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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CASK 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CAMK DAPK1 13
AGC GRK6 186
CMGC MAPK10 64
CAMK MAPKAPK2 64
CAMK PIM1 38
Other PLK1 53
AGC SGK1 98
STE STK24 24
---YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAK-FTSSPGLSTEDL---KREASIC-HML-KHPH--IVELLETYSS--------DGMLYMVFEFMDGA-DLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL----GESGLVAGGRVGTPHFMAPEVVK---REPYGKPVDVWGCGVILFILLSGCLPFYGT-----KERLFEGIIKGKYKMNPRQWSHIS-----------------------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL--
---FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR------EVEIQ-SHL-RHPN--ILRLYGYFHD--------ATRVYLILEYAPLG-TVY-RELQ---KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI--
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR------EISLL-KEL-NHPN--IVKLLDVIHT--------ENKLYLVFEFLHQ--DLK-KFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF--
---YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPITALR------EIKIL-QLL-KHEN--VVNLIEICRTKASPYNRCKGSIYLVFDFCEH--DLA-GLLS--NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQGN-TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF--
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAREADPALNVETEIEIL-KKL-NHPC--IIKIKNFF-D--------AEDYYIVLELMEGG-ELF-DKVV---GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL--
---YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRGVSREDI--EREVSIL-KEI-QHPN--VITLHEVYEN--------KTDVILILELVAGG-ELF-DFLA---EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLSGASPFLGD----TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI--
--F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGEAMAL-----NEKQIL-EKV-NSRF--VVSLAYAYET--------KDALCLVLTLMNGG-DLK-FHIYH-MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH-----VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQQR-KKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF--
---YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYR------ELVLM-KCV-NHKN--IISLLNVFTPQKT--LEEFQDVYLVMELMDA--NLC-QVIQ-----MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL----KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHKILFPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI--
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCP-KAR-------R------EVELH-WRASQCPH--IVRIVDVYENLY----AGRKCLLIVMECLDGG-ELF-SRIQD-RGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE-----TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI--
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGELPNGTRV--PMEVVLL-KKV-SSGFSGVIRLLDWFER--------PDSFVLILERPEPVQDLF-DFIT---ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA------LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD----------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM--
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLKPHQREKMS-----MEISIH-RSL-AHQH--VVGFHGFFED--------NDFVFVVLELCRRR-SLL-ELHK---RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV----EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLVGKPPFETS----CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF--
---FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKA-ILKKKEEKHIM-----SERNVLLKNV-KHPF--LVGLHFSFQT--------ADKLYFVLDYINGG-ELF-YHLQ---RERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD-SQGHI----VLTDFGLCKEN----IEHNSTTSTFCGTPEYLAPEVLH---KQPYDRTVDWWCLGAVLYEMLYGLPPFYSR----NTAEMYDNILNKPLQLKPNIT---------------------------------------NSARHLLEGLLQKDRTKRLGAK-DDFMEIKSHV--FF
---FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-AEDEIEDIQ-Q------EITVL-SQC-DSPY--VTKYYGSYLK--------DTKLWIIMEYLGGG-SAL-DLLE----PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL----TDTQIKRNTFVGTPFWMAPEVIK---QSAYDSKADIWSLGITAIELARGEPPHSEL-HPMKVLFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI--
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