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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK5 4
Other CHUK 15
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC GSK3B 56
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
TK MET 1078
TK SRC 270
-FQKVEKIGEGTYGVVYKARNK----L-T-GE-VVALKKIRLDTETEGV--PSTAIREISLLKEL-N-----HPN-----IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAI-------------------KLADFGLARAF-----GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
-ITMKHKLGGGQYGEVYEGVWK----K-Y-SL-TVAVKTLK-EDTM-EV--EEFL-KEAAVMKEI-K-----HPN-----LVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEV---NAVVLLYMATQISSAMEYLEK--KNFIHRDLAARNCLVG--ENHLV-------------------KVADFGLSRLM-----T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-----------DLSQVYELLEKDYRMERPEGCP---------------------------------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---------
-YTKIEKIGEGTYGVVYKGRHK----T-T-GQ-VVAMKKIRLESEEEGV--PSTAIREISLLKEL-R-----HPN-----IVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLLID--DKGTI-------------------KLADFGLARAF-----GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
-YEKLEKIGEGTYGTVFKAKNR----E-T-HE-IVALKRVRLDDDDEGV--PSSALREICLLKEL-K-----HKN-----IVRLHDVLH--S------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLLIN--RNGEL-------------------KLADFGLARAF-----GIPVRCY--SA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF---------
W-EMRERLGTGGFGNVCLYQHR----E-L-DL-KIAIKSCRLELSTKNR--ER-WCHEIQIMKKL-N-----HAN-----VVKACDVPE--ELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC---GL---KESQILSLLSDIGSGIRYLHE--NKIIHRDLKPENIVLQ--DVGGKI----------------IHKIIDLGYAKD------VDQGSLC--TS---FVGTLQYLAPELFE-NKPYTATVDYWSFGTMVFECIA-GYRP---------------FLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS---------------------------------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
-YEIVDTLGEGAFGKVVECIDH----K-AGGR-HVAVKIVKNVDRYCEA--ARS---EIQVLEHL-NT---TDPNST-FRCVQMLEWFE--H------HGHIC--IVFELLGL---STYDFIK----ENG---FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENILFV--QSDYTEAYNPKIKRDERTLINPDIKVVDFGSA--------TYDDEHH--ST---LVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FPTH-----------DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF---------
-YEIVSTLGEGTFGRVVQCVDH----R-R-GGARVALKIIKNVEKYKEA--AR---LEINVLEKI-NEKDPDNKN----LCVQMFDWFD--Y------HGHMC--ISFELLGL---STFDFLK----DNN---YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENILFV--NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT--------FDHEHH--ST---IVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYV-GFTL---------------FQTH-----------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF---------
-YEIVDTLGEGAFGKVVECIDH----GMD-GM-HVAVKIVKNVGRYREA--ARS---EIQVLEHL-NS---TDPNSV-FRCVQMLEWFD--H------HGHVC--IVFELLGL---STYDFIK----ENS---FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENILFV--KSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA--------TYDDEHH--ST---LVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FQTH-----------DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF---------
-YEIDSLIGKGSFGQVVKAYDR----V-E-QE-WVAIKIIKNKKAFLNQ--AQI---EVRLLELMNK-----HDTEMKYYIVHLKRHFM--F------RNHLC--LVFEMLSY---NLYDLLR-----NT---NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ--------LGQRI--YQ---YIQSRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHT-GEPL---------------FSGA-----------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF---------
-YEIDSLIGKGSFGQVVKAYDH----Q-T-QE-LVAIKIIKNKKAFLNQ--AQI---ELRLLELMNQ-----HDTEMKYYIVHLKRHFM--F------RNHLC--LVFELLSY---NLYDLLR-----NT---HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAI-------------------KIVDFGSSCQ--------LGQRI--YQ---YIQSRFYRSPEVLL-GTPYDLAIDMWSLGCILVEMHT-GEPL---------------FSGS-----------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF---------
-YTDTKVIGNGSFGVVYQAKLC----D-S-GE-LVAIKKVLQDKRFKNR--------ELQIMRKL-D-----HCN-----IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVL-------------------KLCDFGSAKQ------LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---------
-LKFLQQLGKGNFGSVEMCRYDPLQDN-T-GE-VVAVKKLQ-HSTE--EHLRDFE-REIEILKSL-Q-----HDN-----IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNILVE--NENRV-------------------KIGDFGLTKVL-PQ--D--KEYY--KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-----------IVFHLIELLKNNGRLPRPDGCP---------------------------------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-------
L-KYISQLGKGNFGSVELCRYDPLGDN-T-GA-LVAVKQLQ-HSGP-DQ-QRDFQ-REIQILKAL-H-----SDF-----IVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-RARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNILVE--SEAHV-------------------KIADFGLAKLL-PL--D--KDYY--VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P---------ALCRLLELLEEGQRLPAPPACP---------------------------------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL--------
-LKLVERLGAGQFGEVWMGYYN------G-HT-KVAVKSLK-QGSM-SP--DAFL-AEANLMKQL-Q-----HQR-----LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKL---TINKLLDMAAQIAEGMAFIEE--RNYIHRDLRAANILVS--DTLSC-------------------KIADFGLARLI-----E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-----------TNPEVIQNLERGYRMVRPDNCP---------------------------------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
-YTNLSYIGEGAYGMVCSAYDN----V-N-KV-RVAIKKISPFEHQTYC--QRT-LREIKILLRF-R-----HEN-----IIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLN--TTCDL-------------------KICDFGLARVAD--PDHDHTGFL--TE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-----------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN---------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL---------
-YQNLKPIGSGAQGIVCAAYDA----V-L-DR-NVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-N-----HKN-----IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK--SDCTL-------------------KILDFGLART------AGTSFMM--TP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI---------
-VHFNEVIGRGHFGCVYHGTLL-DNDG-K-KI-HCAVKSLN-RITD-IGEVSQFL-TEGIIMKDF-S-----HPN-----VLSLLGICL-RS------EGSPL--VVLPYMKHG--DLRNFIR-----NE-THNP---TVKDLIGFGLQVAKGMKYLAS--KKFVHRDLAARNCMLD--EKFTV-------------------KVADFGLARDM--Y--D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-----------NTFDITVYLLQGRRLLQPEYCP---------------------------------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I---------
L-RLEVKLGQGCFGEVWMGTWN------G-TT-RVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-R-----HEK-----LVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYL---RLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVG--ENLVC-------------------KVADFGLARLI-----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-----------VNREVLDQVERGYRMPCPPECP---------------------------------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
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