|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK2 203
CMGC CDC2 4
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
---FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQ-DLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAI---KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTI---KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILS--SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLSGTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS----------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL
-PD----EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILS--SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWSVGVIMYVSLSGTFPFNED-----EDINDQIQNAAFMYPASPWSHIS----------------------AGAIDLINNLLQVKMRKRYSVDKSLSHPWL
FAD----EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILS--SEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR-SKGYNRSLDMWSVGVIIYVSLSGTFPFNED-----EDINDQIQNAAFMYPPNPWREIS----------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL
|