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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CAMK CASK 12
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
Other EIF2AK2 267
Other ERN1 571
TK FGFR2 481
AGC GRK6 186
CMGC GSK3B 56
TK HCK 241
TKL IRAK4 186
TK LCK 245
STE MAP2K1 68
STE MAP2K4 102
CMGC MAPK10 64
CMGC MAPK12 27
TK MET 1078
TK MST1R 1082
Other NEK2 8
Other NEK7 34
STE OXSR1 17
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCI 245
TK PTK2 422
AGC ROCK1 76
TK SRC 270
STE STK24 24
TK TNK2 150
Other TTK 525
TK ZAP70 338
----FQKVEKIGEGTYGVV-YKARNK-------LTGEVVALKKIRLD--T-ETEGV--P-S-TAIR------EISLLKEL--N-HPN--IVKLLDVIH-T-----------------------------ENKLY--LVFEFLHQ---DLK-KFMDA------SALT-----------------GIPLP--LIKSYLFQLLQGLAFCHS-H-----RVLHRDLKPQNLLIN-TEGAI-----KLADFGLARAF-------GVPVRTY--TH---EVVTLWYRAPEILL----------GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFP-GD------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS------AKAALAHPFF-----------
----ITMKHKLGGGQYGEV-YEGVWK-------KYSLTVAVKTLK-E--D-TM-EV--E-E-FL-K------EAAVMKEI--K-HPN--LVQLLGVCT-R-----------------------------EPPFY--IITEFMTYG--NLL-DYLR---------EC--------------NRQEVNAV--VLLYMATQISSAMEYLEK-K-----NFIHRDLAARNCLVG-ENHLV-----KVADFGLSRLM-------T--GDTY--TAHAGAKFPIKWTAPESLA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SPYP-GI------DLSQVYELL-EKDYRMERPEGCP-------------------------------------------EKVYELMRACWQWNPSD--RPS------FAEIHQA--F-----------
----FEIGRPLGKGKFGNV-YLAREK-------QSKFILALKVLFKA--QLEKAGV--E-H-QLRR------EVEIQSHL--R-HPN--ILRLYGYFH-D-----------------------------ATRVY--LILEYAPLG--TVY-RELQ--------KLS-----------------KFDEQ--RTATYITELANALSYCHS-K-----RVIHRDIKPENLLLG-SAGEL-----KIADFGWSV---------HAPSSRR--TT---LCGTLDYLPPEMIE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PPFE-AN---------TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM------LREVLEHPWI-----------
----YELCEVIGKGPFSVV-RRCINR-------ETGQQFAVKIVDVA--K-FTSSP--G-L-STEDL---KREASICHML--K-HPH--IVELLETYS-S-----------------------------DGMLY--MVFEFMDGA--DLCFEIVKR-----ADAGF-----------------VYSEA--VASHYMRQILEALRYCHD-N-----NIIHRDVKPHCVLLA-SKENSA--PVKLGGFGVAIQL-------GESGLVA--GG---RVGTPHFMAPEVVK-----------REPYGKPVDVWGCGVILFILLS-GC-LPFY-GT----------KERLF-EGIIKGKYKMNPRQWSHIS-------------------------------------ESAKDLVRRMLMLDPAE--RIT------VYEALNHPWL-----------
----YEKLDFLGEGQFATV-YKARDK-------NTNQIVAIKKIKLG--H-RSEAK--D-G-INRTA---LREIKLLQEL--S-HPN--IIGLLDAFG-H-----------------------------KSNIS--LVFDFMET---DLE-VIIK-------DNSL-----------------VLTPS--HIKAYMLMTLQGLEYLHQ-H-----WILHRDLKPNNLLLD-ENGVL-----KLADFGLAKSF-------GSPNRAY--TH---QVVTRWYRAPELLF----------GARMYGVGVDMWAVGCILAELLL-RV-PFLP-GD------SDLDQLTRI-FETLGTPTEEQWPDMCSLPDYVTFKSFPG----------------IPLHHIFSAAGDDLLDLIQGLFLFNPCA--RIT------ATQALKMKYF-----------
----YEKLAKIGQGTFGEV-FKARHR-------KTGQKVALKKVLME--N-EKEGF--P-I-TALR------EIKILQLL--K-HEN--VVNLIEICR-TKASP---------------------YNRCKGSIY--LVFDFCEH---DLA-GLLS-------NVLV-----------------KFTLS--EIKRVMQMLLNGLYYIHR-N-----KILHRDMKAANVLIT-RDGVL-----KLADFGLARAFSL---AKNSQPNRY--TN---RVVTLWYRPPELLL----------GERDYGPPIDLWGAGCIMAEMWT-RS-PIMQ-GN------TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RID------SDDALNHDFF-----------
--YI--MSKTLGSGACGEV-KLAFER-------KTCKKVAIKIISKR--K-FAIGS--A-R-EADPALNVETEIEILKKL--N-HPC--IIKIKNFF--D-----------------------------AEDYY--IVLELMEGG--ELF-DKVV--------GNK-----------------RLKEA--TCKLYFYQMLLAVQYLHE-N-----GIIHRDLKPENVLLS-SQEEDC--LIKITDFGHSKI--------LGETSLM--RT---LCGTPTYLAPEVLVS--------VGTAGYNRAVDCWSLGVILFICLS-GY-PPFS-EH--------RTQVSLK-DQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKA--RFT------TEEALRHPWL-----------
----YQLVRKLGRGKYSEV-FEAINI-------TNNEKVVVKILKPV--K-KKKIK--R-------------EIKILENL-RG-GPN--IITLADIVK-DP---------------------------VSRTPA--LVFEHVNNT--DFK-QLY-----------Q-----------------TLTDY--DIRFYMYEILKALDYCHS-M-----GIMHRDVKPHNVMIDHEHRKL-----RLIDWGLAEF--------YHPGQEY--NV---RVASRYFKGPELLV----------DYQMYDYSLDMWSLGCMLASMIF-RK-EPFFHGH------DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT------AREAMEHPYF-----------
----YDTGEELGSGQFAVV-KKCREK-------STGLQYAAKFIKKR--R-TKSSR--R-G-VSREDI--EREVSILKEI--Q-HPN--VITLHEVYE-N-----------------------------KTDVI--LILELVAGG--ELF-DFLA--------EKE-----------------SLTEE--EATEFLKQILNGVYYLHS-L-----QIAHFDLKPENIMLL-DRNVPKP-RIKIIDFGLAHK--------IDFGNEF--KN---IFGTPEFVAPEIVN-----------YEPLGLEADMWSIGVITYILLS-GA-SPFL-GD---------TKQETL-ANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKK--RMT------IQDSLQHPWI-----------
---F-KEIELIGSGGFGQV-FKAKHR-------IDGKTYVIKRVKYN--N-EKAER----------------EVKALAKL--D-HVN--IVHYNGCWD-GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLE-QWIEK------RRGE-----------------KLDKV--LALELFEQITKGVDYIHS-K-----KLIHRDLKPSNIFLV-DTKQV-----KIGDFGLVTS--------LKNDGKR--TR---SKGTLRYMSPEQIS-----------SQDYGKEVDLYALGLILAELLH-VCDTAFE-T-------------SKF-FTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPED--RPN------TSEILR----TLT--------
-FCP---KDVLGHGAEGTIVYRGMFD-------NRD--VAVKRILPE--C-FSFAD--R-------------EVQLLRES-DE-HPN--VIRYFCTEK-D-----------------------------RQFQY--IAIELCAA---TLQ-EYVE---------QK-----------------DFAHLGLEPITLLQQTTSGLAHLHS-L-----NIVHRDLKPHNILIS-MPNAHGKIKAMISDFGLCKKLA----VGRHSFSRR--SG---VPGTEGWIAPEMLSE--------DCKENPTYTVDIFSAGCVFYYVISEGS-HPFG-KS-------LQRQANIL-LGACSLDCLHPEKHE---D-------------------------------------VIARELIEKMIAMDPQK--RPS------AKHVLKHPFF-----------
----LTLGKPLGEGCFGQV-VMAEAVGIDKDKPKEAVTVAVKMLK-D--D-AT-EKDLS-D-LV-S------EMEMMKMIG-K-HKN--IINLLGACT-Q-----------------------------DGPLY--VIVEYASKG--NLR-EYLR---------ARRPPGMEYSYDINRVPEEQMTFK--DLVSCTYQLARGMEYLAS-Q-----KCIHRDLAARNVLVT-ENNVM-----KIADFGLARDI---N---N--IDYY--KKTTNGRLPVKWMAPEALF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SPYP-GI------PVEELFKLL-KEGHRMDKPANCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPT------FKQLVEDL-------------
---F-RQYRVLGKGGFGEV-CACQVR-------ATGKMYACKKLEKK--R-IKKRK--G-E-AMAL-----NEKQILEKV--N-SRF--VVSLAYAYE-T-----------------------------KDALC--LVLTLMNGG--DLK-FHIYH------MGQA-----------------GFPEA--RAVFYAAEICCGLEDLHR-E-----RIVYRDLKPENILLD-DHGHI-----RISDLGLAVH--------VPEGQTI--KG---RVGTVGYMAPEVVK-----------NERYTFSPDWWALGCLLYEMIA-GQ-SPFQ-QR------KKKIKREEV-ERLVK-EVPEEYSER--FS-------------------------------------PQARSLCSQLLCKDPAE--RLGCR-GGSAREVKEHPLF-----------
----YTDTKVIGNGSFGVV-YQAKLC-------DSGELVAIKKVLQD--K-RFKNR----------------ELQIMRKL--D-HCN--IVRLRYFFY-SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA----RHY----SRAKQ-----------------TLPVI--YVKLYMYQLFRSLAYIHS-F-----GICHRDIKPQNLLLDPDTAVL-----KLCDFGSAKQ--------LVRGEPN--VS---YICSRYYRAPELIF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PIFP-GD------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT------PLEACAHSFF-----------
----LKLEKKLGAGQFGEV-WMATYN--------KHTKVAVKTMK-P--G-SM-SV--E-A-FL-A------EANVMKTL--Q-HDK--LVKLHAVVT-------------------------------KEPIY--IITEFMAKG--SLL-DFLK---------SD--------------EGSKQPLP--KLIDFSAQIAEGMAFIEQ-R-----NYIHRDLRAANILVS-ASLVC-----KIADFGLARVI-------E--DNEY--TAREGAKFPIKWTAPEAIN-----------FGSFTIKSDVWSFGILLMEIVTYGR-IPYP-GM------SNPEVIRAL-ERGYRMPRPENCP-------------------------------------------EELYNIMMRCWKNRPEE--RPT------FEYIQSV--L-----------
-VGG----NKMGEGGFGVV-YKGYVN-------NTT--VAVKKLAAM--V-DITTE--ELK-QQFD-----QEIKVMAKC--Q-HEN--LVELLGFSS-D-----------------------------GDDLC--LVYVYMPNG--SLL-DRLSC-----LDGTP-----------------PLSWH--MRCKIAQGAANGINFLHE-N-----HHIHRDIKSANILLD-EAFTA-----KISDFGLARASE-----KFAQTVMT--SR---IVGTTAYMAPEALR------------GEITPKSDIYSFGVVLLEIIT-GL-PAVD-EH------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNK--RPD------IKKVQQ----LLQ--------
----LKLVERLGAGQFGEV-WMGYYN--------GHTKVAVKSLK-Q--G-SM-SP--D-A-FL-A------EANLMKQL--Q-HQR--LVRLYAVVT-------------------------------QEPIY--IITEYMENG--SLV-DFLK---------TP--------------SGIKLTIN--KLLDMAAQIAEGMAFIEE-R-----NYIHRDLRAANILVS-DTLSC-----KIADFGLARLI-------E--DNEY--TAREGAKFPIKWTAPEAIN-----------YGTFTIKSDVWSFGILLTEIVTHGR-IPYP-GM------TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT------FDYLRSV--L-----------
----FEKISELGAGNGGVV-FKVSHK-------PSGL-VMARKLIHL--E-IKPAI--R-N-QIIR------ELQVLHEC--N-SPY--IVGFYGAFY-S-----------------------------DGEIS--ICMEHMDGG--SLD-QVLK--------KAG-----------------RIPEQ--ILGKVSIAVIKGLTYLREKH-----KIMHRDVKPSNILVN-SRGEI-----KLCDFGVSG---------QLIDSMA--NS---FVGTRSYMSPERLQ-----------GTHYSVQSDIWSMGLSLVEMAV-GR-YPIP-PP------DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE--RAD------LKQLMVHAFI-----------
--LK--DLGEIGRGAYGSV-NKMVHK-------PSGQIMAVKRIRST--V-DEKEQ--K-Q-L-LM------DLDVVMRS-SD-CPY--IVQFYGALF-R-----------------------------EGDCW--ICMELMSTSFDKFY-KYVYS------VLDD-----------------VIPEE--ILGKITLATVKALNHLKE-N----LKIIHRDIKPSNILLD-RSGNI-----KLCDFGISGQ--------LVDSIAK--TR---DAGCRPYMAPERIDP-------SASRQGYDVRSDVWSLGITLYELAT-GR-FPYP-KW-------NSVFDQLT-QVVKGDPPQLSNSEEREFS-------------------------------------PSFINFVNLCLTKDESK--RPK------YKELLKHPFI-----------
----YQNLKPIGSGAQGIV-CAAYDA-------VLDRNVAIKKLSRP--F-QNQTH--A-K-RAYR------ELVLMKCV--N-HKN--IISLLNVFT-PQKT-----------------------LEEFQDVY--LVMELMDA---NLC-QVIQ----------M-----------------ELDHE--RMSYLLYQMLCGIKHLHS-A-----GIIHRDLKPSNIVVK-SDCTL-----KILDFGLART--------AGTSFMM--TP---YVVTRYYRAPEVIL-----------GMGYKENVDIWSVGCIMGEMVR-HK-ILFP-GR------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS------VDDALQHPYI-----------
----YRDLQPVGSGAYGAV-CSAVDG-------RTGAKVAIKKLYRP--F-QSELF--A-K-RAYR------ELRLLKHM--R-HEN--VIGLLDVFT-PDET-----------------------LDDFTDFY--LVMPFMGT---DLG-KLMK---------HE-----------------KLGED--RIQFLVYQMLKGLRYIHA-A-----GIIHRDLKPGNLAVN-EDCEL-----KILDFGLAR----------QADSEM--TG---YVVTRWYRAPEVIL----------NWMRYTQTVDIWSVGCIMAEMIT-GK-TLFK-GS------DHLDQLKEI-MKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-------------KKDFASILTNASPLAVNLLEKMLVLDAEQ--RVT------AGEALAHPYF-----------
----VHFNEVIGRGHFGCV-YHGTLL----DNDGKKIHCAVKSLN-R--I-TD-IGEVS-Q-FL-T------EGIIMKDF--S-HPN--VLSLLGICLRS-----------------------------EGSPL--VVLPYMKHG--DLR-NFIR---------NE---------------THNPTVK--DLIGFGLQVAKGMKYLAS-K-----KFVHRDLAARNCMLD-EKFTV-----KVADFGLARDM---Y---D--KEYYSVHNKTGAKLPVKWMALESLQ-----------TQKFTTKSDVWSFGVLLWELMTRGA-PPYP-DV------NTFDITVYL-LQGRRLLQPEYCP-------------------------------------------DPLYEVMLKCWHPKAEM--RPS------FSELVSR--I-----------
-THS---DRVIGKGHFGVV-YHGEYI----DQAQNRIQCAIKSLS-R--I-TE-MQQVE-A-FL-R------EGLLMRGL--N-HPN--VLALIGIMLPP-----------------------------EGLPH--VLLPYMCHG--DLL-QFIR---------SP---------------QRNPTVK--DLISFGLQVARSMEYLAE-Q-----KFVHRDLAARNCMLD-ESFTV-----KVADFGLARDI---L---D--REYYSVQQHRHARLPVKWMALESLQ-----------TYRFTTKSDVWSFGVLLWELLTRGA-PPYR-HI------DPFDLTHFL-AQGRRLPQPEYCP-------------------------------------------DSLYQVMQQCWEADPAV--RPT------FRVLV----GEV---------
----YEVLYTIGTGSYGRC-QKIRRK-------SDGKILVWKELDYG--S-MTEAE--K-Q-MLVS------EVNLLREL--K-HPN--IVRYYDRII-DR---------------------------TNTTLY--IVMEYCEGG--DLA-SVITKG----TKERQ-----------------YLDEE--FVLRVMTQLTLALKECHR-RSDGGHTVLHRDLKPANVFLD-GKQNV-----KLGDFGLARIL-------NHDTSFA--KT---FVGTPYYMSPEQMN-----------RMSYNEKSDIWSLGCLLYELCA-LM-PPFT-AF---------SQKELA-GKIREGKFRRIPYRY---S-------------------------------------DELNEIITRMLNLKDYH--RPS------VEEILENPL-I----------
----FRIEKKIGRGQFSEV-YRAACL-------LDGVPVALKKVQIF--D-LMDAK--A-R-ADCI-----KEIDLLKQL--N-HPN--VIKYYASFI-E-----------------------------DNELN--IVLELADAG--DLS-RMIKHF----KKQKR-----------------LIPER--TVWKYFVQLCSALEHMHS-R-----RVMHRDIKPANVFIT-ATGVV-----KLGDLGLGRFF-------SSKTTAA--HS---LVGTPYYMSPERIH-----------ENGYNFKSDIWSLGCLLYEMAA-LQ-SPFY-GD-------KMNLYSLC-KKIEQCDYPPLPSDHYS---------------------------------------EELRQLVNMCINPDPEK--RPD------VTYV------YDVA-------
----YELQEVIGSGATAVV-QAAYCA-------PKKEKVAIKRINLE--K-CQTSM--D-E--LLK------EIQAMSQC--H-HPN--IVSYYTSFV-V-----------------------------KDELW--LVMKLLSGG--SVL-DIIKHIVAKGEHKSG-----------------VLDES--TIATILREVLEGLEYLHK-N-----GQIHRDVKAGNILLG-EDGSV-----QIADFGVSAFLAT--GGDITRNKVR--KT---FVGTPCWMAPEVME----------QVRGYDFKADIWSFGITAIELAT-GA-APYH-KY------PPMKVLMLT-LQNDPPSLETGVQDKE--MLK--------------------------------KYGKSFRKMISLCLQKDPEK--RPT------AAELLRHKFF-----------
---F-KFGKILGEGSFSTV-VLAREL-------ATSREYAIKILEKR--H-IIKEN--K-VPYVTR------ERDVMSRL--D-HPF--FVKLYFTFQ-D-----------------------------DEKLY--FGLSYAKNG--ELL-KYIR--------KIG-----------------SFDET--CTRFYTAEIVSALEYLHG-K-----GIIHRDLKPENILLN-EDMHI-----QITDFGTAKVLS-----PESKQARA--NS---FVGTAQYVSPELLT-----------EKSACKSSDLWALGCIIYQLVA-GL-PPFR-AG---------NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATK--RLG------CEEM------EGYGPLKAHPF
----YQVGPLLGSGGFGSV-YSGIRV-------SDNLPVAIKHVEKD--R-ISDWG--E-L-PNGTRV--PMEVVLLKKV--S-SGFSGVIRLLDWFE-R-----------------------------PDSFV--LILERPEPV-QDLF-DFIT--------ERG-----------------ALQEE--LARSFFWQVLEAVRHCHN-C-----GVLHRDIKDENILIDLNRGEL-----KLIDFGSGA---------LLKDTVY--TD---FDGTRVYSPPEWIR----------YHRYHGRSAAVWSLGILLYDMVC-GD-IPFE-HD----------------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSD--RPT------FEEIQNHPWM-----------
--YV--RGRFLGKGGFAKC-FEISDA-------DTKEVFAGKIVPKS--L-LLKPH--Q-R-EKMS-----MEISIHRSL--A-HQH--VVGFHGFFE-D-----------------------------NDFVF--VVLELCRRR--SLL-ELHK--------RRK-----------------ALTEP--EARYYLRQIVLGCQYLHR-N-----RVIHRDLKLGNLFLN-EDLEV-----KIGDFGLATKV-------EYDGERK--KT---LCGTPNYIAPEVLS-----------KKGHSFEVDVWSIGCIMYTLLV-GK-PPFE-TS---------CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT------INELLNDEFF-----------
---F-DLLRVIGRGSYAKV-LLVRLK-------KTDRIYAMKVVKKE--L-VNDDE--D-I-DWVQ-----TEKHVFEQA-SN-HPF--LVGLHSCFQ-T-----------------------------ESRLF--FVIEYVNGG--DLM-FHMQ--------RQR-----------------KLPEE--HARFYSAEISLALNYLHE-R-----GIIYRDLKLDNVLLD-SEGHI-----KLTDYGMCKEG-------LRPGDTT--ST---FCGTPNYIAPEILR-----------GEDYGFSVDWWALGVLMFEMMA-GR-SPFD-IVGSSDNPDQNTEDYLF-QVILEKQIRIPRSLS-----------------------------------------VKAASVLKSFLNKDPKE--RLGCHPQTGFADIQGHPF-F----------
----IELGRCIGEGQFGDV-HQGIYM----SPENPALAVAIKTCK-N--C-TS-DSVRE-K-FL-Q------EALTMRQF--D-HPH--IVKLIGVIT-------------------------------ENPVW--IIMELCTLG--ELR-SFLQ---------VR---------------KYSLDLA--SLILYAYQLSTALAYLES-K-----RFVHRDIAARNVLVS-SNDCV-----KLGDFGLSRYM-------E--DSTY--YKASKGKLPIKWMAPESIN-----------FRRFTSASDVWMFGVCMWEILMHGV-KPFQ-GV------KNNDVIGRI-ENGERLPMPPNCP-------------------------------------------PTLYSLMTKCWAYDPSR--RPR------FTELKAQL-------------
----YEVVKVIGRGAFGEV-QLVRHK-------STRKVYAMKLLSKF--E-MIKRS--D-S-AFFW-----EERDIMAFA--N-SPW--VVQLFYAFQ-D-----------------------------DRYLY--MVMEYMPGG--DLV-NLMS---------NY-----------------DVPEK--WARFYTAEVVLALDAIHS-M-----GFIHRDVKPDNMLLD-KSGHL-----KLADFGTCMKM------NKEGMVRC--DT---AVGTPDYISPEVLKS-------QGGDGYYGRECDWWSVGVFLYEMLV-GD-TPFY-AD---------SLVGTY-SKIMNHKNSLTFPDDNDIS-------------------------------------KEAKNLICAFLTDREVRLGRNG------VEEIKRHLFF-----------
---L-RLEVKLGQGCFGEV-WMGTWN--------GTTRVAIKTLK-P--G-TM-SP--E-A-FL-Q------EAQVMKKL--R-HEK--LVQLYAVVS-------------------------------EEPIY--IVTEYMSKG--SLL-DFLK---------GE--------------TGKYLRLP--QLVDMAAQIASGMAYVER-M-----NYVHRDLRAANILVG-ENLVC-----KVADFGLARLI-------E--DNEY--TARQGAKFPIKWTAPEAAL-----------YGRFTIKSDVWSFGILLTELTTKGR-VPYP-GM------VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPT------FEYLQAF--L-----------
----FTKLEKIGKGSFGEV-FKGIDN-------RTQKVVAIKIIDLE--E-AEDEI--E-D-IQ-Q------EITVLSQC--D-SPY--VTKYYGSYL-K-----------------------------DTKLW--IIMEYLGGG--SAL-DLLE---------PG-----------------PLDET--QIATILREILKGLDYLHS-E-----KKIHRDIKAANVLLS-EHGEV-----KLADFGVAGQL-------TDTQIKR--NT---FVGTPFWMAPEVIK-----------QSAYDSKADIWSLGITAIELAR-GE-PPHS-EL------HPMKVLFLI-PKNNPPTLEGNYS-------------------------------------------KPLKEFVEACLNKEPSF--RPT------AKELLKHKFI-----------
---L-RLLEKLGDGSFGVV-RRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEAMD-D-FI-R------EVNAMHSL--D-HRN--LIRLYGVVL-------------------------------TPPMK--MVTELAPLG--SLL-DRLR---------KH---------------QGHFLLG--TLSRYAVQVAEGMGYLES-K-----RFIHRDLAARNLLLA-TRDLV-----KIGDFGLMRAL--PQ---N--DDHY--VMQEHRKVPFAWCAPESLK-----------TRTFSHASDTWMFGVTLWEMFTYGQ-EPWI-GL------NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPED--RPT------FVALRDF--L-----------
----YSILKQIGSGGSSKV-FQVLNE-------KKQ-IYAIKYVNLE--E-ADNQT--L-D-SYRN------EIAYLNKL-QQHSDK--IIRLYDYEI-T-----------------------------DQYIY--MVMECGNI---DLN-SWLK--------KKK-----------------SIDPW--ERKSYWKNMLEAVHTIHQ-H-----GIVHSDLKPANFLIV--DGML-----KLIDFGIANQMQ-----PDTTSVVK--DS---QVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TPFQ-QI--------INQISKL-HAIIDPNHEIEFPDIPE---------------------------------------KDLQDVLKCCLKRDPKQ--RIS------IPELLAHPYV-----------
LIAD----IELGCGNFGSV-RQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KADTE-E-MM-R------EAQIMHQL--D-NPY--IVRLIGVCQ-------------------------------AEALM--LVMEMAGGG--PLH-KFLV---------GK---------------REEIPVS--NVAELLHQVSMGMKYLEE-K-----NFVHRDLAARNVLLV-NRHYA-----KISDFGLSKAL--GA---D--DSYY--TARSAGKWPLKWYAPECIN-----------FRKFSSRSDVWSYGVTMWEALSYGQ-KPYK-KM------KGPEVMAFI-EQGKRMECPPECP-------------------------------------------PELYALMSDCWIYKWED--RPD------FLTVEQR--M-----------
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