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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other AURKA 203
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
-FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRREVEIQSHLR---HPNILRLYGYFHD-----ATRVYLILEYAPLGTVYRELQ---KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEE---GVPSTAIREISLLKELR---HPNIVSLQDVLMQ-----DSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIREISLLKELN---HPNIVKLLDVIHT-----ENKLYLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDK-APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR--PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
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