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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CMGC CSNK2A2 40
CMGC MAPK14 24
CAMK MAPKAPK2 64
CAMK PIM1 38
CAMK PIM2 132
--W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK----EICINKML-N----HEN--VVKFYGHRRE------GNIQYLFLEY-CSGG-ELFDRIE--PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
---YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKR---------EVKILENLRG----GTN--IIKLIDTVKDP----VSKTPALVFEY-INNT-DFKQLY-----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL---RLIDWGLAEF---YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQ-DNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF-
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR----ELRLLKHM-K----HEN--VIGLLDVFTPARSLEEFNDVYLVTHL-MGA--DLNNIVK---CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR-----HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFP-GT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R----EVELHWRASQ----CPH--IVRIVDVYENLY--AGRKCLLIVMEC-LDGG-ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLCGYPPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI-
---YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV-S----SGFSGVIRLLDWFER------PDSFVLILER-PEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD----------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM-
---YRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV-GAGGGHPG--VIRLLDWFET------QEGFMLVLERPLPAQ-DLFDYIT--EKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCA---KLIDFGSGA----LLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFE-RD----------QEILEAELHFPAHVS----------------------------------PDCCALIRRCLAPKPSSRPSLEEILLDPWM-
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