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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK BTK 203
TK ABL1 261
TK ALK 1116
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
TK EGFR 712
TK FGFR3 472
TK ITK 363
TK JAK2 849
TK KDR 834
TK KIT 589
TK PDGFRB 600
TK SRC 270
TK SYK 371
---LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-EG-SM-SE---DEFI-E-EAKVMMNL-SHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYLR----EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV--L--DDEY-TSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERF-TNSETAEHIAQGLRLYRPHLAS----------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I--
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV---EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM--T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
--I-TLIRGLGHGAFGEVYEGQVSG--MPNDPSPLQVAVKTLP-EV-CS-EQD-ELDFL-M-EALIISKF-NHQNIVRCIGVSL--QSLPRFILLELMAGGDLKSFLR----ETRP--------------------------------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI-YR--ASYY-RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK-SNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I--
---FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV---EHQLRR-EVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS---AGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
---FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEKEG---VEHQLRREIEIQAHL-HHPNILRLYNYFY--DRRRIYLILEYAPRGELYKELQ---KSC----------------------------------------------------------------------------------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGL---KGELKIADFGWSV----HAPSLRR-KT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--
---YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEEGV---PSTAIR-EISLLKEL-RHPNIVSLQDVLM--QDSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
--F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-EA-TS-PKA-NKEIL-D-EAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL-GA--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI-PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-DD-AT-DKD-LSDLV-S-EMEMMKMIGKHKNIINLLGACT--QGGPLYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTE---DNVMKIADFGLARDV-HN--LDYY-KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI-PVEELFKLLKEGHRMDKPANCT----------------------------HDLYMIMRECWHAAPSQRPTFKQLVEDL----
---LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-EG-AM-SE---EDFI-E-EAEVMMKL-SHPKLVQLYGVCL--EQAPICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV--L--DDQY-TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----
---LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE--EH-LRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVLPQD--KEYY-KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV
---LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-EG-AT-HSE-HRALM-S-ELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSE---KNVVKICDFGLARDI-YK--DPDY-VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTT----------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
---LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-PS-AH-LTE-REALM-S-ELKVLSYLGNHMNIVNLLGACT--IGGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI-KN--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGMPVDSKFYKMIKEGFRMLSPEHAP----------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I--
--L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-ST-AR-SSE-KQALM-S-ELKIMSHLGPHLNVVNLLGACT--KGGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI-MR--DSNY-ISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTP---------------YPELPMNEQFYNAIKRGYRMAQPAHAS----------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP---EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-NE-AN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE---AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT---QHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAMLEKGERMGCPAGCP----------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
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