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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
CAMK CHEK1 9
TK FGFR2 481
TK MET 1078
TK PTK2 422
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETEGV--PSTAIREISLLKEL-NHPNIVKLLDVIH-TENKLYLVFEFLHQ-DLKKFMDA-SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF---GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-REPPFYIITEFMTYGNLLDYLR----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM---T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
-FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKAGV--EHQLRREVEIQSHL-RHPNILRLYGYFH-DATRVYLILEYAPLGTVYRELQ---KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV-----HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
-YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLM-QDSRLYLIFEFLSM-DLKKYLDSIPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKR-AVDCP--ENI-KKEICINKML-NHENVVKFYGHRR-EGNIQYLFLEYCSGGELFDRIE---PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFR-YNNRERLL--NK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
-LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLSDLV-SEMEMMKMIGKHKNIINLLGACT-QDGPLYVIVEYASKGNLREYLR----ARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDI-N-N--IDYY--KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT----------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-RI-TD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR----NE---------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDM-Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCK-NC-TS-DSVREKFL-QEALTMRQF-DHPHIVKLIGVIT--ENPVWIIMELCTLGELRSFLQ----VR---------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM---E--DSTY--YKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP----------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL---
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLK----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI---E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
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