIYKIL-----------
----YEPKEILGRGVSSVVRRCIHK-------P-TSQEYAVKVI---DVT--G-GGSFS---P-EEVRELREATLKEVDILRKV-SG------HPNIIQLKDTYE--T-----NTFFF--LVFDLMKRG--ELFDYLT-----------------------EKV-------------------------TLSEKETRKIMRALLEVICTLHKL--NIVHRDLKPENILLD-D---NMNI----KLTDFGFSCQ------------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPP---------------FWHR--------------KQMLML-RMIMSGN---YQFGSPEWDDYS-----------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-----AE-EALAHPFF---------
-YDP---KDVIGRGVSSVVRRCVHR-------A-TGHEFAVKIM---EVT--A-ERLSP---E-QLEEVREA-TRRETHILRQV-AG------HPHIITLIDSYE--S-----SSFMF--LVFDLMRKG--ELFDYLT-----------------------EKV-------------------------ALSEKETRSIMRSLLEAVSFLHAN--NIVHRDLKPENILLD-D---NMQI----RLSDFGFSCH------------LEPGEKL--------------RE---LCGTPGYLAPEILKCSMDETHPG--YGKEVDLWACGVILFTLLA-GSPP---------------FWHR--------------RQILML-RMIMEGQ---YQFSSPEWDDRS-----------------------------------------------------STVKD-LISRLLQVDPEARLT-----AE-QALQHPFF---------
---F-KFLAVLGRGHFGKVLLSEFR-------P-SGELFAIKAL---KKG--D-IVARD---E-VESLM------CEKRILAAV--TS---AGHPFLVNLFGCFQ--T-----PEHVC--FVMEYSAGG--DLMLHIH------------------------SD-------------------------VFSEPRAIFYSACVVLGLQFLHEH--KIVYRDLKLDNLLLD-T---EGYV----KIADFGLCKEG-----------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS--YTRAVDWWGLGVLLYEMLV-GESP---------------FPGD--------------DEEEVF-DSIVNDE---VRYPRFLS---------------------------------------------------------AEAIG-IMRRLLRRNPERRLGSSERDAE-DVKKQPFF---------
--FR--CCAVLGRGHFGKVLLAEYK-------N-TNEMFAIKAL---KKG--D-IVARD---E-VDSLM------CEKRIFETV--NS---VRHPFLVNLFACFQ--T-----KEHVC--FVMEYAAGG--DLMMHIH------------------------TD-------------------------VFSEPRAVFYAACVVLGLQYLHEH--KIVYRDLKLDNLLLD-T---EGFV----KIADFGLCKEG-----------MGYGDRT--------------ST---FCGTPEFLAPEVLT------ETS--YTRAVDWWGLGVLIYEMLV-GESP---------------FPGD--------------DEEEVF-DSIVNDE---VRYPRFLS---------------------------------------------------------TEAIS-IMRRLLRRNPERRLGASEKDAE-DVKKHPFF---------
--YV--RGRFLGKGGFAKCFEISDA-------D-TKEVFAGKIV---PKS--L-LLKPH---Q-REKMS------MEISIHRSL--A------HQHVVGFHGFFE--D-----NDFVF--VVLELCRRR--SLLELHK-----------------------RRK-------------------------ALTEPEARYYLRQIVLGCQYLHRN--RVIHRDLKLGNLFLN-E---DLEV----KIGDFGLATKV-----------EYDGERK--------------KT---LCGTPNYIAPEVLS------KKG--HSFEVDVWSIGCIMYTLLV-GKPP---------------FETS--------------CLKETY-LRIKKNE---YSIPKHIN---------------------------------------------------------PVAAS-LIQKMLQTDPTARPT-----IN-ELLNDEFF---------
--YL--KGRLLGKGGFARCYEATDT-------E-TGSAYAVKVI---PQS--R-VAKPH---Q-REKIL------NEIELHRDL--Q------HRHIVRFSHHFE--D-----ADNIY--IFLELCSRK--SLAHIWK-----------------------ARH-------------------------TLLEPEVRYYLRQILSGLKYLHQR--GILHRDLKLGNFFIT-E---NMEL----KVGDFGLAARL-----------EPPEQRK--------------KT---ICGTPNYVAPEVLL------RQG--HGPEADVWSLGCVMYTLLC-GSPP---------------FETA--------------DLKETY-RCIKQVH---YTLPASLS---------------------------------------------------------LPARQ-LLAAILRASPRDRPS-----ID-QILRHDFF---------
---F-KVGNLLGKGSFAGVYRAESI-------H-TGLEVAIKMI---DKK--A-MYKAG---M-VQRVQ------NEVKIHCQL--K------HPSILELYNYFE--D-----SNYVY--LVLEMCHNG--EMNRYLK----------------------NRVK-------------------------PFSENEARHFMHQIITGMLYLHSH--GILHRDLTLSNLLLT-R---NMNI----KIADFGLATQL-----------KMPHEKH--------------YT---LCGTPNYISPEIAT------RSA--HGLESDVWSLGCMFYTLLI-GRPP---------------FDTD--------------TVKNTL-NKVVLAD---YEMPSFLS---------------------------------------------------------IEAKD-LIHQLLRRNPADRLS-----LS-SVLDHPFM---------
--FI--FHKVLGKGSFGKVLLGELK-------G-RGEYFAIKAL---KKD--V-VLIDD---D-VECTM------VEKRVLTLA-AE------NPFLTHLICTFQ--T-----KDHLF--FVMEFLNGG--DLMYHIQ-----------------------DKG-------------------------RFELYRATFYAAEIMCGLQFLHSK--GIIYRDLKLDNVLLD-R---DGHI----KIADFGMCKEN-----------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLK--YTFSVDWWSFGVLLYEMLI-GQSP---------------FHGD--------------DEDELF-ESIRVDT---PHYPRWIT---------------------------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF---------
--FI--LHKMLGKGSFGKVFLAEFK-------K-TNQFFAIKAL---KKD--V-VLMDD---D-VECTM------VEKRVLSLA-WE------HPFLTHMFCTFQ--T-----KENLF--FVMEYLNGG--DLMYHIQ-----------------------SCH-------------------------KFDLSRATFYAAEIILGLQFLHSK--GIVYRDLKLDNILLD-K---DGHI----KIADFGMCKEN-----------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQK--YNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ--------------DEEELF-HSIRMDN---PFYPRWLE---------------------------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF---------
YNVY----GYTGQGVFSNVVRARDN-------ARANQEVAVKII---RNN--E-LMQKT---G----LK-------ELEFLKKL--NDADPDDKFHCLRLFRHFY--H-----KQHLC--LVFEPLSM---NLREVLKK--------------------YGKDV-------------------------GLHIKAVRSYSQQLFLALKLLKRC--NILHADIKPDNILVN-E---SKTI---LKLCDFGSAS-------------HVADNDI--------------TP---YLVSRFYRAPEIII------GKS--YDYGIDMWSVGCTLYELYT-GKIL---------------FPGK-----------TNNHMLKLA-MDLKGKM---PNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKD-LLDQILMLDPAKRIS-----IN-QALQHAFI---------
---L-VLGKTLGEGEFGKVVKATAFH--LKGRA-GYTTVAVKML---K-E--N-AS-PSE-LR-DLL-S-------EFNVLKQV--N------HPHVIKLYGACS--Q-----DGPLL--LIVEYAKYG--SLRGFLR------------------------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVA-E---GRKM----KISDFGLSRDV-------Y---E--EDSY--------------VKRSQGRIPVKWMAIESLF------DHI--YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-----------PPERLFNLL-KTGHRME---RPDNCS-----------------------------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL-----------
-LES----AELDSGGFGKVSLCFHR---------TQGLMIMKTV--YK-G--P-NC-IEH-NE-ALL-E-------EAKMMNRL--R------HSRVVKLLGVII--E-----EGKYS--LVMEYMEKG--NLMHVLK------------------------AE------------------------MSTPLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVD-N---DFHI----KIADLGLASFKMWSKLNNE-------EHNELR--------EVDGTAKKNGGTLYYMAPEHLN------DVNAKPTEKSDVYSFAVVLWAIFA-NKEP---------------YENA-I---------CEQQLIMCI-KSGNRPDVDDITEYCP-----------------------------------------------------------REIIS-LMKLCWEANPEARPT-----FP-GIEEK--F---------
----WEIIGELGDGAFGKVYKAQNK-------E-TSVLAAAKVI---DTK--S-EEELE---D-YM--V-------EIDILASC--D------HPNIVKLLDAFY--Y-----ENNLW--ILIEFCAGG--AVDAVML----------------------ELER-------------------------PLTESQIQVVCKQTLDALNYLHDN--KIIHRDLKAGNILFT-L---DGDI----KLADFGVSAKN-----------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE-TSKDRP--YDYKADVWSLGITLIEMAE-IEPP---------------HHEL-----------NPMRVLLKI-AKSEPPT---LAQPSRWS---------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TS-QLLQHPFV---------
----WEIVGELGDGAFGKVYKAKNK-------E-TGALAAAKVI---ETK--S-EEELE---D-YI--V-------EIEILATC--D------HPYIVKLLGAYY--H-----DGKLW--IMIEFCPGG--AVDAIML----------------------ELDR-------------------------GLTEPQIQVVCRQMLEALNFLHSK--RIIHRDLKAGNVLMT-L---EGDI----RLADFGVSAKN-----------LKTLQKR--------------DS---FIGTPYWMAPEVVMCE-TMKDTP--YDYKADIWSLGITLIEMAQ-IEPP---------------HHEL-----------NPMRVLLKI-AKSDPPT---LLTPSKWS---------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AA-QLLEHPFV---------
-LCP---GRELGRGKFAVVRKCIKK-------D-SGKEFAAKFM---RKR--R-KGQDC---R-MEIIH-------EIAVLELA-QD------NPWVINLHEVYE--T-----ASEMI--LVLEYAAGG--EIFDQCVA---------------------DREE-------------------------AFKEKDVQRLMRQILEGVHFLHTR--DVVHLDLKPQNILLT-S---ESPLG-DIKIVDFGLSRI------------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLT-GISP---------------FLGN--------------DKQETF-LNISQMN---LSYSEEEFDVLS-----------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AE-ECLKHPWL---------
----FTKLEKIGKGSFGEVFKGIDN-------R-TQKVVAIKII---DLE--E-AEDEI---E-DIQ-Q-------EITVLSQC--D------SPYVTKYYGSYL--K-----DTKLW--IIMEYLGGG--SALDLLE------------------------PG-------------------------PLDETQIATILREILKGLDYLHSE--KKIHRDIKAANVLLS-E---HGEV----KLADFGVAGQL-----------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSA--YDSKADIWSLGITAIELAR-GEPP---------------HSEL-----------HPMKVLFLI-PKNNPPT---LEGNYS-----------------------------------------------------------KPLKE-FVEACLNKEPSFRPT-----AK-ELLKHKFI---------
-TLE---DKELGSGNFGTVKKGYYQ-----MKK-VVKTVAVKIL---K-N--E-AN-DPALKD-ELL-A-------EANVMQQL--D------NPYIVRMIGICE--------AESWM--LVMEMAELG--PLNKYLQ------------------------QN------------------------RHVKDKNIIELVHQVSMGMKYLEES--NFVHRDLAARNVLLV-T---QHYA----KISDFGLSKAL-------R---A--DENY-------------YKAQTHGKWPVKWYAPECIN------YYK--FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-----------KGSEVTAML-EKGERMG---CPAGCP-----------------------------------------------------------REMYD-LMNLCWTYDVENRPG-----FA-AVE----LRL-------
--YL--LLHLLGRGGFSEVYKAFDL-------Y-EQRYAAVKIH---QLN--K-SWRDE---K-KENYHKH--ACREYRIHKEL--D------HPRIVKLYDYFS--L----DTDTFC--TVLEYCEGN--DLDFYLK-----------------------QHK-------------------------LMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLV-D---GTACG-EIKITDFGLSKIMDDD-----SYGVDGMDLT--------------SQ---GAGTYWYLPPECFVV--GKEPPK--ISNKVDVWSVGVIFFQCLY-GRKP---------------FGHN------------QSQQDILQ-ENTILKA---TEVQFPVKPVVS-----------------------------------------------------SEAKA-FIRRCLAYRKEDRFD-----VH-QLANDPYL---------
-VCR---GELLGSGCFGVVHRGLWT----LPSG-KSVPVAVKSLRVGP-E--G-PM-GTE-LG-DFL-R-------EVSVMMNL--E------HPHVLRLHGLVL--------GQPLQ--MVMELAPLG--SLHARLT------------------------AP---------------------APTPPLLVALLCLFLRQLAGAMAYLGAR--GLVHRDLATRNLLLA-S---PRTI----KVADFGLVRPL------GG---A--RGRY--------------VMGGPRPIPYAWCAPESLR------HGA--FSSASDVWMFGVTLWEMFSGGEEP---------------WAGV-----------PPYLILQRL-EDRARLP---RPPLCS-----------------------------------------------------------RALYS-LALRCWAPHPADRPS-----FS-HLE----GLL-------
---L-RLLEKLGDGSFGVVRRGEWD----APSG-KTVSVAVKCL---K-PDVL-SQ-PEA-MD-DFI-R-------EVNAMHSL--D------HRNLIRLYGVVL--------TPPMK--MVTELAPLG--SLLDRLR------------------------KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLA-T---RDLV----KIGDFGLMRAL------PQ---N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT--FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL-----------NGSQILHKIDKEGERLP---RPEDCP-----------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L---------
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