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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK CHEK1 203
CMGC GSK3B 56
CMGC MAPK14 24
AGC ROCK2 92
W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK-EICINKMLNHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK---RREFHAEPVDVWSCGIVLTAMLAGELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSA--RITIPDIKKDRW-Y
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR-------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLTPLEACAHSFF-
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDK--RITAAQALAHAYF-
-YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKM-DETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS------------------------KHAKNLICAFLTDREVRLGRNGVEEIRQHPFF-
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