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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BTK 203
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK CSF1R 582
TK EGFR 712
TK ERBB2 720
TK FLT4 845
TK IGF1R 999
TK INSR 1023
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TK NTRK1 510
STE PAK4 321
TK PDGFRA 593
AGC PDPK1 82
TK RET 724
TK SRC 270
TK TYK2 589
----LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-EG-SM-SE--DE-FI-E-EAKVMMNL-SHEKLVQLYGVCT--KQRP--IFIITEYMANGCLLNYLR-EM-------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLES-KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV----L--DDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHIAQGLRLYRPHLAS--EKVYTIMYSCWHEKADERPT-----FKILLSN--I-----------
---F-EYLKLLGKGTFGKVILVKEK-----ATGRYYAMKILKKEV-IVAKD--EV-AHTLTENRVLQNS-RHPFLTALKYSFQ--THDR--LCFVMEYANGGELFFHLSRER---------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG----IKDGATMKT---FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ----DHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF-----------
----FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EH-QLRR-EVEIQSHL-RHPNILRLYGYFH--DATR--VYLILEYAPLGTVYRELQKLS---------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
----FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VE-HQLRREIEIQAHL-HHPNILRLYNYFY--DRRR--IYLILEYAPRGELYKELQKSC---------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLGLKGELKIADFGWSV------HAPSLRRKT---MCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLP-----LAQVSAHPWV-----------
----FEIGRPLGKGKFGNVYLARLK-----ESHFIVALKVLFKSQ-IEKEG--LE-HQLRREIEIQAHL-QHPNILRLYNYFH--DARR--VYLILEYAPRGELYKELQKSE---------------------------------------------------------------------------------------------------KLDEQRTATIIEELADALTYCHD-KKVIHRDIKPENLLLGFRGEVKIADFGWSV------HTPSLRRKT---MCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLV-GYPP---------------FESA----SHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLP-----LAQILKHPWV-----------
----LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-ST-AH-ADEKEA-LM-S-ELKIMSHLGQHENIVNLLGACT--HGGP--VLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR-----------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLAS-KNCIHRDVAARNVLLTNGHVAKIGDFGLARDI--M-N--DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLVKDGYQMAQPAFAP--KNIYSIMQACWALEPTHRPT-----FQQICSFL-------------
---F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKE-IL-D-EAYVMASV-DNPHVCRLLGICL---TST--VQLITQLMPFGCLLDYVR-EH-------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLED-RRLVHRDLAARNVLVKTPQHVKITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT--IDVYMIMVKCWMIDADSRPK-----FRELI----IEF---------
---L-RKVKVLGSGAFGTVYKGIWIP-DGENVKIPVAIKVLR-EN-TS-PKANKE-IL-D-EAYVMAGV-GSPYVSRLLGICL---TST--VQLVTQLMPYGCLLDHVR-EN-------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLED-VRLVHRDLAARNVLVKSPNHVKITDFGLARLL--D-I--DETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKP---------------YDGI-PAREIPDLLEKGERLPQPPICT--IDVYMIMVKCWMIDSECRPR-----FRELVSE--F-----------
----LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLK-EG-AT-ASEHRA-LM-S-ELKILIHIGNHLNVVNLLGACT-KPQGP--LMVIVEFCKYGNLSNFLR-AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLAS-RKCIHRDLAARNILLSESDVVKICDFGLARDI--Y-K--DPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP---------------YPGVQINEEFCQRLRDGTRMRAPELAT--PAIRRIMLNCWSGDPKARPA-----FSELVEIL-------------
----ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EA-AS-MRERIE-FL-N-EASVMKEF-NCHHVVRLLGVVS--QGQP--TLVIMELMTRGDLKSYLR-SLRPEM----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNA-NKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCP--DMLFELMRMCWQYNPKMRPS-----FLEIISS--I-----------
----ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ES-AS-LRERIE-FL-N-EASVMKGF-TCHHVVRLLGVVS--KGQP--TLVVMELMAHGDLKSYLR-SLRPEA----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNA-KKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI--Y-E--TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL-SNEQVLKFVMDGGYLDQPDNCP--ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL-------------
----LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIR-EG-AM-SE--ED-FI-E-EAEVMMKL-SHPKLVQLYGVCL--EQAP--ICLVFEFMEHGCLSDYLR-TQ-------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEE-ACVIHRDLAARNCLVGENQVIKVSDFGMTRFV----L--DDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS--THVYQIMNHCWKERPEDRPA-----FSRLLRQL-------------
---L-KRIRDLGEGHFGKVELCRYDP-EGDNTGEQVAVKSLK-PE-SG-GNHIAD-LK-K-EIEILRNL-YHENIVKYKGICT-ED-GGNGIKLIMEFLPSGSLKEYLP-KN-------------------------------------------------------------------------------------------------KNKINLKQQLKYAVQICKGMDYLGS-RQYVHRDLAARNVLVESEHQVKIGDFGLTKAI-ET-D--KEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP--DEVYQLMRKCWEFQPSNRTS-----FQNLIE---GF----------
----LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EHLRD-FE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRN--LKLIMEYLPYGSLRDYLQ-KH-------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENENRVKIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP--DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV---------
---L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HS-GP-DQ-QRD-FQ-R-EIQILKAL-HSDFIVKYRGVSYGPGRQS--LRLVMEYLPSGCLRDFLQ-RH-------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEAHVKIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP--AEVHELMKLCWAPSPQDRPS-----FSALGP---QL----------
----LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EG-AT-HSEHRA-LM-S-ELKILIHIGHHLNVVNLLGACT-KPGGP--LMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL--------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLAS-RKCIHRDLAARNILLSEKNVVKICDFGLARDI--Y-K--DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTT--PEMYQTMLDCWHGEPSQRPT-----FSELVEHL-------------
----LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PS-AH-LTEREA-LM-S-ELKVLSYLGNHMNIVNLLGACT--IGGP--TLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLAS-KNCIHRDLAARNILLTHGRITKICDFGLARDI--K-N--DSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMIKEGFRMLSPEHAP--AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I-----------
----LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP--DA-FL-A-EANLMKQL-QHQRLVRLYAVVT---QEP--IYIITEYMENGSLVDFLK-TP------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEE-RNYIHRDLRAANILVSDTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP--EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
--IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-EA-SE-SA-RQD-FQ-R-EAELLTML-QHQHIVRFFGVCT--EGRP--LLMVFEYMRHGDLNRFLR-SHGPDAKL-----------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG-LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI--Y-S--TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP---------------WYQL-SNTEAIDCITQGRELERPRACP--PEVYAIMRGCWQREPQQRHS-----IKDVHARL-------------
DNFI-----KIGEGSTGIVCIATVR-----SSGKLVAVKKMDLRK-QQRRE--L---LFN-EVVIMRDY-QHENVVEMYNSYL--VGDE--LWVVMEFLEGGALTDIVT-HT---------------------------------------------------------------------------------------------------RMNEEQIAAVCLAVLQALSVLHA-QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV----SKEVPRRKS---LVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVD-GEPP---------------YFNE-PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRAT-----AAELLKHPFL-----------
---L-VLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-PT-AR-SSEKQA-LM-S-ELKIMTHLGPHLNIVNLLGACT--KSGP--IYIITEYCFYGDLVNYLH-KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLAS-KNCVHRDLAARNVLLAQGKIVKICDFGLARDI--M-H--DSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTP---------------YPGMMVDSTFYNKIKSGYRMAKPDHAT--SEVYEIMVKCWNSEPEKRPS-----FYHLSE---IV----------
---F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKRH-IIKEN--KVPYVTR-ERDVMSRL-DHPFFVKLYFTFQ--DDEK--LYFGLSYAKNGELLKYIRKIG---------------------------------------------------------------------------------------------------SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
---L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-EN-AS-PSELRD-LL-S-EFNVLKQV-NHPHVIKLYGACS--QDGP--LLLIVEYAKYGSLRGFLR-ESRKVGPGYLGSG--------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE-MKLVHRDLAARNILVAEGRKMKISDFGLSRDV--Y-E--EDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI-PPERLFNLLKTGHRMERPDNCS--EEMYRLMLQCWKQEPDKRPV-----FADISKDL-------------
---L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PG-TM-SP--EA-FL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEP--IYIVTEYMSKGSLLDFLK-GE------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP--ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
---L-KKIRDLGEGHFGKVSLYCYDP-TNDGTGEMVAVKALK-AD-CG-PQHRSG-WK-Q-EIDILRTL-YHEHIIKYKGCCEDQGEKS--LQLVMEYVPLGSLRDYLP-RH---------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHA-QHYIHRDLAARNVLLDNDRLVKIGDFGLAKAV-PE-G--HEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKF-LELIGIAQGQM-TVLRLTELLERGERLPRPDKCP--CEVYHLMKNCWETEASFRPT-----FENLIP---IL----------
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