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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDKL1 5
TK FGFR1 478
CMGC GSK3B 56
TK HCK 241
TK JAK2 849
TK JAK3 822
TK LCK 245
TK LYN 247
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
TK MET 1078
AGC PDPK1 82
Other PLK1 53
Other PLK2 82
Other PLK3 62
TK PTK6 191
TK SRC 270
--FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDT-ETE---GV--PS-TAIR-EISLLKEL-N---HPNIVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTY--TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
--ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-ED-TM----EV--EE-FL-K-EAAVMKEI-K---HPNLVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM----T--GDTY--TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-----------
--FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKAQLEKA---GV--EH-QLRR-EVEIQSHL-R---HPNILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV------HAPSSRR--TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
--FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKSQ-IEK---EG--VE-HQLRREIEIQAHL-H---HPNILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV------HAPSLRR--KT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
--YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLES-EEE---GV--PS-TAIR-EISLLKEL-R---HPNIVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-----------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF----GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
-Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVPN-GGGGGGGL--PI-STVR-EVALLRRL-EAFEHPNVVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI-----YSYQMAL--TP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-----------
--YEKLEKIGEGTYGTVFKAKNR-------ETHEIVALKRVRLDD-DDE---GV--PS-SALR-EICLLKEL-K---HKNIVRLHDVLH--S------DKKLT--LVFEFCDQ---DLKKYFD---SCNG-----------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAF----GIPVRCY--SA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-----------
--YEKIGKIGEGSYGVVFKCRNR-------DTGQIVAIKKFLESE-DDP---VI--KK-IALR-EIRMLKQL-K---HPNLVNLLEVFR--R------KRRLH--LVFEYCDHT--VLHELDR----YQR-----------------GVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLL----AGPSDYY--TD---YVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS-GVPL---------------WPGK-SDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED-----------MEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF-----------
-L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SD-AT----EKDLSD-LI-S-EMEMMKMIGK---HKNIINLLGACT--Q------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDI--H-H--IDYY--KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-------------
--YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDK-RFK---NR----------ELQIMRKL-D---HCNIVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPN--VS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
--LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PG-SM----SV--EA-FL-A-EANVMKTL-Q---HDKLVKLHAVVT---------KEPIY--IITEFMAKG--SLLDFLK-----SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM-SNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L-----------
--LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQ-HS-TE-----EHLRD-FE-R-EIEILKSL-Q---HDNIVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVL-PQ-D--KEYY--KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
-L-KYISQLGKGNFGSVELCRYDP---LGDNTGALVAVKQLQ-HS-GP----DQ-QRD-FQ-R-EIQILKAL-H---SDFIVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLL-PL-D--KDYY--VVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP-----------------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
--LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QG-SM----SP--DA-FL-A-EANLMKQL-Q---HQRLVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEY--TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-----------
--IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-PG-TM----SV--QA-FL-E-EANLMKTL-Q---HDKLVRLYAVVT--R------EEPIY--IITEYMAKG--SLLDFLK-----SD--------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMCKIADFGLARVI----E--DNEY--TAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGR-TNADVMTALSQGYRMPRVENCP-----------------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L-----------
--YQNLKPIGSGAQGIVCAAYDA-------VLDRNVAIKKLSRPF-QNQ---TH--AK-RAYR-ELVLMKCV-N---HKNIISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMM--TP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKIL---------------FPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-----------
--YQNLKPIGSGAQGIVCAAYDA-------ILERNVAIKKLSRPF-QNQ---TH--AK-RAYR-ELVLMKCV-N---HKNIIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----AGTSFMM--TP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FPGR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-----------
--YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRPF-QNQ---TH--AK-RAYR-ELVLLKCV-N---HKNIISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----ACTNFMM--TP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVI---------------FQGT-DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI-----------
--VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-RI-TD----IGEVSQ-FL-T-EGIIMKDF-S---HPNVLSLLGICL-RS------EGSPL--VVLPYMKHG--DLRNFIR-----NE---------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDM--Y-D--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPP---------------YPDV-NTFDITVYLLQGRRLLQPEYCP-----------------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-----------
-F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRH-IIK---EN--KVPYVTR-ERDVMSRL-D---HPFFVKLYFTFQ--D------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS--PESKQARA--NS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSL-LLK---PH--QR-EKMSMEISIHRSL-A---HQHVVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERK--KT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS----CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-----------
-Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHSR-VAK---PH--QR-EKIDKEIELHRIL-H---HKHVVQFYHYFE--D------KENIY--ILLEYCSRR--SMAHILK----ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-EAMELKVGDFGLAARL----EPLEHRR--RT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPP---------------FETT----NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-----------
YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSR-VAK---PH--QR-EKILNEIELHRDL-Q---HRHIVRFSHHFE--D------ADNIY--IFLELCSRK--SLAHIWK----ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMELKVGDFGLAARL----EPPEQRK--KT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPP---------------FETA----DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-----------
-F-TLCRKLGSGYFGEVFEGLWK--------DRVQVAIKVIS-RD-NL----LH-QQM-LQ-S-EIQAMKKL-R---HKHILALYAVVS--V------GDPVY--IITELMAKG--SLLELLR-----DS--------------DEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLI-------KEDV--YLSHDHNIPYKWTAPEALS-RGHYSTKSDVWSFGILLHEMFSRGQVP---------------YPGM-SNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPCFKALRERL-------------
-L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PG-TM----SP--EA-FL-Q-EAQVMKKL-R---HEKLVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEY--TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-----------
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