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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BTK 203
TK ABL1 261
AGC AKT1 150
Other AURKA 133
TK BLK 241
TK BMX 422
TK CSK 195
TK EGFR 712
TK ERBB2 720
TK ERBB4 718
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
TK LYN 247
TK PDGFRB 600
TK PTK6 191
TK RET 724
TK SRC 270
TK SRMS 230
TK TEC 370
TK TNK2 150
TK TXK 271
TK YES1 277
--LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-E--G-SM-SE--DEFI-E-EAKVMMNL-SHEKLVQLYGVCT-KQRPIFIITEYMANGCLLNYLR-EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLES-KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV---L--DDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHI-AQGLRLYRPHLAS--EKVYT-IMYSCWHEKADERPT-----FKILLSN--I--
--ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-E--D-TM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLR-EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVGENHLVKVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP--EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F--
-F-EYLKLLGKGTFGKVILVKEK-----ATGRYYAMKILKKE--V-IVAKD--EVAHTLTENRVLQNS-RHPFLTALKYSFQ-THDRLCFVMEYANGGELFFHLSRER----------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG---IKDGATMKT---FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQ----DHEKLF-ELILMEEIRFPRTLGPEAKS-LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF--
--FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKA--QLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFH-DATRVYLILEYAPLGTVYRELQKLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVTEGARD-LISRLLKHNPSQRPM-----LREVLEHPWI--
-L-RLVRKLGSGQFGEVWMGYYK------NNMKVAIKTLK-E--G-TM-SP--EAFL-G-EANVMKAL-QHERLVRLYAVVT--KEPIYIVTEYMARGCLLDFLK-TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIER-MNSIHRDLRAANILVSEALCCKIADFGLARII------DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGM-SNPEVIRNL-ERGYRMPRPDTCP--PELYRGVIAECWRSRPEERPT-----FEFLQSV--L--
--ITLLKELGSGQFGVVQLGKWK------GQYDVAVKMIK-E--G-SM-SE--DEFF-Q-EAQTMMKL-SHPKLVKFYGVCS-KEYPIYIVTEYISNGCLLNYLR-SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLES-HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYV---L--DDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLY-DNSQVVLKV-SQGHRLYRPHLAS--DTIYQ-IMYSCWHELPEKRPT-----FQQLLSS--I--
--LKLLQTIGKGEFGDVMLGDYR-------GNKVAVKCIK-N--D-AT-AQ---AFL-A-EASVMTQL-RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEG-NNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---------SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRV-EKGYKMDAPDGCP--PAVYE-VMKNCWHLDAAMRPS-----FLQLREQL----
-F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E--A-TS-PKANKEIL-D-EAYVMASV-DNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVR-EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLED-RRLVHRDLAARNVLVKTPQHVKITDFGLAKLL--GA--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT--IDVYM-IMVKCWMIDADSRPK-----FRELI----IEF
-L-RKVKVLGSGAFGTVYKGIWIP-DGENVKIPVAIKVLR-E--N-TS-PKANKEIL-D-EAYVMAGV-GSPYVSRLLGICL--TSTVQLVTQLMPYGCLLDHVR-EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLED-VRLVHRDLAARNVLVKSPNHVKITDFGLARLL--DI--DETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGI-PAREIPDLL-EKGERLPQPPICT--IDVYM-IMVKCWMIDSECRPR-----FRELVSE--F--
-L-KRVKVLGSGAFGTVYKGIWVP-EGETVKIPVAIKILN-E--T-TG-PKANVEFM-D-EALIMASM-DHPHLVRLLGVCL--SPTIQLVTQLMPHGCLLEYVH-EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEE-RRLVHRDLAARNVLVKSPNHVKITDFGLARLL--EG--DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLL-EKGERLPQPPICT--IDVYM-VMVKCWMIDADSRPK-----FKELAAE--F--
--ITLERRLGTGCFGDVWLGTWN------GSTKVAVKTLK-P--G-TM-SP--KAFL-E-EAQVMKLL-RHDKLVQLYAVVS--EEPIYIVTEFMCHGSLLDFLK-NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMER-MNYIHRDLRAANILVGERLACKIADFGLARLI---K--DDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGM-NKREVLEQV-EQGYHMPCPPGCP--ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL----
--IQLLKRLGSGQFGEVWEGLWN------NTTPVAVKTLK-P--G-SM-DP--NDFL-R-EAQIMKNL-RHPKLIQLYAVCT-LEDPIYIITELMRHGSLQEYLQ-ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLES-RNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDN--EDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGM-TGAQVIQML-AQNYRLPQPSNCP--QQFYN-IMLECWNAEPKERPT-----FETLRWK--L--
--LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLK-P--G-TM-SP--ESFL-E-EAQIMKKL-KHDKLVQLYAVVS--EEPIYIVTEYMNKGSLLDFLK-DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIER-MNYIHRDLRSANILVGNGLICKIADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM-NNREVLEQV-ERGYRMPCPQDCP--ISLHE-LMIHCWKKDPEERPT-----FEYLQSFL----
--LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-P--G-SM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT--KEPIYIITEFMAKGSLLDFLK-SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQ-RNYIHRDLRAANILVSASLVCKIADFGLARVI---E--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRAL-ERGYRMPRPENCP--EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L--
--ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-E--A-AS-MRERIEFL-N-EASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR-SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-NKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI--YE--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP--DMLFE-LMRMCWQYNPKMRPS-----FLEIISS--I--
--ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-E--S-AS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVS-KGQPTLVVMELMAHGDLKSYLR-SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI--YE--TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP--ERVTD-LMRMCWQFNPKMRPT-----FLEIVNLL----
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-E--G-AT-HSEHRALM-S-ELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLAS-RKCIHRDLAARNILLSEKNVVKICDFGLARDI--YK--DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL-KEGTRMRAPDYTT--PEMYQ-TMLDCWHGEPSQRPT-----FSELVEHL----
--LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-P--S-AH-LTEREALM-S-ELKVLSYLGNHMNIVNLLGACT-IGGPTLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLAS-KNCIHRDLAARNILLTHGRITKICDFGLARDI--KN--DSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP--AEMYD-IMKTCWDADPLKRPT-----FKQIVQL--I--
--LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q--G-SM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT--QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVSDTLSCKIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP--EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L--
--IKLVKRLGAGQFGEVWMGYYN------NSTKVAVKTLK-P--G-TM-SV--QAFL-E-EANLMKTL-QHDKLVRLYAVVT-REEPIYIITEYMAKGSLLDFLK-SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIER-KNYIHRDLRAANVLVSESLMCKIADFGLARVI---E--DNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGR-TNADVMTAL-SQGYRMPRVENCP--DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L--
-L-VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLK-S--T-AR-SSEKQALM-S-ELKIMSHLGPHLNVVNLLGACT-KGGPIYIITEYCRYGDLVDYLH-RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLAS-KNCVHRDLAARNVLICEGKLVKICDFGLARDI--MR--DSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI-KRGYRMAQPAHAS--DEIYE-IMQKCWEEKFEIRPP-----FSQLVL---LL-
-F-TLCRKLGSGYFGEVFEGLWK------DRVQVAIKVIS-R--D-NL-LH-QQMLQ-S-EIQAMKKL-RHKHILALYAVVS-VGDPVYIITELMAKGSLLELLR-DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLES-QNYIHRDLAARNILVGENTLCKVGDFGLARLI------KEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGM-SNHEAFLRV-DAGYRMPCPLECP--PSVHK-LMLTCWCRDPEQRPC-----FKALRERL----
-L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-E--N-AS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVAEGRKMKISDFGLSRDV--YE--EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLL-KTGHRMERPDNCS--EEMYR-LMLQCWKQEPDKRPV-----FADISKDL----
-L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-P--G-TM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVCKVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP--ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L--
FA--LGRKLGEGYFGEVWEGLWL------GSLPVAIKVIK-S--A-NM-K--LTDLA-K-EIQTLKGL-RHERLIRLHAVCS-GGEPVYIVTELMRKGNLQAFLG-TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEE-QRVVHRDLAARNVLVDDGLACKVADFGLARLL---K--DDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGM-TNHETLQQI-MRGYRLPRPAACP--AEVYV-LMLECWRSSPEERPS-----FATLREKL----
--LTFMRELGSGLFGVVRLGKWR------AQYKVAIKAIR-E--G-AM-CE--EDFI-E-EAKVMMKL-THPKLVQLYGVCT-QQKPIYIVTEFMERGCLLNFLR-QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLER-NSFIHRDLAARNCLVSEAGVVKVSDFGMARYV---L--DDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKY-TNYEVVTMV-TRGHRLYQPKLAS--NYVYE-VMLRCWQEKPEGRPS-----FEDLLRT--I--
-L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVL-SQ-PEAMDDFI-R-EVNAMHSL-DHRNLIRLYGVVL--TPPMKMVTELAPLGSLLDRLR-KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLES-KRFIHRDLAARNLLLATRDLVKIGDFGLMRAL-PQN--DDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP--QDIYN-VMVQCWAHKPEDRPT-----FVALRDF--L--
-L-AFIKEIGSGQFGVVHLGEWR------SHIQVAIKAIN-E--G-SM-SE--EDFI-E-EAKVMMKL-SHSKLVQLYGVCI-QRKPLYIVTEFMENGCLLNYLR-EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLER-NGYIHRDLAARNCLVSSTCIVKISDFGMTRYV---L--DDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENK-SNLQVVEAI-SEGFRLYRPHLAP--MSIYE-VMYSCWHEKPEGRPT-----FAELLR---AV-
-L-RLEVKLGQGCFGEVWMGTWN------GTTKVAIKTLK-P--G-TM-MP--EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS--EEPIYIVTEFMSKGSLLDFLK-EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIER-MNYIHRDLRAANILVGENLVCKIADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGM-VNREVLEQV-ERGYRMPCPQGCP--ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL----
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