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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
TK ABL2 288
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK AXL 527
TK BLK 241
CAMK CAMK2D 14
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK DAPK3 13
TK DDR1 572
CMGC DYRK2 222
Other EIF2AK2 267
TK EPHA5 675
TK EPHB1 619
TK FGFR1 478
TK FGFR2 481
TK FGR 263
TK FRK 234
AGC GRK4 187
CMGC GSK3B 56
TK HCK 241
CMGC HIPK4 -1
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
STE MAP2K5 166
CMGC MAPK10 64
CMGC MAPK4 20
CMGC MAPK9 26
TK MET 1078
AGC PDPK1 82
Other PLK1 53
Other PLK3 62
AGC RPS6KA4 33
Other SBK1 53
CAMK SIK2 20
STE SLK 34
TK SRC 270
STE STK10 36
CAMK STK17A 61
CAMK STK17B 33
Other STK36 4
TKL TNNI3K 463
Other TTK 525
Other ULK3 14
TK YES1 277
---FQKVEKIGEGTYGVVYKARNK----------------LTGEVVALKKIRLD--T-ETE---GV--P-S-TAIR----EISLLKEL--N------HPNIVKLLDVIH--T-----------------------------ENK------LY--LVFEFLHQ---DLKKFMDA--SALT--------------------GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI----KLADFGLARAF------GVPVRTY--TH---EVVTLWYRAPEILL----------GCKY-YSTAVDIWSLGCIFAEMVT-RR--AL---------------FPGD----SEIDQ-LFRI----FRTLG---TPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTLK-E--D-TM----EV--E-E-FL-K----EAAVMKEI--K------HPNLVQLLGVCT--R-----------------------------EPP------FY--IITEFMTYG--NLLDYLR-----EC-----------------NRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM------T--GDTY--TAHAGAKFPIKWTAPESLA-----------YNK-FSIKSDVWAFGVLLWEIATYGM--SP---------------YPGI----DLSQV-YELL----EKDYR---MERPEGCP-----------------------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-----FAEIHQA--F-----------
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTLK-E--D-TM----EV--E-E-FL-K----EAAVMKEI--K------HPNLVQLLGVCT--L-----------------------------EPP------FY--IVTEYMPYG--NLLDYLR-----EC-----------------NREEV---TAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHVV----KVADFGLSRLM------T--GDTY--TAHAGAKFPIKWTAPESLA-----------YNT-FSIKSDVWAFGVLLWEIATYGM--SP---------------YPGI----DLSQV-YDLL----EKGYR---MEQPEGCP-----------------------------------------------------------------------------PKVYE-LMRACWKWSPADRPS-----FAETHQA--F-----------
---FEIGRPLGKGKFGNVYLAREK----------------QSKFILALKVLFKA--QLEKA---GV--E-H-QLRR----EVEIQSHL--R------HPNILRLYGYFH--D-----------------------------ATR------VY--LILEYAPLG--TVYRELQ----KLS--------------------KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLLLG--SAGEL----KIADFGWSV--------HAPSSRR--TT---LCGTLDYLPPEMIE-----------GRM-HDEKVDLWSLGVLCYEFLV-GK--PP---------------FEAN-------TY-QETY----KRISR---VEFTFPDFVT---------------------------------------------------------------------------EGARD-LISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FEIGRPLGKGKFGNVYLAREK----------------KSHFIVALKVLFKS--Q-IEK---EG--V-E-HQLR---REIEIQAHL--H------HPNILRLYNYFY--D-----------------------------RRR------IY--LILEYAPRG--ELYKELQ----KSC--------------------TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLLLG--LKGEL----KIADFGWSV--------HAPSLRR--KT---MCGTLDYLPPEMIE-----------GRM-HNEKVDLWCIGVLCYELLV-GN--PP---------------FESA-------SH-NETY----RRIVK---VDLKFPASVP---------------------------------------------------------------------------MGAQD-LISKLLRHNPSERLP-----LAQVSAHPWV-----------
---FEIGRPLGKGKFGNVYLARLK----------------ESHFIVALKVLFKS--Q-IEK---EG--L-E-HQLR---REIEIQAHL--Q------HPNILRLYNYFH--D-----------------------------ARR------VY--LILEYAPRG--ELYKELQ----KSE--------------------KL---DEQRTATIIEELADALTYCHD--KKVIHRDIKPENLLLG--FRGEV----KIADFGWSV--------HTPSLRR--KT---MCGTLDYLPPEMIE-----------GRT-YDEKVDLWCIGVLCYELLV-GY--PP---------------FESA-------SH-SETY----RRILK---VDVRFPLSMP---------------------------------------------------------------------------LGARD-LISRLLRYQPLERLP-----LAQILKHPWV-----------
--V-ALGKTLGEGEFGAVMEGQLN--------------QDDSILKVAVKTMK-I-AI-CT----RSELE-D-FL-S----EAVCMKEF--D------HPNVMRLIGVCF--Q-----------------------------GSERESFPAPV--VILPFMKHG--DLHSFLL-----YSRL-------------GDQPVYL---PTQMLVKFMADIASGMEYLST--KRFIHRDLAARNCMLN--ENMSV----CVADFGLSKKI---Y--N--GDYY--RQGRIAKMPVKWIAIESLA-----------DRV-YTSKSDVWSFGVTMWEIATRGQ--TP---------------YPGV----ENSEI-YDYL----RQGNR---LKQPADCL-----------------------------------------------------------------------------DGLYA-LMSRCWELNPQDRPS-----FTELREDL-------------
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTLK-E--G-TM----SP--E-A-FL-G----EANVMKAL--Q------HERLVRLYAVVT--------------------------------KEP------IY--IVTEYMARG--CLLDFLK-----TD-----------------EGSRL---SLPRLIDMSAQIAEGMAYIER--MNSIHRDLRAANILVS--EALCC----KIADFGLARII---------DSEY--TAQEGAKFPIKWTAPEAIH-----------FGV-FTIKADVWSFGVLLMEVVTYGR--VP---------------YPGM----SNPEV-IRNL----ERGYR---MPRPDTCP-----------------------------------------------------------------------------PELYRGVIAECWRSRPEERPT-----FEFLQSV--L-----------
---YQLFEELGKGAFSVVRRCMKI----------------PTGQEYAAKIINTK--K-LSA---RD--H-Q-KLER----EARICRLL--K------HPNIVRLHDSIS--E-----------------------------EGF------HY--LVFDLVTGG--ELFEDIV----ARE--------------------YY---SEADASHCIQQILESVNHCHL--NGIVHRDLKPENLLLA--SKSKGA-AVKLADFGLAIEV------QGDQQAW--FG---FAGTPGYLSPEVLR-----------KDP-YGKPVDMWACGVILYILLV-GY--PP---------------FWDE-------DQ-HRLY----QQIKA---GAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKD-LINKMLTINPAKRIT-----ASEALKHPWI-----------
---YTKIEKIGEGTYGVVYKGRHK----------------TTGQVVAMKKIRLE--S-EEE---GV--P-S-TAIR----EISLLKEL--R------HPNIVSLQDVLM--Q-----------------------------DSR------LY--LIFEFLSM---DLKKYLDS-IPPGQ--------------------YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI----KLADFGLARAF------GIPIRVY--TH---EVVTLWYRSPEVLL----------GSAR-YSTPVDIWSIGTIFAELAT-KK--PL---------------FHGD----SEIDQ-LFRI----FRALG---TPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-----GKMALNHPYF-----------
--Y-EPVAEIGVGAYGTVYKARDP----------------HSGHFVALKSVRVP--N-GGGGGGGL--P-I-STVR----EVALLRRL--EA---FEHPNVVRLMDVCA--TSR------------------------TDREIK------VT--LVFEHVDQ---DLRTYLDK--APPP--------------------GL---PAETIKDLMRQFLRGLDFLHA--NCIVHRDLKPENILVT--SGGTV----KLADFGLARI-------YSYQMAL--TP---VVVTLWYRAPEVLL-----------QST-YATPVDMWSVGCIFAEMFR-RK--PL---------------FCGN----SEADQ-LGKI----FDLIG---LPPEDDWPRDVSLPRGAFPPRGPR---------------------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-----AFRALQHSYL-----------
---YEKLEKIGEGTYGTVFKAKNR----------------ETHEIVALKRVRLD--D-DDE---GV--P-S-SALR----EICLLKEL--K------HKNIVRLHDVLH--S-----------------------------DKK------LT--LVFEFCDQ---DLKKYFD---SCNG--------------------DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL----KLADFGLARAF------GIPVRCY--SA---EVVTLWYRPPDVLF----------GAKL-YSTSIDMWSAGCIFAELANAGR--PL---------------FPGN----DVDDQ-LKRI----FRLLG---TPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRD-LLQNLLKCNPVQRIS-----AEEALQHPYF-----------
---YEMGEELGSGQFAIVRKCRQK----------------GTGKEYAAKFIKKR--R-LSS---SR--R-G-VSREEIEREVNILREI--R------HPNIITLHDIFE--N-----------------------------KTD------VV--LILELVSGG--ELFDFLA----EKE--------------------SL---TEDEATQFLKQILDGVHYLHS--KRIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK-------IEAGNEF--KN---IFGTPEFVAPEIVN-----------YEP-LGLEADMWSIGVITYILLS-GA--SP---------------FLGE-------TK-QETL----TNISA---VNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKD-FIRRLLVKDPKRRMT-----IAQSLEHSWI-----------
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR-P--D-AT----KNARN-D-FL-K----EVKIMSRL--K------DPNIIRLLGVCV--Q-----------------------------DDP------LC--MITDYMENG--DLNQFLS-----AHQLEDKAAEGAPGDGQAAQGPTI---SYPMLLHVAAQIASGMRYLAT--LNFVHRDLATRNCLVG--ENFTI----KIADFGMSRNL---Y--A--GDYY--RVQGRAVLPIRWMAWECIL-----------MGK-FTTASDVWAFGVTLWEVLMLCRA-QP---------------FGQL----TDEQV-IENAGEFFRDQGRQVYLSRPPACP-----------------------------------------------------------------------------QGLYE-LMLRCWSRESEQRPP-----FSQLHRFL-------------
---YEVLKVIGKGSFGQVVKAYDH----------------KVHQHVALKMVRNE--K-RFH---RQ--A-A-E-------EIRILEHL--RKQDKDNTMNVIHMLENFT--F-----------------------------RNH------IC--MTFELLSM---NLYELIKK--NKFQ--------------------GF---SLPLVRKFAHSILQCLDALHK--NRIIHCDLKPENILLK--QQGRSG--IKVIDFGSSC---------YEHQRV--YT---YIQSRFYRAPEVIL-----------GAR-YGMPIDMWSLGCILAELLT-GY--PL---------------LPGE----DEGDQ-LACM----IELLG---MPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAVRMT-----PGQALRHPWL-----------
--F-KEIELIGSGGFGQVFKAKHR----------------IDGKTYVIKRVKYN--N-EKA---ER--------------EVKALAKL--D------HVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKC------LF--IQMEFCDKG--TLEQWIEK--RRGE--------------------KL---DKVLALELFEQITKGVDYIHS--KKLIHRDLKPSNIFLV--DTKQV----KIGDFGLVTS-------LKNDGKR--TR---SKGTLRYMSPEQIS-----------SQD-YGKEVDLYALGLILAELLH-VC-DTA---------------FET------------SKF----FTDLR---DGIISDIFDK----------------------------------------------------------------------------KEKT-LLQKLLSKKPEDRPN-----TSEILR----TLT--------
---ITIERVIGAGEFGEVCSGRLK-------------LPGKRELPVAIKTLK-V--G-YT----EKQRR-D-FL-G----EASIMGQF--D------HPNIIHLEGVVT--K-----------------------------SKP------VM--IVTEYMENG--SLDTFLK-----KN------------------DGQF---TVIQLVGMLRGISAGMKYLSD--MGYVHRDLAARNILIN--SNLVC----KVSDFGLSRVL---E--D--DPEA-AYTTRGGKIPIRWTAPEAIA-----------FRK-FTSASDVWSYGIVMWEVVSYGE--RP---------------YWEM----TNQDV-IKAV----EEGYR---LPSPMDCP-----------------------------------------------------------------------------AALYQ-LMLDCWQKERNSRPK-----FDEIVNML-------------
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTLK-A--G-YS----EKQRR-D-FL-S----EASIMGQF--D------HPNIIRLEGVVT--K-----------------------------SRP------VM--IITEFMENG--ALDSFLR-----QN------------------DGQF---TVIQLVGMLRGIAAGMKYLAE--MNYVHRDLAARNILVN--SNLVC----KVSDFGLSRYLQDDT--S--DPTY--TSSLGGKIPVRWTAPEAIA-----------YRK-FTSASDVWSYGIVMWEVMSFGE--RP---------------YWDM----SNQDV-INAI----EQDYR---LPPPMDCP-----------------------------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR-----FAEIVNTL-------------
--L-VLGKPLGEGCFGQVVLAEAIGL---------DKDKPNRVTKVAVKMLK-S--D-AT----EKDLS-D-LI-S----EMEMMKMIG-K------HKNIINLLGACT--Q-----------------------------DGP------LY--VIVEYASKG--NLREYLQ-----ARRPPGLEY---CYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS--KKCIHRDLAARNVLVT--EDNVM----KIADFGLARDI---H--H--IDYY--KKTTNGRLPVKWMAPEALF-----------DRI-YTHQSDVWSFGVLLWEIFTLGG--SP---------------YPGV----PVEEL-FKLL----KEGHR---MDKPSNCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
---LTLGKPLGEGCFGQVVMAEAVGI---------DKDKPKEAVTVAVKMLK-D--D-AT----EKDLS-D-LV-S----EMEMMKMIG-K------HKNIINLLGACT--Q-----------------------------DGP------LY--VIVEYASKG--NLREYLR-----ARRPPGMEY---SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS--QKCIHRDLAARNVLVT--ENNVM----KIADFGLARDI---N--N--IDYY--KKTTNGRLPVKWMAPEALF-----------DRV-YTHQSDVWSFGVLMWEIFTLGG--SP---------------YPGI----PVEEL-FKLL----KEGHR---MDKPANCT-----------------------------------------------------------------------------NELYM-MMRDCWHAVPSQRPT-----FKQLVEDL-------------
---ITLERRLGTGCFGDVWLGTWN-----------------GSTKVAVKTLK-P--G-TM----SP--K-A-FL-E----EAQVMKLL--R------HDKLVQLYAVVS--------------------------------EEP------IY--IVTEFMCHG--SLLDFLK-----NP-----------------EGQDL---RLPQLVDMAAQVAEGMAYMER--MNYIHRDLRAANILVG--ERLAC----KIADFGLARLI------K--DDEY--NPCQGSKFPIKWTAPEAAL-----------FGR-FTIKSDVWSFGILLTELITKGR--IP---------------YPGM----NKREV-LEQV----EQGYH---MPCPPGCP-----------------------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-----FEYLQSFL-------------
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTLK-P--G-SM----DP--N-D-FL-R----EAQIMKNL--R------HPKLIQLYAVCT--L-----------------------------EDP------IY--IITELMRHG--SLQEYLQ-----ND-----------------TGSKI---HLTQQVDMAAQVASGMAYLES--RNYIHRDLAARNVLVG--EHNIY----KVADFGLARVFK-VD--N--EDIY--ESRHEIKLPVKWTAPEAIR-----------SNK-FSIKSDVWSFGILLYEIITYGK--MP---------------YSGM----TGAQV-IQML----AQNYR---LPQPSNCP-----------------------------------------------------------------------------QQFYN-IMLECWNAEPKERPT-----FETLRWK--L-----------
-FR--HYRVLGKGGFGEVCACQVR----------------ATGKMYACKKLQKK--R-IKK---RK--G-E-AMAL---NEKRILEKV--Q------SRFVVSLAYAYE--T-----------------------------KDA------LC--LVLTIMNGG--DLKFHIYN--LGNP--------------------GF---DEQRAVFYAAELCCGLEDLQR--ERIVYRDLKPENILLD--DRGHI----RISDLGLATE-------IPEGQRV--RG---RVGTVGYMAPEVVN-----------NEK-YTFSPDWWGLGCLIYEMIQ-GH--SP---------------FKKY----KEKVK-WEEV----DQRIK---NDTEEYSE---KFS-----------------------------------------------------------------------EDAKS-ICRMLLTKNPSKRLGCRGEGAAGVKQHPV-F----------
---YTDTKVIGNGSFGVVYQAKLC----------------DSGELVAIKKVLQD--K-RFK---NR--------------ELQIMRKL--D------HCNIVRLRYFFY--SSG-------------------------EKKDE------VYLNLVLDYVPETVYRVA---RHYSRAKQ--------------------TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ-------LVRGEPN--VS---YICSRYYRAPELIF----------GATD-YTSSIDVWSAGCVLAELLL-GQ--PI---------------FPGD----SGVDQ-LVEI----IKVLG---TPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-----PLEACAHSFF-----------
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTMK-P--G-SM----SV--E-A-FL-A----EANVMKTL--Q------HDKLVKLHAVVT--------------------------------KEP------IY--IITEFMAKG--SLLDFLK-----SD-----------------EGSKQ---PLPKLIDFSAQIAEGMAFIEQ--RNYIHRDLRAANILVS--ASLVC----KIADFGLARVI------E--DNEY--TAREGAKFPIKWTAPEAIN-----------FGS-FTIKSDVWSFGILLMEIVTYGR--IP---------------YPGM----SNPEV-IRAL----ERGYR---MPRPENCP-----------------------------------------------------------------------------EELYN-IMMRCWKNRPEERPT-----FEYIQSV--L-----------
---YDIIEVLGKGTFGEVAKGWRR----------------STGEMVAIKILKND--A-YRN---RI--I-K-N-------ELKLLHCM--RGL-DPEEAHVIRFLEFFH--D-----------------------------ALK------FY--LVFELLEQ---NLFEFQK-----EN--------------------NFAPLPARHIRTVTLQVLTALARLKE--LAIIHADLKPENIMLV--DQTRCPFRVKVIDFGSASIF------SEVRYVK--EP---YIQSRFYRAPEILL-----------GLP-FCEKVDVWSLGCVMAELHL-GW--PL---------------YPGN----NEYDQ-VRYI----CETQG---LPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVE-LIKRMLTWESHERIS-----PSAALRHPFV-----------
VGG----NKMGEGGFGVVYKGYVN----------------NTT--VAVKKLAAM--V-DIT---TE--ELK-QQFD---QEIKVMAKC--Q------HENLVELLGFSS--D-----------------------------GDD------LC--LVYVYMPNG--SLLDRLSC-LDGTP--------------------PL---SWHMRCKIAQGAANGINFLHE--NHHIHRDIKSANILLD--EAFTA----KISDFGLARASE----KFAQTVMT--SR---IVGTTAYMAPEALR------------GE-ITPKSDIYSFGVVLLEIIT-GL--PA---------------VDEH----REPQL-LLDI----KEEIE---DEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYS-VASQCLHEKKNKRPD-----IKKVQQ----LLQ--------
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKLQ-H--S-TE-----EHLR-D-FE-R----EIEILKSL--Q------HDNIVKYKGVCYSAG-----------------------------RRN------LK--LIMEYLPYG--SLRDYLQ-----KH------------------KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRV----KIGDFGLTKVL--PQ--D--KEYY--KVKEPGESPIFWYAPESLT-----------ESK-FSVASDVWSFGVVLYELFTYIE--KSKSPPAEFMRMIGNDKQGQM----IVFHL-IELL----KNNGR---LPRPDGCP-----------------------------------------------------------------------------DEIYM-IMTECWNNNVNQRPS-----FRDLA----LRV---------
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQLQ-H--S-GP----DQ-QR-D-FQ-R----EIQILKAL--H------SDFIVKYRGVSYGPG-----------------------------RQS------LR--LVMEYLPSG--CLRDFLQ-----RH------------------RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV----KIADFGLAKLL--PL--D--KDYY--VVREPGQSPIFWYAPESLS-----------DNI-FSRQSDVWSFGVVLYELFTYCD--KSCSPSAE--FLRMMGCERDV-P--ALCRL-LELL----EEGQR---LPAPPACP-----------------------------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FSALGP---QL----------
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSLK-Q--G-SM----SP--D-A-FL-A----EANLMKQL--Q------HQRLVRLYAVVT--------------------------------QEP------IY--IITEYMENG--SLVDFLK-----TP-----------------SGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS--DTLSC----KIADFGLARLI------E--DNEY--TAREGAKFPIKWTAPEAIN-----------YGT-FTIKSDVWSFGILLTEIVTHGR--IP---------------YPGM----TNPEV-IQNL----ERGYR---MVRPDNCP-----------------------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-----FDYLRSV--L-----------
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTLK-P--G-TM----SV--Q-A-FL-E----EANLMKTL--Q------HDKLVRLYAVVT--R-----------------------------EEP------IY--IITEYMAKG--SLLDFLK-----SD-----------------EGGKV---LLPKLIDFSAQIAEGMAYIER--KNYIHRDLRAANVLVS--ESLMC----KIADFGLARVI------E--DNEY--TAREGAKFPIKWTAPEAIN-----------FGC-FTIKSDVWSFGILLYEIVTYGK--IP---------------YPGR----TNADV-MTAL----SQGYR---MPRVENCP-----------------------------------------------------------------------------DELYD-IMKMCWKEKAEERPT-----FDYLQSV--L-----------
IRY---RDTLGHGNGGTVYKAYHV----------------PSGKILAVKVILLD--I-TLE---LQ--K-Q-I-MS----ELEILYKC--D------SSYIIGFYGAFF--V-----------------------------ENR------IS--ICTEFMDGG--SLD--------VYR--------------------KM---PEHVLGRIAVAVVKGLTYLWS--LKILHRDVKPSNMLVN--TRGQV----KLCDFGVST--------QLVNSIA--KT---YVGTNAYMAPERIS-----------GEQ-YGIHSDVWSLGISFMELAL-GR--FP---------------YPQI----QKNQG-SLMP----LQLLQ---CIVDEDSPVLPVGEF---------------------------------------------------------------------SEPFVH-FITQCMRKQPKERPA-----PEELMGHPFI-----------
---YQNLKPIGSGAQGIVCAAYDA----------------VLDRNVAIKKLSRP--F-QNQ---TH--A-K-RAYR----ELVLMKCV--N------HKNIISLLNVFT--PQKT-----------------------LEEFQD------VY--LVMELMDA---NLCQVIQ------M--------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL----KILDFGLART-------AGTSFMM--TP---YVVTRYYRAPEVIL-----------GMG-YKENVDIWSVGCIMGEMVR-HK--IL---------------FPGR----DYIDQ-WNKV----IEQLG---TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-----VDDALQHPYI-----------
FVD---FQPLGFGVNGLVLSAVDS----------------RACRKVAVKKIALS--D-ARS---MK--H----ALR----EIKIIRRL--D------HDNIVKVYEVLG--PKGTDL------------------QGELFKFSV------AY--IVQEYMET---DLARLLE-----QG--------------------TL---AEEHAKLFMYQLLRGLKYIHS--ANVLHRDLKPANIFIS-TEDLVL----KIGDFGLARIVD---QHYSHKGYL--SE---GLVTKWYRSPRLLL----------SPNN-YTKAIDMWAAGCILAEMLT-GR--ML---------------FAGA----HELEQ-MQLI----LETIP---VIREEDKDELLRVMPSFVSSTWEVK-------------------------------------------------RPLRKLLPEVNSEAID-FLEKILTFNPMDRLT-----AEMGLQHPYM-----------
---YQQLKPIGSGAQGIVCAAFDT----------------VLGINVAVKKLSRP--F-QNQ---TH--A-K-RAYR----ELVLLKCV--N------HKNIISLLNVFT--PQKT-----------------------LEEFQD------VY--LVMELMDA---NLCQVIH------M--------------------EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL----KILDFGLART-------ACTNFMM--TP---YVVTRYYRAPEVIL-----------GMG-YKENVDIWSVGCIMGELVK-GC--VI---------------FQGT----DHIDQ-WNKV----IEQLG---TPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDKRIS-----VDEALRHPYI-----------
---VHFNEVIGRGHFGCVYHGTLL-------------DNDGKKIHCAVKSLN-R--I-TD----IGEVS-Q-FL-T----EGIIMKDF--S------HPNVLSLLGICL-RS-----------------------------EGS------PL--VVLPYMKHG--DLRNFIR-----NE------------------THNP---TVKDLIGFGLQVAKGMKYLAS--KKFVHRDLAARNCMLD--EKFTV----KVADFGLARDM---Y--D--KEYYSVHNKTGAKLPVKWMALESLQ-----------TQK-FTTKSDVWSFGVLLWELMTRGA--PP---------------YPDV----NTFDI-TVYL----LQGRR---LLQPEYCP-----------------------------------------------------------------------------DPLYE-VMLKCWHPKAEMRPS-----FSELVSR--I-----------
--F-KFGKILGEGSFSTVVLAREL----------------ATSREYAIKILEKR--H-IIK---EN--K-VPYVTR----ERDVMSRL--D------HPFFVKLYFTFQ--D-----------------------------DEK------LY--FGLSYAKNG--ELLKYIR----KIG--------------------SF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENILLN--EDMHI----QITDFGTAKVLS----PESKQARA--NS---FVGTAQYVSPELLT-----------EKS-ACKSSDLWALGCIIYQLVA-GL--PP---------------FRAG-------NE-YLIF----QKIIK---LEYDFPEKFF---------------------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDA----------------DTKEVFAGKIVPKS--L-LLK---PH--Q-R-EKMS---MEISIHRSL--A------HQHVVGFHGFFE--D-----------------------------NDF------VF--VVLELCRRR--SLLELHK----RRK--------------------AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLFLN--EDLEV----KIGDFGLATKV------EYDGERK--KT---LCGTPNYIAPEVLS-----------KKG-HSFEVDVWSIGCIMYTLLV-GK--PP---------------FETS-------CL-KETY----LRIKK---NEYSIPKHIN---------------------------------------------------------------------------PVAAS-LIQKMLQTDPTARPT-----INELLNDEFF-----------
-YL--KGRLLGKGGFARCYEATDT----------------ETGSAYAVKVIPQS--R-VAK---PH--Q-R-EKIL---NEIELHRDL--Q------HRHIVRFSHHFE--D-----------------------------ADN------IY--IFLELCSRK--SLAHIWK----ARH--------------------TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFFIT--ENMEL----KVGDFGLAARL------EPPEQRK--KT---ICGTPNYVAPEVLL-----------RQG-HGPEADVWSLGCVMYTLLC-GS--PP---------------FETA-------DL-KETY----RCIKQ---VHYTLPASLS---------------------------------------------------------------------------LPARQ-LLAAILRASPRDRPS-----IDQILRHDFF-----------
REP-----ALGQGSFSVCRRCRQR----------------QSGQEFAVKILSRR--L-EAN---TQ--R-----------EVAALRLC-QS------HPNVVNLHEVHH--D-----------------------------QLH------TY--LVLELLRGG--ELLEHIR----KKR--------------------HF---SESEASQILRSLVSAVSFMHE-EAGVVHRDLKPENILYA--DDT-PGAPVKIIDFGFARLR-----PQSPGVPM--QT---PCFTLQYAAPELLA-----------QQG-YDESCDLWSLGVILYMMLS-GQ--VP---------------FQGASGQGGQSQA-AEIM----CKIRE---GRFSLDGEAWQGVS-----------------------------------------------------------------------EEAKE-LVRGLLTVDPAKRLK-----LEGLRGSSW-L----------
---YELVRELGKGTYGKVDLVVYK----------------GTGTKMALKFVNKS--K-TKL---KN--F-----LR----EVSITNSL-SS------SPFIIKVFDVVF--E----------------------------TEDC------YV--FAQEYAPAG--DLFDIIP----PQV--------------------GL---PEDTVKRCVQQLGLALDFMHG--RQLVHRDIKPENVLLFDRECRRV----KLADFGMTR---------RVGCRV--KR---VSGTIPYTAPEVCQAG------RADGLA-VDTGVDVWAFGVLIFCVLT-GN--FP---------------WEAA----SGADAFFEEF----VRWQR---GRLPGLPSQWRRFT-----------------------------------------------------------------------EPALR-MFQRLLALEPERRGP-----AKEVF-----RFLKH------
---YDIEGTLGKGNFAVVKLGRHR----------------ITKTEVAIKIIDKS--Q-LDA---VN--L-E-KIYR----EVQIMKML--D------HPHIIKLYQVME--T-----------------------------KSM------LY--LVTEYAKNG--EIFDYLA----NHG--------------------RL---NESEARRKFWQILSAVDYCHG--RKIVHRDLKAENLLLD--NNMNI----KIADFGFGNF-------FKSGELL--AT---WCGSPPYAAPEVFE----------GQQY-EGPQLDIWSMGVVLYVLVC-GA--LP---------------FDGP-------TL-PILR----QRVLE---GRFRIPYFMS---------------------------------------------------------------------------EDCEH-LIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
---WEIIGELGDGAFGKVYKAQNK----------------ETSVLAAAKVIDTK--S-EEE---LE--D-Y-M--V----EIDILASC--D------HPNIVKLLDAFY--Y-----------------------------ENN------LW--ILIEFCAGG--AVDAVML---ELER--------------------PL---TESQIQVVCKQTLDALNYLHD--NKIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN------TRTIQRR--DS---FIGTPYWMAPEVVMCE------TSKDRP-YDYKADVWSLGITLIEMAE-IE--PP---------------HHEL----NPMRV-LLKI----AKSEP---PTLAQPSRWS---------------------------------------------------------------------------SNFKD-FLKKCLEKNVDARWT-----TSQLLQHPFV-----------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTLK-P--G-TM----SP--E-A-FL-Q----EAQVMKKL--R------HEKLVQLYAVVS--------------------------------EEP------IY--IVTEYMSKG--SLLDFLK-----GE-----------------TGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC----KVADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL-----------YGR-FTIKSDVWSFGILLTELTTKGR--VP---------------YPGM----VNREV-LDQV----ERGYR---MPCPPECP-----------------------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-----FEYLQAF--L-----------
---WEIVGELGDGAFGKVYKAKNK----------------ETGALAAAKVIETK--S-EEE---LE--D-Y-I--V----EIEILATC--D------HPYIVKLLGAYY--H-----------------------------DGK------LW--IMIEFCPGG--AVDAIML---ELDR--------------------GL---TEPQIQVVCRQMLEALNFLHS--KRIIHRDLKAGNVLMT--LEGDI----RLADFGVSAKN------LKTLQKR--DS---FIGTPYWMAPEVVMCE------TMKDTP-YDYKADIWSLGITLIEMAQ-IE--PP---------------HHEL----NPMRV-LLKI----AKSDP---PTLLTPSKWS---------------------------------------------------------------------------VEFRD-FLKIALDKNPETRPS-----AAQLLEHPFV-----------
LCP---GRELGRGKFAVVRKCIKK----------------DSGKEFAAKFMRKR--R-KGQ---DC--R-M-EIIH----EIAVLELA-QD------NPWVINLHEVYE--T-----------------------------ASE------MI--LVLEYAAGG--EIFDQCVA--DREE--------------------AF---KEKDVQRLMRQILEGVHFLHT--RDVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI-------LKNSEEL--RE---IMGTPEYVAPEILS-----------YDP-ISMATDMWSIGVLTYVMLT-GI--SP---------------FLGN-------DK-QETF----LNISQ---MNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-----AEECLKHPWL-----------
ILT---SKELGRGKFAVVRQCISK----------------STGQEYAAKFLKKR--R-RGQ---DC--R-A-EILH----EIAVLELA-KS------CPRVINLHEVYE--N-----------------------------TSE------II--LILEYAAGG--EIFSLCLP--ELAE--------------------MV---SENDVIRLIKQILEGVYYLHQ--NNIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK-------IGHACEL--RE---IMGTPEYLAPEILN-----------YDP-ITTATDMWNIGIIAYMLLT-HT--SP---------------FVGE-------DN-QETY----LNISQ---VNVDYSEETFSSVS-----------------------------------------------------------------------QLATD-FIQSLLVKNPEKRPT-----AEICLSHSWL-----------
---YHVLEMIGEGSFGRVYKGRRK----------------YSAQVVALKFIPKL--G-RSE---KE--L-R-NLQR----EIEIMRGL--R------HPNIVHMLDSFE--T-----------------------------DKE------VV--VVTDYAEG---ELFQILE----DDG--------------------KL---PEDQVQAIAAQLVSALYYLHS--HRILHRDMKPQNILLA--KGGGI----KLCDFGFARAM------STNTMVL--TS---IKGTPLYMSPELVE-----------ERP-YDHTADLWSVGCILYELAV-GT--PP---------------FYAT-------SI-FQLV----SLILK---DPVRWPSTIS---------------------------------------------------------------------------PCFKN-FLQGLLTKDPRQRLS-----WPDLLYHPFI-----------
---IEFHEIIGSGSFGKVYKGRCR------------------NKIVAIKRYR-ANTY-CS----KSDVD-M-FC-R----EVSILCQL--N------HPCVIQFVGACL-ND-----------------------------PSQ------FA--IVTQYISGG--SLFSLLH-----EQ------------------KRIL---DLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLY--EDGHA----VVADFGESRFL---Q--S--LD-E--DNMTKQPGNLRWMAPEVFT-----------QCTRYTIKADVFSYALCLWEILT-GE--IP---------------FAHL----KPAAA-AADM---AYHHIR---PPIGYSIP-----------------------------------------------------------------------------KPISS-LLIRGWNACPEGRPE-----FSEVVMKL-------------
---YSILKQIGSGGSSKVFQVLNE----------------KKQ-IYAIKYVNLE--E-ADN---QT--L-D-SYRN----EIAYLNKL-QQ-----HSDKIIRLYDYEI--T-----------------------------DQY------IY--MVMECGNI---DLNSWLK----KKK--------------------SI---DPWERKSYWKNMLEAVHTIHQ--HGIVHSDLKPANFLIV---DGML----KLIDFGIANQMQ----PDTTSVVK--DS---QVGTVNYMPPEAIKDMSSSRENGKSKSK-ISPKSDVWSLGCILYYMTY-GK--TP---------------FQQI------INQ-ISKL----HAIID---PNHEIEFPDIPE-------------------------------------------------------------------------KDLQD-VLKCCLKRDPKQRIS-----IPELLAHPYV-----------
-FI--LTERLGSGTYATVYKAYAKK---------------DTREVVAIKCVAKK--S-LNK---AS--V-E-NLLT----EIEILKGI--R------HPHIVQLKDFQW--D-----------------------------SDN------IY--LIMEFCAGG--DLSRFIH----TRR--------------------IL---PEKVARVFMQQLASALQFLHE--RNISHLDLKPQNILLSSLEKPHL----KLADFGFAQH-------MSPWDEK--HV---LRGSPLYMAPEMVC-----------QRQ-YDARVDLWSMGVILYEALF-GQ--PP---------------FASR----SFSEL-EEKI----RSNRV---IELPLRPLLS---------------------------------------------------------------------------RDCRD-LLQRLLERDPSRRIS-----FQDFFAHPWV-----------
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTLK-P--G-TM----MP--E-A-FL-Q----EAQIMKKL--R------HDKLVPLYAVVS--------------------------------EEP------IY--IVTEFMSKG--SLLDFLK-----EG-----------------DGKYL---KLPQLVDMAAQIADGMAYIER--MNYIHRDLRAANILVG--ENLVC----KIADFGLARLI------E--DNEY--TARQGAKFPIKWTAPEAAL-----------YGR-FTIKSDVWSFGILQTELVTKGR--VP---------------YPGM----VNREV-LEQV----ERGYR---MPCPQGCP-----------------------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-----FEYIQSFL-------------
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