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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CMGC CDK2 4
CMGC MAPK14 24
TK SRC 270
W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KKEICINKMLNHENVVKFYGHRRE------GNIQYLFLEYCSGGELFDRIE--PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDASALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK---CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-QEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK---GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
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