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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other CAMKK2 203
Other CAMKK1 128
CAMK CHEK1 9
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
TK JAK3 822
CAMK PIM1 38
CAMK PIM3 40
Other TBK1 9
---YTLKDEIGKGSYGVVKLAYNE----NDNTYYAMKVLSKKKLIRQA-GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D----HPN--VVKLVEVLD--DPNEDHLYMVFELVNQG-PVMEVPT----LK--PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLL--VG-EDGHI----KIADFGVSNEF----KGSDALLSN---TVGTPAFMAPESLS-------ETRKIFSGKALDVWAMGVTLYCFVF-GQCP-------------FM-DE-----RIMCLHSKIKSQALEFPDQPDIA--------------------------------EDLKDLITRMLDKNPESRIVVPEIKLHPWV------------------------------------------------------
---YKLQSEIGKGAYGVVRLAYNE----SEDRHYAMKVLSKKKLLKQY-GFPR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL-D----HVN--VVKLIEVLD--DPAEDNLYLVFDLLRKG-PVMEVPC----DK--PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLL--LG-DDGHV----KIADFGVSNQF----EGNDAQLSS---TAGTPAFMAPEAISD-----SGQSF--SGKALDVWATGVTLYCFVY-GKCP-------------FI-DD-----FILALHRKIKNEPVVFPEEPEIS--------------------------------EELKDLILKMLDKNPETRIGVPDIKLHPWV------------------------------------------------------
--W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVDCP-ENI-KK-------------------------EICINKML-N----HEN--VVKFYGHRR--E--GNIQYLFLEYCSGG-ELFDRIE---PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLL--LD-ERDNL----KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK-------RREF--HAEPVDVWSCGIVLTAMLA-GELP-------------WD-QP----SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-----------------------------------------------------
---YQLVRKLGRGKYSEVFEAINI----TNNEKVVVKILKPVKKKKIK-R------------------------------EIKILENLRG----GPN--IITLADIVK--DPVSRTPALVFEHVNNT-DFKQLY------Q--TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVM--IDHEHRKL----RLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLV-------DYQM--YDYSLDMWSLGCMLASMIF-RKEP-------------FFHGH--DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF------------------------------------------------------
---YQLVRKLGRGKYSEVFEAINI----TNNERVVVKILKPVKKKKIK-R------------------------------EVKILENLRG----GTN--IIKLIDTVK--DPVSKTPALVFEYINNT-DFKQLY------Q--ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVM--IDHQQKKL----RLIDWGLAEF-----YHPAQEYNV---RVASRYFKGPELLV-------DYQM--YDYSLDMWSLGCMLASMIF-RREP-------------FFHGQ--DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF------------------------------------------------------
---YDTGEELGSGQFAVVKKCREK----STGLQYAAKFIKKRRTKSSR-RGVSREDI---------------------EREVSILKEI-Q----HPN--VITLHEVYE--N--KTDVILILELVAGG-ELFDFLA---EKE--SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIM--LL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKN---IFGTPEFVAPEIVN--------YEP--LGLEADMWSIGVITYILLS-GASP-------------FL-GD-----TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI------------------------------------------------------
--L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP-DQQRDFQ-R-------------------------EIQILKAL-H----SDF--IVKYRGVSYGPG--RQSLRLVMEYLPSG-CLRDFLQ----RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNIL--VE-SEAHV----KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS--------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCER-DVP-ALCRLLELLEEGQRLPAPPACP------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-----------------------------------------------------
---YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWG-ELPNGTRV---------------------PMEVVLLKKV-S----SGFSGVIRLLDWFE--R--PDSFVLILERPEPVQDLFDFIT---ERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENIL--IDLNRGEL----KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR-------YHRY--HGRSAAVWSLGILLYDMVC-GDIP-------------FE-HD-----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM------------------------------------------------------
---YQVGAVLGSGGFGTVYAGSRI----ADGLPVAVKHVVKERVTEWG-SLGGATV----------------------PLEVVLLRKV-GAAGGARG--VIRLLDWFE--R--PDGFLLVLERPEPAQDLFDFIT---ERG--ALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLL--VDLRSGEL----KLIDFGSGA------LLKDTVYTD---FDGTRVYSPPEWIR-------YHRY--HGRSATVWSLGVLLYDMVC-GDIP-------------FE-QD-----------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPSLDQIAAHPWM------------------------------------------------------
WLL---SDILGQGATANVFRGRHK----KTGDLFAIKVFNNISFLRPV-DVQ-MR-------------------------EFEVLKKL-N----HKN--IVKLFAIEE--ETTTRHKVLIMEFCPCG-SLYTVLEEPSNAY--GLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIG-EDGQSV--YKLTDFGAARE-----LEDDEQFVS---LYGTEEYLHPDMYERAVLRKDHQKK--YGATVDLWSIGVTFYHAAT-GSLP-------------FR-PF-EGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDM---------PVSCSLSRGLQV-----------------------------LLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY
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