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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK6 13
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TK ITK 363
TK JAK3 822
TK LCK 245
CMGC MAPK1 13
CMGC MAPK14 24
-FQKVEKIGEGTYGVVYKARNK-------LTGE-VVALKKIRLDT-ETE---GV--PSTAIREISLLKEL-N---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
-FEIGRPLGKGKFGNVYLAREK-------QSKF-ILALKVLFKAQLEKA---GV--EHQLRREVEIQSHL-R---HPNILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV-------HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
-YTKIEKIGEGTYGVVYKGRHK-------TTGQ-VVAMKKIRLES-EEE---GV--PSTAIREISLLKEL-R---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL-------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
Y-EPVAEIGVGAYGTVYKARDP-------HSGH-FVALKSVRVPN-GGGGGGGL--PISTVREVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL-------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-
-YECVAEIGEGAYGKVFKARDL-------KNGGRFVALKRVRVQT-GEE---GM--PLSTIREVAVLRHL-ETFEHPNVVRLFDVCT--VSR-TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP-----------------GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQIKLADFGLARI------YSFQMALTS---VVVTLWYRAPEVLL-QSSYATPVDLWSVGCIFAEMFR-RKPL-------------FRGS-SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ----PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF-
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT-KVAVKMLK-SD-AT----EKDLSDLI-SEMEMMKMIGK---HKNIINLLGACT--Q------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDI--H--H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP-------------YPGV-PVEELFKLLKEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
-YTDIKVIGNGSFGVVYQARLA-------ETRE-LVAIKKVLQDK-RFK---NR--------ELQIMRKL-D---HCNIVRLRYFFY--SSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI-------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
-YTDTKVIGNGSFGVVYQAKLC-------DSGE-LVAIKKVLQDK-RFK---NR--------ELQIMRKL-D---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI-------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
-LTFVQEIGSGQFGLVHLGYWL--------NKD-KVAIKTIR-EG-AM----SE--EDFI-EEAEVMMKL-S---HPKLVQLYGVCL--E------QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV-----L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP-------------YENR-SNSEVVEDISTGFRLYKPRLAS------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL---
L-KYISQLGKGNFGSVELCRYDP---LGDNTGA-LVAVKQLQ-HS-GP----DQ-QRDFQ-REIQILKAL-H---SDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACP------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL
-LKLVERLGAGQFGEVWMGYYN--------GHT-KVAVKSLK-QG-SM----SP--DAFL-AEANLMKQL-Q---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI-----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP-------------YPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
-YTNLSYIGEGAYGMVCSAYDN-------VNKV-RVAIKKISPFE-HQT---YC--QRT-LREIKILLRF-R---HENIIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-----------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI-------------FPGK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-
-YQNLSPVGSGAYGSVCAAFDT-------KTGL-RVAVKKLSRPF-QSI---IH--AKRTYRELRLLKHM-K---HENVIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL-------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
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