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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CMGC CDK4 6
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK7 55
Other PLK1 53
TK SRC 270
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIR-EISLLKELN---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIR-EISLLKELR---HPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK---NR-------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQ---THAKRAYR-ELVLMKCVN---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
--YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVV---TNAKRTLR-ELKILKHFK---HDNIIAIKDILRPTVPYGEFKSVY--VVLDLMES---DLHQIIH----SSQ---PLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTE---YVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLA-RRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQ-----------PVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK---PHQREKMSMEISIHRSLA---HQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK---ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
-L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM----SPEAFL-Q-EAQVMKKLR---HEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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