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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC CDKL1 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2B 14
CAMK CAMK2D 14
CAMK CAMK2G 14
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDC2L6 20
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK8 2.7.11.23
CMGC CDK9 2.7.11.23
CMGC CDKL2 4
CMGC CDKL3 4
CMGC CDKL5 13
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
CMGC DYRK3 209
Other EIF2AK2 267
AGC GRK1 190
AGC GRK5 186
AGC GRK6 186
AGC GRK7 191
CMGC GSK3A 119
CMGC GSK3B 56
CMGC HIPK1 190
CMGC HIPK2 199
CMGC HIPK3 197
CMGC HIPK4 -1
CAMK HUNK 61
CMGC ICK 4
Other IKBKE 9
TK JAK2 849
TK JAK3 822
CAMK KIAA0999 66
CMGC MAK 4
STE MAP2K1 68
STE MAP2K5 166
STE MAP3K1 1242
STE MAP3K15 649
STE MAP3K2 356
STE MAP3K3 362
STE MAP3K4 1342
STE MAP3K5 677
STE MAP3K6 645
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK14 24
CMGC MAPK8 26
CAMK MAPKAPK2 64
CAMK MARK1 60
CAMK MARK2 53
CAMK MARK4 59
CMGC NLK 126
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK1 270
STE PAK2 249
STE PAK3 268
STE PAK4 321
STE PAK6 407
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
AGC PDPK1 82
CMGC PFTK1 117
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM3 40
AGC PKN2 657
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCE 408
AGC PRKCQ 380
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
CMGC PRPF4B 687
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
AGC RPS6KB1 91
AGC RPS6KB2 67
CAMK SIK1 27
CAMK SIK2 20
CAMK SNRK 16
STE STK10 36
CAMK STK11 49
AGC STK32A 23
AGC STK32B 23
AGC STK32C 93
Other STK36 4
STE YSK4 1162
----YEKIGKIGEGSYGVV---FKCRN---R----D-T-GQ---IVAIKKFLESE-DDPVI--KK-IALR-------EIRMLKQL-K------HPN-----LVNLLEVFR--R-----------------------------KRRLH--LVFEYCDHT--VLHELDR---------YQR--GV---PEHLVKSITWQTLQAVNFCHK--HNCIHRDVKPENIL--IT----KHSVI--------------------KLCDFGFARLL--------AGPSDYYTD---YVATRWYRSPEL----LV-------GDTQYGPPVDVWAIGCVFAELLS-GV-PL---------------WP-GK---------SDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPED-----------------------------------------------MEPLELKFPNISYPALGLLKGCLHMDPTQRLT-------CE-QLLHHPYF-------------------------------------------------------
----FEIGRPLGKGKFGNV---YLARE---K----Q-S-KF---ILALKVLFKAQLEKAGV--EH-QLRR-------EVEIQSHL-R------HPN-----ILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ---------KLS--KF---DEQRTATYITELANALSYCHS--KRVIHRDIKPENLL--LG----SAGEL--------------------KIADFGWSV----------HAPSSRRTT---LCGTLDYLPPEM----IE--------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FE-AN------------TYQETYKRISRVEFTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM-------LR-EVLEHPWI-------------------------------------------------------
----FEIGRPLGKGKFGNV---YLARE---K----K-S-HF---IVALKVLFKSQ-IEKEG--VE-HQLR------REIEIQAHL-H------HPN-----ILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ---------KSC--TF---DEQRTATIMEELADALMYCHG--KKVIHRDIKPENLL--LG----LKGEL--------------------KIADFGWSV----------HAPSLRRKT---MCGTLDYLPPEM----IE--------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FE-SA------------SHNETYRRIVKVDLKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP-------LA-QVSAHPWV-------------------------------------------------------
----FEIGRPLGKGKFGNV---YLARL---K----E-S-HF---IVALKVLFKSQ-IEKEG--LE-HQLR------REIEIQAHL-Q------HPN-----ILRLYNYFH--D-----------------------------ARRVY--LILEYAPRG--ELYKELQ---------KSE--KL---DEQRTATIIEELADALTYCHD--KKVIHRDIKPENLL--LG----FRGEV--------------------KIADFGWSV----------HTPSLRRKT---MCGTLDYLPPEM----IE--------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FE-SA------------SHSETYRRILKVDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP-------LA-QILKHPWV-------------------------------------------------------
----YRLEKTLGKGQTGLV---KLGVH---C----I-T-GQ---KVAIKIVNREK-LSESV--LM-KVER-------EIAILKLI-E------HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEHVSGG--ELFDYLV---------KKG--RL---TPKEARKFFRQIVSALDFCHS--YSICHRDLKPENLL--LD----EKNNI--------------------RIADFGMASL---------QVGDSLLET---SCGSPHYACPEV----IK-------GEKYDGRRADMWSCGVILFALLV-GA-LP---------------FD-DD------------NLRQLLEKVKRGVFHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-------LE-QIQKHPW-Y------------------------------------------------------
----YRLEKTLGKGQTGLV---KLGVH---C----V-T-CQ---KVAIKIVNREK-LSESV--LM-KVER-------EIAILKLI-E------HPH-----VLKLHDVYE--N-----------------------------KKYLY--LVLEHVSGG--ELFDYLV---------KKG--RL---TPKEARKFFRQIISALDFCHS--HSICHRDLKPENLL--LD----EKNNI--------------------RIADFGMASL---------QVGDSLLET---SCGSPHYACPEV----IR-------GEKYDGRKADVWSCGVILFALLV-GA-LP---------------FD-DD------------NLRQLLEKVKRGVFHMPHFIP---------------------------------------------------------------------------PDCQSLLRGMIEVDAARRLT-------LE-HIQKHIW-Y------------------------------------------------------
----YQLYEDIGKGAFSVV---RRCVK---L----C-T-GH---EYAAKIINTKK-LSARD--HQ-KLER-------EARICRLL-K------HSN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV---------ARE--YY---SEADASHCIQQILEAVLHCHQ--MGVVHRDLKPENLL--LA----SKCKGA-----------------AVKLADFGLAIEV--------QGDQQAWFG---FAGTPGYLSPEV----LR--------KEAYGKPVDIWACGVILYILLV-GY-PP---------------FW-DE------------DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-------AH-EALKHPWV-------------------------------------------------------
----YQLFEELGKGAFSVV---RRCMK---I----P-T-GQ---EYAAKIINTKK-LSARD--HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV---------ARE--YY---SEADASHCIQQILESVNHCHL--NGIVHRDLKPENLL--LA----SKSKGA-----------------AVKLADFGLAIEV--------QGDQQAWFG---FAGTPGYLSPEV----LR--------KDPYGKPVDMWACGVILYILLV-GY-PP---------------FW-DE------------DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-------AS-EALKHPWI-------------------------------------------------------
----YQLFEELGKGAFSVV---RRCVK---K----T-S-TQ---EYAAKIINTKK-LSARD--HQ-KLER-------EARICRLL-K------HPN-----IVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV---------ARE--YY---SEADASHCIHQILESVNHIHQ--HDIVHRDLKPENLL--LA----SKCKGA-----------------AVKLADFGLAIEV--------QGEQQAWFG---FAGTPGYLSPEV----LR--------KDPYGKPVDIWACGVILYILLV-GY-PP---------------FW-DE------------DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKNLINQMLTINPAKRIT-------AD-QALKHPWV-------------------------------------------------------
----YTKIEKIGEGTYGVV---YKGRH---K----T-T-GQ---VVAMKKIRLES-EEEGV--PS-TAIR-------EISLLKEL-R------HPN-----IVSLQDVLM--Q-----------------------------DSRLY--LIFEFLSM---DLKKYLDS------IPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--RRVLHRDLKPQNLL--ID----DKGTI--------------------KLADFGLARAF--------GIPIRVYTH---EVVTLWYRSPEV----LL-------GSARYSTPVDIWSIGTIFAELAT-KK-PL---------------FH-GD---------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------------------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-------GK-MALNHPYF-------------------------------------------------------
---F-DIIGIIGEGTYGQV---YKARD---K----D-T-GE---MVALKKVRLDN-EKEGF--PI-TAIR-------EIKILRQL-T------HQS-----IINMKEIVT--DKEDAL-------------------DFKKDKGAFY--LVFEYMDH---DLMGLLE--------SGLV--HF---NENHIKSFMRQLMEGLDYCHK--KNFLHRDIKCSNIL--LN----NRGQI--------------------KLADFGLARLY-------SSEESRPYTN---KVITLWYRPPEL----LL-------GEERYTPAIDVWSCGCILGELFT-KK-PI---------------FQ-AN---------QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY------------------------------------------------RRKLREEFVFIPAAALDLFDYMLALDPSKRCT-------AE-QALQCEF-L------------------------------------------------------
-EGC-----KVGRGTYGHV---YKARR---K----D-G-KDE-KEYALKQIEGTG-ISMSA--C-----R-------EIALLREL-K------HPN-----VIALQKVFL--SH---------------------------SDRKVW--LLFDYAEH---DLWHIIKFHR--ASKANKK--PMQ-LPRSMVKSLLYQILDGIHYLHA--NWVLHRDLKPANIL--VMGEGPERGRV--------------------KIADMGFARLFN-----SPLKPLADLDP---VVVTFWYRAPEL----LL-------GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FH-CRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA----------------------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRIT-------SE-QALQDPYF-------------------------------------------------------
--YL--NLEKLGEGSYATV---YKGIS---R----I-N-GQ---LVALKVISMNA-EEGVP---F-TAIR-------EASLLKGL-K------HAN-----IVLLHDIIH--T-----------------------------KETLT--FVFEYMHT---DLAQYMS--------QHPG--GL---HPHNVRLFMFQLLRGLAYIHH--QHVLHRDLKPQNLL--IS----HLGEL--------------------KLADFGLARAK--------SIPSQTYSS---EVVTLWYRPPDA----LL-------GATEYSSELDIWGAGCIFIEMFQ-GQ-PL---------------FP-GV--------SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP----------------------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVS-------AQ-EALVHDYF-------------------------------------------------------
----FQKVEKIGEGTYGVV---YKARN---K----L-T-GE---VVALKKIRLDT-ETEGV--PS-TAIR-------EISLLKEL-N------HPN-----IVKLLDVIH--T-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA-------SALT--GI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLL--IN----TEGAI--------------------KLADFGLARAF--------GVPVRTYTH---EVVTLWYRAPEI----LL-------GCKYYSTAVDIWSLGCIFAEMVT-RR-AL---------------FP-GD---------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------------------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-------AK-AALAHPFF-------------------------------------------------------
----FQKVEKIGEGTYGVV---YKAKN---R----E-T-GQ---LVALKKIRLDL-EMEGV--PS-TAIR-------EISLLKEL-K------HPN-----IVRLLDVVH--N-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS-------TPGS--EL---PLHLIKSYLFQLLQGVSFCHS--HRVIHRDLKPQNLL--IN----ELGAI--------------------KLADFGLARAF--------GVPLRTYTH---EVVTLWYRAPEI----LL-------GSKFYTTAVDIWSIGCIFAEMVT-RK-AL---------------FP-GD---------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------------------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-------AK-TALAHPYF-------------------------------------------------------
----YEKLEKIGEGTYGTV---FKAKN---R----E-T-HE---IVALKRVRLDD-DDEGV--PS-SALR-------EICLLKEL-K------HKN-----IVRLHDVLH--S-----------------------------DKKLT--LVFEFCDQ---DLKKYFD--------SCNG--DL---DPEIVKSFLFQLLKGLGFCHS--RNVLHRDLKPQNLL--IN----RNGEL--------------------KLADFGLARAF--------GIPVRCYSA---EVVTLWYRPPDV----LF-------GAKLYSTSIDMWSAGCIFAELANAGR-PL---------------FP-GN---------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------------------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-------AE-EALQHPYF-------------------------------------------------------
----YECVAEIGEGAYGKV---FKARD---L----K-N-GG--RFVALKRVRVQT-GEEGM--PL-STIR-------EVAVLRHL-ET---FEHPN-----VVRLFDVCT--VSR------------------------TDRETKLT--LVFEHVDQ---DLTTYLDK-------VPEP--GV---PTETIKDMMFQLLRGLDFLHS--HRVVHRDLKPQNIL--VT----SSGQI--------------------KLADFGLARI---------YSFQMALTS---VVVTLWYRAPEV----LL--------QSSYATPVDLWSVGCIFAEMFR-RK-PL---------------FR-GS---------SDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ---------------------------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-------AY-SALSHPYF-------------------------------------------------------
-EGC-----KVGRGTYGHV---YKAKR---K----D-G-KDD-KDYALKQIEGTG-ISMSA--C-----R-------EIALLREL-K------HPN-----VISLQKVFL--SH---------------------------ADRKVW--LLFDYAEH---DLWHIIKFHRASKANKKPV--QL---PRGMVKSLLYQILDGIHYLHA--NWVLHRDLKPANIL--VMGEGPERGRV--------------------KIADMGFARLFN-----SPLKPLADLDP---VVVTFWYRAPEL----LL-------GARHYTKAIDIWAIGCIFAELLT-SE-PI---------------FH-CRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYT----------------------------------------NCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRIT-------SE-QAMQDPYF-------------------------------------------------------
----YEKLAKIGQGTFGEV---FKARH---R----K-T-GQ---KVALKKVLMEN-EKEGF--PI-TALR-------EIKILQLL-K------HEN-----VVNLIEICR--TKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS--------NVLV--KF---TLSEIKRVMQMLLNGLYYIHR--NKILHRDMKAANVL--IT----RDGVL--------------------KLADFGLARAFSL----AKNSQPNRYTN---RVVTLWYRPPEL----LL-------GERDYGPPIDLWGAGCIMAEMWT-RS-PI---------------MQ-GN---------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------------------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-------SD-DALNHDFF-------------------------------------------------------
----YENLGLVGEGSYGMV---MKCRN---K----D-T-GR---IVAIKKFLESD-DDKMV--KK-IAMR-------EIKLLKQL-R------HEN-----LVNLLEVCK--K-----------------------------KKRWY--LVFEFVDHT--ILDDLEL---------FPN--GL---DYQVVQKYLFQIINGIGFCHS--HNIIHRDIKPENIL--VS----QSGVV--------------------KLCDFGFARTL--------AAPGEVYTD---YVATRWYRAPEL----LV-------GDVKYGKAVDVWAIGCLVTEMFM-GE-PL---------------FP-GD---------SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE-----------------------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPF-------CA-ELLHHDFF-------------------------------------------------------
----YETLGKVGEGSYGTV---MKCKH---K----N-T-GQ---IVAIKIFYERP-EQSVN--K--IAMR-------EIKFLKQF-H------HEN-----LVNLIEVFR--Q-----------------------------KKKIH--LVFEFIDHT--VLDELQH---------YCH--GL---ESKRLRKYLFQILRAIDYLHS--NNIIHRDIKPENIL--VS----QSGIT--------------------KLCDFGFARTL--------AAPGDIYTD---YVATRWYRAPEL----VL-------KDTSYGKPVDIWALGCMIIEMAT-GN-PY---------------LP-SS---------SDLDLLHKIVLKVGN-LSPHLQNIFSKSPIFAGVVLPQVQ----------------------------------------------HPKNARKKYPKLNGLLADIVHACLQIDPADRIS-------SS-DLLHHEYF-------------------------------------------------------
----FEILGVVGEGAYGVV---LKCRH---K----E-T-HE---IVAIKKFKDSE-ENEEV--KE-TTLR-------ELKMLRTL-K------QEN-----IVELKEAFR--R-----------------------------RGKLY--LVFEYVEK---NMLELLE--------EMPN--GV---PPEKVKSYIYQLIKAIHWCHK--NDIVHRDIKPENLL--IS----HNDVL--------------------KLCDFGFARNL-------SEGNNANYTE---YVATRWYRSPEL----LL--------GAPYGKSVDMWSVGCILGELSD-GQ-PL---------------FP-GE---------SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH----------------------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYL-------TE-QCLNHPTF-------------------------------------------------------
---W-DLVQTLGEGAYGEV---QLAVN---R----V-T-EE---AVAVKIVDMKR-AVDCP--EN-I-KK-------EICINKML-N------HEN-----VVKFYGHRR--E-----------------------------GNIQY--LFLEYCSGG--ELFDRIE---------PDI--GM---PEPDAQRFFHQLMAGVVYLHG--IGITHRDIKPENLL--LD----ERDNL--------------------KISDFGLATVFR------YNNRERLLNK---MCGTLPYVAPEL----LK-------RREFHAEPVDVWSCGIVLTAMLA-GE-LP---------------WD-QP-----------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------------------------------------------SAPLALLHKILVENPSARIT-------IP-DIKKDRW-Y------------------------------------------------------
--YI--MSKTLGSGACGEV---KLAFE---R----K-T-CK---KVAIKIISKRK-FAIGS--AR-EADPALN-VETEIEILKKL-N------HPC-----IIKIKNFF---D-----------------------------AEDYY--IVLELMEGG--ELFDKVV---------GNK--RL---KEATCKLYFYQMLLAVQYLHE--NGIIHRDLKPENVL--LS----SQEEDC-----------------LIKITDFGHSKI---------LGETSLMRT---LCGTPTYLAPEV----LVS-----VGTAGYNRAVDCWSLGVILFICLS-GY-PP---------------FS-EH-----------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------------------------------------------EKALDLVKKLLVVDPKARFT-------TE-EALRHPWL-------------------------------------------------------
----YEIVDTLGEGAFGKV---VECID---H----K-AGGR---HVAVKIVKNVD-RYCEA--AR-S----------EIQVLEHL-NT----TDPNST-FRCVQMLEWFE--H-----------------------------HGHIC--IVFELLGL---STYDFIK---------ENG--FLP-FRLDHIRKMAYQICKSVNFLHS--NKLTHTDLKPENIL--FV----QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA-----------TYDDEHHST---LVSTRHYRAPEV----IL--------ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FP-TH---------DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY----------------------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRIT-------LR-EALKHPFF-------------------------------------------------------
----YEIVSTLGEGTFGRV---VQCVD---H----R-R-GG--ARVALKIIKNVE-KYKEA--AR----L-------EINVLEKI-NEK-DPDNKN----LCVQMFDWFD--Y-----------------------------HGHMC--ISFELLGL---STFDFLK---------DNN--YLP-YPIHQVRHMAFQLCQAVKFLHD--NKLTHTDLKPENIL--FV----NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT-----------FDHEHHST---IVSTRHYRAPEV----IL--------ELGWSQPCDVWSIGCIIFEYYV-GF-TL---------------FQ-TH---------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY----------------------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLT-------LG-EALQHPFF-------------------------------------------------------
----YEIVGNLGEGTFGKV---VECLD---H----A-R-GK--SQVALKIIRNVG-KYREA--AR----L-------EINVLKKI-KE---KDKENK--FLCVLMSDWFN--F-----------------------------HGHMC--IAFELLGK---NTFEFLK----------EN--NFQPYPLPHVRHMAYQLCHALRFLHE--NQLTHTDLKPENIL--FV----NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT-----------FDHEHHTT---IVATRHYRPPEV----IL--------ELGWAQPCDVWSIGCILFEYYR-GF-TL---------------FQ-TH---------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY----------------------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRIT-------LA-EALLHPFF-------------------------------------------------------
----YEIVDTLGEGAFGKV---VECID---H----GMD-GM---HVAVKIVKNVG-RYREA--AR-S----------EIQVLEHL-NS----TDPNSV-FRCVQMLEWFD--H-----------------------------HGHVC--IVFELLGL---STYDFIK---------ENS--FLP-FQIDHIRQMAYQICQSINFLHH--NKLTHTDLKPENIL--FV----KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA-----------TYDDEHHST---LVSTRHYRAPEV----IL--------ALGWSQPCDVWSIGCILIEYYL-GF-TV---------------FQ-TH---------DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY----------------------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRIT-------LD-EALQHPFF-------------------------------------------------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-N-NE---KVVVKILKPVK-KKKIK--R-------------EIKILENLRG------GPN-----IITLADIVK--DP---------------------------VSRTPA--LVFEHVNNT--DFKQLY------------Q--TL---TDYDIRFYMYEILKALDYCHS--MGIMHRDVKPHNVM--ID---HEHRKL--------------------RLIDWGLAEF---------YHPGQEYNV---RVASRYFKGPEL----LV-------DYQMYDYSLDMWSLGCMLASMIF-RK-EP---------------FFHGH---------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----------------------------------------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-------AR-EAMEHPYF-------------------------------------------------------
----YQLVRKLGRGKYSEV---FEAIN---I----T-N-NE---RVVVKILKPVK-KKKIK--R-------------EVKILENLRG------GTN-----IIKLIDTVK--DP---------------------------VSKTPA--LVFEYINNT--DFKQLY------------Q--IL---TDFDIRFYMYELLKALDYCHS--KGIMHRDVKPHNVM--ID---HQQKKL--------------------RLIDWGLAEF---------YHPAQEYNV---RVASRYFKGPEL----LV-------DYQMYDYSLDMWSLGCMLASMIF-RR-EP---------------FFHGQ---------DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRK-----------------------------------------RWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-------AK-EAMEHPYF-------------------------------------------------------
----YEIDSLIGKGSFGQV---VKAYD---R----V-E-QE---WVAIKIIKNKK-AFLNQ--AQ-I----------EVRLLELMNK------HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFEMLSY---NLYDLLR----------NT--NFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENIL--LCN--PKRSAI--------------------KIVDFGSSCQ-----------LGQRIYQ---YIQSRFYRSPEV----LL--------GMPYDLAIDMWSLGCILVEMHT-GE-PL---------------FS-GA---------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT--------------RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQ-------PY-YALQHSFF-------------------------------------------------------
----YEIDSLIGKGSFGQV---VKAYD---H----Q-T-QE---LVAIKIIKNKK-AFLNQ--AQ-I----------ELRLLELMNQ------HDTEMKYYIVHLKRHFM--F-----------------------------RNHLC--LVFELLSY---NLYDLLR----------NT--HFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENIL--LCN--PKRSAI--------------------KIVDFGSSCQ-----------LGQRIYQ---YIQSRFYRSPEV----LL--------GTPYDLAIDMWSLGCILVEMHT-GE-PL---------------FS-GS---------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGT--------------RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARIS-------PL-GALQHGFF-------------------------------------------------------
----YEVLKVIGKGSFGQV---VKAYD---H----K-V-HQ---HVALKMVRNEK-RFHRQ--AA-E----------EIRILEHL-RKQDKDNTMN-----VIHMLENFT--F-----------------------------RNHIC--MTFELLSM---NLYELIKK-------NKFQ--GF---SLPLVRKFAHSILQCLDALHK--NRIIHCDLKPENIL--LK----QQGRSG------------------IKVIDFGSSC-----------YEHQRVYT---YIQSRFYRAPEV----IL--------GARYGMPIDMWSLGCILAELLT-GY-PL---------------LP-GE---------DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-------PG-QALRHPWL-------------------------------------------------------
----YEVLKIIGKGSFGQV---ARVYD---H----K-L-RQ---YVALKMVRNEK-RFHRQ--AA-E----------EIRILEHL-KKQDKTGSMN-----VIHMLESFT--F-----------------------------RNHVC--MAFELLSI---DLYELIKK-------NKFQ--GF---SVQLVRKFAQSILQSLDALHK--NKIIHCDLKPENIL--LK----HHGRSS------------------TKVIDFGSSCF-----------EYQKLYT---YIQSRFYRAPEI----IL--------GSRYSTPIDIWSFGCILAELLT-GQ-PL---------------FP-GE---------DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVG-------------------GRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLT-------PA-QALRHPWI-------------------------------------------------------
---F-KEIELIGSGGFGQV---FKAKH---R----I-D-GK---TYVIKRVKYNN-EKAER----------------EVKALAKL-D------HVN-----IVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK-------RRGE--KL---DKVLALELFEQITKGVDYIHS--KKLIHRDLKPSNIF--LV----DTKQV--------------------KIGDFGLVTS---------LKNDGKRTR---SKGTLRYMSPEQ----IS--------SQDYGKEVDLYALGLILAELLH-VCDTA---------------FE-T----------------SKFFTDLRDGIISDIFDK----------------------------------------------------------------------------KEKTLLQKLLSKKPEDRPN-------TS-EILR----TLT----------------------------------------------------
FLDF----RVLGKGGFGEV---SACQM---K----A-T-GK---LYACKKLNKKR-LKKRK--GY-QGAM------VEKKILMKV-H------SRF-----IVSLAYAFE--T-----------------------------KADLC--LVMTIMNGG--DIRYHIYNV-----NEENP--GF---PEPRALFYTAQIICGLEHLHQ--RRIVYRDLKPENVL--LD----NDGNV--------------------RISDLGLAVEL--------LDGQSKTKG---YAGTPGFMAPEL----LQ--------GEEYDFSVDYFALGVTLYEMIA-AR-GP---------------FR-AR--------GEKVENKELKHRIISEPVKYPDKFS---------------------------------------------------------------------------QASKDFCEALLEKDPEKRLG-------FR-D-------ETCDKLRAHPLF-------------------------------------------
---F-RQYRVLGKGGFGEV---CACQV---R----A-T-GK---MYACKRLEKKR-IKKRK--GE-SMAL------NEKQILEKV-N------SQF-----VVNLAYAYE--T-----------------------------KDALC--LVLTIMNGG--DLKFHIYN-------MGNP--GF---EEERALFYAAEILCGLEDLHR--ENTVYRDLKPENIL--LD----DYGHI--------------------RISDLGLAVK---------IPEGDLIRG---RVGTVGYMAPEV----LN--------NQRYGLSPDYWGLGCLIYEMIE-GQ-SP---------------FR-GR------------KEKVKREEVDRRVLETEEVYSHKFS-----------------------------------------------------------------------EEAKSICKMLLTKDAKQRLGCQ--EEGAA-EVKRHPFF-------------------------------------------------------
---F-RQYRVLGKGGFGEV---CACQV---R----A-T-GK---MYACKKLEKKR-IKKRK--GE-AMAL------NEKQILEKV-N------SRF-----VVSLAYAYE--T-----------------------------KDALC--LVLTLMNGG--DLKFHIYH-------MGQA--GF---PEARAVFYAAEICCGLEDLHR--ERIVYRDLKPENIL--LD----DHGHI--------------------RISDLGLAVH---------VPEGQTIKG---RVGTVGYMAPEV----VK--------NERYTFSPDWWALGCLLYEMIA-GQ-SP---------------FQ-QR---------KKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------------------------------------------PQARSLCSQLLCKDPAERLGCR--GGSAR-EVKEHPLF-------------------------------------------------------
---F-TEFRVLGKGGFGEV---CAVQV---K----N-T-GK---MYACKKLDKKR-LKKKG--GE-KMAL------LEKEILEKV-S------SPF-----IVSLAYAFE--S-----------------------------KTHLC--LVMSLMNGG--DLKFHIYN-------VGTR--GL---DMSRVIFYSAQIACGMLHLHE--LGIVYRDMKPENVL--LD----DLGNC--------------------RLSDLGLAVE---------MKGGKPITQ---RAGTNGYMAPEI----LM-------EKVSYSYPVDWFAMGCSIYEMVA-GR-TP---------------FK-DY--------KEKVSKEDLKQRTLQDEVKFQHDNF---T-----------------------------------------------------------------------EEAKDICRLFLAKKPEQRLG-------SR-E-------KSDDPR-------------------------------------------------
----YTDIKVIGNGSFGVV---YQARL---A----E-T-RE---LVAIKKVLQDK-RFKNR----------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT--------KAKL--TI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLL--VD---PDTAVL--------------------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPEL----IF-------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-------PL-EACAHSFF-------------------------------------------------------
----YTDTKVIGNGSFGVV---YQAKL---C----D-S-GE---LVAIKKVLQDK-RFKNR----------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHY-----SRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLL--LD---PDTAVL--------------------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPEL----IF-------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FP-GD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-------PL-EACAHSFF-------------------------------------------------------
----YEVLEFLGRGTFGQV---AKCWK---R----S-T-KE---IVAIKILKNHP-SYARQ--GQ-I----------EVSILSRL-S------SENADEYNFVRSYECFQ--H-----------------------------KNHTC--LVFEMLEQ---NLYDFLKQ-------NKFS--PL---PLKYIRPILQQVATALMKLKS--LGLIHADLKPENIM--LV----DPVRQPY----------------RVKVIDFGSAS----------HVSKAVCST---YLQSRYYRAPEI----IL--------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE------ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT-------PL-KTLNHQFV-------------------------------------------------------
----YEVLEFLGRGTFGQV---VKCWK---R----G-T-NE---IVAIKILKNHP-SYARQ--GQ-I----------EVSILARL-STE-SADDYN-----FVRAYECFQ--H-----------------------------KNHTC--LVFEMLEQ---NLYDFLKQ-------NKFS--PL---PLKYIRPVLQQVATALMKLKS--LGLIHADLKPENIM--LV----DPSRQPY----------------RVKVIDFGSAS----------HVSKAVCST---YLQSRYYRAPEI----IL--------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------SEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKE------ARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRIT-------PI-ETLNHPFV-------------------------------------------------------
----YEVLDFLGRGTFGQV---VKCWK---R----G-T-NE---IVAIKILKNHP-SYARQ--GQ-I----------EVSILARL-S------TENADEYNFVRAYECFQ--H-----------------------------RNHTC--LVFEMLEQ---NLYDFLKQ-------NKFS--PL---PLKVIRPILQQVATALKKLKS--LGLIHADLKPENIM--LV----DPVRQPY----------------RVKVIDFGSAS----------HVSKTVCST---YLQSRYYRAPEI----IL--------GLPFCEAIDMWSLGCVIAELFL-GW-PL---------------YP-GA---------LEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKE------ARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRIT-------PA-ETLNHPFV-------------------------------------------------------
----YDIIEVLGKGTFGEV---AKGWR---R----S-T-GE---MVAIKILKNDA-YRNRI--IK-N----------ELKLLHCM-RGL-DPEEAH-----VIRFLEFFH--D-----------------------------ALKFY--LVFELLEQ---NLFEFQK----------EN--NFAPLPARHIRTVTLQVLTALARLKE--LAIIHADLKPENIM--LV----DQTRCPF----------------RVKVIDFGSASIF--------SEVRYVKEP---YIQSRFYRAPEI----LL--------GLPFCEKVDVWSLGCVMAELHL-GW-PL---------------YP-GN---------NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-------PS-AALRHPFV-------------------------------------------------------
-IGS----RKLGEGSFAKV---REGLH---V----L-T-GE---KVAIKVIDKKR-AKKDT--YV-TKNLR-----REGQIQQMI-R------HPN-----ITQLLDILE--T-----------------------------ENSYY--LVMELCPGG--NLMHKIY---------EKK--RL---EESEARRYIRQLISAVEHLHR--AGVVHRDLKIENLL--LD----EDNNI--------------------KLIDFGLSNCAG------ILGYSDPFST---QCGSPAYAAPEL----LA--------RKKYGPKIDVWSIGVNMYAMLT-GT-LP---------------FT-VE----------PFSLRALYQKMVD-KEMNPLPTQ--LS-----------------------------------------------------------------------TGAISFLRSLLEPDPVKRPN-------IQ-QALANRWL-------------------------------------------------------
----YTTIRQLGDGTYGSV---LLGRS---I----E-S-GE---LIAIKKMKRKF-YSWEE--C--MNLR-------EVKSLKKL-N------HAN-----VVKLKEVIR--E-----------------------------NDHLY--FIFEYMKE---NLYQLIK--------ERNK--LF---PESAIRNIMYQILQGLAFIHK--HGFFHRDLKPENLL--CM----GPELV--------------------KIADFGLARE---------IRSKPPYTD---YVSTRWYRAPEV----LL-------RSTNYSSPIDVWAVGCIMAEVYT-LR-PL---------------FP-GA---------SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV------------------------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPT-------AS-QALRYPYF-------------------------------------------------------
---W-HTDDLLGQGATASV---YKARN---K----K-S-GE---LVAVKVFNTTS-YLRPR--EV--QVR-------EFEVLRKL-N------HQN-----IVKLFAVEE--TG---------------------------GSRQKV--LVMEYCSSG--SLLSVLES------PENAF--GL---PEDEFLVVLRCVVAGMNHLRE--NGIVHRDIKPGNIMRLVG----EEGQSI------------------YKLTDFGAARE---------LDDDEKFVS---VYGTEEYLHPDM----YERAVLRKPQQKAFGVTVDLWSIGVTLYHAAT-GS-LP---------------FI-PF--------GGPRRNKEIMYRITTEKPAGAIA-------------------------------------------------------------------------------------------------------------------GAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFAET
----LKFLQQLGKGNFGSV---EMCRY---DPLQDN-T-GE---VVAVKKLQ-HS-TE--EHLRD-FE-R-------EIEILKSL-Q------HDN-----IVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ----------KHKERI---DHIKLLQYTSQICKGMEYLGT--KRYIHRDLATRNIL--VE----NENRV--------------------KIGDFGLTKVL---PQ---D--KEYYKVKEPGESPIFWYAPES----LT--------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQG-QM---------IVFHLIELLKNNGRLPRPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-------FR-DLA----LRV-----------------------------------------------------
---L-KYISQLGKGNFGSV---ELCRY---DPLGDN-T-GA---LVAVKQLQ-HS-GP-DQ-QRD-FQ-R-------EIQILKAL-H------SDF-----IVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ----------RHRARL---DASRLLLYSSQICKGMEYLGS--RRCVHRDLAARNIL--VE----SEAHV--------------------KIADFGLAKLL---PL---D--KDYYVVREPGQSPIFWYAPES----LS--------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCER-DV-P-------ALCRLLELLEEGQRLPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-------FS-ALGP---QL------------------------------------------------------
----YEIDRTIGKGNFAVV---KRATH---L----V-T-KA---KVAIKIIDKTQ-LDEEN--LK-KIFR-------EVQIMKML-C------HPH-----IIRLYQVME--T-----------------------------ERMIY--LVTEYASGG--EIFDHLV---------AHG--RM---AEKEARRKFKQIVTAVYFCHC--RNIVHRDLKAENLL--LD----ANLNI--------------------KIADFGFSNL---------FTPGQLLKT---WCGSPPYAAPEL----FE-------GKEYDGPKVDIWSLGVVLYVLVC-GA-LP---------------FD-GS------------TLQNLRARVLSGKFRIPFFMS---------------------------------------------------------------------------TECEHLIRHMLVLDPNKRLS-------ME-QICKHKWM-------------------------------------------------------
----YTTMRQLGDGTYGSV---LMGKS---N----E-S-GE---LVAIKRMKRKF-YSWDE--CM--NLR-------EVKSLKKL-N------HAN-----VIKLKEVIR--E-----------------------------NDHLY--FIFEYMKE---NLYQLMK--------DRNK--LF---PESVIRNIMYQILQGLAFIHK--HGFFHRDMKPENLL--CM----GPELV--------------------KIADFGLARE---------LRSQPPYTD---YVSTRWYRAPEV----LL-------RSSVYSSPIDVWAVGSIMAELYM-LR-PL---------------FP-GT---------SEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV------------------------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPT-------AS-QALKHPYF-------------------------------------------------------
----FEKISELGAGNGGVV---FKVSH---K----P-S-GL----VMARKLIHLE-IKPAI--RN-QIIR-------ELQVLHEC-N------SPY-----IVGFYGAFY--S-----------------------------DGEIS--ICMEHMDGG--SLDQVLK---------KAG--RI---PEQILGKVSIAVIKGLTYLRE-KHKIMHRDVKPSNIL--VN----SRGEI--------------------KLCDFGVSG----------QLIDSMANS---FVGTRSYMSPER----LQ--------GTHYSVQSDIWSMGLSLVEMAV-GR-YP---------------IP-PP---------DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE----------------------------------LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-------LK-QLMVHAFI-------------------------------------------------------
-IRY---RDTLGHGNGGTV---YKAYH---V----P-S-GK---ILAVKVILLDI-TLELQ--KQ-I-MS-------ELEILYKC-D------SSY-----IIGFYGAFF--V-----------------------------ENRIS--ICTEFMDGG--SLD-------------VYR--KM---PEHVLGRIAVAVVKGLTYLWS--LKILHRDVKPSNML--VN----TRGQV--------------------KLCDFGVST----------QLVNSIAKT---YVGTNAYMAPER----IS--------GEQYGIHSDVWSLGISFMELAL-GR-FP---------------YP-QI---------QKNQGSLMPLQLLQCIVDEDSPVLPVGEF---------------------------------------------------------------------SEPFVHFITQCMRKQPKERPA-------PE-ELMGHPFI-------------------------------------------------------
--WL--KGQQIGLGAFSSC---YQAQD---V----G-T-GT---LMAVKQVTYVR-NTSSE--QE-EVVEAL---REEIRMMSHL-N------HPN-----IIRMLGATC--E-----------------------------KSNYN--LFIEWMAGG--SVAHLLS---------KYG--AF---KESVVINYTEQLLRGLSYLHE--NQIIHRDVKGANLL--ID----STGQR-------------------LRIADFGAAARLAS----KGTGAGEFQGQ---LLGTIAFMAPEV----LR--------GQQYGRSCDVWSVGCAIIEMAC-AK-PP---------------WN-AE---------KHSNHLALIFKIASATTAPSIPSHLS-------------------------------------------------------------------------PGLRDVALRCLELQPQDRPP-------SR-ELLKHPVF-------------------------------------------------------
-ERV-----VLGKGTYGIV---YAGRD---L----S-N-QV---RIAIKEIPERD-SRYSQ--PL-H--E-------EIALHKYL-K------HRN-----IVQYLGSVS--E-----------------------------NGYIK--IFMEQVPGG--SLSALLR--------SKWG--PM---KEPTIKFYTKQILEGLKYLHE--NQIVHRDIKGDNVL--VN---TYSGVV--------------------KISDFGTSKRL--------AGVNPCTET---FTGTLQYMAPEI----ID------QGPRGYGAPADIWSLGCTIIEMAT-SK-PP---------------FH-EL-----------GEPQAAMFKVGMFKIHPEIPEALS-------------------------------------------------------------------------AEARAFILSCFEPDPHKRAT-------TA-ELLREGF-L------------------------------------------------------
----WRLGKLLGQGAFGRV---YLCYD---V----D-T-GR---ELAVKQVQFDP-DSPET--SK-EVNAL----ECEIQLLKNL-L------HER-----IVQYYGCLR--DP---------------------------QEKTLS--IFMEYMPGG--SIKDQLK---------AYG--AL---TENVTRKYTRQILEGVHYLHS--NMIVHRDIKGANIL--RD----STGNV--------------------KLGDFGASKRLQ-----TICLSGTGMKS---VTGTPYWMSPEV----IS--------GEGYGRKADIWSVACTVVEMLT-EK-PP---------------WA-EF------------EAMAAIFKIATQPTNPKLPPHVS-------------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS-------AD-ELLRHMF-V------------------------------------------------------
---W-RRGKLLGQGAFGRV---YLCYD---V----D-T-GR---ELASKQVQFDP-DSPET--SK-EVSAL----ECEIQLLKNL-Q------HER-----IVQYYGCLR--DR---------------------------AEKTLT--IFMEYMPGG--SVKDQLK---------AYG--AL---TESVTRKYTRQILEGMSYLHS--NMIVHRDIKGANIL--RD----SAGNV--------------------KLGDFGASKRLQ-----TICMSGTGMRS---VTGTPYWMSPEV----IS--------GEGYGRKADVWSLGCTVVEMLT-EK-PP---------------WA-EY------------EAMAAIFKIATQPTNPQLPSHIS-------------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS-------AE-ELLTHHF-A------------------------------------------------------
---W-QRGNKIGEGQYGKV---YTCIS---V----D-T-GE---LMAMKEIRFQP-NDHKT--IK-ETAD-------ELKIFEGI-K------HPN-----LVRYFGVEL--H-----------------------------REEMY--IFMEYCDEG--TLEEVS-----------RL--GL---QEHVIRLYSKQITIAINVLHE--HGIVHRDIKGANIF--LT----SSGLI--------------------KLGDFGCSVKLKN----NAQTMPGEVNS---TLGTAAYMAPEV----ITR-----AKGEGHGRAADIWSLGCVVIEMVT-GK-RP---------------WH-EY----------EHNFQIMYKVGMGHKPPIPERLS---------------------------------------------------------------------------PEGKDFLSHCLESDPKMRWT-------AS-QLLDHSFV-------------------------------------------------------
-DRV-----VLGKGTYGIV---YAGRD---L----S-N-QV---RIAIKEIPERD-SRYSQ--PL-H--E-------EIALHKHL-K------HKN-----IVQYLGSFS--E-----------------------------NGFIK--IFMEQVPGG--SLSALLR--------SKWG--PLK-DNEQTIGFYTKQILEGLKYLHD--NQIVHRDIKGDNVL--IN---TYSGVL--------------------KISDFGTSKRL--------AGINPCTET---FTGTLQYMAPEI----ID------KGPRGYGKAADIWSLGCTIIEMAT-GK-PP---------------FY-EL-----------GEPQAAMFKVGMFKVHPEIPESMS-------------------------------------------------------------------------AEAKAFILKCFEPDPDKRAC-------AN-DLLVDEF-L------------------------------------------------------
-ERL-----VLGKGTYGVV---YAGRD---R----H-T-RV---RIAIKEIPERD-SRFSQ--PL-H--E-------EIALHRRL-R------HKN-----IVRYLGSAS--Q-----------------------------GGYLK--IFMEEVPGG--SLSSLLR--------SVWG--PLK-DNESTISFYTRQILQGLGYLHD--NHIVHRDIKGDNVL--IN---TFSGLL--------------------KISDFGTSKRL--------AGITPCTET---FTGTLQYMAPEI----ID------QGPRGYGKAADIWSLGCTVIEMAT-GR-PP---------------FH-EL-----------GSPQAAMFQVGMYKVHPPMPSSLS-------------------------------------------------------------------------AEAQAFLLRTFEPDPRLRAS-------AQ-TLLGDPFL-------------------------------------------------------
----YTNLSYIGEGAYGMV---CSAYD---N----V-N-KV---RVAIKKISPFE-HQTYC--QR-T-LR-------EIKILLRF-R------HEN-----IIGINDIIR--APT------------------------IEQMKDVY--IVQDLMET---DLYKLLK----------TQ--HL---SNDHICYFLYQILRGLKYIHS--ANVLHRDLKPSNLL--LN----TTCDL--------------------KICDFGLARVAD-----PDHDHTGFLTE---YVATRWYRAPEI----ML-------NSKGYTKSIDIWSVGCILAEMLS-NR-PI---------------FP-GK---------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------------------------------------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-------VE-QALAHPYL-------------------------------------------------------
----YQNLKPIGSGAQGIV---CAAYD---A----V-L-DR---NVAIKKLSRPF-QNQTH--AK-RAYR-------ELVLMKCV-N------HKN-----IISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ-----------M--EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIV--VK----SDCTL--------------------KILDFGLART---------AGTSFMMTP---YVVTRYYRAPEV----IL--------GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FP-GR---------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-------VD-DALQHPYI-------------------------------------------------------
----YRDLQPVGSGAYGAV---CSAVD---G----R-T-GA---KVAIKKLYRPF-QSELF--AK-RAYR-------ELRLLKHM-R------HEN-----VIGLLDVFT--PDET-----------------------LDDFTDFY--LVMPFMGT---DLGKLMK----------HE--KL---GEDRIQFLVYQMLKGLRYIHA--AGIIHRDLKPGNLA--VN----EDCEL--------------------KILDFGLAR-----------QADSEMTG---YVVTRWYRAPEV----IL-------NWMRYTQTVDIWSVGCIMAEMIT-GK-TL---------------FK-GS---------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------------------------------------------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-------AG-EALAHPYF-------------------------------------------------------
YVSP----THVGSGAYGSV---CSAID---K----R-S-GE---KVAIKKLSRPF-QSEIF--AK-RAYR-------ELLLLKHM-Q------HEN-----VIGLLDVFT--PASS-----------------------LRNFYDFY--LVMPFMQT---DLQKIM-----------GM--EF---SEEKIQYLVYQMLKGLKYIHS--AGVVHRDLKPGNLA--VN----EDCEL--------------------KILDFGLAR-----------HADAEMTG---YVVTRWYRAPEV----IL-------SWMHYNQTVDIWSVGCIMAEMLT-GK-TL---------------FK-GK---------DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP-----------------------------------------------RKDFTQLFPRASPQAADLLEKMLELDVDKRLT-------AA-QALTHPFF-------------------------------------------------------
----YQNLSPVGSGAYGSV---CAAFD---T----K-T-GL---RVAVKKLSRPF-QSIIH--AK-RTYR-------ELRLLKHM-K------HEN-----VIGLLDVFT--PARS-----------------------LEEFNDVY--LVTHLMGA---DLNNIVK----------CQ--KL---TDDHVQFLIYQILRGLKYIHS--ADIIHRDLKPSNLA--VN----EDCEL--------------------KILDFGLAR-----------HTDDEMTG---YVATRWYRAPEI----ML-------NWMHYNQTVDIWSVGCIMAELLT-GR-TL---------------FP-GT---------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------------------------------------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-------AA-QALAHAYF-------------------------------------------------------
----YQNLKPIGSGAQGIV---CAAYD---A----I-L-ER---NVAIKKLSRPF-QNQTH--AK-RAYR-------ELVLMKCV-N------HKN-----IIGLLNVFT--PQKS-----------------------LEEFQDVY--IVMELMDA---NLCQVIQ-----------M--EL---DHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIV--VK----SDCTL--------------------KILDFGLART---------AGTSFMMTP---YVVTRYYRAPEV----IL--------GMGYKENVDLWSVGCIMGEMVC-HK-IL---------------FP-GR---------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEK------------------------------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-------VD-EALQHPYI-------------------------------------------------------
-KVT---SQVLGLGINGKV---LQIFN---K----R-T-QE---KFALKMLQDCP-KAR----------R-------EVELHWRASQ------CPH-----IVRIVDVYE--NLY-------------------------AGRKCLL--IVMECLDGG--ELFSRIQD-------RGDQ--AF---TEREASEIMKSIGEAIQYLHS--INIAHRDVKPENLL--YT----SKRPNA-----------------ILKLTDFGFAKE---------TTSHNSLTT---PCYTPYYVAPEV----LG--------PEKYDKSCDMWSLGVIMYILLC-GY-PP---------------FY-SN--------HGLAISPGMKTRIRMGQYEFPNPEWSEVS-----------------------------------------------------------------------EEVKMLIRNLLKTEPTQRMT-------IT-EFMNHPWI-------------------------------------------------------
----YRLQKTIGKGNFAKV---KLARH---V----L-T-GR---EVAVKIIDKTQ-LNPTS--LQ-KLFR-------EVRIMKIL-N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEYASGG--EVFDYLV---------AHG--RM---KEKEARAKFRQIVSAVQYCHQ--KYIVHRDLKAENLL--LD----GDMNI--------------------KIADFGFSNE---------FTVGNKLDT---FCGSPPYAAPEL----FQ-------GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ------------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCENLLKKLLVLNPIKRGS-------LE-QIMKDRWM-------------------------------------------------------
----YRLLKTIGKGNFAKV---KLARH---I----L-T-GK---EVAVKIIDKTQ-LNSSS--LQ-KLFR-------EVRIMKVL-N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEYASGG--EVFDYLV---------AHG--RM---KEKEARAKFRQIVSAVQYCHQ--KFIVHRDLKAENLL--LD----ADMNI--------------------KIADFGFSNE---------FTFGNKLDT---FCGSPPYAAPEL----FQ-------GKKYDGPEVDVWSLGVILYTLVS-GS-LP---------------FD-GQ------------NLKELRERVLRGKYRIPFYMS---------------------------------------------------------------------------TDCENLLKKFLILNPSKRGT-------LE-QIMKDRWM-------------------------------------------------------
----YRLLRTIGKGNFAKV---KLARH---I----L-T-GR---EVAIKIIDKTQ-LNPSS--LQ-KLFR-------EVRIMKGL-N------HPN-----IVKLFEVIE--T-----------------------------EKTLY--LVMEYASAG--EVFDYLV---------SHG--RM---KEKEARAKFRQIVSAVHYCHQ--KNIVHRDLKAENLL--LD----AEANI--------------------KIADFGFSNE---------FTLGSKLDT---FCGSPPYAAPEL----FQ-------GKKYDGPEVDIWSLGVILYTLVS-GS-LP---------------FD-GH------------NLKELRERVLRGKYRVPFYMS---------------------------------------------------------------------------TDCESILRRFLVLNPAKRCT-------LE-QIMKDKWI-------------------------------------------------------
-IEP---DRPIGYGAFGVV---WSVTD---P----R-D-GK---RVALKKMPNVF-QNLVS--CK-RVFR-------ELKMLCFF-K------HDN-----VLSALDILQ--PPH------------------------IDYFEEIY--VVTELMQS---DLHKIIV---------SPQ--PL---SSDHVKVFLYQILRGLKYLHS--AGILHRDIKPGNLL--VN----SNCVL--------------------KICDFGLARVE-------ELDESRHMTQ---EVVTQYYRAPEI----LM-------GSRHYSNAIDIWSVGCIFAELLG-RR-IL---------------FQ-AQ---------SPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------------------------------------------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-------AK-DALAHPYL-------------------------------------------------------
----YELQETLGKGTYGKV---KRATE---R----F-S-GR---VVAIKSIRKDK-IKDEQ--DM-VHIR------REIEIMSSL-N------HPH-----IISIYEVFE--N-----------------------------KDKIV--IIMEYASKG--ELYDYIS---------ERR--RL---SERETRHFFRQIVSAVHYCHK--NGVVHRDLKLENIL--LD----DNCNI--------------------KIADFGLSNL---------YQKDKFLQT---FCGSPLYASPEI----VN-------GRPYRGPEVDSWALGVLLYTLVY-GT-MP---------------FD-GF------------DHKNLIRQISSGEYREPTQP----------------------------------------------------------------------------SDARGLIRWMLMVNPDRRAT-------IE-DIANHWW-V------------------------------------------------------
----YEFLETLGKGTYGKV---KKARE---S----S-G-R----LVAIKSIRKDK-IKDEQ--DL-MHIR------REIEIMSSL-N------HPH-----IIAIHEVFE--N-----------------------------SSKIV--IVMEYASRG--DLYDYIS---------ERQ--QL---SEREARHFFRQIVSAVHYCHQ--NRVVHRDLKLENIL--LD----ANGNI--------------------KIADFGLSNL---------YHQGKFLQT---FCGSPLYASPEI----VN-------GKPYTGPEVDSWSLGVLLYILVH-GT-MP---------------FD-GH------------DHKILVKQISNGAYREPPK-----P-----------------------------------------------------------------------SDACGLIRWLLMVNPTRRAT-------LE-DVASHWW-V------------------------------------------------------
----YTRFEKIGQGASGTV---YTAMD---V----A-T-GQ---EVAIKQMNLQQ-QPKKE--LI-I--N-------EILVMREN-K------NPN-----IVNYLDSYL--V-----------------------------GDELW--VVMEYLAGG--SLTDVVT----------ET--CM---DEGQIAAVCRECLQALEFLHS--NQVIHRDIKSDNIL--LG----MDGSV--------------------KLTDFGFCAQI--------TPEQSKRST---MVGTPYWMAPEV----VT--------RKAYGPKVDIWSLGIMAIEMIE-GE-PP---------------YL-NE---------NPLRALYLIATNGTPELQNPEKLS---------------------------------------------------------------------------AIFRDFLNRCLEMDVEKRGS-------AK-ELLQHQFL-------------------------------------------------------
----YTRYEKIGQGASGTV---FTATD---V----A-L-GQ---EVAIKQINLQK-QPKKE--LI-I--N-------EILVMKEL-K------NPN-----IVNFLDSYL--V-----------------------------GDELF--VVMEYLAGG--SLTDVVT----------ET--CM---DEAQIAAVCRECLQALEFLHA--NQVIHRDIKSDNVL--LG----MEGSV--------------------KLTDFGFCAQI--------TPEQSKRST---MVGTPYWMAPEV----VT--------RKAYGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE---------NPLRALYLIATNGTPELQNPEKLS---------------------------------------------------------------------------PIFRDFLNRCLEMDVEKRGS-------AK-ELLQHPFL-------------------------------------------------------
----YTRFEKIGQGASGTV---YTALD---I----A-T-GQ---EVAIKQMNLQQ-QPKKE--LI-I--N-------EILVMREN-K------NPN-----IVNYLDSYL--V-----------------------------GDELW--VVMEYLAGG--SLTDVVT----------ET--CM---DEGQIAAVCRECLQALDFLHS--NQVIHRDIKSDNIL--LG----MDGSV--------------------KLTDFGFCAQI--------TPEQSKRST---MVGTPYWMAPEV----VT--------RKAYGPKVDIWSLGIMAIEMVE-GE-PP---------------YL-NE---------NPLRALYLIATNGTPELQNPERLS---------------------------------------------------------------------------AVFRDFLNRCLEMDVDRRGS-------AK-ELLQHPFL-------------------------------------------------------
DNFI-----KIGEGSTGIV---CIATV---R----S-S-GK---LVAVKKMDLRK-QQRRE--L---LFN-------EVVIMRDY-Q------HEN-----VVEMYNSYL--V-----------------------------GDELW--VVMEFLEGG--ALTDIVT----------HT--RM---NEEQIAAVCLAVLQALSVLHA--QGVIHRDIKSDSIL--LT----HDGRV--------------------KLSDFGFCAQV--------SKEVPRRKS---LVGTPYWMAPEL----IS--------RLPYGPEVDIWSLGIMVIEMVD-GE-PP---------------YF-NE---------PPLKAMKMIRDNLPPRLKNLHKVS---------------------------------------------------------------------------PSLKGFLDRLLVRDPAQRAT-------AA-ELLKHPFL-------------------------------------------------------
DSYV-----KIGEGSTGIV---CLARE---K----H-S-GR---QVAVKMMDLRK-QQRRE--L---LFN-------EVVIMRDY-Q------HFN-----VVEMYKSYL--V-----------------------------GEELW--VLMEFLQGG--ALTDIVS----------QV--RL---NEEQIATVCEAVLQALAYLHA--QGVIHRDIKSDSIL--LT----LDGRV--------------------KLSDFGFCAQI--------SKDVPKRKS---LVGTPYWMAPEV----IS--------RSLYATEVDIWSLGIMVIEMVD-GE-PP---------------YF-SD---------SPVQAMKRLRDSPPPKLKNSHKVS---------------------------------------------------------------------------PVLRDFLERMLVRDPQERAT-------AQ-ELLDHPFL-------------------------------------------------------
---Y-IKLDKLGEGTYATV---YKGKS---K----L-T-DN---LVALKEIRLEH-EEGAP--C--TAIR-------EVSLLKDL-K------HAN-----IVTLHDIIH--T-----------------------------EKSLT--LVFEYLDK---DLKQYLD--------DCGN--II---NMHNVKLFLFQLLRGLAYCHR--QKVLHRDLKPQNLL--IN----ERGEL--------------------KLADFGLARAK--------SIPTKTYSN---EVVTLWYRPPDI----LL-------GSTDYSTQIDMWGVGCIFYEMAT-GR-PL---------------FP-GS---------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR------------------------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRIS-------AE-DAMKHPFF-------------------------------------------------------
---Y-IKLEKLGEGTYATV---YKGRS---K----L-T-EN---LVALKEIRLEH-EEGAP--C--TAIR-------EVSLLKDL-K------HAN-----IVTLHDIVH--T-----------------------------DKSLT--LVFEYLDK---DLKQYMD--------DCGN--IM---SMHNVKLFLYQILRGLAYCHR--RKVLHRDLKPQNLL--IN----EKGEL--------------------KLADFGLARAK--------SVPTKTYSN---EVVTLWYRPPDV----LL-------GSSEYSTQIDMWGVGCIFFEMAS-GR-PL---------------FP-GS---------TVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYK------------------------------------------------PQPLINHAPRLDSEGIELITKFLQYESKKRVS-------AE-EAMKHVYF-------------------------------------------------------
----YVKLDKLGEGTYATV---FKGRS---K----L-T-EN---LVALKEIRLEH-EEGAP--C--TAIR-------EVSLLKNL-K------HAN-----IVTLHDLIH--T-----------------------------DRSLT--LVFEYLDS---DLKQYLD---------HCG--NL--MSMHNVKIFMFQLLRGLAYCHH--RKILHRDLKPQNLL--IN----ERGEL--------------------KLADFGLARAK--------SVPTKTYSN---EVVTLWYRPPDV----LL-------GSTEYSTPIDMWGVGCIHYEMAT-GR-PL---------------FP-GS---------TVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYL------------------------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKSRMS-------AE-AALSHSYF-------------------------------------------------------
---F-KFGKILGEGSFSTV---VLARE---L----A-T-SR---EYAIKILEKRH-IIKEN--KVPYVTR-------ERDVMSRL-D------HPF-----FVKLYFTFQ--D-----------------------------DEKLY--FGLSYAKNG--ELLKYIR---------KIG--SF---DETCTRFYTAEIVSALEYLHG--KGIIHRDLKPENIL--LN----EDMHI--------------------QITDFGTAKVLS------PESKQARANS---FVGTAQYVSPEL----LT--------EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FR-AG------------NEYLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF--------------------------------------------
----YEKLEKLGEGSYATV---YKGKS---K----V-N-GK---LVALKVIRLQE-EEGTP--F--TAIR-------EASLLKGL-K------HAN-----IVLLHDIIH--T-----------------------------KETLT--LVFEYVHT---DLCQYMD--------KHPG--GL---HPDNVKLFLFQLLRGLSYIHQ--RYILHRDLKPQNLL--IS----DTGEL--------------------KLADFGLARAK--------SVPSHTYSN---EVVTLWYRPPDV----LL-------GSTEYSTCLDMWGVGCIFVEMIQ-GV-AA---------------FP-GM--------KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS----------------------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLS-------AQ-AALSHEYF-------------------------------------------------------
----YEPKEILGRGVSSVV---RRCIH---K----P-T-SQ---EYAVKVIDVTG-GGSFS--PE-EVRELREATLKEVDILRKVSG------HPN-----IIQLKDTYE--T-----------------------------NTFFF--LVFDLMKRG--ELFDYLT---------EKV--TL---SEKETRKIMRALLEVICTLHK--LNIVHRDLKPENIL--LD----DNMNI--------------------KLTDFGFSCQ---------LEPGERLRE---VCGTPSYLAPEI----IECS--MNEDHPGYGKEVDMWSTGVIMYTLLA-GS-PP---------------FW-HR------------KQMLMLRMIMSGNYQFGSPEWDDYS-----------------------------------------------------------------------DTVKDLVSRFLVVQPQNRYT-------AE-EALAHPFF-------------------------------------------------------
-YDP---KDVIGRGVSSVV---RRCVH---R----A-T-GH---EFAVKIMEVTA-ERLSP--EQ-LEEVREA-TRRETHILRQVAG------HPH-----IITLIDSYE--S-----------------------------SSFMF--LVFDLMRKG--ELFDYLT---------EKV--AL---SEKETRSIMRSLLEAVSFLHA--NNIVHRDLKPENIL--LD----DNMQI--------------------RLSDFGFSCH---------LEPGEKLRE---LCGTPGYLAPEI----LKCS--MDETHPGYGKEVDLWACGVILFTLLA-GS-PP---------------FW-HR------------RQILMLRMIMEGQYQFSSPEWDDRS-----------------------------------------------------------------------STVKDLISRLLQVDPEARLT-------AE-QALQHPFF-------------------------------------------------------
----YQVGAVLGSGGFGTV---YAGSR---I----A-D-GL---PVAVKHVVKER-VTEWG--SL-GGATV----PLEVVLLRKV-GAA--GGARG-----VIRLLDWFE--R-----------------------------PDGFL--LVLERPEPA-QDLFDFIT---------ERG--AL---DEPLARRFFAQVLAAVRHCHS--CGVVHRDIKDENLL--VD---LRSGEL--------------------KLIDFGSGA----------LLKDTVYTD---FDGTRVYSPPEW----IR-------YHRYHGRSATVWSLGVLLYDMVC-GD-IP---------------FE-QD------------------EEILRGRLLFRRRVS---------------------------------------------------------------------------PECQQLIRWCLSLRPSERPS-------LD-QIAAHPWM-------------------------------------------------------
--FR--CCAVLGRGHFGKV---LLAEY---K----N-T-NE---MFAIKALKKGD-IVARD--EV-DSLM------CEKRIFETV-NS---VRHPF-----LVNLFACFQ--T-----------------------------KEHVC--FVMEYAAGG--DLMMHIH----------TD--VF---SEPRAVFYAACVVLGLQYLHE--HKIVYRDLKLDNLL--LD----TEGFV--------------------KIADFGLCKEG--------MGYGDRTST---FCGTPEFLAPEV----LT--------ETSYTRAVDWWGLGVLIYEMLV-GE-SP---------------FP-GD------------DEEEVFDSIVNDEVRYPRFLS---------------------------------------------------------------------------TEAISIMRRLLRRNPERRLGAS--EKDAE-DVKKHPFF-------------------------------------------------------
--YV--RGRFLGKGGFAKC---FEISD---A----D-T-KE---VFAGKIVPKSL-LLKPH--QR-EKMS------MEISIHRSL-A------HQH-----VVGFHGFFE--D-----------------------------NDFVF--VVLELCRRR--SLLELHK---------RRK--AL---TEPEARYYLRQIVLGCQYLHR--NRVIHRDLKLGNLF--LN----EDLEV--------------------KIGDFGLATKV--------EYDGERKKT---LCGTPNYIAPEV----LS--------KKGHSFEVDVWSIGCIMYTLLV-GK-PP---------------FE-TS------------CLKETYLRIKKNEYSIPKHIN---------------------------------------------------------------------------PVAASLIQKMLQTDPTARPT-------IN-ELLNDEFF-------------------------------------------------------
---Y-CRGKVLGKGGFAKC---YEMTD---L----T-N-NK---VYAAKIIPHSR-VAKPH--QR-EKID------KEIELHRIL-H------HKH-----VVQFYHYFE--D-----------------------------KENIY--ILLEYCSRR--SMAHILK---------ARK--VL---TEPEVRYYLRQIVSGLKYLHE--QEILHRDLKLGNFF--IN----EAMEL--------------------KVGDFGLAARL--------EPLEHRRRT---ICGTPNYLSPEV----LN--------KQGHGCESDIWALGCVMYTMLL-GR-PP---------------FE-TT------------NLKETYRCIREARYTMPSSLL---------------------------------------------------------------------------APAKHLIASMLSKNPEDRPS-------LD-DIIRHDFF-------------------------------------------------------
--YL--KGRLLGKGGFARC---YEATD---T----E-T-GS---AYAVKVIPQSR-VAKPH--QR-EKIL------NEIELHRDL-Q------HRH-----IVRFSHHFE--D-----------------------------ADNIY--IFLELCSRK--SLAHIWK---------ARH--TL---LEPEVRYYLRQILSGLKYLHQ--RGILHRDLKLGNFF--IT----ENMEL--------------------KVGDFGLAARL--------EPPEQRKKT---ICGTPNYVAPEV----LL--------RQGHGPEADVWSLGCVMYTLLC-GS-PP---------------FE-TA------------DLKETYRCIKQVHYTLPASLS---------------------------------------------------------------------------LPARQLLAAILRASPRDRPS-------ID-QILRHDFF-------------------------------------------------------
---F-NFLMVLGKGSFGKV---MLADR---K----G-T-EE---LYAIKILKKDV-VIQDD--DV-ECTM------VEKRVLALLDK------PPF-----LTQLHSCFQ--T-----------------------------VDRLY--FVMEYVNGG--DLMYHIQ---------QVG--KF---KEPQAVFYAAEISIGLFFLHK--RGIIYRDLKLDNVM--LD----SEGHI--------------------KIADFGMCKEH--------MMDGVTTRT---FCGTPDYIAPEI----IA--------YQPYGKSVDWWAYGVLLYEMLA-GQ-PP---------------FD-GE------------DEDELFQSIMEHNVSYPKSLS---------------------------------------------------------------------------KEAVSVCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF-----------------------------------------
--FI--FHKVLGKGSFGKV---LLGEL---K----G-R-GE---YFAIKALKKDV-VLIDD--DV-ECTM------VEKRVLTLAAE------NPF-----LTHLICTFQ--T-----------------------------KDHLF--FVMEFLNGG--DLMYHIQ---------DKG--RF---ELYRATFYAAEIMCGLQFLHS--KGIIYRDLKLDNVL--LD----RDGHI--------------------KIADFGMCKEN--------IFGESRAST---FCGTPDYIAPEI----LQ--------GLKYTFSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GD------------DEDELFESIRVDTPHYPRWIT---------------------------------------------------------------------------KESKDILEKLFEREPTKRLG------VTG-NIKIHPFF-------------------------------------------------------
---F-NFIKVLGKGSFGKV---MLAEL---K----G-K-DE---VYAVKVLKKDV-ILQDD--DV-DCTM------TEKRILALARK------HPY-----LTQLYCCFQ--T-----------------------------KDRLF--FVMEYVNGG--DLMFQIQ---------RSR--KF---DEPRSRFYAAEVTSALMFLHQ--HGVIYRDLKLDNIL--LD----AEGHC--------------------KLADFGMCKEG--------ILNGVTTTT---FCGTPDYIAPEI----LQ--------ELEYGPSVDWWALGVLMYEMMA-GQ-PP---------------FE-AD------------NEDDLFESILHDDVLYPVWLS---------------------------------------------------------------------------KEAVSILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF-----------------------------------------------------
--FI--LHKMLGKGSFGKV---FLAEF---K----K-T-NQ---FFAIKALKKDV-VLMDD--DV-ECTM------VEKRVLSLAWE------HPF-----LTHMFCTFQ--T-----------------------------KENLF--FVMEYLNGG--DLMYHIQ---------SCH--KF---DLSRATFYAAEIILGLQFLHS--KGIVYRDLKLDNIL--LD----KDGHI--------------------KIADFGMCKEN--------MLGDAKTNT---FCGTPDYIAPEI----LL--------GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FH-GQ------------DEEELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-------VRGDIRQHPLF-------------------------------------------------------
--PD----EVLGSGQFGIV---YGGKH---R----K-T-GR---DVAIKIIDKLR-FPTKQ--ES-QLRN-------EVAILQNL-H------HPG-----VVNLECMFE--T-----------------------------PERVF--VVMEKLHGD--MLEMILS--------SEKG--RL---PEHITKFLITQILVALRHLHF--KNIVHCDLKPENVL--LA----SADPFP-----------------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEV----LR--------NKGYNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED--------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------------------------------------------HEAIDLINNLLQVKMRKRYS-------VD-KTLSHPWL-------------------------------------------------------
--PD----EVLGSGQFGVV---YGGKH---R----K-T-GR---DVAVKVIDKLR-FPTKQ--ES-QLRN-------EVAILQSL-R------HPG-----IVNLECMFE--T-----------------------------PEKVF--VVMEKLHGD--MLEMILS--------SEKG--RL---PERLTKFLITQILVALRHLHF--KNIVHCDLKPENVL--LA----SADPFP-----------------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEV----LL--------NQGYNRSLDMWSVGVIMYVSLS-GT-FP---------------FN-ED--------------EDINDQIQNAAFMYPASPWSHIS-----------------------------------------------------------------------AGAIDLINNLLQVKMRKRYS-------VD-KSLSHPWL-------------------------------------------------------
-FAD----EVLGSGQFGIV---YGGKH---R----K-T-GR---DVAIKVIDKMR-FPTKQ--ES-QLRN-------EVAILQNL-H------HPG-----IVNLECMFE--T-----------------------------PERVF--VVMEKLHGD--MLEMILS--------SEKS--RL---PERITKFMVTQILVALRNLHF--KNIVHCDLKPENVL--LA----SAEPFP-----------------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEV----LR--------SKGYNRSLDMWSVGVIIYVSLS-GT-FP---------------FN-ED--------------EDINDQIQNAAFMYPPNPWREIS-----------------------------------------------------------------------GEAIDLINNLLQVKMRKRYS-------VD-KSLSHPWL-------------------------------------------------------
YNVY----GYTGQGVFSNV---VRARD---N----ARA-NQ---EVAVKIIRNNE-LMQKT--G----LK-------ELEFLKKL-NDADPDDKFH-----CLRLFRHFY--H-----------------------------KQHLC--LVFEPLSM---NLREVLKK------YGKDV--GL---HIKAVRSYSQQLFLALKLLKR--CNILHADIKPDNIL--VN----ESKTI-------------------LKLCDFGSAS----------HVADNDITP---YLVSRFYRAPEI----II--------GKSYDYGIDMWSVGCTLYELYT-GK-IL---------------FP-GK---------TNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVM------------------STINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRIS-------IN-QALQHAFI-------------------------------------------------------
----FELLKVLGQGSFGKVFLVRKVTR---P----D-S-GH---LYAMKVLKKAT-LKVRD--RV-RTKM-------ERDILADV-N------HPF-----VVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS---------KEV--MF---TEEDVKFYLAELALGLDHLHS--LGIIYRDLKPENIL--LD----EEGHI--------------------KLTDFGLSKEA--------IDHEKKAYS---FCGTVEYMAPEV----VN--------RQGHSHSADWWSYGVLMFEMLT-GS-LP---------------FQ-GK------------DRKETMTLILKAKLGMPQFLS---------------------------------------------------------------------------TEAQSLLRALFKRNPANRLGSG--PDGAE-EIKRHV--FY-----------------------------------------------------
----FELLKVLGQGSYGKV---FLVRK---V----K-G-SDAGQLYAMKVLKKAT-LKVRD--RV-RSKM-------ERDILAEV-N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS---------KEV--MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENIL--LD----EEGHI--------------------KITDFGLSKEA--------IDHDKRAYS---FCGTIEYMAPEV----VN--------RRGHTQSADWWSFGVLMFEMLT-GS-LP---------------FQ-GK------------DRKETMALILKAKLGMPQFLS---------------------------------------------------------------------------GEAQSLLRALFKRNPCNRLGAG--IDGVE-EIKRHPFF-------------------------------------------------------
----FELLKVLGQGSFGKV---FLVKK---I----S-G-SDARQLYAMKVLKKAT-LKVRD--RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DLFTRLS---------KEV--MF---TEEDVKFYLAELALALDHLHS--LGIIYRDLKPENIL--LD----EEGHI--------------------KLTDFGLSKES--------IDHEKKAYS---FCGTVEYMAPEV----VN--------RRGHTQSADWWSFGVLMFEMLT-GT-LP---------------FQ-GK------------DRKETMTMILKAKLGMPQFLS---------------------------------------------------------------------------PEAQSLLRMLFKRNPANRLGAG--PDGVE-EIKRHSFF-------------------------------------------------------
----FELLKVLGQGSFGKV---FLVRK---K----T-G-PDAGQLYAMKVLKKAS-LKVRD--RV-RTKM-------ERDILVEV-N------HPF-----IVKLHYAFQ--T-----------------------------EGKLY--LILDFLRGG--DVFTRLS---------KEV--LF---TEEDVKFYLAELALALDHLHQ--LGIVYRDLKPENIL--LD----EIGHI--------------------KLTDFGLSKES--------VDQEKKAYS---FCGTVEYMAPEV----VN--------RRGHSQSADWWSYGVLMFEMLT-GT-LP---------------FQ-GK------------DRNETMNMILKAKLGMPQFLS---------------------------------------------------------------------------AEAQSLLRMLFKRNPANRLGS----EGVE-EIKRHLFF-------------------------------------------------------
----FELLRVLGKGGYGKV---FQVRKVTGA----N-T-GK---IFAMKVLKKAM-IVRNA--KD-TAHTK-----AERNILEEV-K------HPF-----IVDLIYAFQ--T-----------------------------GGKLY--LILEYLSGG--ELFMQLE---------REG--IF---MEDTACFYLAEISMALGHLHQ--KGIIYRDLKPENIM--LN----HQGHV--------------------KLTDFGLCKES--------IHDGTVTHT---FCGTIEYMAPEI----LM--------RSGHNRAVDWWSLGALMYDMLT-GA-PP---------------FT-GE------------NRKKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAG--PGDAG-EVQAHPFF-------------------------------------------------------
----FELLRVLGKGGYGKV---FQVRK---V----Q-G-TNLGKIYAMKVLRKAK-IVRNA--KD-TAHTR-----AERNILESV-K------HPF-----IVELAYAFQ--T-----------------------------GGKLY--LILECLSGG--ELFTHLE---------REG--IF---LEDTACFYLAEITLALGHLHS--QGIIYRDLKPENIM--LS----SQGHI--------------------KLTDFGLCKES--------IHEGAVTHT---FCGTIEYMAPEI----LV--------RSGHNRAVDWWSLGALMYDMLT-GS-PP---------------FT-AE------------NRKKTMDKIIRGKLALPPYLT---------------------------------------------------------------------------PDARDLVKKFLKRNPSQRIGGG--PGDAA-DVQRHPFF-------------------------------------------------------
----YDIERTLGKGNFAVV---KLARH---R----V-T-KT---QVAIKIIDKTR-LDSSN--LE-KIYR-------EVQLMKLL-N------HPH-----IIKLYQVME--T-----------------------------KDMLY--IVTEFAKNG--EMFDYLT---------SNG--HL---SENEARKKFWQILSAVEYCHD--HHIVHRDLKTENLL--LD----GNMDI--------------------KLADFGFGNF---------YKSGEPLST---WCGSPPYAAPEV----FE-------GKEYEGPQLDIWSLGVVLYVLVC-GS-LP---------------FD-GP------------NLPTLRQRVLEGRFRIPFFMS---------------------------------------------------------------------------QDCESLIRRMLVVDPARRIT-------IA-QIRQHRWM-------------------------------------------------------
----YDIEGTLGKGNFAVV---KLGRH---R----I-T-KT---EVAIKIIDKSQ-LDAVN--LE-KIYR-------EVQIMKML-D------HPH-----IIKLYQVME--T-----------------------------KSMLY--LVTEYAKNG--EIFDYLA---------NHG--RL---NESEARRKFWQILSAVDYCHG--RKIVHRDLKAENLL--LD----NNMNI--------------------KIADFGFGNF---------FKSGELLAT---WCGSPPYAAPEV----FE-------GQQYEGPQLDIWSMGVVLYVLVC-GA-LP---------------FD-GP------------TLPILRQRVLEGRFRIPYFMS---------------------------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-------IA-QIKEHKWM-------------------------------------------------------
----YDLDKTLGRGHFAVV---KLARH---V----F-T-GE---KVAVKVIDKTK-LDTLA--TG-HLFQ-------EVRCMKLV-Q------HPN-----IVRLYEVID--T-----------------------------QTKLY--LILELGDGG--DMFDYIM--------KHEE--GL---NEDLAKKYFAQIVHAISYCHK--LHVVHRDLKPENVV--FF---EKQGLV--------------------KLTDFGFSNK---------FQPGKKLTT---SCGSLAYSAPEI----LL-------GDEYDAPAVDIWSLGVILFMLVC-GQ-PP---------------FQ-EA------------NDSETLTMIMDCKYTVPSHVS---------------------------------------------------------------------------KECKDLITRMLQRDPKRRAS-------LE-EIENHPWL-------------------------------------------------------
----WEIVGELGDGAFGKV---YKAKN---K----E-T-GA---LAAAKVIETKS-EEELE--DY-I--V-------EIEILATC-D------HPY-----IVKLLGAYY--H-----------------------------DGKLW--IMIEFCPGG--AVDAIML--------ELDR--GL---TEPQIQVVCRQMLEALNFLHS--KRIIHRDLKAGNVL--MT----LEGDI--------------------RLADFGVSAKN--------LKTLQKRDS---FIGTPYWMAPEV----VMCE---TMKDTPYDYKADIWSLGITLIEMAQ-IE-PP---------------HH-EL---------NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------------------------------------------VEFRDFLKIALDKNPETRPS-------AA-QLLEHPFV-------------------------------------------------------
-YLM---GDLLGEGSYGKV---KEVLD---S----E-T-LC---RRAVKILKKKK-LRRIP--NG-EANVK-----KEIQLLRRL-R------HKN-----VIQLVDVLY--NE---------------------------EKQKMY--MVMEYCVCGMQEMLDSVP----------EK--RF---PVCQAHGYFCQLIDGLEYLHS--QGIVHKDIKPGNLL--LT----TGGTL--------------------KISDLGVAEALH------PFAADDTCRT---SQGSPAFQPPEI----AN------GLDTFSGFKVDIWSAGVTLYNITT-GL-YP---------------FE-GD------------NIYKLFENIGKGSYAIPGDCG---------------------------------------------------------------------------PPLSDLLKGMLEYEPAKRFS-------IR-QIRQHSWF-------------------------------------------------------
----FEILRAIGKGSFGKV---CIVQK---N----D-T-KK---MYAMKYMNKQK-CVERN--EV-RNVF------KELQIMQGL-E------HPF-----LVNLWYSFQ--D-----------------------------EEDMF--MVVDLLLGG--DLRYHLQ---------QNV--HF---KEETVKLFICELVMALDYLQN--QRIIHRDMKPDNIL--LD----EHGHV--------------------HITDFNIAAM---------LPRETQITT---MAGTKPYMAPEMF--SSR-------KGAGYSFAVDWWSLGVTAYELLR-GR-RP---------------YH-IR---------SSTSSKEIVHTFETTVVTYPSAWS---------------------------------------------------------------------------QEMVSLLKKLLEPNPDQRFS------QLS-DVQNFPY-M------------------------------------------------------
----FQILRAIGKGSFGKV---CIVQK---R----D-T-KK---MYAMKYMNKQK-CIERD--EV-RNVF------RELQIMQGL-E------HPF-----LVNLWYSFQ--D-----------------------------EEDMF--MVVDLLLGG--DLRYHLQ---------QNV--HF---TEGTVKLYICELALALEYLQR--YHIIHRDIKPDNIL--LD----EHGHV--------------------HITDFNIATV---------VKGAERASS---MAGTKPYMAPEV----FQVY---MDRGPGYSYPVDWWSLGITAYELLR-GW-RP---------------YE-IH---------SVTPIDEILNMFKVERVHYSSTWC---------------------------------------------------------------------------KGMVALLRKLLTKDPESRVS------SLH-DIQS----VPYL---------------------------------------------------
----FQILRAIGKGSFGKV---CIVQK---R----D-T-EK---MYAMKYMNKQQ-CIERD--EV-RNVF------RELEILQEI-E------HVF-----LVNLWYSFQ--D-----------------------------EEDMF--MVVDLLLGG--DLRYHLQ---------QNV--QF---SEDTVRLYICEMALALDYLRG--QHIIHRDVKPDNIL--LD----ERGHA--------------------HLTDFNIATI---------IKDGERATA---LAGTKPYMAPEIFHSFVN-------GGTGYSFEVDWWSVGVMAYELLR-GW-RP---------------YD-IH---------SSNAVESLVQLFSTVSVQYVPTWS---------------------------------------------------------------------------KEMVALLRKLLTVNPEHRLS-------SL-Q-------DVQAAPA------------------------------------------------
----YHVLEMIGEGSFGRV---YKGRR---K----Y-S-AQ---VVALKFIPKLG-RSEKE--LR-NLQR-------EIEIMRGL-R------HPN-----IVHMLDSFE--T-----------------------------DKEVV--VVTDYAEG---ELFQILE---------DDG--KL---PEDQVQAIAAQLVSALYYLHS--HRILHRDMKPQNIL--LA----KGGGI--------------------KLCDFGFARAM--------STNTMVLTS---IKGTPLYMSPEL----VE--------ERPYDHTADLWSVGCILYELAV-GT-PP---------------FY-AT------------SIFQLVSLILKDPVRWPSTIS---------------------------------------------------------------------------PCFKNFLQGLLTKDPRQRLS-------WP-DLLYHPFI-------------------------------------------------------
----WTKGEILGKGAYGTV---YCGLT---S----Q-G-Q----LIAVKQVALDT-SNKLA--AE-KEYRKL---QEEVDLLKAL-K------HVN-----IVAYLGTCL--Q-----------------------------ENTVS--IFMEFVPGG--SISSIIN---------RFG--PL---PEMVFCKYTKQILQGVAYLHE--NCVVHRDIKGNNVM--LM----PTGII--------------------KLIDFGCARRLAWA--GLNGTHSDMLKS---MHGTPYWMAPEV----IN--------ESGYGRKSDIWSIGCTVFEMAT-GK-PP---------------LA-SM-----------DRMAAMFYIGAHRGLMPPLPDHFS-------------------------------------------------------------------------ENAADFVRMCLTRDQHERPS-------AL-QLLKHSFL-------------------------------------------------------
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