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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BTK 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
TK BLK 241
TKL BMPR1B 204
TK BMX 422
TKL BRAF 456
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA1 624
TK EPHA3 621
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK EPHB3 633
TK EPHB4 615
TK EPHB6 670
TK ERBB2 720
TK ERBB3 709
TK ERBB4 718
TK FGFR2 481
TK FGFR3 472
TK FGR 263
TK FRK 234
TK FYN 271
TK HCK 241
TK INSR 1023
TK JAK2 849
TK JAK3 822
TK KDR 834
TK KIT 589
TK LCK 245
TKL LIMK1 339
TKL LIMK2 331
TK LYN 247
Other NEK2 8
TK PDGFRA 593
TK PDGFRB 600
TK PTK6 191
TK RET 724
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK10 36
Other STK36 4
TK SYK 371
TK TEC 370
TK TNK2 150
TK TXK 271
TK TYK2 589
TK YES1 277
---LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAI-KMIK-E--G-SM-SE---DEFI-E-EAKVMMNL-SHEKLVQLYGVCT--K----QRPIFIITEYMANGCLLNYLR-----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK--------QFLHRDLAARNCLVNDQGVVKVSDFGLSRYV----------------L--DDEY------------TSSVGSKFPVRWSPPEVLM------YSK---FSSKSDIWAFGVLMWEIYSLGK--------------MP---------------YERF-----TNSETAEHI----AQ----GLR----LYRPHLAS------EKVYT-IMYSCWHEKADERPTFKILLSN--I--
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAV-KTLK-E--D-TM-EV---EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--R----EPPFYIITEFMTYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHLVKVADFGLSRLM----------------T--GDTY------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYELL----EK----DYR----MERPEGCP------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAV-KTLK-E--D-TM-EV---EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--L----EPPFYIVTEYMPYGNLLDYLR-----EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKK--------NFIHRDLAARNCLVGENHVVKVADFGLSRLM----------------T--GDTY------------TAHAGAKFPIKWTAPESLA------YNT---FSIKSDVWAFGVLLWEIATYGM--------------SP---------------YPGI-----DLSQVYDLL----EK----GYR----MEQPEGCP------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
---FEIGRPLGKGKFGNVYLAREK----------------QSKFILAL-KVLFKA--QLEKAGV---EHQLRR-EVEIQSHL-RHPNILRLYGYFH--D----ATRVYLILEYAPLGTVYRELQ----KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK--------RVIHRDIKPENLLLGSAGELKIADFGWSV------------------HAPSSRR------------TT---LCGTLDYLPPEMIE------GRM---HDEKVDLWSLGVLCYEFLV-GK--------------PP---------------FEAN--------TYQETY----KR----ISR----VEFTFPDFVT----EGARD-LISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK----------------KSHFIVAL-KVLFKS--Q-IEKEG---VEHQLRREIEIQAHL-HHPNILRLYNYFY--D----RRRIYLILEYAPRGELYKELQ----KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGK--------KVIHRDIKPENLLLGLKGELKIADFGWSV------------------HAPSLRR------------KT---MCGTLDYLPPEMIE------GRM---HNEKVDLWCIGVLCYELLV-GN--------------PP---------------FESA--------SHNETY----RR----IVK----VDLKFPASVP----MGAQD-LISKLLRHNPSERLPLAQVSAHPWV--
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAI-KTLK-E--G-TM-SP---EAFL-G-EANVMKAL-QHERLVRLYAVVT-------KEPIYIVTEYMARGCLLDFLK-----TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERM--------NSIHRDLRAANILVSEALCCKIADFGLARII-------------------DSEY------------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR--------------VP---------------YPGM-----SNPEVIRNL----ER----GYR----MPRPDTCP------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
--I-QMVKQIGKGRYGEVWMGKWR----------------GEK--VAV-KVFFTT--E-EASWF---RET----EIYQTVLM-RHENILGFIAADI--KGTGSWTQLYLITDYHENGSLYDYLK-----ST----------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFIS------------DTNEVDIPP------------NT---RVGTKRYMPPEVLDESLNRNHFQ---SYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVPSDPSYEDMREIV----CI----KKL----RPSFPNRWSSDECLRQMGK-LMTECWAHNPASRLTALRVKK----TL
---ITLLKELGSGQFGVVQLGKWK-----------------GQYDVAV-KMIK-E--G-SM-SE---DEFF-Q-EAQTMMKL-SHPKLVKFYGVCS--K----EYPIYIVTEYISNGCLLNYLR-----SH--------------------------------------------------------------------------------------------------GKGLEPSQLLEMCYDVCEGMAFLESH--------QFIHRDLAARNCLVDRDLCVKVSDFGMTRYV----------------L--DDQY------------VSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK--------------QP---------------YDLY-----DNSQVVLKV----SQ----GHR----LYRPHLAS------DTIYQ-IMYSCWHELPEKRPTFQQLLSS--I--
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAV-KMLN-V-TA-PT-PQQ-LQAFK-N-EVGVLRKT-RHVNILLFMGYST-------KPQLAIVTQWCEGSSLYHHLH-----II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVK-------------S--R--WSGS------------HQFEQLSGSILWMAPEVIR------MQDKNPYSFQSDVYAFGIVLYELMT-GQ--------------LP---------------YSNI-N---NRDQIIFMV----GR----GYLSPDLSKVRSNCP------KAMKR-LMAECLKKKRDERPLFPQILA---SI-
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAV-KMLK-S--T-AH-ADE-KEALM-S-ELKIMSHLGQHENIVNLLGACT--H----GGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--------NCIHRDVAARNVLLTNGHVAKIGDFGLARDI-------------M--N--DSNY------------IVKGNARLPVKWMAPESIF------DCV---YTVQSDVWSYGILLWEIFSLGL--------------NP---------------YPGI-L---VNSKFYKLV----KD----GYQ----MAQPAFAP------KNIYS-IMQACWALEPTHRPTFQQICSFL----
---LKLLQTIGKGEFGDVMLGDYR------------------GNKVAV-KCIK-N--D-AT-AQ----AFL-A-EASVMTQL-RHSNLVQLLGVIV-EE----KGGLYIVTEYMAKGSLVDYLR-----SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN--------NFVHRDLAARNVLVSEDNVAKVSDFGLTKEA----------------------S------------STQDTGKLPVKWTAPEALR------EKK---FSTKSDVWSFGILLWEIYSFGR--------------VP---------------YPRI-----PLKDVVPRV----EK----GYK----MDAPDGCP------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAV-KILR-P--D-AT-KNA-RNDFL-K-EVKIMSRL-KDPNIIRLLGVCV--Q----DDPLCMITDYMENGDLNQFLS-----AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATL--------NFVHRDLATRNCLVGENFTIKIADFGMSRNL-------------Y--A--GDYY------------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRA-------------QP---------------FGQL-----TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAV-KMLR-A--D-AN-KNA-RNDFL-K-EIKIMSRL-KDPNIIHLLAVCI--T----DDPLCMITEYMENGDLNQFLS-----RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSL--------NFVHRDLATRNCLVGKNYTIKIADFGMSRNL-------------Y--S--GDYY------------RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQE-------------QP---------------YSQL-----SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL-
--F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAI-KELR-E--A-TS-PKA-NKEIL-D-EAYVMASV-DNPHVCRLLGICL-------TSTVQLITQLMPFGCLLDYVR-----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR--------RLVHRDLAARNVLVKTPQHVKITDFGLAKLL-------------G--A--EEKE------------YHAEGGKVPIKWMALESIL------HRI---YTHQSDVWSYGVTVWELMTFGS--------------KP---------------YDGI-----PASEISSIL----EK----GER----LPQPPICT------IDVYM-IMVKCWMIDADSRPKFRELI----IEF
-LM--VDTVIGEGEFGEVYRGTLR-------------LPSQDCKTVAI-KTLK-D--T-SP-GGQ-WWNFL-R-EATIMGQF-SHPHILHLEGVVT--K----RKPIMIITEFMENGALDAFLR-----ER--------------------------------------------------------------------------------------------------EDQLVPGQLVAMLQGIASGMNYLSNH--------NYVHRDLAARNILVNQNLCCKVSDFGLTRLL-------------D--D--FDGT------------YETQGGKIPIRWTAPEAIA------HRI---FTTASDVWSFGIVMWEVLSFGD--------------KP---------------YGEM-----SNQEVMKSI----ED----GYR----LPPPVDCP------APLYE-LMKNCWAYDRARRPHFQKLQAHL----
--I-SIDKVVGAGEFGEVCSGRLK-------------LPSKKEISVAI-KTLK-V--G-YT-EKQ-RRDFL-G-EASIMGQF-DHPNIIRLEGVVT--K----SKPVMIVTEYMENGSLDSFLR-----KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDM--------GYVHRDLAARNILINSNLVCKVSDFGLSRVL-------------E--D--DPEA-----------AYTTRGGKIPIRWTSPEAIA------YRK---FTSASDVWSYGIVLWEVMSYGE--------------RP---------------YWEM-----SNQDVIKAV----DE----GYR----LPPPMDCP------AALYQ-LMLDCWQKDRNNRPKFEQIVSIL----
---IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAI-KALK-A--G-YT-ERQ-RRDFL-S-EASIMGQF-DHPNIIRLEGVVT--R----GRLAMIVTEYMENGSLDTFLR-----TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDL--------GYVHRDLAARNVLVDSNLVCKVSDFGLSRVL-------------E--D--DPDA-----------AYTTTGGKIPIRWTAPEAIA------FRT---FSSASDVWSFGVVMWEVLAYGE--------------RP---------------YWNM-----TNRDVISSV----EE----GYR----LPAPMGCP------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL----
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAI-KTLK-A--G-YS-EKQ-RRDFL-S-EASIMGQF-DHPNIIRLEGVVT--K----SRPVMIITEFMENGALDSFLR-----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQ----------DDT--S--DPTY------------TSSLGGKIPVRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPMDCP------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----
--V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAI-KTLK-S--G-YT-EKQ-RRDFL-S-EASIMGQF-DHPNVIHLEGVVT--K----STPVMIITEFMENGSLDSFLR-----QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRFLE----------DDT--S--DPTY------------TSALGGKIPIRWTAPEAIQ------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----TNQDVINAI----EQ----DYR----LPPPMDCP------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL----
--V-KIEEVIGAGEFGEVCRGRLK-------------QPGRREVFVAI-KTLK-V--G-YT-ERQ-RRDFL-S-EASIMGQF-DHPNIIRLEGVVT--K----SRPVMILTEFMENCALDSFLR-----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLSEM--------NYVHRDLAARNILVNSNLVCKVSDFGLSRFLE----------DDP--S--DPTY------------TSSLGGKIPIRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSYGE--------------RP---------------YWDM-----SNQDVINAV----EQ----DYR----LPPPMDCP------TALHQ-LMLDCWVRDRNLRPKFSQIVNTL----
--V-KIEEVIGAGEFGEVCRGRLK-------------APGKKESCVAI-KTLK-G--G-YT-ERQ-RREFL-S-EASIMGQF-EHPNIIRLEGVVT--N----SMPVMILTEFMENGALDSFLR-----LN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIASGMRYLAEM--------SYVHRDLAARNILVNSNLVCKVSDFGLSRFLE----------ENS--S--DPTY------------TSSLGGKIPIRWTAPEAIA------FRK---FTSASDAWSYGIVMWEVMSFGE--------------RP---------------YWDM-----SNQDVINAI----EQ----DYR----LPPPPDCP------TSLHQ-LMLDCWQKDRNARPRFPQVVSAL----
---IKIEEVIGTGSFGEVRQGRLQ-------------PRGRREQTVAI-QALW-A--G-GA-ESL-QMTFL-G-RAAVLGQF-QHPNILRLEGVVT--K----SRPLMVLTEFMELGPLDSFLR-----QR--------------------------------------------------------------------------------------------------EGQFSSLQLVAMQRGVAAAMQYLSSF--------AFVHRSLSAHSVLVNSHLVCKVARLGHSPQG----------------------------------------PSCLLRWAAPEVIA------HGK---HTTSSDVWSFGILMWEVMSYGE--------------RP---------------YWDM-----SEQEVLNAI----EQ----EFR----LPPPPGCP------PGLHL-LMLDTWQKDRARRPHFDQLVA---AF-
--L-RKVKVLGSGAFGTVYKGIWIP------------DGENVKIPVAI-KVLR-E--N-TS-PKA-NKEIL-D-EAYVMAGV-GSPYVSRLLGICL-------TSTVQLVTQLMPYGCLLDHVR-----EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV--------RLVHRDLAARNVLVKSPNHVKITDFGLARLL-------------D--I--DETE------------YHADGGKVPIKWMALESIL------RRR---FTHQSDVWSYGVTVWELMTFGA--------------KP---------------YDGI-----PAREIPDLL----EK----GER----LPQPPICT------IDVYM-IMVKCWMIDSECRPRFRELVSE--F--
--L-RKLKVLGSGVFGTVHKGVWIP------------EGESIKIPVCI-KVIE-D--K-SG-RQS-FQAVT-D-HMLAIGSL-DHAHIVRLLGLCP-------GSSLQLVTQYLPLGSLLDHVR-----QH--------------------------------------------------------------------------------------------------RGALGPQLLLNWGVQIAKGMYYLEEH--------GMVHRNLAARNVLLKSPSQVQVADFGVADLL-------------P--P--DDKQ------------LLYSEAKTPIKWMALESIH------FGK---YTHQSDVWSYGVTVWELMTFGA--------------EP---------------YAGL-----RLAEVPDLL----EK----GER----LAQPQICT------IDVYM-VMVKCWMIDENIRPTFKELANE--F--
--L-KRVKVLGSGAFGTVYKGIWVP------------EGETVKIPVAI-KILN-E--T-TG-PKA-NVEFM-D-EALIMASM-DHPHLVRLLGVCL-------SPTIQLVTQLMPHGCLLEYVH-----EH--------------------------------------------------------------------------------------------------KDNIGSQLLLNWCVQIAKGMMYLEER--------RLVHRDLAARNVLVKSPNHVKITDFGLARLL-------------E--G--DEKE------------YNADGGKMPIKWMALECIH------YRK---FTHQSDVWSYGVTIWELMTFGG--------------KP---------------YDGI-----PTREIPDLL----EK----GER----LPQPPICT------IDVYM-VMVKCWMIDADSRPKFKELAAE--F--
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAV-KMLK-D--D-AT-EKD-LSDLV-S-EMEMMKMIGKHKNIINLLGACT--Q----DGPLYVIVEYASKGNLREYLR-----ARRPPGMEY-----------------------------------------------------------------------------------SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ--------KCIHRDLAARNVLVTENNVMKIADFGLARDI-------------N--N--IDYY------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT------NELYM-MMRDCWHAVPSQRPTFKQLVEDL----
---LTLGKPLGEGCFGQVVMAEAIGI---------DKDRAAKPVTVAV-KMLK-D--D-AT-DKD-LSDLV-S-EMEMMKMIGKHKNIINLLGACT--Q----GGPLYVLVEYAAKGNLREFLR-----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQ--------KCIHRDLAARNVLVTEDNVMKIADFGLARDV-------------H--N--LDYY------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLLWEIFTLGG--------------SP---------------YPGI-----PVEELFKLL----KE----GHR----MDKPANCT------HDLYM-IMRECWHAAPSQRPTFKQLVEDL----
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAV-KTLK-P--G-TM-SP---KAFL-E-EAQVMKLL-RHDKLVQLYAVVS-------EEPIYIVTEFMCHGSLLDFLK-----NP-------------------------------------------------------------------------------------------------EGQDLRLPQLVDMAAQVAEGMAYMERM--------NYIHRDLRAANILVGERLACKIADFGLARLI----------------K--DDEY------------NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR--------------IP---------------YPGM-----NKREVLEQV----EQ----GYH----MPCPPGCP------ASLYE-AMEQTWRLDPEERPTFEYLQSFL----
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAV-KTLK-P--G-SM-DP---NDFL-R-EAQIMKNL-RHPKLIQLYAVCT--L----EDPIYIITELMRHGSLQEYLQ-----ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESR--------NYIHRDLAARNVLVGEHNIYKVADFGLARVFK-----------VD--N--EDIY------------ESRHEIKLPVKWTAPEAIR------SNK---FSIKSDVWSFGILLYEIITYGK--------------MP---------------YSGM-----TGAQVIQML----AQ----NYR----LPQPSNCP------QQFYN-IMLECWNAEPKERPTFETLRWK--L--
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAI-KTLK-P--G-TM-SP---ESFL-E-EAQIMKKL-KHDKLVQLYAVVS-------EEPIYIVTEYMNKGSLLDFLK-----DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM--------NYIHRDLRSANILVGNGLICKIADFGLARLI----------------E--DNEY------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR--------------VP---------------YPGM-----NNREVLEQV----ER----GYR----MPCPQDCP------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAV-KTMK-P--G-SM-SV---EAFL-A-EANVMKTL-QHDKLVKLHAVVT-------KEPIYIITEFMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR--------NYIHRDLRAANILVSASLVCKIADFGLARVI----------------E--DNEY------------TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR--------------IP---------------YPGM-----SNPEVIRAL----ER----GYR----MPRPENCP------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--
---ITLLRELGQGSFGMVYEGNARD-----------IIKGEAETRVAV-KTVN-E--S-AS-LRE-RIEFL-N-EASVMKGF-TCHHVVRLLGVVS--K----GQPTLVVMELMAHGDLKSYLR-----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK--------KFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-------------Y--E--TDYY------------RKGGKGLLPVRWMAPESLK------DGV---FTTSSDMWSFGVVLWEITSLAE--------------QP---------------YQGL-----SNEQVLKFV----MD----GGY----LDQPDNCP------ERVTD-LMRMCWQFNPKMRPTFLEIVNLL----
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAV-KKLQ-H--S-TE--EH-LRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG----RRNLKLIMEYLPYGSLRDYLQ-----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK--------RYIHRDLATRNILVENENRVKIGDFGLTKVL------------PQ--D--KEYY------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM-----IVFHLIELL----KN----NGR----LPRPDGCP------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAV-KQLQ-H--S-GP-DQ--QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG----RQSLRLVMEYLPSGCLRDFLQ-----RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR--------RCVHRDLAARNILVESEAHVKIADFGLAKLL------------PL--D--KDYY------------VVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCD--------------KSCSPSAE--FLRMMGCERDV-P---ALCRLLELL----EE----GQR----LPAPPACP------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL-
---LKLGKPLGRGAFGQVIEADAFG-----------IDKTATCRTVAV-KMLK-E--G-AT-HSE-HRALM-S-ELKILIHIGHHLNVVNLLGACT-KP----GGPLMVIVEFCKFGNLSTYLR-----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR--------KCIHRDLAARNILLSEKNVVKICDFGLARDI-------------Y--K--DPDY------------VRKGDARLPLKWMAPETIF------DRV---YTIQSDVWSFGVLLWEIFSLGA--------------SP---------------YPGV-K---IDEEFCRRL----KE----GTR----MRAPDYTT------PEMYQ-TMLDCWHGEPSQRPTFSELVEHL----
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAV-KMLK-P--S-AH-LTE-REALM-S-ELKVLSYLGNHMNIVNLLGACT--I----GGPTLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--------NCIHRDLAARNILLTHGRITKICDFGLARDI-------------K--N--DSNY------------VVKGNARLPVKWMAPESIF------NCV---YTFESDVWSYGIFLWELFSLGS--------------SP---------------YPGM-P---VDSKFYKMI----KE----GFR----MLSPEHAP------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAV-KSLK-Q--G-SM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER--------NYIHRDLRAANILVSDTLSCKIADFGLARLI----------------E--DNEY------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR--------------IP---------------YPGM-----TNPEVIQNL----ER----GYR----MVRPDNCP------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
-LI--HGEVLGKGCFGQAIKVTHR----------------ETGEVMVM-KELI----R-FD-EET-QRTFL-K-EVKVMRCL-EHPNVLKFIGVLY--K----DKRLNFITEYIKGGTLRGIIK-----SM--------------------------------------------------------------------------------------------------DSQYPWSQRVSFAKDIASGMAYLHSM--------NIIHRDLNSHNCLVRENKNVVVADFGLARLM-------------V--D--EKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMIN------GRS---YDEKVDVFSFGIVLCEIIGRVN--------------AD---------------PDYL-P---RTMDFGLNV----RG----FLD----RYCPPNCP------PSFFP-ITVRCCDLDPEKRPSFVKLEH---WL-
-LI--HGEVLGKGFFGQAIKVTHK-----------------ATGKVMVMKEL--I--R-CD-EET-QKTFL-T-EVKVMRSL-DHPNVLKFIGVLY--K----DKKLNLLTEYIEGGTLKDFLR-----SM---------------------------------------------------------------------------------------------------DPFPWQQKVRFAKGIASGMAYLHSM--------CIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATT--------KKRTL---RKNDRKKRYTVVGNPYWMAPEMLN------GKS---YDETVDIFSFGIVLCEIIGQVY--------------AD---------------PDCL-P---RTLDFGLNV----KL----FWE----KFVPTDCP------PAFFP-LAAICCRLEPESRPAFSKLED---SF-
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAV-KTLK-P--G-TM-SV---QAFL-E-EANLMKTL-QHDKLVRLYAVVT--R----EEPIYIITEYMAKGSLLDFLK-----SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK--------NYIHRDLRAANVLVSESLMCKIADFGLARVI----------------E--DNEY------------TAREGAKFPIKWTAPEAIN------FGC---FTIKSDVWSFGILLYEIVTYGK--------------IP---------------YPGR-----TNADVMTAL----SQ----GYR----MPRVENCP------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--
---YEVLYTIGTGSYGRCQKIRRK----------------SDGKILVW-KELDYG--S-MTEAE---KQMLVS-EVNLLREL-KHPNIVRYYDRII--DR--TNTTLYIVMEYCEGGDLASVITKGTKERQ----------------------------------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSD---GGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL----------------NHDTSFA------------KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM--------------PP---------------FTAF--------SQKELA----GK----IRE----GKFRRIPYRY---SDELNE-IITRMLNLKDYHRPSVEEILENPL-I-
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAV-KMLK-P--T-AR-SSE-KQALM-S-ELKIMTHLGPHLNIVNLLGACT--K----SGPIYIITEYCFYGDLVNYLH-----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--------NCVHRDLAARNVLLAQGKIVKICDFGLARDI-------------M--H--DSNY------------VSKGSTFLPVKWMAPESIF------DNL---YTTLSDVWSYGILLWEIFSLGG--------------TP---------------YPGM-M---VDSTFYNKI----KS----GYR----MAKPDHAT------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV-
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAV-KMLK-S--T-AR-SSE-KQALM-S-ELKIMSHLGPHLNVVNLLGACT--K----GGPIYIITEYCRYGDLVDYLH-----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASK--------NCVHRDLAARNVLICEGKLVKICDFGLARDI-------------M--R--DSNY------------ISKGSTFLPLKWMAPESIF------NSL---YTTLSDVWSFGILLWEIFTLGG--------------TP---------------YPEL-P---MNEQFYNAI----KR----GYR----MAQPAHAS------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL-
--F-TLCRKLGSGYFGEVFEGLWK-----------------DRVQVAI-KVIS-R--D-NL-LH--QQMLQ-S-EIQAMKKL-RHKHILALYAVVS--V----GDPVYIITELMAKGSLLELLR-----DS-------------------------------------------------------------------------------------------------DEKVLPVSELLDIAWQVAEGMCYLESQ--------NYIHRDLAARNILVGENTLCKVGDFGLARLI-------------------KEDV------------YLSHDHNIPYKWTAPEALS------RGH---YSTKSDVWSFGILLHEMFSRGQ--------------VP---------------YPGM-----SNHEAFLRV----DA----GYR----MPCPLECP------PSVHK-LMLTCWCRDPEQRPCFKALRERL----
--L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAV-KMLK-E--N-AS-PSE-LRDLL-S-EFNVLKQV-NHPHVIKLYGACS--Q----DGPLLLIVEYAKYGSLRGFLR-----ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM--------KLVHRDLAARNILVAEGRKMKISDFGLSRDV-------------Y--E--EDSY------------VKRSQGRIPVKWMAIESLF------DHI---YTTQSDVWSFGVLLWEIVTLGG--------------NP---------------YPGI-----PPERLFNLL----KT----GHR----MERPDNCS------EEMYR-LMLQCWKQEPDKRPVFADISKDL----
---WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAA-KVIDTK--S-EEELE---DYM--V-EIDILASC-DHPNIVKLLDAFY--Y----ENNLWILIEFCAGGAVDAVML---ELER----------------------------------------------------------------------------------------------------PLTESQIQVVCKQTLDALNYLHDN--------KIIHRDLKAGNILFTLDGDIKLADFGVSAKN----------------TRTIQRR------------DS---FIGTPYWMAPEVVMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SEP----PTLAQPSRWS----SNFKD-FLKKCLEKNVDARWTTSQLLQHPFV--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAI-KTLK-P--G-TM-SP---EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK-----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM--------NYVHRDLRAANILVGENLVCKVADFGLARLI----------------E--DNEY------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR--------------VP---------------YPGM-----VNREVLDQV----ER----GYR----MPCPPECP------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
-FA--LGRKLGEGYFGEVWEGLWL-----------------GSLPVAI-KVIK-S--A-NM-K---LTDLA-K-EIQTLKGL-RHERLIRLHAVCS--G----GEPVYIVTELMRKGNLQAFLG-----TP-------------------------------------------------------------------------------------------------EGRALRLPPLLGFACQVAEGMSYLEEQ--------RVVHRDLAARNVLVDDGLACKVADFGLARLL----------------K--DDIY------------SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ--------------CP---------------YEGM-----TNHETLQQI----MR----GYR----LPRPAACP------AEVYV-LMLECWRSSPEERPSFATLREKL----
---WEIVGELGDGAFGKVYKAKNK----------------ETGALAAA-KVIETK--S-EEELE---DYI--V-EIEILATC-DHPYIVKLLGAYY--H----DGKLWIMIEFCPGGAVDAIML---ELDR----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK--------RIIHRDLKAGNVLMTLEGDIRLADFGVSAKN----------------LKTLQKR------------DS---FIGTPYWMAPEVVMCE-TMKDTP---YDYKADIWSLGITLIEMAQ-IE--------------PP---------------HHEL-----NPMRVLLKI----AK----SDP----PTLLTPSKWS----VEFRD-FLKIALDKNPETRPSAAQLLEHPFV--
---YHVLEMIGEGSFGRVYKGRRK----------------YSAQVVAL-KFIPKL--G-RSEKE---LRNLQR-EIEIMRGL-RHPNIVHMLDSFE--T----DKEVVVVTDYAEG-ELFQILE----DDG----------------------------------------------------------------------------------------------------KLPEDQVQAIAAQLVSALYYLHSH--------RILHRDMKPQNILLAKGGGIKLCDFGFARAM----------------STNTMVL------------TS---IKGTPLYMSPELVE------ERP---YDHTADLWSVGCILYELAV-GT--------------PP---------------FYAT--------SIFQLV----SL----ILK----DPVRWPSTIS----PCFKN-FLQGLLTKDPRQRLSWPDLLYHPFI--
TLE---DKELGSGNFGTVKKGYYQ--------------MKKVVKTVAV-KILK-N--E-AN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE-------AESWMLVMEMAELGPLNKYLQ-----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES--------NFVHRDLAARNVLLVTQHYAKISDFGLSKAL-------------R--A--DENY-----------YKAQTHGKWPVKWYAPECIN------YYK---FSSKSDVWSFGVLMWEAFSYGQ--------------KP---------------YRGM-----KGSEVTAML----EK----GER----MGCPAGCP------REMYD-LMNLCWTYDVENRPGFAAVE----LRL
---LTFMRELGSGLFGVVRLGKWR-----------------AQYKVAI-KAIR-E--G-AM-CE---EDFI-E-EAKVMMKL-THPKLVQLYGVCT--Q----QKPIYIVTEFMERGCLLNFLR-----QR--------------------------------------------------------------------------------------------------QGHFSRDVLLSMCQDVCEGMEYLERN--------SFIHRDLAARNCLVSEAGVVKVSDFGMARYV----------------L--DDQY------------TSSSGAKFPVKWCPPEVFN------YSR---FSSKSDVWSFGVLMWEVFTEGR--------------MP---------------FEKY-----TNYEVVTMV----TR----GHR----LYQPKLAS------NYVYE-VMLRCWQEKPEGRPSFEDLLRT--I--
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAV-KCLK-PDVL-SQ-PEA-MDDFI-R-EVNAMHSL-DHRNLIRLYGVVL-------TPPMKMVTELAPLGSLLDRLR-----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK--------RFIHRDLAARNLLLATRDLVKIGDFGLMRAL------------PQ--N--DDHY------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ--------------EP---------------WIGL-----NGSQILHKI---DKE----GER----LPRPEDCP------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--
--L-AFIKEIGSGQFGVVHLGEWR-----------------SHIQVAI-KAIN-E--G-SM-SE---EDFI-E-EAKVMMKL-SHSKLVQLYGVCI--Q----RKPLYIVTEFMENGCLLNYLR-----EN--------------------------------------------------------------------------------------------------KGKLRKEMLLSVCQDICEGMEYLERN--------GYIHRDLAARNCLVSSTCIVKISDFGMTRYV----------------L--DDEY------------VSSFGAKFPIKWSPPEVFL------FNK---YSSKSDVWSFGVLMWEVFTEGK--------------MP---------------FENK-----SNLQVVEAI----SE----GFR----LYRPHLAP------MSIYE-VMYSCWHEKPEGRPTFAELLR---AV-
--L-KKIRDLGEGHFGKVSLYCYDP------------TNDGTGEMVAV-KALK-A--D-CG-PQH-RSGWK-Q-EIDILRTL-YHEHIIKYKGCCEDQG----EKSLQLVMEYVPLGSLRDYLP-----RH----------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ--------HYIHRDLAARNVLLDNDRLVKIGDFGLAKAV------------PE--G--HEYY------------RVREDGDSPVFWYAPECLK------EYK---FYYASDVWSFGVTLYELLTHCD--------------SSQSPPTKF-LELIGIAQGQM-----TVLRLTELL----ER----GER----LPRPDKCP------CEVYH-LMKNCWETEASFRPTFENLIP---IL-
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAI-KTLK-P--G-TM-MP---EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS-------EEPIYIVTEFMSKGSLLDFLK-----EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERM--------NYIHRDLRAANILVGENLVCKIADFGLARLI----------------E--DNEY------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR--------------VP---------------YPGM-----VNREVLEQV----ER----GYR----MPCPQGCP------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----
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