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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
TK BMX 422
CMGC CDK4 6
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CLK3 156
CMGC CLK4 159
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
TK FER 563
TK FGFR1 478
TK FYN 271
CMGC GSK3A 119
CMGC GSK3B 56
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
TKL MAP3K11 117
TKL MAP3K9 144
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCA 339
AGC PRKCD 349
AGC ROCK1 76
AGC ROCK2 92
STE SLK 34
TK SRC 270
CAMK STK33 116
TK TNK2 150
TK YES1 277
---FQKVEKIGEGTYGVVYKARNK-------L-TGE-VVALKKIRLD--T-ETE---GV-----P-S-TAIR------EISLLKEL--N---HPN----IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------------GI---PLPLIKSYLFQLLQGLAFCHS-H---R---VLHRDLKPQNLLIN-T--------EGAI--------------------KLADFGLARAF----GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-----------SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF--------------
---ITMKHKLGGGQYGEVYVGVWK-------K-YSL-TVAVKTLK-E--D-TM----EV-----E-E-FL-K------EAAVMKEI--K---HPN----LVQLLGVCT--L------EPPFY--IVTEYMPYG--NLLDYLR-----EC--------------NREEV---TAVVLLYMATQISSAMEYLEK-K---N---FIHRDLAARNCLVG-E--------NHVV--------------------KVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNTFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI-----------DLSQVYDLL-EKGYRMEQPEGCP-------------------------------------------PKVYELMRACWKWSPAD--RPS-----FAETHQA--F--------------
--F-EYLKLLGKGTFGKVILVKEK-------A-TGR-YYAMKILKKE--V-IVA---KD-----E-V-AHTL-----TENRVLQNS--R---HPF----LTALKYSFQ--T------HDRLC--FVMEYANGG--ELFFHLS----RER-----------------VF---SEDRARFYGAEIVSALDYLHSEK---N---VVYRDLKLENLMLD-K--------DGHI--------------------KITDFGLCKEG----IKDGATM--------------KT---FCGTPEYLAPEVLE-----DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FY-NQ--------------DHEKLF-ELILMEEIRFPRTLG-----------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF--------------
---FEIGRPLGKGKFGNVYLAREK-------Q-SKF-ILALKVLFKA--QLEKA---GV-----E-H-QLRR------EVEIQSHL--R---HPN----ILRLYGYFH--D------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------------KF---DEQRTATYITELANALSYCHS-K---R---VIHRDIKPENLLLG-S--------AGEL--------------------KIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FE-AN--------------TYQETY-KRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI--------------
---FEIGRPLGKGKFGNVYLAREK-------K-SHF-IVALKVLFKS--Q-IEK---EG-----V-E-HQLR-----REIEIQAHL--H---HPN----ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------------TF---DEQRTATIMEELADALMYCHG-K---K---VIHRDIKPENLLLG-L--------KGEL--------------------KIADFGWSV------HAPSLRR--------------KT---MCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA--------------SHNETY-RRIVKVDLKFPASVP-----------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV--------------
---ITLLKELGSGQFGVVQLGKWK---------GQY-DVAVKMIK-E--G-SM----SE-----D-E-FF-Q------EAQTMMKL--S---HPK----LVKFYGVCS--K------EYPIY--IVTEYISNG--CLLNYLR-----SH---------------GKGL---EPSQLLEMCYDVCEGMAFLES-H---Q---FIHRDLAARNCLVD-R--------DLCV--------------------KVSDFGMTRYV----L--DDQY--------------VSSVGTKFPVKWSAPEVFH-----YFKYSSKSDVWAFGILMWEVFSLGKQP---------------YD-LY-----------DNSQVVLKV-SQGHRLYRPHLAS-------------------------------------------DTIYQIMYSCWHELPEK--RPT-----FQQLLSS--I--------------
--Y-EPVAEIGVGAYGTVYKARDP-------H-SGH-FVALKSVRVP--N-GGGGGGGL-----P-I-STVR------EVALLRRL--EAFEHPN----VVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-----------------GL---PAETIKDLMRQFLRGLDFLHA-N---C---IVHRDLKPENILVT-S--------GGTV--------------------KLADFGLARI-----YSYQMAL--------------TP---VVVTLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-----------SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-----------------PVQSVVPEMEESGAQLLLEMLTFNPHK--RIS-----AFRALQHSYL--------------
--W-DLVQTLGEGAYGEVQLAVNR-------V-TEE-AVAVKIVDMK--R-AVD---CP-----E-N-I-KK------EICINKML--N---HEN----VVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI-----------------GM---PEPDAQRFFHQLMAGVVYLHG-I---G---ITHRDIKPENLLLD-E--------RDNL--------------------KISDFGLATVFR--YNNRERLL--------------NK---MCGTLPYVAPELLK----RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP-------------SDSCQEY-SDWKEKKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSA--RIT-----IPDIKKDRW-Y-------------
-YI--MSKTLGSGACGEVKLAFER-------K-TCK-KVAIKIISKR--K-FAI---GS-----A-R-EADPALNVETEIEILKKL--N---HPC----IIKIKNFF---D------AEDYY--IVLELMEGG--ELFDKVV----GNK-----------------RL---KEATCKLYFYQMLLAVQYLHE-N---G---IIHRDLKPENVLLS-S--------QEEDC-----------------LIKITDFGHSKI-----LGETSLM--------------RT---LCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FS-EH-------------RTQVSLK-DQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL--------------
--W-EMRERLGTGGFGNVCLYQHR-------E-LDL-KIAIKSCRLE--L-STK---NR-----E-R--WCH------EIQIMKKL--N---HAN----VVKACDVPE--ELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC-----------------GL---KESQILSLLSDIGSGIRYLHE-N---K---IIHRDLKPENIVLQ-D--------VGGKI-----------------IHKIIDLGYAKD-----VDQGSLC--------------TS---FVGTLQYLAPELFE-----NKPYTATVDYWSFGTMVFECIA-GYRP---------------FL-HHLQPFTWHEKIKKKDPKCIFA-CEEMSGEVRFSSHLPQPNSLCS-------------------------------LVVEPMENWLQLMLNWDPQQ--RG----------------GPVDLTLKQ-----
---YEIVGNLGEGTFGKVVECLDH-------A-RGKSQVALKIIRNV--G-KYR---EA-----A-R----L------EINVLKKI--KEKDKENK-FLCVLMSDWFN--F------HGHMC--IAFELLGK---NTFEFLK-----EN-----------------NFQPYPLPHVRHMAYQLCHALRFLHE-N---Q---LTHTDLKPENILFV-N--------SE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-------FDHEHH--------------TT---IVATRHYRPPEVIL-----ELGWAQPCDVWSIGCILFEYYR-GFTL---------------FQ-TH-----------ENREHLVMM-EKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQ--RIT-----LAEALLHPFF--------------
---YEIVDTLGEGAFGKVVECIDH-------GMDGM-HVAVKIVKNV--G-RYR---EA-----A-R-S---------EIQVLEHL--NS-TDPNSVFRCVQMLEWFD--H------HGHVC--IVFELLGL---STYDFIK----ENS-----------------FLP-FQIDHIRQMAYQICQSINFLHH-N---K---LTHTDLKPENILFV-K--------SDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA-------TYDDEHH--------------ST---LVSTRHYRAPEVIL-----ALGWSQPCDVWSIGCILIEYYL-GFTV---------------FQ-TH-----------DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQ--RIT-----LDEALQHPFF--------------
---YQLVRKLGRGKYSEVFEAINI-------T-NNE-KVVVKILKPV--K-KKK---IK-----R-------------EIKILENL-RG---GPN----IITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-----------------TL---TDYDIRFYMYEILKALDYCHS-M---G---IMHRDVKPHNVMIDHE--------HRKL--------------------RLIDWGLAEF-----YHPGQEY--------------NV---RVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-----------DNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQS--RLT-----AREAMEHPYF--------------
---YQLVRKLGRGKYSEVFEAINI-------T-NNE-RVVVKILKPV--K-KKK---IK-----R-------------EVKILENL-RG---GTN----IIKLIDTVK--DP----VSKTPA--LVFEYINNT--DFKQLY-------Q-----------------IL---TDFDIRFYMYELLKALDYCHS-K---G---IMHRDVKPHNVMIDHQ--------QKKL--------------------RLIDWGLAEF-----YHPAQEY--------------NV---RVASRYFKGPELLV----DYQMYDYSLDMWSLGCMLASMIF-RREP---------------FFHGQ-----------DNYDQLVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQ--RLT-----AKEAMEHPYF--------------
---YDTGEELGSGQFAVVKKCREK-------S-TGL-QYAAKFIKKR--R-TKS---SR-----R-G-VSREDI--EREVSILKEI--Q---HPN----VITLHEVYE--N------KTDVI--LILELVAGG--ELFDFLA----EKE-----------------SL---TEEEATEFLKQILNGVYYLHS-L---Q---IAHFDLKPENIMLL-D--------RNVPKP----------------RIKIIDFGLAHK-----IDFGNEF--------------KN---IFGTPEFVAPEIVN-----YEPLGLEADMWSIGVITYILLS-GASP---------------FL-GD--------------TKQETL-ANVSAVNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKK--RMT-----IQDSLQHPWI--------------
-VI--LGELLGKGNFGEVYKGTLK---------DKT-SVAVKTCK-E--D-LP----QEL---KI-K-FL-Q------EAKILKQY--D---HPN----IVKLIGVCT--Q------RQPVY--IIMELVSGG--DFLTFLR-----RK---------------KDEL---KLKQLVKFSLDAAAGMLYLES-K---N---CIHRDLAARNCLVG-E--------NNVL--------------------KISDFGMSRQE----D--GGVY--------------SSSGLKQIPIKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGVCP---------------YP-GM-----------TNQQAREQV-ERGYRMSAPQHCP-------------------------------------------EDISKIMMKCWDYKPEN--RPK-----FSELQKEL----------------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPN-RVT-KVAVKMLK-S--D-AT----EKD---LS-D-LI-S------EMEMMKMIG-K---HKN----IINLLGACT--Q------DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEYCYNPSHNPEEQL---SSKDLVSCAYQVARGMEYLAS-K---K---CIHRDLAARNVLVT-E--------DNVM--------------------KIADFGLARDI--H-H--IDYY--------------KKTTNGRLPVKWMAPEALF-----DRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YP-GV-----------PVEELFKLL-KEGHRMDKPSNCT-------------------------------------------NELYMMMRDCWHAVPSQ--RPT-----FKQLVEDL----------------
---LQLIKRLGNGQFGEVWMGTWN---------GNT-KVAIKTLK-P--G-TM----SP-----E-S-FL-E------EAQIMKKL--K---HDK----LVQLYAVVS---------EEPIY--IVTEYMNKG--SLLDFLK-----DG--------------EGRAL---KLPNLVDMAAQVAAGMAYIER-M---N---YIHRDLRSANILVG-N--------GLIC--------------------KIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELVTKGRVP---------------YP-GM-----------NNREVLEQV-ERGYRMPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEE--RPT-----FEYLQSFL----------------
---YTDIKVIGNGSFGVVYQARLA-------E-TRE-LVAIKKVLQD--K-RFK---NR-------------------ELQIMRKL--D---HCN----IVRLRYFFY--SSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------------TI---PILYVKVYMYQLFRSLAYIHS-Q---G---VCHRDIKPQNLLVDPD--------TAVL--------------------KLCDFGSAKQ-----LVRGEPN--------------VS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF--------------
---YTDTKVIGNGSFGVVYQAKLC-------D-SGE-LVAIKKVLQD--K-RFK---NR-------------------ELQIMRKL--D---HCN----IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------------TL---PVIYVKLYMYQLFRSLAYIHS-F---G---ICHRDIKPQNLLLDPD--------TAVL--------------------KLCDFGSAKQ-----LVRGEPN--------------VS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-----------SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF--------------
VGG----NKMGEGGFGVVYKGYVN-------N-TT---VAVKKLAAM--V-DIT---TE-----ELK-QQFD-----QEIKVMAKC--Q---HEN----LVELLGFSS--D------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-----------------PL---SWHMRCKIAQGAANGINFLHE-N---H---HIHRDIKSANILLD-E--------AFTA--------------------KISDFGLARASE--KFAQTVMT--------------SR---IVGTTAYMAPEALR------GEITPKSDIYSFGVVLLEIIT-GLPA---------------VD-EH-----------REPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNK--RPD-----IKKVQQ----LLQ-----------
---LTFVQEIGSGQFGLVHLGYWL---------NKD-KVAIKTIR-E--G-AM----SE-----E-D-FI-E------EAEVMMKL--S---HPK----LVQLYGVCL--E------QAPIC--LVFEFMEHG--CLSDYLR-----TQ---------------RGLF---AAETLLGMCLDVCEGMAYLEE-A---C---VIHRDLAARNCLVG-E--------NQVI--------------------KVSDFGMTRFV----L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YE-NR-----------SNSEVVEDI-STGFRLYKPRLAS-------------------------------------------THVYQIMNHCWKERPED--RPA-----FSRLLRQL----------------
---LKFLQQLGKGNFGSVEMCRYDP---LQDN-TGE-VVAVKKLQ-H--S-TE-----EH---LR-D-FE-R------EIEILKSL--Q---HDN----IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH---------------KERI---DHIKLLQYTSQICKGMEYLGT-K---R---YIHRDLATRNILVE-N--------ENRV--------------------KIGDFGLTKVL-PQ-D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-----------IVFHLIELL-KNNGRLPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQ--RPS-----FRDLA----LRV------------
--L-KYISQLGKGNFGSVELCRYDP---LGDN-TGA-LVAVKQLQ-H--S-GP----DQ----QR-D-FQ-R------EIQILKAL--H---SDF----IVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH---------------RARL---DASRLLLYSSQICKGMEYLGS-R---R---CVHRDLAARNILVE-S--------EAHV--------------------KIADFGLAKLL-PL-D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DV-P---------ALCRLLELL-EEGQRLPAPPACP-------------------------------------------AEVHELMKLCWAPSPQD--RPS-----FSALGP---QL-------------
---LKLVERLGAGQFGEVWMGYYN---------GHT-KVAVKSLK-Q--G-SM----SP-----D-A-FL-A------EANLMKQL--Q---HQR----LVRLYAVVT---------QEPIY--IITEYMENG--SLVDFLK-----TP--------------SGIKL---TINKLLDMAAQIAEGMAFIEE-R---N---YIHRDLRAANILVS-D--------TLSC--------------------KIADFGLARLI----E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YP-GM-----------TNPEVIQNL-ERGYRMVRPDNCP-------------------------------------------EELYQLMRLCWKERPED--RPT-----FDYLRSV--L--------------
---LRLEEVIGIGGFGKVYRGSWR----------GE-LVAVKAAR-Q--D-PD----EDISVTAE-S-VR-Q------EARLFAML--A---HPN----IIALKAVCL--E------EPNLC--LVMEYAAGG--PLSRALA-----GR-----------------RV---PPHVLVNWAVQIARGMHYLHC-E---ALVPVIHRDLKSNNILLL-QPIESDDMEHKTL--------------------KITDFGLAREW---------HK--------------TTQMSAAGTYAWMAPEVIK-----ASTFSKGSDVWSFGVLLWELLT-GEVP---------------YR-GI-----------DCLAVAYGVAVNKLTLPIPSTCP-------------------------------------------EPFAQLMADCWAQDPHR--RPD-----FASILQQL----------------
--L-TLEEIIGIGGFGKVYRAFWI-------G-DE---VAVKAARHDP-D-EDI---SQ-----T-I-ENVR-----QEAKLFAML--K---HPN----IIALRGVCL--K------EPNLC--LVMEFARGG--PLNRVLS-----GK-----------------RI---PPDILVNWAVQIARGMNYLHD-EAIVP---IIHRDLKSSNILIL-Q--------KVENGDLS------------NKILKITDFGLAR------EWHRTTK--------------MS---AAGTYAWMAPEVIR-----ASMFSKGSDVWSYGVLLWELLT-GEVP---------------FR-GI--------------DGLAVA-YGVAMNKLALPIPSTCP---------------------------------------EPFAKLMEDCWNPDPHS--RPS-----FTNILDQ---LT------------
---YQNLSPVGSGAYGSVCAAFDT-------K-TGL-RVAVKKLSRP--F-QSI---IH-----A-K-RTYR------ELRLLKHM--K---HEN----VIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------------KL---TDDHVQFLIYQILRGLKYIHS-A---D---IIHRDLKPSNLAVN-E--------DCEL--------------------KILDFGLAR-------HTDDEM--------------TG---YVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-----------DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF--------------
---YQNLKPIGSGAQGIVCAAYDA-------I-LER-NVAIKKLSRP--F-QNQ---TH-----A-K-RAYR------ELVLMKCV--N---HKN----IIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-----------------EL---DHERMSYLLYQMLCGIKHLHS-A---G---IIHRDLKPSNIVVK-S--------DCTL--------------------KILDFGLART-----AGTSFMM--------------TP---YVVTRYYRAPEVIL-----GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR-----------DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK--LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASK--RIS-----VDEALQHPYI--------------
---YQQLKPIGSGAQGIVCAAFDT-------V-LGI-NVAVKKLSRP--F-QNQ---TH-----A-K-RAYR------ELVLLKCV--N---HKN----IISLLNVFT--PQKTLEEFQDVY--LVMELMDA---NLCQVIH------M-----------------EL---DHERMSYLLYQMLCGIKHLHS-A---G---IIHRDLKPSNIVVK-S--------DCTL--------------------KILDFGLART-----ACTNFMM--------------TP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGELVK-GCVI---------------FQ-GT-----------DHIDQWNKV-IEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE--LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDK--RIS-----VDEALRHPYI--------------
--I-VLKRELGEGAFGKVFLAECYN--LCPEQ-DKI-LVAVKTLK-D--A-SD----NA----RK-D-FH-R------EAELLTNL--Q---HEH----IVKFYGVCV--E------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV---LMAEGNPPTEL---TQSQMLHIAQQIAAGMVYLAS-Q---H---FVHRDLATRNCLVG-E--------NLLV--------------------KIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSLGVVLWEIFTYGKQP---------------WY-QL-----------SNNEVIECI-TQGRVLQRPRTCP-------------------------------------------QEVYELMLGCWQREPHM--RKN-----IKGIHTL--L--------------
--I-VLKRELGEGAFGKVFLAECYN--LSPTK-DKM-LVAVKALK-D--P-TL----AA----RK-D-FQ-R------EAELLTNL--Q---HEH----IVKFYGVCG--D------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMILVDGQPRQAKGEL---GLSQMLHIASQIASGMVYLAS-Q---H---FVHRDLATRNCLVG-A--------NLLV--------------------KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRKFTTESDVWSFGVILWEIFTYGKQP---------------WF-QL-----------SNTEVIECI-TQGRVLERPRVCP-------------------------------------------KEVYDVMLGCWQREPQQ--RLN-----IKEIYKIL----------------
---YELQETLGKGTYGKVKRATER-------F-SGR-VVAIKSIRKD--K-IKD---EQ-----D-M-VHIR-----REIEIMSSL--N---HPH----IISIYEVFE--N------KDKIV--IIMEYASKG--ELYDYIS----ERR-----------------RL---SERETRHFFRQIVSAVHYCHK-N---G---VVHRDLKLENILLD-D--------NCNI--------------------KIADFGLSNL-----YQKDKFL--------------QT---FCGSPLYASPEIVN----GRPYRGPEVDSWALGVLLYTLVY-GTMP---------------FD-GF--------------DHKNLI-RQISSGEYREPTQP------------------------------------------SDARGLIRWMLMVNPDR--RAT-----IEDIANHWW-V-------------
--F-KFGKILGEGSFSTVVLAREL-------A-TSR-EYAIKILEKR--H-IIK---EN-----K-VPYVTR------ERDVMSRL--D---HPF----FVKLYFTFQ--D------DEKLY--FGLSYAKNG--ELLKYIR----KIG-----------------SF---DETCTRFYTAEIVSALEYLHG-K---G---IIHRDLKPENILLN-E--------DMHI--------------------QITDFGTAKVLS--PESKQARA--------------NS---FVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG--------------NEYLIF-QKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATK--RLG-----CEEM------EGYGPLKAHPF---
---YQVGPLLGSGGFGSVYSGIRV-------S-DNL-PVAIKHVEKD--R-ISD---WG-----E-L-PNGTRV--PMEVVLLKKV--S---SGFS--GVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG-----------------AL---QEELARSFFWQVLEAVRHCHN-C---G---VLHRDIKDENILIDLN--------RGEL--------------------KLIDFGSGA------LLKDTVY--------------TD---FDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FE-HD---------------------EEIIRGQVFFRQRVS-----------------------------------------SECQHLIRWCLALRPSD--RPT-----FEEIQNHPWM--------------
-YV--RGRFLGKGGFAKCFEISDA-------D-TKE-VFAGKIVPKS--L-LLK---PH-----Q-R-EKMS-----MEISIHRSL--A---HQH----VVGFHGFFE--D------NDFVF--VVLELCRRR--SLLELHK----RRK-----------------AL---TEPEARYYLRQIVLGCQYLHR-N---R---VIHRDLKLGNLFLN-E--------DLEV--------------------KIGDFGLATKV----EYDGERK--------------KT---LCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FE-TS--------------CLKETY-LRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF--------------
--F-NFLMVLGKGSFGKVMLADRK-------G-TEE-LYAIKILKKD--V-VIQ---DD-----D-V-ECTM-----VEKRVLALL-DK---PPF----LTQLHSCFQ--T------VDRLY--FVMEYVNGG--DLMYHIQ----QVG-----------------KF---KEPQAVFYAAEISIGLFFLHK-R---G---IIYRDLKLDNVMLD-S--------EGHI--------------------KIADFGMCKEH----MMDGVTT--------------RT---FCGTPDYIAPEIIA-----YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FD-GE--------------DEDELF-QSIMEHNVSYPKSLS-----------------------------------------KEAVSVCKGLMTKHPAK--RLG-----C---------GPEGERDVREHAFF
-FI--FHKVLGKGSFGKVLLGELK-------G-RGE-YFAIKALKKD--V-VLI---DD-----D-V-ECTM-----VEKRVLTLA-AE---NPF----LTHLICTFQ--T------KDHLF--FVMEFLNGG--DLMYHIQ----DKG-----------------RF---ELYRATFYAAEIMCGLQFLHS-K---G---IIYRDLKLDNVLLD-R--------DGHI--------------------KIADFGMCKEN----IFGESRA--------------ST---FCGTPDYIAPEILQ-----GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD--------------DEDELF-ESIRVDTPHYPRWIT-----------------------------------------KESKDILEKLFEREPTK--RLG----VTGNIKIHPFF--------------
---YEVVKVIGRGAFGEVQLVRHK-------S-TRK-VYAMKLLSKF--E-MIK---RS-----D-S-AFFW-----EERDIMAFA--N---SPW----VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DV---PEKWARFYTAEVVLALDAIHS-M---G---FIHRDVKPDNMLLD-K--------SGHL--------------------KLADFGTCMKM---NKEGMVRC--------------DT---AVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD--------------SLVGTY-SKIMNHKNSLTFPDDNDIS-------------------------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF--------------
---YDVVKVIGRGAFGEVQLVRHK-------A-SQK-VYAMKLLSKF--E-MIK---RS-----D-S-AFFW-----EERDIMAFA--N---SPW----VVQLFYAFQ--D------DRYLY--MVMEYMPGG--DLVNLMS-----NY-----------------DV---PEKWAKFYTAEVVLALDAIHS-M---G---LIHRDVKPDNMLLD-K--------HGHL--------------------KLADFGTCMKM---DETGMVHC--------------DT---AVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLV-GDTP---------------FY-AD--------------SLVGTY-SKIMDHKNSLCFPEDAEIS-------------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF--------------
---WEIIGELGDGAFGKVYKAQNK-------E-TSV-LAAAKVIDTK--S-EEE---LE-----D-Y-M--V------EIDILASC--D---HPN----IVKLLDAFY--Y------ENNLW--ILIEFCAGG--AVDAVML---ELER-----------------PL---TESQIQVVCKQTLDALNYLHD-N---K---IIHRDLKAGNILFT-L--------DGDI--------------------KLADFGVSAKN----TRTIQRR--------------DS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IEPP---------------HH-EL-----------NPMRVLLKI-AKSEPPTLAQPSRWS-----------------------------------------SNFKDFLKKCLEKNVDA--RWT-----TSQLLQHPFV--------------
--L-RLEVKLGQGCFGEVWMGTWN---------GTT-RVAIKTLK-P--G-TM----SP-----E-A-FL-Q------EAQVMKKL--R---HEK----LVQLYAVVS---------EEPIY--IVTEYMSKG--SLLDFLK-----GE--------------TGKYL---RLPQLVDMAAQIASGMAYVER-M---N---YVHRDLRAANILVG-E--------NLVC--------------------KVADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGRVP---------------YP-GM-----------VNREVLDQV-ERGYRMPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEE--RPT-----FEYLQAF--L--------------
---YTFGRILGKGSFGIVIEATDK-------E-TET-KWAIKKVNKE--K-AGS---SA-----V-K-LLER------EVNILKSV--K---HEH----IIHLEQVFE--T------PKKMY--LVMELCEDG--ELKEILD----RKG-----------------HF---SENETRWIIQSLASAIAYLHN-N---D---IVHRDLKLENIMVK-S--------SLIDDNNE-----------INLNIKVTDFGLAVKK---QSRSEAML--------------QA---TCGTPIYMAPEVIS-----AHDYSQQCDIWSIGVVMYMLLR-GEPP---------------FL-AS--------------SEEKLF-ELIRKGELHFENAVWNSIS-------------------------------------DCAKSVLKQLMKVDPAH--RIT-----AKELLDNQWL--------------
--L-RLLEKLGDGSFGVVRRGEWD----APSG-KTV-SVAVKCLK-PDVL-SQ----PEA---MD-D-FI-R------EVNAMHSL--D---HRN----LIRLYGVVL---------TPPMK--MVTELAPLG--SLLDRLR-----KH---------------QGHF---LLGTLSRYAVQVAEGMGYLES-K---R---FIHRDLAARNLLLA-T--------RDLV--------------------KIGDFGLMRAL-PQ-N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WI-GL-----------NGSQILHKIDKEGERLPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPED--RPT-----FVALRDF--L--------------
--L-RLEVKLGQGCFGEVWMGTWN---------GTT-KVAIKTLK-P--G-TM----MP-----E-A-FL-Q------EAQIMKKL--R---HDK----LVPLYAVVS---------EEPIY--IVTEFMSKG--SLLDFLK-----EG--------------DGKYL---KLPQLVDMAAQIADGMAYIER-M---N---YIHRDLRAANILVG-E--------NLVC--------------------KIADFGLARLI----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILQTELVTKGRVP---------------YP-GM-----------VNREVLEQV-ERGYRMPCPQGCP-------------------------------------------ESLHELMNLCWKKDPDE--RPT-----FEYIQSFL----------------
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