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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
CAMK MAPKAPK2 64
CAMK MYLK 1464
TK RET 724
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EHQLRREVEIQSHL--R---HPNILRLYGYFHD-----ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM----EV--EEFL-KEAAVMKEI--K---HPNLVQLLGVCTR-----EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PSTAIREISLLKEL--R---HPNIVSLQDVLMQ-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF-GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PSTAIREISLLKEL--N---HPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
--Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PISTVREVALLRRL--EAFEHPNVVRLMDVCATSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI--YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT----EKDLSDLI-SEMEMMKMIG-K---HKNIINLLGACTQ-----DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM---KIADFGLARDIHH--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL--
---YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQDK-RFK---NR--------ELQIMRKL--D---HCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDK-RFK---NR--------ELQIMRKL--D---HCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EG-AM----SE--EDFI-EEAEVMMKL--S---HPKLVQLYGVCLE-----QAPIC--LVFEFMEHG--CLSDYLR-----TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI---KVSDFGMTRFV-L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIPYENR-SNSEVVEDISTGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL--
KVT---SQVLGLGINGKVLQIFNK-------RTQEKFALKMLQDCP-KAR------------REVELHWRA-SQ---CPHIVRIVDVYENLY-AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE--TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI
---YDIEERLGSGKFGQVFRLVEK-------KTRKVWAGKFFKAYS-AKE---KE--NIR--QEISIMNCL--H---HPKLVQCVDAFEE-----KANIV--MVLEIVSGG--ELFERII---DEDF-------------------------ELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV-NKTGTR-IKLIDFGLARR--LENAGSLKV---LFGTPEFVAPEVIN-YEPIGYATDMWSIGVICYILVS-GLSPFMGD----NDNETLANVTSATWDFDDEAFDEIS----------------------DDAKDFISNLLKKDMKNRLDCTQCLQHPWL
--L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-EN-AS----PSELRDLL-SEFNVLKQV--N---HPHVIKLYGACSQ-----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM---KISDFGLSRDVYE--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL--
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