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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CAMK4 203
CAMK CAMK2A 13
CMGC CDC2 4
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CAMK DCLK3 356
CMGC MAPK8 26
STE PAK4 321
STE PAK7 449
AGC ROCK1 76
AGC ROCK2 92
STE SLK 34
STE STK24 24
----FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKK---IVR----T-EIGVLLRLS---HPNIIKLKEIFET------PTEISLVLELVTGGELFDRIV---EKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYAT-PAPDAPLKIADFGLSKI--VEHQVLMKTVCGTPGYCAPEILR-----GCAYGPEVDMWSVGIITYILLCGFEPFYDE--RGDQFMFRRILNCEYYFISPWWDEVS-----------------------------------LNAKDLVRKLIVLDPKK--RLTTFQALQHPWV
----YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSA---RDHQKLER-EARICRLLK---HPNIVRLHDSISE------EGHHYLIFDLVTGGELFEDIV---AREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGA-AVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLR-----KDPYGKPVDLWACGVILYILLVGYPPFWDE---DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKDLINKMLTINPSK--RITAAEALKHPWI
----YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIR-EISLLKELR---HPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI----KLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF
----FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE---GFPITSLR-EINTILKAQ---HPNIVTVREIVVGS----NMDKIYIVMNYVEH-DLKSLME--TMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL----KVGDFGLAREY-GSPLKAYTPVVVTLWYRAPELLL----GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPY-----------NNLRKRFGALLSDQGFDLMNKFLTYFPGR--RISAEDGLKHEYF
----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIR-EISLLKELN---HPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI----KLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF
----FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEME---GVPSTAIR-EISLLKELK---HPNIVRLLDVVHN------ERKLYLVFEFLSQ-DLKKYMDS-TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAI----KLADFGLARAF-GVPLRTYTHEVVTLWYRAPEILL----GSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RITAKTALAHPYF
---Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVTLVFEHVDQ-DLRTYLDK-APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV----KLADFGLARI--YSYQMALTPVVVTLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL
----YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKG---KEDMV-DS-EILIIQSLS---HPNIVKLHEVYET------DMEIYLILEYVQGGDLFDAII---ESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK----HVVRPIFTVCGTPTYVAPEILS-----EKGYGLEVDMWAAGVILYILLCGFPPFRSP-ERDQDELFNIIQLGHFEFLPPYWDNIS-----------------------------------DAAKDLVSRLLVVDPKK--RYTAHQVLQHPWI
----YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQ---THAKRAYR-ELVLMKCVN---HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ-----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL----KILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RISVDEALQHPYI
DNFI-----KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR---REL--LFN-EVVIMRDYQ---HENVVEMYNSYLV------GDELWVVMEFLEGGALTDIVT----HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRV----KLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELIS-----RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS---------------------------------------PSLKGFLDRLLVRDPAQ--RATAAELLKHPFL
ANFI-----KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR---REL--LFN-EVVIMRDYH---HDNVVDMYSSYLV------GDELWVVMEFLEGGALTDIVT----HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRI----KLSDFGFCAQV-SKEVPKRKSLVGTPYWMAPEVIS-----RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHK----VS-----------------------------------SVLRGFLDLMLVREPSQ--RATAQELLGHPFL
----YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIK---RSDSAFFWEERDIMAFAN---SPWVVQLFYAFQD------DRYLYMVMEYMPGGDLVNLMS----NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHL----KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMNHKNSLTFPDDNDIS-----------------------------------KEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
----YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIK---RSDSAFFWEERDIMAFAN---SPWVVQLFYAFQD------DRYLYMVMEYMPGGDLVNLMS----NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHL----KLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF
----WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEE---LEDYM--V-EIDILASCD---HPNIVKLLDAFYY------ENNLWILIEFCAGGAVDAVML--ELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDI----KLADFGVSAKN-TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDA--RWTTSQLLQHPFV
----FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED---EIEDIQ-Q-EITVLSQCD---SPYVTKYYGSYLK------DTKLWIIMEYLGGGSALDLLE----PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEV----KLADFGVAGQL-TDTQIKRNTFVGTPFWMAPEVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSF--RPTAKELLKHKFI
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