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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CAMK CHEK1 9
TK FGFR1 478
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDASALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKRAVDCP--ENI-KKEICINKML-NHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIE--PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQ---ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-H-H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLK---GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
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