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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
TK AXL 527
TK BLK 241
TK BMX 422
CAMK CAMK2A 13
Other CAMKK2 165
CAMK CASK 12
CMGC CDK15 103
CMGC CDK4 6
CMGC CDK7 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CAMK DCLK3 356
TK DDR1 572
TK DDR2 563
TK EPHA1 624
TK EPHB1 619
TK EPHB3 633
TK FER 563
TK FES 561
TK FGFR2 481
TK FGR 263
TK FYN 271
Other GAK 40
AGC GRK4 187
AGC GRK7 191
TK HCK 241
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
STE MAP2K1 68
STE MAP2K4 102
STE MAP2K5 166
TKL MAP3K7 36
CMGC MAPK14 24
CMGC MAPK7 55
AGC MAST1 374
TK MET 1078
TK MST1R 1082
Other NEK1 4
Other NEK11 29
Other NEK2 8
Other NEK4 6
CMGC NLK 126
TK NTRK2 538
TK NTRK3 538
STE PAK1 270
STE PAK2 249
STE PAK3 268
CMGC PCTK1 165
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN1 615
AGC PKN2 657
Other PLK1 53
Other PLK2 82
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
TK PTK2 422
AGC ROCK1 76
AGC ROCK2 92
STE SLK 34
TK SRC 270
TK SRMS 230
STE STK24 24
Other STK35 202
Other STK36 4
STE STK39 63
Other TLK2 440
TK TNK2 150
TKL TNNI3K 463
TK YES1 277
TK ZAP70 338
----FQKVEKIGEGTYGVVYKARNK----------------L-T-GE---VVALKKIRLD--TET-E---GV--P-STAIR-------------------------EISLLKEL--N-----HPN-----IVKLLDVIH--T-------------------------------------ENK------LYLVFEFLHQ---DLK-KFMDA------SALT---------------------GI---PLPLIKSYLFQLLQGLAFCHS--H-----R---VLHRDLKPQNLLINTEG-AI--------------------KLADFGLARAF--------------------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY---YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD---SEIDQLFRI----FR----TLG---TPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNK--RIS-------AK-AALAHPFF--------------
----ITMKHKLGGGQYGEVYEGVWK----------------K-Y-SL---TVAVKTLK-E--DTM-----EV--E-EFL-K-------------------------EAAVMKEI--K-----HPN-----LVQLLGVCT--R-------------------------------------EPP------FYIITEFMTYG--NLL-DYLR---------EC-----------------NR-QEV---NAVVLLYMATQISSAMEYLEK--K-----N---FIHRDLAARNCLVGENH-LV--------------------KVADFGLSRLM--------------------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI---DLSQVYELL----EK----DYR---MERPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSD--RPS-------FA-EIHQA--F--------------
---V-ALGKTLGEGEFGAVMEGQLN--------------QDD-S-IL---KVAVKTMK-I-AICT-----RSELE-DFL-S-------------------------EAVCMKEF--D-----HPN-----VMRLIGVCF--Q-------------------------------------GSERESFPAPVVILPFMKHG--DLH-SFLL---------YSRL-------------GDQP-VYL---PTQMLVKFMADIASGMEYLST--K-----R---FIHRDLAARNCMLNENM-SV--------------------CVADFGLSKKI----------Y---------N--GDYY--------------RQGRIAKMPVKWIAIESLA------DRV---YTSKSDVWSFGVTMWEIATRGQ-TP---------------YPGV---ENSEIYDYL----RQ----GNR---LKQPADCL-----------------------------------------------------------------------------DGLYA-LMSRCWELNPQD--RPS-------FT-ELREDL----------------
---L-RLVRKLGSGQFGEVWMGYYK------------------N-NM---KVAIKTLK-E--GTM-----SP--E-AFL-G-------------------------EANVMKAL--Q-----HER-----LVRLYAVVT----------------------------------------KEP------IYIVTEYMARG--CLL-DFLK---------TD-----------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--M-----N---SIHRDLRAANILVSEAL-CC--------------------KIADFGLARII-----------------------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM---SNPEVIRNL----ER----GYR---MPRPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEE--RPT-------FE-FLQSV--L--------------
----ITLLKELGSGQFGVVQLGKWK------------------G-QY---DVAVKMIK-E--GSM-----SE--D-EFF-Q-------------------------EAQTMMKL--S-----HPK-----LVKFYGVCS--K-------------------------------------EYP------IYIVTEYISNG--CLL-NYLR---------SH------------------G-KGL---EPSQLLEMCYDVCEGMAFLES--H-----Q---FIHRDLAARNCLVDRDL-CV--------------------KVSDFGMTRYV--------------------L--DDQY--------------VSSVGTKFPVKWSAPEVFH------YFK---YSSKSDVWAFGILMWEVFSLGK-QP---------------YDLY---DNSQVVLKV----SQ----GHR---LYRPHLAS-----------------------------------------------------------------------------DTIYQ-IMYSCWHELPEK--RPT-------FQ-QLLSS--I--------------
----YQLFEELGKGAFSVVRRCVKV----------------L-A-GQ---EYAAKIINTK--KLS-A---RD--H-QKLER-------------------------EARICRLL--K-----HPN-----IVRLHDSIS--E-------------------------------------EGH------HYLIFDLVTGG--ELF-EDIV--------ARE---------------------YY---SEADASHCIQQILEAVLHCHQ--M-----G---VVHRDLKPENLLLASKL-KGA-----------------AVKLADFGLAIEV--------------------EGEQQAW--------------FG---FAGTPGYLSPEVLR------KDP---YGKPVDLWACGVILYILLV-GY-PP---------------FWDE------DQHRLY----QQ----IKA---GAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKD-LINKMLTINPSK--RIT-------AA-EALKHPWI--------------
----YTLKDEIGKGSYGVVKLAYNE----------------N-D-NT---YYAMKVLSKK--KLI-R---QA--G-FPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D-----HPN-----VVKLVEVLD--DP-----------------------------------NEDH------LYMVFELVNQG--PVM-EVPT---------LK---------------------PL---SEDQARFYFQDLIKGIEYLHY--Q-----K---IIHRDIKPSNLLVGEDG-HI--------------------KIADFGVSNEF--------------------KGSDALL--------------SN---TVGTPAFMAPESLS-----ETRKIF-SGKALDVWAMGVTLYCFVF-GQ-CP---------------FMDE------RIMCLH----SK----IKS---QALEFPDQPDIA-------------------------------------------------------------------------EDLKD-LITRMLDKNPES--RIV-------VP-EIKLHPWV--------------
----YELCEVIGKGPFSVVRRCINR----------------E-T-GQ---QFAVKIVDVA--KFT-S---SP--G-LSTEDL----------------------KREASICHML--K-----HPH-----IVELLETYS--S-------------------------------------DGM------LYMVFEFMDGA--DLCFEIVKR-----ADAGF---------------------VY---SEAVASHYMRQILEALRYCHD--N-----N---IIHRDVKPHCVLLASKE-NSA-----------------PVKLGGFGVAIQL--------------------GESGLVA--------------GG---RVGTPHFMAPEVVK------REP---YGKPVDVWGCGVILFILLS-GC-LP---------------FYGT-------KERLF----EG----IIK---GKYKMNPRQWSHIS-----------------------------------------------------------------------ESAKD-LVRRMLMLDPAE--RIT-------VY-EALNHPWL--------------
--YL--NLEKLGEGSYATVYKGISR----------------I-N-GQ---LVALKVISMN--AEE-G---VP----FTAIR-------------------------EASLLKGL--K-----HAN-----IVLLHDIIH--T-------------------------------------KET------LTFVFEYMHT---DLA-QYMS-------QHPG---------------------GL---HPHNVRLFMFQLLRGLAYIHH--Q-----H---VLHRDLKPQNLLISHLG-EL--------------------KLADFGLARAK--------------------SIPSQTY--------------SS---EVVTLWYRPPDALL-----GATE---YSSELDIWGAGCIFIEMFQ-GQ-PL---------------FPGV--SNILEQLEKI----WE----VLG---VPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAED-LASQMLKGFPRD--RVS-------AQ-EALVHDYF--------------
---Y-EPVAEIGVGAYGTVYKARDP----------------H-S-GH---FVALKSVRVP--NGG-GGGGGL--P-ISTVR-------------------------EVALLRRL--EA--FEHPN-----VVRLMDVCA--TSR--------------------------------TDREIK------VTLVFEHVDQ---DLR-TYLDK------APPP---------------------GL---PAETIKDLMRQFLRGLDFLHA--N-----C---IVHRDLKPENILVTSGG-TV--------------------KLADFGLARI---------------------YSYQMAL--------------TP---VVVTLWYRAPEVLL------QST---YATPVDMWSVGCIFAEMFR-RK-PL---------------FCGN---SEADQLGKI----FD----LIG---LPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHK--RIS-------AF-RALQHSYL--------------
----YEKLDFLGEGQFATVYKARDK----------------N-T-NQ---IVAIKKIKLG--HRS-E---AK--D-GINRTA----------------------LREIKLLQEL--S-----HPN-----IIGLLDAFG--H-------------------------------------KSN------ISLVFDFMET---DLE-VIIK-------DNSL---------------------VL---TPSHIKAYMLMTLQGLEYLHQ--H-----W---ILHRDLKPNNLLLDENG-VL--------------------KLADFGLAKSF--------------------GSPNRAY--------------TH---QVVTRWYRAPELLF-----GARM---YGVGVDMWAVGCILAELLL-RV-PF---------------LPGD---SDLDQLTRI----FE----TLG---TPTEEQWPDMCSLPDYVTFKSFPG--------------------------------------------------IPLHHIFSAAGDDLLD-LIQGLFLFNPCA--RIT-------AT-QALKMKYF--------------
---W-DLVQTLGEGAYGEVQLAVNR----------------V-T-EE---AVAVKIVDMK--RAV-D---CP--E-NI-KK-------------------------EICINKML--N-----HEN-----VVKFYGHRR--E-------------------------------------GNI------QYLFLEYCSGG--ELF-DRIE--------PDI---------------------GM---PEPDAQRFFHQLMAGVVYLHG--I-----G---ITHRDIKPENLLLDERD-NL--------------------KISDFGLATVFR------------------YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREF---HAEPVDVWSCGIVLTAMLA-GE-LP---------------WDQP-----SDSCQEY----SD----WKE---KKTYLNPWKKI--D-----------------------------------------------------------------------SAPLA-LLHKILVENPSA--RIT-------IP-DIKKDRW-Y-------------
--YI--MSKTLGSGACGEVKLAFER----------------K-T-CK---KVAIKIISKR--KFA-I---GS--A-READPALN-------------------VETEIEILKKL--N-----HPC-----IIKIKNFF---D-------------------------------------AED------YYIVLELMEGG--ELF-DKVV--------GNK---------------------RL---KEATCKLYFYQMLLAVQYLHE--N-----G---IIHRDLKPENVLLSSQE-EDC-----------------LIKITDFGHSKI---------------------LGETSLM--------------RT---LCGTPTYLAPEVLVS---VGTAG---YNRAVDCWSLGVILFICLS-GY-PP---------------FSEH-----RTQVSLK----DQ----ITS---GKYNFIPEVWAEVS-----------------------------------------------------------------------EKALD-LVKKLLVVDPKA--RFT-------TE-EALRHPWL--------------
----YEIVDTLGEGAFGKVVECIDH----------------K-AGGR---HVAVKIVKNV--DRY-C---EA--A-RS----------------------------EIQVLEHL--NT---TDPNST-FRCVQMLEWFE--H-------------------------------------HGH------ICIVFELLGL---STY-DFIK--------ENG---------------------FLP-FRLDHIRKMAYQICKSVNFLHS--N-----K---LTHTDLKPENILFVQSD-YTEAYNPKIKR-DERTLINPDIKVVDFGSA-----------------------TYDDEHH--------------ST---LVSTRHYRAPEVIL------ALG---WSQPCDVWSIGCILIEYYL-GF-TV---------------FPTH---DSKEHLAMM----ER----ILG---PLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY----------------------------------VSRRCKPLKEFMLSQDVEHERLFD-LIQKMLEYDPAK--RIT-------LR-EALKHPFF--------------
----YEIVSTLGEGTFGRVVQCVDH----------------R-R-GG--ARVALKIIKNV--EKY-K---EA--A-R---L-------------------------EINVLEKI--NEKDPDNKN----LCVQMFDWFD--Y-------------------------------------HGH------MCISFELLGL---STF-DFLK--------DNN---------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--N-----K---LTHTDLKPENILFVNSD-YELTYNLEKKR-DERSVKSTAVRVVDFGSAT-----------------------FDHEHH--------------ST---IVSTRHYRAPEVIL------ELG---WSQPCDVWSIGCIIFEYYV-GF-TL---------------FQTH---DNREHLAMM----ER----ILG---PIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAK--RLT-------LG-EALQHPFF--------------
----YEIVGNLGEGTFGKVVECLDH----------------A-R-GK--SQVALKIIRNV--GKY-R---EA--A-R---L-------------------------EINVLKKI--KE--KDKENK--FLCVLMSDWFN--F-------------------------------------HGH------MCIAFELLGK---NTF-EFLK---------EN---------------------NFQPYPLPHVRHMAYQLCHALRFLHE--N-----Q---LTHTDLKPENILFVNSE--FETLYNEHKSCEEKSVKNTSIRVADFGSAT-----------------------FDHEHH--------------TT---IVATRHYRPPEVIL------ELG---WAQPCDVWSIGCILFEYYR-GF-TL---------------FQTH---ENREHLVMM----EK----ILG---PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFD-LMRRMLEFDPAQ--RIT-------LA-EALLHPFF--------------
----YEIVDTLGEGAFGKVVECIDH----------------GMD-GM---HVAVKIVKNV--GRY-R---EA--A-RS----------------------------EIQVLEHL--NS---TDPNSV-FRCVQMLEWFD--H-------------------------------------HGH------VCIVFELLGL---STY-DFIK--------ENS---------------------FLP-FQIDHIRQMAYQICQSINFLHH--N-----K---LTHTDLKPENILFVKSD-YVVKYNSKMKR-DERTLKNTDIKVVDFGSA-----------------------TYDDEHH--------------ST---LVSTRHYRAPEVIL------ALG---WSQPCDVWSIGCILIEYYL-GF-TV---------------FQTH---DSKEHLAMM----ER----ILG---PIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY----------------------------------VRRRCKPLKEFMLCHDEEHEKLFD-LVRRMLEYDPTQ--RIT-------LD-EALQHPFF--------------
----YETGRVIGDGNFAVVKECRHR----------------E-T-RQ---AYAMKIIDKS--RLK-G---KE--D-MV-DS-------------------------EILIIQSL--S-----HPN-----IVKLHEVYE--T-------------------------------------DME------IYLILEYVQGG--DLF-DAII--------ESV---------------------KF---PEPDAALMIMDLCKALVHMHD--K-----S---IVHRDLKPENLLVQRNE-DKST----------------TLKLADFGLAK-----------------------HVVRPI--------------FT---VCGTPTYVAPEILS------EKG---YGLEVDMWAAGVILYILLC-GF-PP---------------FRSP----ERDQDELF----NI----IQL---GHFEFLPPYWDNIS-----------------------------------------------------------------------DAAKD-LVSRLLVVDPKK--RYT-------AH-QVLQHPWI--------------
----LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKG-H-PL---LVAVKILR-P--DAT-----KNARN-DFL-K-------------------------EVKIMSRL--K-----DPN-----IIRLLGVCV--Q-------------------------------------DDP------LCMITDYMENG--DLN-QFLS---------AHQLEDKAAEGAPGDGQAAQG-PTI---SYPMLLHVAAQIASGMRYLAT--L-----N---FVHRDLATRNCLVGENF-TI--------------------KIADFGMSRNL----------Y---------A--GDYY--------------RVQGRAVLPIRWMAWECIL------MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL---TDEQVIENAGEFFRD----QGRQVYLSRPPACP-----------------------------------------------------------------------------QGLYE-LMLRCWSRESEQ--RPP-------FS-QLHRFL----------------
----LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN-Q-PV---LVAVKMLR-A--DAN-----KNARN-DFL-K-------------------------EIKIMSRL--K-----DPN-----IIHLLAVCI--T-------------------------------------DDP------LCMITEYMENG--DLN-QFLS---------RHEPPN---------SSSSDV-RTV---SYTNLKFMATQIASGMKYLSS--L-----N---FVHRDLATRNCLVGKNY-TI--------------------KIADFGMSRNL----------Y---------S--GDYY--------------RIQGRAVLPIRWMSWESIL------LGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL---SDEQVIENT----GEFFRDQGRQTYLPQPAICP-----------------------------------------------------------------------------DSVYK-LMLSCWRRDTKN--RPS-------FQ-EIHL---LL-------------
--LM--VDTVIGEGEFGEVYRGTLR-------------LPSQ-D-CK---TVAIKTLK-D--TSP-----GGQWW-NFL-R-------------------------EATIMGQF--S-----HPH-----ILHLEGVVT--K-------------------------------------RKP------IMIITEFMENG--ALD-AFLR---------ER------------------E-DQL---VPGQLVAMLQGIASGMNYLSN--H-----N---YVHRDLAARNILVNQNL-CC--------------------KVSDFGLTRLL----------D---------D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRI---FTTASDVWSFGIVMWEVLSFGD-KP---------------YGEM---SNQEVMKSI----ED----GYR---LPPPVDCP-----------------------------------------------------------------------------APLYE-LMKNCWAYDRAR--RPH-------FQ-KLQAHL----------------
---V-KIEEVIGAGEFGEVYKGRLK-------------LPGK-R-EI---YVAIKTLK-A--GYS-----EKQRR-DFL-S-------------------------EASIMGQF--D-----HPN-----IIRLEGVVT--K-------------------------------------SRP------VMIITEFMENG--ALD-SFLR---------QN------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--M-----N---YVHRDLAARNILVNSNL-VC--------------------KVSDFGLSRYLQ-------DDT---------S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM---SNQDVINAI----EQ----DYR---LPPPMDCP-----------------------------------------------------------------------------AALHQ-LMLDCWQKDRNS--RPR-------FA-EIVNTL----------------
---V-KIEEVIGAGEFGEVCRGRLK-------------QPGR-R-EV---FVAIKTLK-V--GYT-----ERQRR-DFL-S-------------------------EASIMGQF--D-----HPN-----IIRLEGVVT--K-------------------------------------SRP------VMILTEFMENC--ALD-SFLR---------LN------------------D-GQF---TVIQLVGMLRGIAAGMKYLSE--M-----N---YVHRDLAARNILVNSNL-VC--------------------KVSDFGLSRFLE-------DDP---------S--DPTY--------------TSSLGGKIPIRWTAPEAIA------YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM---SNQDVINAV----EQ----DYR---LPPPMDCP-----------------------------------------------------------------------------TALHQ-LMLDCWVRDRNL--RPK-------FS-QIVNTL----------------
--VI--LGELLGKGNFGEVYKGTLK------------------D-KT---SVAVKTCK-E--DLP-----QELKI-KFL-Q-------------------------EAKILKQY--D-----HPN-----IVKLIGVCT--Q-------------------------------------RQP------VYIIMELVSGG--DFL-TFLR---------RK------------------K-DEL---KLKQLVKFSLDAAAGMLYLES--K-----N---CIHRDLAARNCLVGENN-VL--------------------KISDFGMSRQE--------------------D--GGVY--------------SSSGLKQIPIKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGV-CP---------------YPGM---TNQQAREQV----ER----GYR---MSAPQHCP-----------------------------------------------------------------------------EDISK-IMMKCWDYKPEN--RPK-------FS-ELQKEL----------------
---L-VLGEQIGRGNFGEVFSGRLR----------------A-D-NT---LVAVKSCR-E--TLP-----PDLKA-KFL-Q-------------------------EARILKQY--S-----HPN-----IVRLIGVCT--Q-------------------------------------KQP------IYIVMELVQGG--DFL-TFLR---------TE------------------G-ARL---RVKTLLQMVGDAAAGMEYLES--K-----C---CIHRDLAARNCLVTEKN-VL--------------------KISDFGMSREE----------A---------D--GVYA--------------ASGGLRQVPVKWTAPEALN------YGR---YSSESDVWSFGILLWETFSLGA-SP---------------YPNL---SNQQTREFV----EK----GGR---LPCPELCP-----------------------------------------------------------------------------DAVFR-LMEQCWAYEPGQ--RPS-------FS-TIYQEL----------------
----LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPK-E-AV---TVAVKMLK-D--DAT-----EKDLS-DLV-S-------------------------EMEMMKMIG-K-----HKN-----IINLLGACT--Q-------------------------------------DGP------LYVIVEYASKG--NLR-EYLR---------ARRPPGMEY---SYDINRVPE-EQM---TFKDLVSCTYQLARGMEYLAS--Q-----K---CIHRDLAARNVLVTENN-VM--------------------KIADFGLARDI----------N---------N--IDYY--------------KKTTNGRLPVKWMAPEALF------DRV---YTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI---PVEELFKLL----KE----GHR---MDKPANCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQ--RPT-------FK-QLVEDL----------------
----ITLERRLGTGCFGDVWLGTWN------------------G-ST---KVAVKTLK-P--GTM-----SP--K-AFL-E-------------------------EAQVMKLL--R-----HDK-----LVQLYAVVS----------------------------------------EEP------IYIVTEFMCHG--SLL-DFLK---------NP-----------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--M-----N---YIHRDLRAANILVGERL-AC--------------------KIADFGLARLI--------------------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR---FTIKSDVWSFGILLTELITKGR-IP---------------YPGM---NKREVLEQV----EQ----GYH---MPCPPGCP-----------------------------------------------------------------------------ASLYE-AMEQTWRLDPEE--RPT-------FE-YLQSFL----------------
----LQLIKRLGNGQFGEVWMGTWN------------------G-NT---KVAIKTLK-P--GTM-----SP--E-SFL-E-------------------------EAQIMKKL--K-----HDK-----LVQLYAVVS----------------------------------------EEP------IYIVTEYMNKG--SLL-DFLK---------DG-----------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--M-----N---YIHRDLRSANILVGNGL-IC--------------------KIADFGLARLI--------------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM---NNREVLEQV----ER----GYR---MPCPQDCP-----------------------------------------------------------------------------ISLHE-LMIHCWKKDPEE--RPT-------FE-YLQSFL----------------
--LR--VRRVLAEGGFAFVYEAQDV----------------G-S-GR---EYALKRLLSN--EEE-K---NR--A-I--IQ-------------------------EVCFMKKL-SG-----HPN-----IVQFCSAAS--IGKEE-----------------------------SDTGQAE------FLLLTELCKG---QLV-EFLKK-----MESRG---------------------PL---SCDTVLKIFYQTCRAVQHMHR--QK---PP---IIHRDLKVENLLLSNQG-TI--------------------KLCDFGSATTISHYPDY--------SWSAQRRALVEEE--------------IT---RNTTPMYRTPEIIDL---YSNFP---IGEKQDIWALGCILYLLCF-RQ-HP---------------FEDG------AKLRIV----NG----KYS----IPPHDTQY----------------------------------------------------------------------------TVFHS-LIRAMLQVNPEE--RLS-------IA-EVVHQ---L-------------
--FR--HYRVLGKGGFGEVCACQVR----------------A-T-GK---MYACKKLQKK--RIK-K---RK--G-EAMAL------------------------NEKRILEKV--Q-----SRF-----VVSLAYAYE--T-------------------------------------KDA------LCLVLTIMNGG--DLK-FHIYN------LGNP---------------------GF---DEQRAVFYAAELCCGLEDLQR--E-----R---IVYRDLKPENILLDDRG-HI--------------------RISDLGLATE---------------------IPEGQRV--------------RG---RVGTVGYMAPEVVN------NEK---YTFSPDWWGLGCLIYEMIQ-GH-SP---------------FKKY---KEKVKWEEV----DQ----RIK---NDTEEYSE---KFS-----------------------------------------------------------------------EDAKS-ICRMLLTKNPSK--RLGCR--GEGAA-GVKQHPV-F-------------
---F-TEFRVLGKGGFGEVCAVQVK----------------N-T-GK---MYACKKLDKK--RLK-K---KG--G-EKMAL------------------------LEKEILEKV--S-----SPF-----IVSLAYAFE--S-------------------------------------KTH------LCLVMSLMNGG--DLK-FHIYN------VGTR---------------------GL---DMSRVIFYSAQIACGMLHLHE--L-----G---IVYRDMKPENVLLDDLG-NC--------------------RLSDLGLAVE---------------------MKGGKPI--------------TQ---RAGTNGYMAPEILM-----EKVS---YSYPVDWFAMGCSIYEMVA-GR-TP---------------FKDY--KEKVSKEDLK----QR----TLQ---DEVKFQHDNF---T-----------------------------------------------------------------------EEAKD-ICRLFLAKKPEQ--RLG-------SR-E-------KSDDPR--------
----LKLEKKLGAGQFGEVWMATYN------------------K-HT---KVAVKTMK-P--GSM-----SV--E-AFL-A-------------------------EANVMKTL--Q-----HDK-----LVKLHAVVT----------------------------------------KEP------IYIITEFMAKG--SLL-DFLK---------SD-----------------EG-SKQ---PLPKLIDFSAQIAEGMAFIEQ--R-----N---YIHRDLRAANILVSASL-VC--------------------KIADFGLARVI--------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM---SNPEVIRAL----ER----GYR---MPRPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEE--RPT-------FE-YIQSV--L--------------
----YEVLEFLGRGTFGQVAKCWKR----------------S-T-KE---IVAIKILKNH--PSY-A---RQ--G-QI----------------------------EVSILSRL--S-----SENADEYNFVRSYECFQ--H-------------------------------------KNH------TCLVFEMLEQ---NLY-DFLKQ------NKFS---------------------PL---PLKYIRPILQQVATALMKLKS--L-----G---LIHADLKPENIMLVDPV-RQPY----------------RVKVIDFGSAS----------------------HVSKAVC--------------ST---YLQSRYYRAPEIIL------GLP---FCEAIDMWSLGCVIAELFL-GW-PL---------------YPGA---SEYDQIRYI----SQ----TQG---LPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYID-LLKKMLTIDADK--RIT-------PL-KTLNHQFV--------------
----YEVLEFLGRGTFGQVVKCWKR----------------G-T-NE---IVAIKILKNH--PSY-A---RQ--G-QI----------------------------EVSILARL--STESADDYN-----FVRAYECFQ--H-------------------------------------KNH------TCLVFEMLEQ---NLY-DFLKQ------NKFS---------------------PL---PLKYIRPVLQQVATALMKLKS--L-----G---LIHADLKPENIMLVDPS-RQPY----------------RVKVIDFGSAS----------------------HVSKAVC--------------ST---YLQSRYYRAPEIIL------GLP---FCEAIDMWSLGCVIAELFL-GW-PL---------------YPGA---SEYDQIRYI----SQ----TQG---LPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFID-LLKKMLTIDADK--RIT-------PI-ETLNHPFV--------------
----YEVLDFLGRGTFGQVVKCWKR----------------G-T-NE---IVAIKILKNH--PSY-A---RQ--G-QI----------------------------EVSILARL--S-----TENADEYNFVRAYECFQ--H-------------------------------------RNH------TCLVFEMLEQ---NLY-DFLKQ------NKFS---------------------PL---PLKVIRPILQQVATALKKLKS--L-----G---LIHADLKPENIMLVDPV-RQPY----------------RVKVIDFGSAS----------------------HVSKTVC--------------ST---YLQSRYYRAPEIIL------GLP---FCEAIDMWSLGCVIAELFL-GW-PL---------------YPGA---LEYDQIRYI----SQ----TQG---LPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVS-LLKKMLLIDADL--RIT-------PA-ETLNHPFV--------------
----YDIIEVLGKGTFGEVAKGWRR----------------S-T-GE---MVAIKILKND--AYR-N---RI--I-KN----------------------------ELKLLHCM--RGLDPEEAH-----VIRFLEFFH--D-------------------------------------ALK------FYLVFELLEQ---NLF-EFQK---------EN---------------------NFAPLPARHIRTVTLQVLTALARLKE--L-----A---IIHADLKPENIMLVDQT-RCPF----------------RVKVIDFGSASIF--------------------SEVRYVK--------------EP---YIQSRFYRAPEILL------GLP---FCEKVDVWSLGCVMAELHL-GW-PL---------------YPGN---NEYDQVRYI----CE----TQG---LPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHE--RIS-------PS-AALRHPFV--------------
-VGG----NKMGEGGFGVVYKGYVN----------------N-T-T-----VAVKKLAAM--VDI-T---TE--ELKQQFD------------------------QEIKVMAKC--Q-----HEN-----LVELLGFSS--D-------------------------------------GDD------LCLVYVYMPNG--SLL-DRLSC-----LDGTP---------------------PL---SWHMRCKIAQGAANGINFLHE--N-----H---HIHRDIKSANILLDEAF-TA--------------------KISDFGLARASE------------------KFAQTVMT--------------SR---IVGTTAYMAPEALR-------GE---ITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH---REPQLLLDI----KE----EIE---DEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYS-VASQCLHEKKNK--RPD-------IK-KVQQ----LLQ-----------
----LTFVQEIGSGQFGLVHLGYWL------------------N-KD---KVAIKTIR-E--GAM-----SE--E-DFI-E-------------------------EAEVMMKL--S-----HPK-----LVQLYGVCL--E-------------------------------------QAP------ICLVFEFMEHG--CLS-DYLR---------TQ------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--A-----C---VIHRDLAARNCLVGENQ-VI--------------------KVSDFGMTRFV--------------------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR---SNSEVVEDI----ST----GFR---LYKPRLAS-----------------------------------------------------------------------------THVYQ-IMNHCWKERPED--RPA-------FS-RLLRQL----------------
----LKFLQQLGKGNFGSVEMCRYDP------------LQDN-T-GE---VVAVKKLQ-H--STE------EHLR-DFE-R-------------------------EIEILKSL--Q-----HDN-----IVKYKGVCYSAG-------------------------------------RRN------LKLIMEYLPYG--SLR-DYLQ---------KH------------------K-ERI---DHIKLLQYTSQICKGMEYLGT--K-----R---YIHRDLATRNILVENEN-RV--------------------KIGDFGLTKVL---------PQ---------D--KEYY--------------KVKEPGESPIFWYAPESLT------ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM---IVFHLIELL----KN----NGR---LPRPDGCP-----------------------------------------------------------------------------DEIYM-IMTECWNNNVNQ--RPS-------FR-DLA----LRV------------
---L-KYISQLGKGNFGSVELCRYDP------------LGDN-T-GA---LVAVKQLQ-H--SGP-----DQ-QR-DFQ-R-------------------------EIQILKAL--H-----SDF-----IVKYRGVSYGPG-------------------------------------RQS------LRLVMEYLPSG--CLR-DFLQ---------RH------------------R-ARL---DASRLLLYSSQICKGMEYLGS--R-----R---CVHRDLAARNILVESEA-HV--------------------KIADFGLAKLL---------PL---------D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDV-P-ALCRLLELL----EE----GQR---LPAPPACP-----------------------------------------------------------------------------AEVHE-LMKLCWAPSPQD--RPS-------FS-ALGP---QL-------------
----LKLVERLGAGQFGEVWMGYYN------------------G-HT---KVAVKSLK-Q--GSM-----SP--D-AFL-A-------------------------EANLMKQL--Q-----HQR-----LVRLYAVVT----------------------------------------QEP------IYIITEYMENG--SLV-DFLK---------TP-----------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--R-----N---YIHRDLRAANILVSDTL-SC--------------------KIADFGLARLI--------------------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM---TNPEVIQNL----ER----GYR---MVRPDNCP-----------------------------------------------------------------------------EELYQ-LMRLCWKERPED--RPT-------FD-YLRSV--L--------------
----FEKISELGAGNGGVVFKVSHK----------------P-S-GL----VMARKLIHL--EIK-P---AI--R-NQIIR-------------------------ELQVLHEC--N-----SPY-----IVGFYGAFY--S-------------------------------------DGE------ISICMEHMDGG--SLD-QVLK--------KAG---------------------RI---PEQILGKVSIAVIKGLTYLRE-KH-----K---IMHRDVKPSNILVNSRG-EI--------------------KLCDFGVSG----------------------QLIDSMA--------------NS---FVGTRSYMSPERLQ------GTH---YSVQSDIWSMGLSLVEMAV-GR-YP---------------IPPP---DAKELELMF----GC----QVE---GDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------------------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAE--RAD-------LK-QLMVHAFI--------------
--LK--DLGEIGRGAYGSVNKMVHK----------------P-S-GQ---IMAVKRIRST--VDE-K---EQ--K-QL-LM-------------------------DLDVVMRS-SD-----CPY-----IVQFYGALF--R-------------------------------------EGD------CWICMELMSTSFDKFY-KYVYS------VLDD---------------------VI---PEEILGKITLATVKALNHLKE--N----LK---IIHRDIKPSNILLDRSG-NI--------------------KLCDFGISGQ---------------------LVDSIAK--------------TR---DAGCRPYMAPERIDP--SASRQG---YDVRSDVWSLGITLYELAT-GR-FP---------------YPKW----NSVFDQLT----QV----VKG---DPPQLSNSEEREFS-----------------------------------------------------------------------PSFIN-FVNLCLTKDESK--RPK-------YK-ELLKHPFI--------------
-IRY---RDTLGHGNGGTVYKAYHV----------------P-S-GK---ILAVKVILLD--ITL-E---LQ--K-QI-MS-------------------------ELEILYKC--D-----SSY-----IIGFYGAFF--V-------------------------------------ENR------ISICTEFMDGG--SLD-------------VYR---------------------KM---PEHVLGRIAVAVVKGLTYLWS--L-----K---ILHRDVKPSNMLVNTRG-QV--------------------KLCDFGVST----------------------QLVNSIA--------------KT---YVGTNAYMAPERIS------GEQ---YGIHSDVWSLGISFMELAL-GR-FP---------------YPQI---QKNQGSLMP----LQ----LLQ---CIVDEDSPVLPVGEF---------------------------------------------------------------------SEPFVH-FITQCMRKQPKE--RPA-------PE-ELMGHPFI--------------
----IEVEEVVGRGAFGVVCKAKWR--------------------AK---DVAIKQIE------S-----ESERK-AFI-V-------------------------ELRQLSRV--N-----HPN-----IVKLYGACL-----------------------------------------NP------VCLVMEYAEGG--SLY-NVLH---------GA-----------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--M-----QPKALIHRDLKPPNLLLVAGGTVL--------------------KICDFGTACDI--------------------------Q--------------THMTNNKGSAAWMAPEVFE------GSN---YSEKCDVFSWGIILWEVITR-R-KP---------------FDEIGG-PAFRIMWAV----HN----GTR---PPLIKNLP-----------------------------------------------------------------------------KPIES-LMTRCWSKDPSQ--RPS-------ME-EIVKI--M--------------
----YQNLSPVGSGAYGSVCAAFDT----------------K-T-GL---RVAVKKLSRP--FQS-I---IH--A-KRTYR-------------------------ELRLLKHM--K-----HEN-----VIGLLDVFT--PARS-------------------------------LEEFND------VYLVTHLMGA---DLN-NIVK---------CQ---------------------KL---TDDHVQFLIYQILRGLKYIHS--A-----D---IIHRDLKPSNLAVNEDC-EL--------------------KILDFGLAR-----------------------HTDDEM--------------TG---YVATRWYRAPEIML-----NWMH---YNQTVDIWSVGCIMAELLT-GR-TL---------------FPGT---DHIDQLKLI----LR----LVG---TPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVD-LLEKMLVLDSDK--RIT-------AA-QALAHAYF--------------
----YEIIETIGNGAYGVVSSARRR----------------L-T-GQ---QVAIKKIPNA--FDV-V---TN--A-KRTLR-------------------------ELKILKHF--K-----HDN-----IIAIKDILR--PTVP-------------------------------YGEFKS------VYVVLDLMES---DLH-QIIH--------SSQ---------------------PL---TLEHVRYFLYQLLRGLKYMHS--A-----Q---VIHRDLKPSNLLVNENC-EL--------------------KIGDFGMARGLCT----------------SPAEHQYFM--------------TE---YVATRWYRAPELML-----SLHE---YTQAIDLWSVGCIFGEMLA-RR-QL---------------FPGK---NYVHQLQLI----MM----VLG---TPSPAVIQAVGAERVRAYIQSLPPRQ-----------------------------------------------PVPWETVYPGADRQALS-LLGRMLRFEPSA--RIS-------AA-AALRHPFL--------------
--FD--TIKLISNGAYGAVYLVRHR----------------D-T-RQ---RFAMKKINKQ--NLILR---NQ--I-QQAFV-------------------------ERDILTFA--E-----NPF-----VVGMFCSFE--T-------------------------------------RRH------LCMVMEYVEGG--DCA-TLLK--------NIG---------------------AL---PVEMARMYFAETVLALEYLHN--Y-----G---IVHRDLKPDNLLITSMG-HI--------------------KLTDFGLSKMGLMSLTTN-----LYEGHIEKDAREFLD--------------KQ---VCGTPEYIAPEVIL------RQG---YGKPVDWWAMGIILYEFLV-GC-VP---------------FFGD------TPEELF----GQ----VIS---DDILWPEGDE-ALP-----------------------------------------------------------------------TEAQL-LISSLLQTNPLV--RLGA----GGAF-EVKQHSFF--------------
----VHFNEVIGRGHFGCVYHGTLL-------------DNDG-K-KI---HCAVKSLN-R--ITD-----IGEVS-QFL-T-------------------------EGIIMKDF--S-----HPN-----VLSLLGICL-RS-------------------------------------EGS------PLVVLPYMKHG--DLR-NFIR---------NE------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--K-----K---FVHRDLAARNCMLDEKF-TV--------------------KVADFGLARDM----------Y---------D--KEYYS------------VHNKTGAKLPVKWMALESLQ------TQK---FTTKSDVWSFGVLLWELMTRGA-PP---------------YPDV---NTFDITVYL----LQ----GRR---LLQPEYCP-----------------------------------------------------------------------------DPLYE-VMLKCWHPKAEM--RPS-------FS-ELVSR--I--------------
-THS---DRVIGKGHFGVVYHGEYI-------------DQAQ-N-RI---QCAIKSLS-R--ITE-----MQQVE-AFL-R-------------------------EGLLMRGL--N-----HPN-----VLALIGIML-PP-------------------------------------EGL------PHVLLPYMCHG--DLL-QFIR---------SP------------------Q-RNP---TVKDLISFGLQVARSMEYLAE--Q-----K---FVHRDLAARNCMLDESF-TV--------------------KVADFGLARDI----------L---------D--REYYS------------VQQHRHARLPVKWMALESLQ------TYR---FTTKSDVWSFGVLLWELLTRGA-PP---------------YRHI---DPFDLTHFL----AQ----GRR---LPQPEYCP-----------------------------------------------------------------------------DSLYQ-VMQQCWEADPAV--RPT-------FR-VLV----GEV------------
---Y-VRLQKIGEGSFGKAILVKST----------------E-D-GR---QYVIKEINIS--RMS-S---KE--R-EESRR-------------------------EVAVLANM--K-----HPN-----IVQYRESFE--E-------------------------------------NGS------LYIVMDYCEGG--DLF-KRINA------QKGV---------------------LF---QEDQILDWFVQICLALKHVHD--R-----K---ILHRDIKSQNIFLTKDG-TV--------------------QLGDFGIARVL--------------------NSTVELA--------------RT---CIGTPYYLSPEICE------NKP---YNNKSDIWALGCVLYELCT-LK-HA---------------FEAG------SMKNLV----LK----IIS---GSFPPVSLHYS--------------------------------------------------------------------------YDLRS-LVSQLFKRNPRD--RPS-------VN-SILEKGF-I-------------
----YVLQQKLGSGSFGTVYLVSDK----------------K-A-KRGEELKVLKEISVG--ELN-P---NE--T-VQANL-------------------------EAQLLSKL--D-----HPA-----IVKFHASFV--E-------------------------------------QDN------FCIITEYCEGR--DLD-DKIQEY----KQAGK---------------------IF---PENQIIEWFIQLLLGVDYMHE--R-----R---ILHRDLKSKNVFLK-NN-LL--------------------KIGDFGVSRLL--------------------MGSCDLA--------------TT---LTGTPHYMSPEALK------HQG---YDTKSDIWSLACILYEMCC-MN-HA---------------FAGS------NFLSIV----LK----IVE---GDTPSLPERY-P-------------------------------------------------------------------------KELNA-IMESMLNKNPSL--RPS-------AI-EILKIPYL--------------
----YEVLYTIGTGSYGRCQKIRRK----------------S-D-GK---ILVWKELDYG--SMT-E---AE--K-QMLVS-------------------------EVNLLREL--K-----HPN-----IVRYYDRII--DR-----------------------------------TNTT------LYIVMEYCEGG--DLA-SVITKG----TKERQ---------------------YL---DEEFVLRVMTQLTLALKECHR--RSDGGHT---VLHRDLKPANVFLDGKQ-NV--------------------KLGDFGLARIL--------------------NHDTSFA--------------KT---FVGTPYYMSPEQMN------RMS---YNEKSDIWSLGCLLYELCA-LM-PP---------------FTAF------SQKELA----GK----IRE---GKFRRIPYRY---S-----------------------------------------------------------------------DELNE-IITRMLNLKDYH--RPS-------VE-EILENPL-I-------------
---Y-CYLRVVGKGSYGEVTLVKHR----------------R-D-GK---QYVIKKLNLR--NAS-S---RE--R-RAAEQ-------------------------EAQLLSQL--K-----HPN-----IVTYKESWE--G------------------------------------GDGL------LYIVMGFCEGG--DLY-RKLKE------QKGQ---------------------LL---PENQVVEWFVQIAMALQYLHE--K-----H---ILHRDLKTQNVFLTRTN-II--------------------KVGDLGIARVL--------------------ENHCDMA--------------ST---LIGTPYYMSPELFS------NKP---YNYKSDVWALGCCVYEMAT-LK-HA---------------FNAK------DMNSLV----YR----IIE---GKLPPMPRDY---S-----------------------------------------------------------------------PELAE-LIRTMLSKRPEE--RPS-------VR-SILRQPYI--------------
-IEP---DRPIGYGAFGVVWSVTDP----------------R-D-GK---RVALKKMPNV--FQN-L---VS--C-KRVFR-------------------------ELKMLCFF--K-----HDN-----VLSALDILQ--PPH--------------------------------IDYFEE------IYVVTELMQS---DLH-KIIV--------SPQ---------------------PL---SSDHVKVFLYQILRGLKYLHS--A-----G---ILHRDIKPGNLLVNSNC-VL--------------------KICDFGLARVE-------------------ELDESRHM--------------TQ---EVVTQYYRAPEILM-----GSRH---YSNAIDIWSVGCIFAELLG-RR-IL---------------FQAQ---SPIQQLDLI----TD----LLG---TPSLEAMRTACEGAKAHILRGPHKQP----------------------------------------------SLPVLYTLSSQATHEAVH-LLCRMLVFDPSK--RIS-------AK-DALAHPYL--------------
---I-VLKRELGEGAFGKVFLAECYN-----------LCPEQ-D-KI---LVAVKTLK-D--ASD-----NA-RK-DFH-R-------------------------EAELLTNL--Q-----HEH-----IVKFYGVCV--E-------------------------------------GDP------LIMVFEYMKHG--DLN-KFLR---------AHGPDAV------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--Q-----H---FVHRDLATRNCLVGENL-LV--------------------KIGDFGMSRDV----------Y---------S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL---SNNEVIECI----TQ----GRV---LQRPRTCP-----------------------------------------------------------------------------QEVYE-LMLGCWQREPHM--RKN-------IK-GIHTL--L--------------
---I-VLKRELGEGAFGKVFLAECYN-----------LSPTK-D-KM---LVAVKALK-D--PTL-----AA-RK-DFQ-R-------------------------EAELLTNL--Q-----HEH-----IVKFYGVCG--D-------------------------------------GDP------LIMVFEYMKHG--DLN-KFLR---------AHGPDAMIL---VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--Q-----H---FVHRDLATRNCLVGANL-LV--------------------KIGDFGMSRDV----------Y---------S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL---SNTEVIECI----TQ----GRV---LERPRVCP-----------------------------------------------------------------------------KEVYD-VMLGCWQREPQQ--RLN-------IK-EIYKIL----------------
----YTRFEKIGQGASGTVYTAMDV----------------A-T-GQ---EVAIKQMNLQ--QQP-K---KE--L-II--N-------------------------EILVMREN--K-----NPN-----IVNYLDSYL--V-------------------------------------GDE------LWVVMEYLAGG--SLT-DVVT---------ET---------------------CM---DEGQIAAVCRECLQALEFLHS--N-----Q---VIHRDIKSDNILLGMDG-SV--------------------KLTDFGFCAQI--------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT------RKA---YGPKVDIWSLGIMAIEMIE-GE-PP---------------YLNE---NPLRALYLI----AT----NGT---PELQNPEKLS---------------------------------------------------------------------------AIFRD-FLNRCLEMDVEK--RGS-------AK-ELLQHQFL--------------
----YTRYEKIGQGASGTVFTATDV----------------A-L-GQ---EVAIKQINLQ--KQP-K---KE--L-II--N-------------------------EILVMKEL--K-----NPN-----IVNFLDSYL--V-------------------------------------GDE------LFVVMEYLAGG--SLT-DVVT---------ET---------------------CM---DEAQIAAVCRECLQALEFLHA--N-----Q---VIHRDIKSDNVLLGMEG-SV--------------------KLTDFGFCAQI--------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT------RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE---NPLRALYLI----AT----NGT---PELQNPEKLS---------------------------------------------------------------------------PIFRD-FLNRCLEMDVEK--RGS-------AK-ELLQHPFL--------------
----YTRFEKIGQGASGTVYTALDI----------------A-T-GQ---EVAIKQMNLQ--QQP-K---KE--L-II--N-------------------------EILVMREN--K-----NPN-----IVNYLDSYL--V-------------------------------------GDE------LWVVMEYLAGG--SLT-DVVT---------ET---------------------CM---DEGQIAAVCRECLQALDFLHS--N-----Q---VIHRDIKSDNILLGMDG-SV--------------------KLTDFGFCAQI--------------------TPEQSKR--------------ST---MVGTPYWMAPEVVT------RKA---YGPKVDIWSLGIMAIEMVE-GE-PP---------------YLNE---NPLRALYLI----AT----NGT---PELQNPERLS---------------------------------------------------------------------------AVFRD-FLNRCLEMDVDR--RGS-------AK-ELLQHPFL--------------
---Y-IKLDKLGEGTYATVYKGKSK----------------L-T-DN---LVALKEIRLE--HEE-G---AP--C--TAIR-------------------------EVSLLKDL--K-----HAN-----IVTLHDIIH--T-------------------------------------EKS------LTLVFEYLDK---DLK-QYLD-------DCGN---------------------II---NMHNVKLFLFQLLRGLAYCHR--Q-----K---VLHRDLKPQNLLINERG-EL--------------------KLADFGLARAK--------------------SIPTKTY--------------SN---EVVTLWYRPPDILL-----GSTD---YSTQIDMWGVGCIFYEMAT-GR-PL---------------FPGS---TVEEQLHFI----FR----ILG---TPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGAD-LLTKLLQFEGRN--RIS-------AE-DAMKHPFF--------------
----YEKLEKLGEGSYATVYKGKSK----------------V-N-GK---LVALKVIRLQ--EEE-G---TP--F--TAIR-------------------------EASLLKGL--K-----HAN-----IVLLHDIIH--T-------------------------------------KET------LTLVFEYVHT---DLC-QYMD-------KHPG---------------------GL---HPDNVKLFLFQLLRGLSYIHQ--R-----Y---ILHRDLKPQNLLISDTG-EL--------------------KLADFGLARAK--------------------SVPSHTY--------------SN---EVVTLWYRPPDVLL-----GSTE---YSTCLDMWGVGCIFVEMIQ-GV-AA---------------FPGM--KDIQDQLERI----FL----VLG---TPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAED-LASKLLQCSPKN--RLS-------AQ-AALSHEYF--------------
----YEPKEILGRGVSSVVRRCIHK----------------P-T-SQ---EYAVKVIDVT--GGG-S---FS--P-EEVRELRE------------------ATLKEVDILRKV-SG-----HPN-----IIQLKDTYE--T-------------------------------------NTF------FFLVFDLMKRG--ELF-DYLT--------EKV---------------------TL---SEKETRKIMRALLEVICTLHK--L-----N---IVHRDLKPENILLDDNM-NI--------------------KLTDFGFSCQ---------------------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPG---YGKEVDMWSTGVIMYTLLA-GS-PP---------------FWHR------KQMLML----RM----IMS---GNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKD-LVSRFLVVQPQN--RYT-------AE-EALAHPFF--------------
-YDP---KDVIGRGVSSVVRRCVHR----------------A-T-GH---EFAVKIMEVT--AER-L---SP--E-QLEEVREA-------------------TRRETHILRQV-AG-----HPH-----IITLIDSYE--S-------------------------------------SSF------MFLVFDLMRKG--ELF-DYLT--------EKV---------------------AL---SEKETRSIMRSLLEAVSFLHA--N-----N---IVHRDLKPENILLDDNM-QI--------------------RLSDFGFSCH---------------------LEPGEKL--------------RE---LCGTPGYLAPEILKCSMDETHPG---YGKEVDLWACGVILFTLLA-GS-PP---------------FWHR------RQILML----RM----IME---GQYQFSSPEWDDRS-----------------------------------------------------------------------STVKD-LISRLLQVDPEA--RLT-------AE-QALQHPFF--------------
---F-KFLAVLGRGHFGKVLLSEFR----------------P-S-GE---LFAIKALKKG--DIV-A---RD--E-VESLM------------------------CEKRILAAV--TS--AGHPF-----LVNLFGCFQ--T-------------------------------------PEH------VCFVMEYSAGG--DLM-LHIH---------SD---------------------VF---SEPRAIFYSACVVLGLQFLHE--H-----K---IVYRDLKLDNLLLDTEG-YV--------------------KIADFGLCKEG--------------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS---YTRAVDWWGLGVLLYEMLV-GE-SP---------------FPGD------DEEEVF----DS----IVN---DEVRYPRFLS---------------------------------------------------------------------------AEAIG-IMRRLLRRNPER--RLGSS--ERDAE-DVKKQPFF--------------
--FR--CCAVLGRGHFGKVLLAEYK----------------N-T-NE---MFAIKALKKG--DIV-A---RD--E-VDSLM------------------------CEKRIFETV--NS--VRHPF-----LVNLFACFQ--T-------------------------------------KEH------VCFVMEYAAGG--DLM-MHIH---------TD---------------------VF---SEPRAVFYAACVVLGLQYLHE--H-----K---IVYRDLKLDNLLLDTEG-FV--------------------KIADFGLCKEG--------------------MGYGDRT--------------ST---FCGTPEFLAPEVLT------ETS---YTRAVDWWGLGVLIYEMLV-GE-SP---------------FPGD------DEEEVF----DS----IVN---DEVRYPRFLS---------------------------------------------------------------------------TEAIS-IMRRLLRRNPER--RLGAS--EKDAE-DVKKHPFF--------------
--YV--RGRFLGKGGFAKCFEISDA----------------D-T-KE---VFAGKIVPKS--LLL-K---PH--Q-REKMS------------------------MEISIHRSL--A-----HQH-----VVGFHGFFE--D-------------------------------------NDF------VFVVLELCRRR--SLL-ELHK--------RRK---------------------AL---TEPEARYYLRQIVLGCQYLHR--N-----R---VIHRDLKLGNLFLNEDL-EV--------------------KIGDFGLATKV--------------------EYDGERK--------------KT---LCGTPNYIAPEVLS------KKG---HSFEVDVWSIGCIMYTLLV-GK-PP---------------FETS------CLKETY----LR----IKK---NEYSIPKHIN---------------------------------------------------------------------------PVAAS-LIQKMLQTDPTA--RPT-------IN-ELLNDEFF--------------
---Y-CRGKVLGKGGFAKCYEMTDL----------------T-N-NK---VYAAKIIPHS--RVA-K---PH--Q-REKID------------------------KEIELHRIL--H-----HKH-----VVQFYHYFE--D-------------------------------------KEN------IYILLEYCSRR--SMA-HILK--------ARK---------------------VL---TEPEVRYYLRQIVSGLKYLHE--Q-----E---ILHRDLKLGNFFINEAM-EL--------------------KVGDFGLAARL--------------------EPLEHRR--------------RT---ICGTPNYLSPEVLN------KQG---HGCESDIWALGCVMYTMLL-GR-PP---------------FETT------NLKETY----RC----IRE---ARYTMPSSLL---------------------------------------------------------------------------APAKH-LIASMLSKNPED--RPS-------LD-DIIRHDFF--------------
---F-NFLMVLGKGSFGKVMLADRK----------------G-T-EE---LYAIKILKKD--VVI-Q---DD--D-VECTM------------------------VEKRVLALL-DK-----PPF-----LTQLHSCFQ--T-------------------------------------VDR------LYFVMEYVNGG--DLM-YHIQ--------QVG---------------------KF---KEPQAVFYAAEISIGLFFLHK--R-----G---IIYRDLKLDNVMLDSEG-HI--------------------KIADFGMCKEH--------------------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQP---YGKSVDWWAYGVLLYEMLA-GQ-PP---------------FDGE------DEDELF----QS----IME---HNVSYPKSLS---------------------------------------------------------------------------KEAVS-VCKGLMTKHPAK--RLG-------C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKVLLGELK----------------G-R-GE---YFAIKALKKD--VVL-I---DD--D-VECTM------------------------VEKRVLTLA-AE-----NPF-----LTHLICTFQ--T-------------------------------------KDH------LFFVMEFLNGG--DLM-YHIQ--------DKG---------------------RF---ELYRATFYAAEIMCGLQFLHS--K-----G---IIYRDLKLDNVLLDRDG-HI--------------------KIADFGMCKEN--------------------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLK---YTFSVDWWSFGVLLYEMLI-GQ-SP---------------FHGD------DEDELF----ES----IRV---DTPHYPRWIT---------------------------------------------------------------------------KESKD-ILEKLFEREPTK--RLG------VTG-NIKIHPFF--------------
---F-NFIKVLGKGSFGKVMLAELK----------------G-K-DE---VYAVKVLKKD--VIL-Q---DD--D-VDCTM------------------------TEKRILALA-RK-----HPY-----LTQLYCCFQ--T-------------------------------------KDR------LFFVMEYVNGG--DLM-FQIQ--------RSR---------------------KF---DEPRSRFYAAEVTSALMFLHQ--H-----G---VIYRDLKLDNILLDAEG-HC--------------------KLADFGMCKEG--------------------ILNGVTT--------------TT---FCGTPDYIAPEILQ------ELE---YGPSVDWWALGVLMYEMMA-GQ-PP---------------FEAD------NEDDLF----ES----ILH---DDVLYPVWLS---------------------------------------------------------------------------KEAVS-ILKAFMTKNPHK--RLGCVASQNGED-AIKQHP--FF------------
--FI--LHKMLGKGSFGKVFLAEFK----------------K-T-NQ---FFAIKALKKD--VVL-M---DD--D-VECTM------------------------VEKRVLSLA-WE-----HPF-----LTHMFCTFQ--T-------------------------------------KEN------LFFVMEYLNGG--DLM-YHIQ--------SCH---------------------KF---DLSRATFYAAEIILGLQFLHS--K-----G---IVYRDLKLDNILLDKDG-HI--------------------KIADFGMCKEN--------------------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQK---YNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ------DEEELF----HS----IRM---DNPFYPRWLE---------------------------------------------------------------------------KEAKD-LLVKLFVREPEK--RLG-------VRGDIRQHPLF--------------
--PD----EVLGSGQFGIVYGGKHR----------------K-T-GR---DVAIKIIDKL--RFP-T---KQ--E-SQLRN-------------------------EVAILQNL--H-----HPG-----VVNLECMFE--T-------------------------------------PER------VFVVMEKLHGD--MLE-MILS-------SEKG---------------------RL---PEHITKFLITQILVALRHLHF--K-----N---IVHCDLKPENVLLASAD-PFP-----------------QVKLCDFGFARI---------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------NKG---YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED--------EDIH----DQ----IQN---AAFMYPPNPWKEIS-----------------------------------------------------------------------HEAID-LINNLLQVKMRK--RYS-------VD-KTLSHPWL--------------
--PD----EVLGSGQFGVVYGGKHR----------------K-T-GR---DVAVKVIDKL--RFP-T---KQ--E-SQLRN-------------------------EVAILQSL--R-----HPG-----IVNLECMFE--T-------------------------------------PEK------VFVVMEKLHGD--MLE-MILS-------SEKG---------------------RL---PERLTKFLITQILVALRHLHF--K-----N---IVHCDLKPENVLLASAD-PFP-----------------QVKLCDFGFARI---------------------IGEKSFR--------------RS---VVGTPAYLAPEVLL------NQG---YNRSLDMWSVGVIMYVSLS-GT-FP---------------FNED--------EDIN----DQ----IQN---AAFMYPASPWSHIS-----------------------------------------------------------------------AGAID-LINNLLQVKMRK--RYS-------VD-KSLSHPWL--------------
-FAD----EVLGSGQFGIVYGGKHR----------------K-T-GR---DVAIKVIDKM--RFP-T---KQ--E-SQLRN-------------------------EVAILQNL--H-----HPG-----IVNLECMFE--T-------------------------------------PER------VFVVMEKLHGD--MLE-MILS-------SEKS---------------------RL---PERITKFMVTQILVALRNLHF--K-----N---IVHCDLKPENVLLASAE-PFP-----------------QVKLCDFGFARI---------------------IGEKSFR--------------RS---VVGTPAYLAPEVLR------SKG---YNRSLDMWSVGVIIYVSLS-GT-FP---------------FNED--------EDIN----DQ----IQN---AAFMYPPNPWREIS-----------------------------------------------------------------------GEAID-LINNLLQVKMRK--RYS-------VD-KSLSHPWL--------------
----IELGRCIGEGQFGDVHQGIYM-------------SPEN-P-AL---AVAIKTCK-N--CTS-----DSVRE-KFL-Q-------------------------EALTMRQF--D-----HPH-----IVKLIGVIT----------------------------------------ENP------VWIIMELCTLG--ELR-SFLQ---------VR------------------K-YSL---DLASLILYAYQLSTALAYLES--K-----R---FVHRDIAARNVLVSSND-CV--------------------KLGDFGLSRYM--------------------E--DSTY--------------YKASKGKLPIKWMAPESIN------FRR---FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV---KNNDVIGRI----EN----GER---LPMPPNCP-----------------------------------------------------------------------------PTLYS-LMTKCWAYDPSR--RPR-------FT-ELKAQL----------------
----YEVVKVIGRGAFGEVQLVRHK----------------S-T-RK---VYAMKLLSKF--EMI-K---RS--D-SAFFW------------------------EERDIMAFA--N-----SPW-----VVQLFYAFQ--D-------------------------------------DRY------LYMVMEYMPGG--DLV-NLMS---------NY---------------------DV---PEKWARFYTAEVVLALDAIHS--M-----G---FIHRDVKPDNMLLDKSG-HL--------------------KLADFGTCMKM-------------------NKEGMVRC--------------DT---AVGTPDYISPEVLKS--QGGDGY---YGRECDWWSVGVFLYEMLV-GD-TP---------------FYAD------SLVGTY----SK----IMN---HKNSLTFPDDNDIS-----------------------------------------------------------------------KEAKN-LICAFLTDREVRLGRNG-------VE-EIKRHLFF--------------
----YDVVKVIGRGAFGEVQLVRHK----------------A-S-QK---VYAMKLLSKF--EMI-K---RS--D-SAFFW------------------------EERDIMAFA--N-----SPW-----VVQLFYAFQ--D-------------------------------------DRY------LYMVMEYMPGG--DLV-NLMS---------NY---------------------DV---PEKWAKFYTAEVVLALDAIHS--M-----G---LIHRDVKPDNMLLDKHG-HL--------------------KLADFGTCMKM-------------------DETGMVHC--------------DT---AVGTPDYISPEVLKS--QGGDGF---YGRECDWWSVGVFLYEMLV-GD-TP---------------FYAD------SLVGTY----SK----IMD---HKNSLCFPEDAEIS-----------------------------------------------------------------------KHAKN-LICAFLTDREVRLGRNG-------VE-EIRQHPFF--------------
----WEIIGELGDGAFGKVYKAQNK----------------E-T-SV---LAAAKVIDTK--SEE-E---LE--D-YM--V-------------------------EIDILASC--D-----HPN-----IVKLLDAFY--Y-------------------------------------ENN------LWILIEFCAGG--AVD-AVML-------ELER---------------------PL---TESQIQVVCKQTLDALNYLHD--N-----K---IIHRDLKAGNILFTLDG-DI--------------------KLADFGVSAKN--------------------TRTIQRR--------------DS---FIGTPYWMAPEVVMCE-TSKDRP---YDYKADVWSLGITLIEMAE-IE-PP---------------HHEL---NPMRVLLKI----AK----SEP---PTLAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDA--RWT-------TS-QLLQHPFV--------------
---L-RLEVKLGQGCFGEVWMGTWN------------------G-TT---RVAIKTLK-P--GTM-----SP--E-AFL-Q-------------------------EAQVMKKL--R-----HEK-----LVQLYAVVS----------------------------------------EEP------IYIVTEYMSKG--SLL-DFLK---------GE-----------------TG-KYL---RLPQLVDMAAQIASGMAYVER--M-----N---YVHRDLRAANILVGENL-VC--------------------KVADFGLARLI--------------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM---VNREVLDQV----ER----GYR---MPCPPECP-----------------------------------------------------------------------------ESLHD-LMCQCWRKEPEE--RPT-------FE-YLQAF--L--------------
--FA--LGRKLGEGYFGEVWEGLWL------------------G-SL---PVAIKVIK-S--ANM-----K--LT-DLA-K-------------------------EIQTLKGL--R-----HER-----LIRLHAVCS--G-------------------------------------GEP------VYIVTELMRKG--NLQ-AFLG---------TP-----------------EG-RAL---RLPPLLGFACQVAEGMSYLEE--Q-----R---VVHRDLAARNVLVDDGL-AC--------------------KVADFGLARLL--------------------K--DDIY--------------SPSSSSKIPVKWTAPEAAN------YRV---FSQKSDVWSFGVLLHEVFTYGQ-CP---------------YEGM---TNHETLQQI----MR----GYR---LPRPAACP-----------------------------------------------------------------------------AEVYV-LMLECWRSSPEE--RPS-------FA-TLREKL----------------
----FTKLEKIGKGSFGEVFKGIDN----------------R-T-QK---VVAIKIIDLE--EAE-D---EI--E-DIQ-Q-------------------------EITVLSQC--D-----SPY-----VTKYYGSYL--K-------------------------------------DTK------LWIIMEYLGGG--SAL-DLLE---------PG---------------------PL---DETQIATILREILKGLDYLHS--E-----K---KIHRDIKAANVLLSEHG-EV--------------------KLADFGVAGQL--------------------TDTQIKR--------------NT---FVGTPFWMAPEVIK------QSA---YDSKADIWSLGITAIELAR-GE-PP---------------HSEL---HPMKVLFLI----PK----NNP---PTLEGNYS-----------------------------------------------------------------------------KPLKE-FVEACLNKEPSF--RPT-------AK-ELLKHKFI--------------
----YSLLAEIGRGSYGVVYEAVAG----------------R-S-GA---RVAVKKIRCD--APE-N---VE--L---ALA-------------------------EFWALTSLKRR-----HQN-----VVQFEECVL--QRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCY------LWFVMEFCEGG--DLN-QYVL---------SR---------------------RP---DPATNKSFMLQLTSAIAFLHK--N-----H---IVHRDLKPDNILITERS-GTP-----------------ILKVADFGLSKVCAGLAPRGK---EGNQDNKNVNVNKYWL--------------SS---ACGSDFYMAPEVWE-------GH---YTAKADIFALGIIIWAMIE-RI-TF---------------IDSE---TKKELLGTY----IK----QGT---EIVPVGEALLENPKMELHIPQ---------------------------------------------------------KRRTSMSEGIKQ-LLKDMLAANPQD--RPD-------AF-EL------ETRM----------
----YHVLEMIGEGSFGRVYKGRRK----------------Y-S-AQ---VVALKFIPKL--GRS-E---KE--L-RNLQR-------------------------EIEIMRGL--R-----HPN-----IVHMLDSFE--T-------------------------------------DKE------VVVVTDYAEG---ELF-QILE--------DDG---------------------KL---PEDQVQAIAAQLVSALYYLHS--H-----R---ILHRDMKPQNILLAKGG-GI--------------------KLCDFGFARAM--------------------STNTMVL--------------TS---IKGTPLYMSPELVE------ERP---YDHTADLWSVGCILYELAV-GT-PP---------------FYAT------SIFQLV----SL----ILK---DPVRWPSTIS---------------------------------------------------------------------------PCFKN-FLQGLLTKDPRQ--RLS-------WP-DLLYHPFI--------------
----YELQEVIGSGATAVVQAALCK----------------P-R-QE---RVAIKRINLE--KCQ-T---SM--D-E-LLK-------------------------EIQAMSQC--S-----HPN-----VVTYYTSFV--V-------------------------------------KDE------LWLVMKLLSGG--SML-DIIKYIVNRGEHKNG---------------------VL---EEAIIATILKEVLEGLDYLHR--N-----G---QIHRDLKAGNILLGEDG-SV--------------------QIADFGVSAFLAT---------------GGDVTRNKVR--------------KT---FVGTPCWMAPEVME-----QVRG---YDFKADMWSFGITAIELAT-GA-AP---------------YHKY---PPMKVLMLT----LQ----NDP---PTLETGVEDKE--MMK------------------------------------------------------------------KYGKSFRK-LLSLCLQKDPSK--RPT-------AA-ELLKCKFF--------------
--YL--LLHLLGRGGFSEVYKAFDL----------------T-E-QR---YVAVKIHQLN--KNW-R---DE--K-KENYHKH--------------------ACREYRIHKEL--D-----HPR-----IVKLYDYFS--L------------------------------------DTDS------FCTVLEYCEGN--DLD-FYLK--------QHK---------------------LM---SEKEARSIIMQIVNALKYLNE--IK---PP---IIHYDLKPGNILLVNGT-ACG-----------------EIKITDFGLSKIMDDD-------------SYNSVDGMELT--------------SQ---GAGTYWYLPPECFVV--GKEPPK---ISNKVDVWSVGVIFYQCLY-GR-KP---------------FGHN----QSQQDILQ----EN----TIL---KATEVQFPPKPVVT-----------------------------------------------------------------------PEAKA-FIRRCLAYRKED--RID-------VQ-QLACDPYL--------------
---L-RLLEKLGDGSFGVVRRGEWD-------------APSG-K-TV---SVAVKCLK-PDVLSQ-----PEAMD-DFI-R-------------------------EVNAMHSL--D-----HRN-----LIRLYGVVL----------------------------------------TPP------MKMVTELAPLG--SLL-DRLR---------KH------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--K-----R---FIHRDLAARNLLLATRD-LV--------------------KIGDFGLMRAL---------PQ---------N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT---FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL---NGSQILHKI---DKE----GER---LPRPEDCP-----------------------------------------------------------------------------QDIYN-VMVQCWAHKPED--RPT-------FV-ALRDF--L--------------
----IEFHEIIGSGSFGKVYKGRCR--------------------NK---IVAIKRYR-ANTYCS-----KSDVD-MFC-R-------------------------EVSILCQL--N-----HPC-----VIQFVGACL-ND-------------------------------------PSQ------FAIVTQYISGG--SLF-SLLH---------EQ------------------K-RIL---DLQSKLIIAVDVAKGMEYLHNLTQ-----P---IIHRDLNSHNILLYEDG-HA--------------------VVADFGESRFL----------Q---------S--LD-E--------------DNMTKQPGNLRWMAPEVFT------QCT--RYTIKADVFSYALCLWEILT-GE-IP---------------FAHL---KPAAAAADM---AYH----HIR---PPIGYSIP-----------------------------------------------------------------------------KPISS-LLIRGWNACPEG--RPE-------FS-EVVMKL----------------
---L-RLEVKLGQGCFGEVWMGTWN------------------G-TT---KVAIKTLK-P--GTM-----MP--E-AFL-Q-------------------------EAQIMKKL--R-----HDK-----LVPLYAVVS----------------------------------------EEP------IYIVTEFMSKG--SLL-DFLK---------EG-----------------DG-KYL---KLPQLVDMAAQIADGMAYIER--M-----N---YIHRDLRAANILVGENL-VC--------------------KIADFGLARLI--------------------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM---VNREVLEQV----ER----GYR---MPCPQGCP-----------------------------------------------------------------------------ESLHE-LMNLCWKKDPDE--RPT-------FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR--------------MRK-K-QI---DVAIKVLK-Q--GTE-----KADTE-EMM-R-------------------------EAQIMHQL--D-----NPY-----IVRLIGVCQ----------------------------------------AEA------LMLVMEMAGGG--PLH-KFLV---------GK------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--K-----N---FVHRDLAARNVLLVNRH-YA--------------------KISDFGLSKAL---------GA---------D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK---FSSRSDVWSYGVTMWEALSYGQ-KP---------------YKKM---KGPEVMAFI----EQ----GKR---MECPPECP-----------------------------------------------------------------------------PELYA-LMSDCWIYKWED--RPD-------FL-TVEQR--M--------------
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