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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
Other PLK1 53
AGC ROCK1 76
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIR---EISLLKELN---HPNIVKLLDVIHT--------ENKLYLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RISAKAALAHPFF
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRR---EVEIQSHLR---HPNILRLYGYFHD--------ATRVYLILEYAPLGTVYRELQ---KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT-----------------------------EGARDLISRLLKHNPSQ--RPMLREVLEHPWI
--FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEK---EGVEHQLR--REIEIQAHLH---HPNILRLYNYFYD--------RRRIYLILEYAPRGELYKELQ---KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSV------HAPSLRRKTMCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLVGNPPFESA---SHNETYRRIVKVDLKFPASVP-----------------------------MGAQDLISKLLRHNPSE--RLPLAQVSAHPWV
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEE---GVPSTAIR---EISLLKELR---HPNIVSLQDVLMQ--------DSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLL---GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---GSLASHVKNLDENGLDLLSKMLIYDPAK--RISGKMALNHPYF
-Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVR---EVALLRRLEAFEHPNVVRLMDVCATSR---TDREIKVTLVFEHVDQ-DLRTYLDK-APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-----YSYQMALTPVVVTLWYRAPEVLL----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----PVQSVVPEMEESGAQLLLEMLTFNPHK--RISAFRALQHSYL
--YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGH-RSE---AKDGINRTALREIKLLQELS---HPNIIGLLDAFGH--------KSNISLVFDFMET-DLEVIIK--DNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF----GSPNRAYTHQVVTRWYRAPELLF---GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG----IPLHHIFSAAGDDLLDLIQGLFLFNPCA--RITATQALKMKYF
--YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKE---GFPITALR---EIKILQLLK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL---GERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQ--RIDSDDALNHDFF
YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSL-LLK---PHQREKMS--MEISIHRSLA---HQHVVGFHGFFED--------NDFVFVVLELCRRRSLLELHK---RRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV----EYDGERKKTLCGTPNYIAPEVLS----KKGHSFEVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIKKNEYSIPKHIN-----------------------------PVAASLIQKMLQTDPTA--RPTINELLNDEFF
--YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFE-MIK---RSDSAFFW--EERDIMAFAN---SPWVVQLFYAFQD--------DRYLYMVMEYMPGGDLVNLMS----NYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKM---NKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMNHKNSLTFPDDNDIS-------------------------KEAKNLICAFLTDREVRLGRNGVEEIKRHLFF
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