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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDK9 203
TKL BMPR1B 204
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDC2L6 20
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK8 2.7.11.23
CMGC CDKL5 13
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC DYRK1A 150
CMGC DYRK1B 111
Other EIF2AK2 267
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CMGC ICK 4
TKL IRAK4 186
TK JAK2 849
CMGC MAK 4
CMGC MAPK10 64
CMGC MAPK8 26
CAMK NUAK2 97
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PHKG2 24
AGC PRKCQ 380
CAMK PRKD2 551
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
CAMK STK17A 61
CAMK STK17B 33
Other STK35 202
---YEKLAKIGQGTFGEV---FKARHR----KT-GQ---KVALKKVLMENEKEGF--P-ITALR-------EIKILQLL--K-----HEN-----VVNLIEICR--TKASP-----------------------------YNRCKGSIY--LVFDFCEH---DLAGLLS--------NVLV--KF---TLSEIKRVMQMLLNGLYYIHR--N--------KILHRDMKAANVLIT----RDGVL--------------------KLADFGLARAFSL---------------AKNSQPNRYTN---RVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWT-RS--------------PI---------------MQGN---------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SD-DALNHDFF----
--I-QMVKQIGKGRYGEV---WMGKWR----GE-K-----VAVKVFFTTEEASWF--R-ET----------EIYQTVLM--R-----HEN-----ILGFIAADI--KGT---------------------------------GSWTQLY--LITDYHENG--SLYDYLK----------ST--TL---DAKSMLKLAYSSVSGLCHLHT--EIFSTQGKPAIAHRDLKSKNILVK----KNGTC--------------------CIADLGLAVKFIS---------------DTNEVDIPPNT---RVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVAR-RCVSGGIVEEYQLPYHD-------------------LVP----SDPSYEDMREIVCIKKLRPSFPNRWSSDECL-----------------------------------------------------------------------RQMGKLMTECWAHNPASRLT-----AL-RVKK----TL--
---YQLYEDIGKGAFSVV---RRCVKL----CT-GH---EYAAKIINTKKLSARD--H-QKLER-------EARICRLL--K-----HSN-----IVRLHDSIS--E-------------------------------------EGFHY--LVFDLVTGG--ELFEDIV---------ARE--YY---SEADASHCIQQILEAVLHCHQ--M--------GVVHRDLKPENLLLA----SKCKGA-----------------AVKLADFGLAIEV-------------------QGDQQAWFG---FAGTPGYLSPEVLR------KEAYGKPVDIWACGVILYILLV-GY--------------PP---------------FWDE------------DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-----AH-EALKHPWV----
---YQLFEELGKGAFSVV---RRCMKI----PT-GQ---EYAAKIINTKKLSARD--H-QKLER-------EARICRLL--K-----HPN-----IVRLHDSIS--E-------------------------------------EGFHY--LVFDLVTGG--ELFEDIV---------ARE--YY---SEADASHCIQQILESVNHCHL--N--------GIVHRDLKPENLLLA----SKSKGA-----------------AVKLADFGLAIEV-------------------QGDQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDMWACGVILYILLV-GY--------------PP---------------FWDE------------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-----AS-EALKHPWI----
---YQLFEELGKGAFSVV---RRCVKK----TS-TQ---EYAAKIINTKKLSARD--H-QKLER-------EARICRLL--K-----HPN-----IVRLHDSIS--E-------------------------------------EGFHY--LVFDLVTGG--ELFEDIV---------ARE--YY---SEADASHCIHQILESVNHIHQ--H--------DIVHRDLKPENLLLA----SKCKGA-----------------AVKLADFGLAIEV-------------------QGEQQAWFG---FAGTPGYLSPEVLR------KDPYGKPVDIWACGVILYILLV-GY--------------PP---------------FWDE------------DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-----AD-QALKHPWV----
---YTKIEKIGEGTYGVV---YKGRHK----TT-GQ---VVAMKKIRLESEEEGV--P-STAIR-------EISLLKEL--R-----HPN-----IVSLQDVLM--Q-------------------------------------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--R--------RVLHRDLKPQNLLID----DKGTI--------------------KLADFGLARAF-------------------GIPIRVYTH---EVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KK--------------PL---------------FHGD---------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GK-MALNHPYF----
--F-DIIGIIGEGTYGQV---YKARDK----DT-GE---MVALKKVRLDNEKEGF--P-ITAIR-------EIKILRQL--T-----HQS-----IINMKEIVT--DKEDAL---------------------------DFKKDKGAFY--LVFEYMDH---DLMGLLE--------SGLV--HF---NENHIKSFMRQLMEGLDYCHK--K--------NFLHRDIKCSNILLN----NRGQI--------------------KLADFGLARLY------------------SSEESRPYTN---KVITLWYRPPELLL-----GEERYTPAIDVWSCGCILGELFT-KK--------------PI---------------FQAN---------QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------------------------------------------RRKLREEFVFIPAAALDLFDYMLALDPSKRCT-----AE-QALQCEF-L---
EGC-----KVGRGTYGHV---YKARRK----DG-KDE-KEYALKQIEGTGISMSA--C-----R-------EIALLREL--K-----HPN-----VIALQKVFL--SH-----------------------------------SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--PMQ-LPRSMVKSLLYQILDGIHYLHA--N--------WVLHRDLKPANILVMGEGPERGRV--------------------KIADMGFARLFN----------------SPLKPLADLDP---VVVTFWYRAPELLL-----GARHYTKAIDIWAIGCIFAELLT-SE--------------PI---------------FHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA----------------------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT-----SE-QALQDPYF----
-YL--NLEKLGEGSYATV---YKGISR----IN-GQ---LVALKVISMNAEEGVP----FTAIR-------EASLLKGL--K-----HAN-----IVLLHDIIH--T-------------------------------------KETLT--FVFEYMHT---DLAQYMS--------QHPG--GL---HPHNVRLFMFQLLRGLAYIHH--Q--------HVLHRDLKPQNLLIS----HLGEL--------------------KLADFGLARAK-------------------SIPSQTYSS---EVVTLWYRPPDALL-----GATEYSSELDIWGAGCIFIEMFQ-GQ--------------PL---------------FPGV--------SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS-----AQ-EALVHDYF----
---FQKVEKIGEGTYGVV---YKARNK----LT-GE---VVALKKIRLDTETEGV--P-STAIR-------EISLLKEL--N-----HPN-----IVKLLDVIH--T-------------------------------------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--GI---PLPLIKSYLFQLLQGLAFCHS--H--------RVLHRDLKPQNLLIN----TEGAI--------------------KLADFGLARAF-------------------GVPVRTYTH---EVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RR--------------AL---------------FPGD---------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AK-AALAHPFF----
---FQKVEKIGEGTYGVV---YKAKNR----ET-GQ---LVALKKIRLDLEMEGV--P-STAIR-------EISLLKEL--K-----HPN-----IVRLLDVVH--N-------------------------------------ERKLY--LVFEFLSQ---DLKKYMDS-------TPGS--EL---PLHLIKSYLFQLLQGVSFCHS--H--------RVIHRDLKPQNLLIN----ELGAI--------------------KLADFGLARAF-------------------GVPLRTYTH---EVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RK--------------AL---------------FPGD---------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AK-TALAHPYF----
---YEKLEKIGEGTYGTV---FKAKNR----ET-HE---IVALKRVRLDDDDEGV--P-SSALR-------EICLLKEL--K-----HKN-----IVRLHDVLH--S-------------------------------------DKKLT--LVFEFCDQ---DLKKYFD--------SCNG--DL---DPEIVKSFLFQLLKGLGFCHS--R--------NVLHRDLKPQNLLIN----RNGEL--------------------KLADFGLARAF-------------------GIPVRCYSA---EVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGR--------------PL---------------FPGN---------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AE-EALQHPYF----
---YECVAEIGEGAYGKV---FKARDL----KN-GG--RFVALKRVRVQTGEEGM--P-LSTIR-------EVAVLRHL--ET--FEHPN-----VVRLFDVCT--VSR--------------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK-------VPEP--GV---PTETIKDMMFQLLRGLDFLHS--H--------RVVHRDLKPQNILVT----SSGQI--------------------KLADFGLARI--------------------YSFQMALTS---VVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RK--------------PL---------------FRGS---------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AY-SALSHPYF----
EGC-----KVGRGTYGHV---YKAKRK----DG-KDD-KDYALKQIEGTGISMSA--C-----R-------EIALLREL--K-----HPN-----VISLQKVFL--SH-----------------------------------ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--QL---PRGMVKSLLYQILDGIHYLHA--N--------WVLHRDLKPANILVMGEGPERGRV--------------------KIADMGFARLFN----------------SPLKPLADLDP---VVVTFWYRAPELLL-----GARHYTKAIDIWAIGCIFAELLT-SE--------------PI---------------FHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT----------------------------------------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT-----SE-QAMQDPYF----
---FEILGVVGEGAYGVV---LKCRHK----ET-HE---IVAIKKFKDSEENEEV--K-ETTLR-------ELKMLRTL--K-----QEN-----IVELKEAFR--R-------------------------------------RGKLY--LVFEYVEK---NMLELLE--------EMPN--GV---PPEKVKSYIYQLIKAIHWCHK--N--------DIVHRDIKPENLLIS----HNDVL--------------------KLCDFGFARNL------------------SEGNNANYTE---YVATRWYRSPELLL------GAPYGKSVDMWSVGCILGELSD-GQ--------------PL---------------FPGE---------SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-----TE-QCLNHPTF----
---YEIVDTLGEGAFGKV---VECIDH----KAGGR---HVAVKIVKNVDRYCEA--A-RS----------EIQVLEHL--NT---TDPNST-FRCVQMLEWFE--H-------------------------------------HGHIC--IVFELLGL---STYDFIK---------ENG--FLP-FRLDHIRKMAYQICKSVNFLHS--N--------KLTHTDLKPENILFV----QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA----------------------TYDDEHHST---LVSTRHYRAPEVIL------ALGWSQPCDVWSIGCILIEYYL-GF--------------TV---------------FPTH---------DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY----------------------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRIT-----LR-EALKHPFF----
---YEIVSTLGEGTFGRV---VQCVDH----RR-GG--ARVALKIIKNVEKYKEA--A-R---L-------EINVLEKI--NEKDPDNKN----LCVQMFDWFD--Y-------------------------------------HGHMC--ISFELLGL---STFDFLK---------DNN--YLP-YPIHQVRHMAFQLCQAVKFLHD--N--------KLTHTDLKPENILFV----NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT----------------------FDHEHHST---IVSTRHYRAPEVIL------ELGWSQPCDVWSIGCIIFEYYV-GF--------------TL---------------FQTH---------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-----LG-EALQHPFF----
---YEIVGNLGEGTFGKV---VECLDH----AR-GK--SQVALKIIRNVGKYREA--A-R---L-------EINVLKKI--KE--KDKENK--FLCVLMSDWFN--F-------------------------------------HGHMC--IAFELLGK---NTFEFLK----------EN--NFQPYPLPHVRHMAYQLCHALRFLHE--N--------QLTHTDLKPENILFV----NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT----------------------FDHEHHTT---IVATRHYRPPEVIL------ELGWAQPCDVWSIGCILFEYYR-GF--------------TL---------------FQTH---------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-----LA-EALLHPFF----
---YEIDSLIGKGSFGQV---VKAYDR----VE-QE---WVAIKIIKNKKAFLNQ--A-QI----------EVRLLELM-NK-----HDTEMKYYIVHLKRHFM--F-------------------------------------RNHLC--LVFEMLSY---NLYDLLR----------NT--NFRGVSLNLTRKFAQQMCTALLFLATPEL--------SIIHCDLKPENILLCN--PKRSAI--------------------KIVDFGSSCQ----------------------LGQRIYQ---YIQSRFYRSPEVLL------GMPYDLAIDMWSLGCILVEMHT-GE--------------PL---------------FSGA---------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-----PY-YALQHSFF----
---YEIDSLIGKGSFGQV---VKAYDH----QT-QE---LVAIKIIKNKKAFLNQ--A-QI----------ELRLLELM-NQ-----HDTEMKYYIVHLKRHFM--F-------------------------------------RNHLC--LVFELLSY---NLYDLLR----------NT--HFRGVSLNLTRKLAQQLCTALLFLATPEL--------SIIHCDLKPENILLCN--PKRSAI--------------------KIVDFGSSCQ----------------------LGQRIYQ---YIQSRFYRSPEVLL------GTPYDLAIDMWSLGCILVEMHT-GE--------------PL---------------FSGS---------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-----PL-GALQHGFF----
--F-KEIELIGSGGFGQV---FKAKHR----ID-GK---TYVIKRVKYNNEKAER----------------EVKALAKL--D-----HVN-----IVHYNGCWD--GFDYDPETSDDSLES--------SDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK-------RRGE--KL---DKVLALELFEQITKGVDYIHS--K--------KLIHRDLKPSNIFLV----DTKQV--------------------KIGDFGLVTS--------------------LKNDGKRTR---SKGTLRYMSPEQIS------SQDYGKEVDLYALGLILAELLH-VC-------------DTA---------------FET----------------SKFFTDLRDGIISDIFDK----------------------------------------------------------------------------KEKTLLQKLLSKKPEDRPN-----TS-EILR----TLT-
---YTDIKVIGNGSFGVV---YQARLA----ET-RE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D-----HCN-----IVRLRYFFY--SSG---------------------------------EKKDELYLNLVLEYVPETVYRVARHFT--------KAKL--TI---PILYVKVYMYQLFRSLAYIHS--Q--------GVCHRDIKPQNLLVD---PDTAVL--------------------KLCDFGSAKQ--------------------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ--------------PI---------------FPGD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PL-EACAHSFF----
---YTDTKVIGNGSFGVV---YQAKLC----DS-GE---LVAIKKVLQDKRFKNR----------------ELQIMRKL--D-----HCN-----IVRLRYFFY--SSG---------------------------------EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--F--------GICHRDIKPQNLLLD---PDTAVL--------------------KLCDFGSAKQ--------------------LVRGEPNVS---YICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQ--------------PI---------------FPGD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PL-EACAHSFF----
---YEVLEFLGRGTFGQV---AKCWKR----ST-KE---IVAIKILKNHPSYARQ--G-QI----------EVSILSRL--S-----SENADEYNFVRSYECFQ--H-------------------------------------KNHTC--LVFEMLEQ---NLYDFLKQ-------NKFS--PL---PLKYIRPILQQVATALMKLKS--L--------GLIHADLKPENIMLV----DPVRQPY----------------RVKVIDFGSAS---------------------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GW--------------PL---------------YPGA---------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-----PL-KTLNHQFV----
---YEVLEFLGRGTFGQV---VKCWKR----GT-NE---IVAIKILKNHPSYARQ--G-QI----------EVSILARL--STESADDYN-----FVRAYECFQ--H-------------------------------------KNHTC--LVFEMLEQ---NLYDFLKQ-------NKFS--PL---PLKYIRPVLQQVATALMKLKS--L--------GLIHADLKPENIMLV----DPSRQPY----------------RVKVIDFGSAS---------------------HVSKAVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GW--------------PL---------------YPGA---------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-----PI-ETLNHPFV----
---YEVLDFLGRGTFGQV---VKCWKR----GT-NE---IVAIKILKNHPSYARQ--G-QI----------EVSILARL--S-----TENADEYNFVRAYECFQ--H-------------------------------------RNHTC--LVFEMLEQ---NLYDFLKQ-------NKFS--PL---PLKVIRPILQQVATALKKLKS--L--------GLIHADLKPENIMLV----DPVRQPY----------------RVKVIDFGSAS---------------------HVSKTVCST---YLQSRYYRAPEIIL------GLPFCEAIDMWSLGCVIAELFL-GW--------------PL---------------YPGA---------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-----PA-ETLNHPFV----
---YDIIEVLGKGTFGEV---AKGWRR----ST-GE---MVAIKILKNDAYRNRI--I-KN----------ELKLLHCM--RGLDPEEAH-----VIRFLEFFH--D-------------------------------------ALKFY--LVFELLEQ---NLFEFQK----------EN--NFAPLPARHIRTVTLQVLTALARLKE--L--------AIIHADLKPENIMLV----DQTRCPF----------------RVKVIDFGSASIF-------------------SEVRYVKEP---YIQSRFYRAPEILL------GLPFCEKVDVWSLGCVMAELHL-GW--------------PL---------------YPGN---------NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PS-AALRHPFV----
---YTTIRQLGDGTYGSV---LLGRSI----ES-GE---LIAIKKMKRKFYSWEE--C--MNLR-------EVKSLKKL--N-----HAN-----VVKLKEVIR--E-------------------------------------NDHLY--FIFEYMKE---NLYQLIK--------ERNK--LF---PESAIRNIMYQILQGLAFIHK--H--------GFFHRDLKPENLLCM----GPELV--------------------KIADFGLARE--------------------IRSKPPYTD---YVSTRWYRAPEVLL-----RSTNYSSPIDVWAVGCIMAEVYT-LR--------------PL---------------FPGA---------SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-----AS-QALRYPYF----
VGG----NKMGEGGFGVV---YKGYVN----NT-T-----VAVKKLAAMVDITTE--ELKQQFD------QEIKVMAKC--Q-----HEN-----LVELLGFSS--D-------------------------------------GDDLC--LVYVYMPNG--SLLDRLSC------LDGTP--PL---SWHMRCKIAQGAANGINFLHE--N--------HHIHRDIKSANILLD----EAFTA--------------------KISDFGLARASE-----------------KFAQTVMTSR---IVGTTAYMAPEALR-------GEITPKSDIYSFGVVLLEIIT-GL--------------PA---------------VDEH---------REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD-----IK-KVQQ----LLQ-
---LKFLQQLGKGNFGSV---EMCRYDPLQDNT-GE---VVAVKKLQ-HSTE--EHLR-DFE-R-------EIEILKSL--Q-----HDN-----IVKYKGVCYSAG-------------------------------------RRNLK--LIMEYLPYG--SLRDYLQ----------KHKERI---DHIKLLQYTSQICKGMEYLGT--K--------RYIHRDLATRNILVE----NENRV--------------------KIGDFGLTKVL--------PQ---------D--KEYYKVKEPGESPIFWYAPESLT------ESKFSVASDVWSFGVVLYELFTYIE--------------KSKSPPAEFMRMIGNDKQGQM---------IVFHLIELLKNNGRLPRPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-----FR-DLA----LRV--
---YTTMRQLGDGTYGSV---LMGKSN----ES-GE---LVAIKRMKRKFYSWDE--C-M-NLR-------EVKSLKKL--N-----HAN-----VIKLKEVIR--E-------------------------------------NDHLY--FIFEYMKE---NLYQLMK--------DRNK--LF---PESVIRNIMYQILQGLAFIHK--H--------GFFHRDMKPENLLCM----GPELV--------------------KIADFGLARE--------------------LRSQPPYTD---YVSTRWYRAPEVLL-----RSSVYSSPIDVWAVGSIMAELYM-LR--------------PL---------------FPGT---------SEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-----AS-QALKHPYF----
---YQNLKPIGSGAQGIV---CAAYDA----VL-DR---NVAIKKLSRPFQNQTH--A-KRAYR-------ELVLMKCV--N-----HKN-----IISLLNVFT--PQKT-------------------------------LEEFQDVY--LVMELMDA---NLCQVIQ-----------M--EL---DHERMSYLLYQMLCGIKHLHS--A--------GIIHRDLKPSNIVVK----SDCTL--------------------KILDFGLART--------------------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDIWSVGCIMGEMVR-HK--------------IL---------------FPGR---------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VD-DALQHPYI----
---YQNLKPIGSGAQGIV---CAAYDA----IL-ER---NVAIKKLSRPFQNQTH--A-KRAYR-------ELVLMKCV--N-----HKN-----IIGLLNVFT--PQKS-------------------------------LEEFQDVY--IVMELMDA---NLCQVIQ-----------M--EL---DHERMSYLLYQMLCGIKHLHS--A--------GIIHRDLKPSNIVVK----SDCTL--------------------KILDFGLART--------------------AGTSFMMTP---YVVTRYYRAPEVIL------GMGYKENVDLWSVGCIMGEMVC-HK--------------IL---------------FPGR---------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VD-EALQHPYI----
---YEFLETLGKGTYGKV---KKARES----SG-R----LVAIKSIRKDKIKDEQ--D-LMHIR------REIEIMSSL--N-----HPH-----IIAIHEVFE--N-------------------------------------SSKIV--IVMEYASRG--DLYDYIS---------ERQ--QL---SEREARHFFRQIVSAVHYCHQ--N--------RVVHRDLKLENILLD----ANGNI--------------------KIADFGLSNL--------------------YHQGKFLQT---FCGSPLYASPEIVN-----GKPYTGPEVDSWSLGVLLYILVH-GT--------------MP---------------FDGH------------DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT-----LE-DVASHWW-V---
--Y-IKLDKLGEGTYATV---YKGKSK----LT-DN---LVALKEIRLEHEEGAP--C--TAIR-------EVSLLKDL--K-----HAN-----IVTLHDIIH--T-------------------------------------EKSLT--LVFEYLDK---DLKQYLD--------DCGN--II---NMHNVKLFLFQLLRGLAYCHR--Q--------KVLHRDLKPQNLLIN----ERGEL--------------------KLADFGLARAK-------------------SIPTKTYSN---EVVTLWYRPPDILL-----GSTDYSTQIDMWGVGCIFYEMAT-GR--------------PL---------------FPGS---------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-----AE-DAMKHPFF----
--Y-IKLEKLGEGTYATV---YKGRSK----LT-EN---LVALKEIRLEHEEGAP--C--TAIR-------EVSLLKDL--K-----HAN-----IVTLHDIVH--T-------------------------------------DKSLT--LVFEYLDK---DLKQYMD--------DCGN--IM---SMHNVKLFLYQILRGLAYCHR--R--------KVLHRDLKPQNLLIN----EKGEL--------------------KLADFGLARAK-------------------SVPTKTYSN---EVVTLWYRPPDVLL-----GSSEYSTQIDMWGVGCIFFEMAS-GR--------------PL---------------FPGS---------TVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYK------------------------------------------------PQPLINHAPRLDSEGIELITKFLQYESKKRVS-----AE-EAMKHVYF----
---YVKLDKLGEGTYATV---FKGRSK----LT-EN---LVALKEIRLEHEEGAP--C--TAIR-------EVSLLKNL--K-----HAN-----IVTLHDLIH--T-------------------------------------DRSLT--LVFEYLDS---DLKQYLD---------HCG--NL--MSMHNVKIFMFQLLRGLAYCHH--R--------KILHRDLKPQNLLIN----ERGEL--------------------KLADFGLARAK-------------------SVPTKTYSN---EVVTLWYRPPDVLL-----GSTEYSTPIDMWGVGCIHYEMAT-GR--------------PL---------------FPGS---------TVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYL------------------------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKSRMS-----AE-AALSHSYF----
---YEKLEKLGEGSYATV---YKGKSK----VN-GK---LVALKVIRLQEEEGTP--F--TAIR-------EASLLKGL--K-----HAN-----IVLLHDIIH--T-------------------------------------KETLT--LVFEYVHT---DLCQYMD--------KHPG--GL---HPDNVKLFLFQLLRGLSYIHQ--R--------YILHRDLKPQNLLIS----DTGEL--------------------KLADFGLARAK-------------------SVPSHTYSN---EVVTLWYRPPDVLL-----GSTEYSTCLDMWGVGCIFVEMIQ-GV--------------AA---------------FPGM--------KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS-----AQ-AALSHEYF----
---YEPKEILGRGVSSVV---RRCIHK----PT-SQ---EYAVKVIDVTGGGSFS--P-EEVRELREATLKEVDILRKV-SG-----HPN-----IIQLKDTYE--T-------------------------------------NTFFF--LVFDLMKRG--ELFDYLT---------EKV--TL---SEKETRKIMRALLEVICTLHK--L--------NIVHRDLKPENILLD----DNMNI--------------------KLTDFGFSCQ--------------------LEPGERLRE---VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GS--------------PP---------------FWHR------------KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AE-EALAHPFF----
YDP---KDVIGRGVSSVV---RRCVHR----AT-GH---EFAVKIMEVTAERLSP--E-QLEEVREA-TRRETHILRQV-AG-----HPH-----IITLIDSYE--S-------------------------------------SSFMF--LVFDLMRKG--ELFDYLT---------EKV--AL---SEKETRSIMRSLLEAVSFLHA--N--------NIVHRDLKPENILLD----DNMQI--------------------RLSDFGFSCH--------------------LEPGEKLRE---LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLA-GS--------------PP---------------FWHR------------RQILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT-----AE-QALQHPFF----
-FI--LHKMLGKGSFGKV---FLAEFK----KT-NQ---FFAIKALKKDVVLMDD--D-VECTM------VEKRVLSLA-WE-----HPF-----LTHMFCTFQ--T-------------------------------------KENLF--FVMEYLNGG--DLMYHIQ---------SCH--KF---DLSRATFYAAEIILGLQFLHS--K--------GIVYRDLKLDNILLD----KDGHI--------------------KIADFGMCKEN-------------------MLGDAKTNT---FCGTPDYIAPEILL------GQKYNHSVDWWSFGVLLYEMLI-GQ--------------SP---------------FHGQ------------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF----
-PD----EVLGSGQFGVV---YGGKHR----KT-GR---DVAVKVIDKLRFPTKQ--E-SQLRN-------EVAILQSL--R-----HPG-----IVNLECMFE--T-------------------------------------PEKVF--VVMEKLHGD--MLEMILS--------SEKG--RL---PERLTKFLITQILVALRHLHF--K--------NIVHCDLKPENVLLA----SADPFP-----------------QVKLCDFGFARI--------------------IGEKSFRRS---VVGTPAYLAPEVLL------NQGYNRSLDMWSVGVIMYVSLS-GT--------------FP---------------FNED--------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VD-KSLSHPWL----
---FELLKVLGQGSFGKVFLVRKVTRP----DS-GH---LYAMKVLKKATLKVRD--R-VRTKM-------ERDILADV--N-----HPF-----VVKLHYAFQ--T-------------------------------------EGKLY--LILDFLRGG--DLFTRLS---------KEV--MF---TEEDVKFYLAELALGLDHLHS--L--------GIIYRDLKPENILLD----EEGHI--------------------KLTDFGLSKEA-------------------IDHEKKAYS---FCGTVEYMAPEVVN------RQGHSHSADWWSYGVLMFEMLT-GS--------------LP---------------FQGK------------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAE-EIKRHV--FY--
---FELLKVLGQGSYGKV---FLVRKV----KG-SDAGQLYAMKVLKKATLKVRD--R-VRSKM-------ERDILAEV--N-----HPF-----IVKLHYAFQ--T-------------------------------------EGKLY--LILDFLRGG--DLFTRLS---------KEV--MF---TEEDVKFYLAELALALDHLHS--L--------GIIYRDLKPENILLD----EEGHI--------------------KITDFGLSKEA-------------------IDHDKRAYS---FCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GS--------------LP---------------FQGK------------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVE-EIKRHPFF----
---FELLKVLGQGSFGKV---FLVRKK----TG-PDAGQLYAMKVLKKASLKVRD--R-VRTKM-------ERDILVEV--N-----HPF-----IVKLHYAFQ--T-------------------------------------EGKLY--LILDFLRGG--DVFTRLS---------KEV--LF---TEEDVKFYLAELALALDHLHQ--L--------GIVYRDLKPENILLD----EIGHI--------------------KLTDFGLSKES-------------------VDQEKKAYS---FCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GT--------------LP---------------FQGK------------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVE-EIKRHLFF----
LCP---GRELGRGKFAVV---RKCIKK----DS-GK---EFAAKFMRKRRKGQDC--R-MEIIH-------EIAVLELA-QD-----NPW-----VINLHEVYE--T-------------------------------------ASEMI--LVLEYAAGG--EIFDQCVA-------DREE--AF---KEKDVQRLMRQILEGVHFLHT--R--------DVVHLDLKPQNILLT----SESPLG-----------------DIKIVDFGLSRI--------------------LKNSEELRE---IMGTPEYVAPEILS------YDPISMATDMWSIGVLTYVMLT-GI--------------SP---------------FLGN------------DKQETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AE-ECLKHPWL----
ILT---SKELGRGKFAVV---RQCISK----ST-GQ---EYAAKFLKKRRRGQDC--R-AEILH-------EIAVLELA-KS-----CPR-----VINLHEVYE--N-------------------------------------TSEII--LILEYAAGG--EIFSLCLP-------ELAE--MV---SENDVIRLIKQILEGVYYLHQ--N--------NIVHLDLKPQNILLS----SIYPLG-----------------DIKIVDFGMSRK--------------------IGHACELRE---IMGTPEYLAPEILN------YDPITTATDMWNIGIIAYMLLT-HT--------------SP---------------FVGE------------DNQETYLNISQVNVDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT-----AE-ICLSHSWL----
---YSLLAEIGRGSYGVV---YEAVAG----RS-GA---RVAVKKIRCDAPENVE--L---ALA-------EFWALTSLKRR-----HQN-----VVQFEECVL--QRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW--FVMEFCEGG--DLNQYVL----------SR--RP---DPATNKSFMLQLTSAIAFLHK--N--------HIVHRDLKPDNILIT----ERSGTP-----------------ILKVADFGLSKVCAGLAPRGK--EGNQDNKNVNVNKYWLSS---ACGSDFYMAPEVWE-------GHYTAKADIFALGIIIWAMIE-RI--------------TF---------------IDSE---------TKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQ---------------------------------------------------------KRRTSMSEGIKQLLKDMLAANPQDRPD-----AF-EL------ETRM
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